GREMLIN Database
RHAB - Rhamnulokinase
UniProt: O05262 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 485 (464)
Sequences: 12518 (8632)
Seq/√Len: 400.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_P196_E4.3021.00
105_T137_E3.7421.00
19_E23_G3.6781.00
15_I58_G3.4461.00
378_A472_I3.2031.00
108_K137_E3.1541.00
378_A382_K2.9731.00
178_N181_T2.9331.00
418_A462_T2.9161.00
121_K185_D2.8971.00
385_E417_K2.8401.00
91_L142_L2.8141.00
323_T364_E2.8141.00
409_Q413_D2.7851.00
353_Q365_L2.7721.00
177_L202_L2.7521.00
37_F93_E2.7211.00
405_D459_K2.7201.00
394_Q420_Y2.6851.00
163_K201_P2.6801.00
17_V62_V2.6361.00
443_K447_E2.6321.00
204_E207_C2.5921.00
444_D447_E2.5681.00
52_L159_C2.5491.00
92_R139_D2.5061.00
86_E147_D2.4731.00
183_N196_E2.4521.00
49_D159_C2.4491.00
85_D145_K2.4091.00
178_N185_D2.3891.00
189_L196_E2.3321.00
312_S315_Q2.2501.00
186_P190_E2.2351.00
232_T237_S2.2061.00
157_G231_A2.1581.00
16_M428_A2.1551.00
6_I55_I2.1511.00
148_K164_A2.1141.00
464_K467_D2.1101.00
31_H61_K2.0651.00
299_V369_I2.0631.00
31_H57_Q2.0441.00
213_R216_W2.0411.00
49_D89_D2.0241.00
108_K112_T2.0181.00
117_A120_Q1.9681.00
328_Q364_E1.9651.00
416_G468_R1.9531.00
61_K65_L1.9461.00
322_K363_G1.9321.00
361_T364_E1.9271.00
40_R43_H1.9251.00
385_E391_P1.9201.00
4_T59_L1.9071.00
161_T228_M1.9031.00
3_Y436_M1.8891.00
258_S296_G1.8851.00
397_I408_N1.8851.00
311_Y315_Q1.8801.00
4_T15_I1.8781.00
29_E61_K1.8501.00
214_N224_A1.8461.00
8_V13_G1.8381.00
315_Q318_E1.7941.00
229_T438_A1.7781.00
203_T207_C1.7761.00
303_V369_I1.7351.00
249_W394_Q1.7291.00
121_K187_E1.7241.00
85_D89_D1.7221.00
208_E211_K1.7201.00
12_S30_I1.7161.00
88_G158_Y1.7051.00
117_A187_E1.7021.00
420_Y460_V1.6961.00
117_A121_K1.6861.00
413_D464_K1.6801.00
165_V203_T1.6791.00
107_D111_H1.6701.00
418_A460_V1.6621.00
472_I476_Q1.6621.00
104_H108_K1.6541.00
301_Q305_Q1.6431.00
208_E229_T1.6411.00
319_E363_G1.6321.00
265_K285_N1.6211.00
82_V152_I1.6151.00
83_L198_Q1.6131.00
110_E115_K1.6011.00
350_Y357_K1.5791.00
319_E322_K1.5751.00
180_S267_P1.5691.00
3_Y441_E1.5481.00
413_D467_D1.5151.00
63_K66_G1.5061.00
47_D50_H1.5031.00
141_E144_K1.4991.00
382_K385_E1.4981.00
223_P226_K1.4911.00
157_G209_L1.4581.00
20_L441_E1.4511.00
436_M442_V1.4481.00
116_A120_Q1.4461.00
318_E322_K1.4341.00
161_T210_G1.4271.00
52_L56_L1.4121.00
195_L198_Q1.4091.00
34_A50_H1.4081.00
405_D421_A1.4031.00
49_D53_K1.3991.00
330_I474_S1.3931.00
468_R472_I1.3931.00
319_E362_A1.3851.00
367_C371_S1.3811.00
316_L366_A1.3801.00
320_A406_F1.3761.00
84_L150_M1.3721.00
406_F410_L1.3681.00
247_D265_K1.3651.00
374_A410_L1.3591.00
211_K225_C1.3391.00
6_I59_L1.3381.00
71_T435_Q1.3371.00
250_A392_I1.3331.00
189_L199_F1.3241.00
155_Y159_C1.3211.00
103_D107_D1.3191.00
78_A233_H1.3141.00
254_S411_T1.3131.00
394_Q418_A1.3061.00
405_D461_F1.2861.00
375_I474_S1.2851.00
13_G55_I1.2811.00
139_D142_L1.2801.00
168_I182_G1.2771.00
317_A321_K1.2751.00
315_Q319_E1.2651.00
374_A414_M1.2641.00
374_A411_T1.2641.00
252_I411_T1.2621.00
22_E26_D1.2551.00
105_T136_F1.2551.00
26_D65_L1.2511.00
465_D468_R1.2501.00
403_R424_I1.2501.00
117_A191_A1.2481.00
112_T191_A1.2391.00
421_A461_F1.2361.00
157_G165_V1.2331.00
203_T209_L1.2321.00
378_A475_F1.2301.00
13_G54_Q1.2281.00
232_T434_M1.2271.00
326_F329_F1.2271.00
163_K203_T1.2261.00
118_I126_F1.2181.00
132_I192_V1.2171.00
53_K57_Q1.2161.00
246_N449_R1.2161.00
88_G164_A1.2061.00
208_E227_V1.2041.00
408_N461_F1.2001.00
80_D94_A1.1921.00
26_D62_V1.1891.00
45_L93_E1.1811.00
307_L365_L1.1791.00
290_F294_I1.1771.00
6_I15_I1.1771.00
378_A415_S1.1731.00
314_Q317_A1.1721.00
187_E190_E1.1691.00
295_I299_V1.1671.00
29_E58_G1.1611.00
416_G472_I1.1571.00
410_L414_M1.1541.00
246_N249_W1.1471.00
37_F50_H1.1441.00
83_L146_T1.1391.00
317_A405_D1.1381.00
55_I156_L1.1341.00
143_L146_T1.1331.00
47_D93_E1.1301.00
165_V209_L1.1291.00
208_E438_A1.1281.00
356_Q360_R1.1241.00
318_E321_K1.1231.00
57_Q61_K1.1221.00
104_H107_D1.1211.00
150_M164_A1.1211.00
106_I126_F1.1181.00
317_A404_N1.1171.00
295_I298_W1.1161.00
168_I202_L1.1141.00
120_Q269_I1.1051.00
28_Q65_L1.1031.00
447_E450_Q1.1011.00
168_I177_L1.0971.00
249_W396_H1.0971.00
332_L337_F1.0971.00
329_F332_L1.0921.00
464_K468_R1.0921.00
332_L353_Q1.0881.00
246_N446_K1.0841.00
29_E62_V1.0811.00
146_T198_Q1.0701.00
71_T439_A1.0701.00
360_R364_E1.0671.00
48_I82_V1.0671.00
3_Y439_A1.0661.00
51_L152_I1.0641.00
469_S473_Q1.0621.00
396_H420_Y1.0601.00
72_V226_K1.0531.00
471_I474_S1.0521.00
475_F478_T1.0491.00
375_I414_M1.0471.00
18_G432_L1.0441.00
107_D110_E1.0411.00
475_F479_V1.0391.00
141_E145_K1.0391.00
319_E366_A1.0381.00
18_G24_K1.0351.00
83_L135_L1.0341.00
351_C356_Q1.0311.00
74_I157_G1.0231.00
250_A262_V1.0221.00
394_Q460_V1.0221.00
61_K64_T1.0131.00
50_H53_K1.0121.00
293_N376_I1.0111.00
105_T138_E1.0111.00
381_I415_S1.0101.00
437_I448_A1.0101.00
158_Y164_A1.0071.00
60_Q64_T1.0031.00
55_I59_L1.0031.00
15_I62_V1.0011.00
92_R142_L0.9991.00
44_C98_R0.9971.00
105_T108_K0.9941.00
378_A414_M0.9901.00
373_L401_G0.9901.00
75_D427_T0.9871.00
34_A37_F0.9851.00
36_G46_W0.9831.00
474_S477_Q0.9821.00
367_C406_F0.9791.00
83_L149_I0.9781.00
436_M441_E0.9771.00
375_I471_I0.9761.00
56_L60_Q0.9741.00
17_V69_H0.9711.00
71_T229_T0.9711.00
108_K111_H0.9651.00
248_G393_E0.9621.00
132_I175_Q0.9561.00
140_R144_K0.9551.00
321_K406_F0.9551.00
251_Y398_I0.9541.00
131_T134_Q0.9511.00
70_C439_A0.9461.00
433_L448_A0.9431.00
30_I33_F0.9421.00
211_K227_V0.9401.00
401_G407_L0.9391.00
63_K69_H0.9381.00
4_T17_V0.9381.00
260_I381_I0.9361.00
177_L181_T0.9351.00
108_K136_F0.9341.00
18_G429_T0.9341.00
142_L145_K0.9331.00
182_G204_E0.9331.00
89_D159_C0.9271.00
180_S269_I0.9221.00
189_L194_V0.9201.00
356_Q365_L0.9181.00
229_T439_A0.9151.00
118_I175_Q0.9131.00
472_I475_F0.9121.00
81_Y149_I0.9091.00
288_I292_K0.9081.00
74_I156_L0.9071.00
469_S472_I0.9051.00
120_Q180_S0.9041.00
395_F415_S0.9041.00
114_S191_A0.9031.00
166_T171_V0.9021.00
162_G213_R0.8971.00
246_N393_E0.8901.00
67_Y223_P0.8881.00
8_V156_L0.8881.00
135_L149_I0.8871.00
4_T69_H0.8771.00
258_S377_Y0.8731.00
168_I204_E0.8721.00
147_D197_Q0.8711.00
203_T230_V0.8661.00
73_G229_T0.8651.00
459_K463_P0.8631.00
433_L452_V0.8621.00
336_R353_Q0.8621.00
146_T149_I0.8611.00
8_V55_I0.8591.00
74_I160_L0.8591.00
165_V201_P0.8571.00
415_S418_A0.8561.00
154_D166_T0.8561.00
310_D316_L0.8531.00
137_E140_R0.8531.00
272_L386_T0.8491.00
382_K472_I0.8491.00
21_N451_V0.8471.00
353_Q369_I0.8471.00
382_K386_T0.8461.00
183_N201_P0.8461.00
308_Q362_A0.8451.00
410_L471_I0.8441.00
69_H226_K0.8431.00
422_G454_N0.8431.00
437_I444_D0.8381.00
79_V173_T0.8331.00
313_F316_L0.8281.00
100_R127_Q0.8281.00
59_L63_K0.8271.00
177_L182_G0.8271.00
470_T474_S0.8231.00
314_Q318_E0.8221.00
246_N450_Q0.8211.00
238_A398_I0.8171.00
114_S117_A0.8171.00
106_I133_Y0.8151.00
168_I281_E0.8151.00
171_V184_L0.8151.00
214_N225_C0.8131.00
70_C441_E0.8121.00
212_L226_K0.8091.00
84_L88_G0.8081.00
290_F293_N0.8081.00
320_A367_C0.8071.00
180_S266_T0.8041.00
211_K224_A0.8021.00
397_I411_T0.8011.00
381_I385_E0.7991.00
473_Q476_Q0.7991.00
110_E126_F0.7981.00
151_M174_T0.7951.00
48_I93_E0.7951.00
422_G453_R0.7941.00
252_I377_Y0.7931.00
349_H352_R0.7931.00
130_N134_Q0.7931.00
437_I445_I0.7931.00
19_E25_L0.7911.00
281_E286_N0.7901.00
262_V384_L0.7901.00
326_F330_I0.7891.00
132_I176_L0.7861.00
370_Y410_L0.7851.00
402_A424_I0.7831.00
91_L145_K0.7821.00
466_I469_S0.7801.00
136_F193_S0.7791.00
56_L216_W0.7791.00
32_R61_K0.7781.00
166_T200_A0.7781.00
250_A395_F0.7771.00
166_T202_L0.7761.00
135_L176_L0.7761.00
303_V366_A0.7751.00
31_H34_A0.7751.00
183_N186_P0.7741.00
442_V448_A0.7731.00
187_E191_A0.7721.00
370_Y404_N0.7691.00
78_A170_N0.7691.00
39_Q43_H0.7681.00
5_A73_G0.7681.00
332_L369_I0.7631.00
463_P468_R0.7631.00
104_H138_E0.7611.00
304_K313_F0.7611.00
235_T259_L0.7571.00
33_F54_Q0.7571.00
409_Q464_K0.7571.00
242_A251_Y0.7561.00
3_Y71_T0.7541.00
184_L199_F0.7531.00
242_A398_I0.7521.00
84_L164_A0.7521.00
321_K409_Q0.7501.00
397_I421_A0.7501.00
402_A408_N0.7491.00
31_H58_G0.7471.00
190_E196_E0.7471.00
252_I258_S0.7451.00
50_H54_Q0.7441.00
88_G147_D0.7411.00
121_K178_N0.7411.00
374_A407_L0.7401.00
85_D91_L0.7401.00
452_V455_S0.7391.00
10_A96_S0.7391.00
45_L101_R0.7381.00
302_E305_Q0.7351.00
18_G423_P0.7351.00
169_T280_N0.7331.00
122_T188_L0.7321.00
323_T363_G0.7321.00
340_P343_M0.7291.00
265_K287_T0.7291.00
153_P231_A0.7281.00
382_K479_V0.7271.00
326_F371_S0.7271.00
49_D155_Y0.7261.00
124_I130_N0.7241.00
72_V212_L0.7241.00
53_K56_L0.7231.00
288_I293_N0.7211.00
382_K476_Q0.7211.00
169_T232_T0.7191.00
185_D188_L0.7161.00
303_V365_L0.7151.00
106_I128_P0.7151.00
383_E386_T0.7141.00
472_I478_T0.7131.00
321_K405_D0.7121.00
83_L91_L0.7121.00
104_H137_E0.7101.00
71_T227_V0.7101.00
422_G455_S0.7081.00
52_L216_W0.7071.00
109_L192_V0.7071.00
222_L226_K0.7071.00
56_L159_C0.7061.00
8_V54_Q0.7051.00
59_L62_V0.7051.00
97_Y257_W0.7031.00
447_E451_V0.7031.00
244_G251_Y0.7031.00
238_A427_T0.7011.00
95_I101_R0.7001.00
155_Y158_Y0.6991.00
157_G161_T0.6991.00
448_A452_V0.6991.00
49_D90_R0.6971.00
118_I188_L0.6961.00
382_K475_F0.6961.00
320_A366_A0.6931.00
85_D147_D0.6931.00
224_A227_V0.6911.00
436_M440_K0.6901.00
178_N183_N0.6901.00
291_L294_I0.6891.00
323_T326_F0.6881.00
212_L222_L0.6861.00
78_A291_L0.6841.00
442_V451_V0.6841.00
209_L230_V0.6810.99
296_G373_L0.6790.99
16_M24_K0.6780.99
446_K449_R0.6780.99
222_L225_C0.6770.99
86_E145_K0.6770.99
397_I419_V0.6770.99
393_E417_K0.6760.99
350_Y354_T0.6750.99
346_E349_H0.6740.99
379_I479_V0.6740.99
448_A451_V0.6730.99
394_Q417_K0.6720.99
107_D348_Q0.6710.99
252_I395_F0.6700.99
129_F134_Q0.6680.99
84_L158_Y0.6680.99
473_Q477_Q0.6680.99
32_R301_Q0.6670.99
332_L368_C0.6660.99
461_F468_R0.6640.99
449_R452_V0.6630.99
234_D256_T0.6620.99
311_Y362_A0.6600.99
371_S410_L0.6590.99
317_A406_F0.6530.99
301_Q313_F0.6510.99
204_E281_E0.6510.99
462_T465_D0.6500.99
216_W225_C0.6480.99
395_F419_V0.6450.99
265_K286_N0.6450.99
66_G69_H0.6450.99
144_K148_K0.6440.99
288_I294_I0.6430.99
300_I317_A0.6430.99
301_Q304_K0.6420.99
449_R453_R0.6420.99
325_P329_F0.6410.99
344_I379_I0.6410.99
288_I291_L0.6410.99
395_F417_K0.6410.99
433_L451_V0.6400.99
325_P470_T0.6400.99
465_D469_S0.6390.99
205_P231_A0.6390.99
323_T328_Q0.6390.99
76_T170_N0.6370.99
330_I360_R0.6360.99
57_Q60_Q0.6330.99
409_Q461_F0.6310.99
18_G428_A0.6300.99
336_R340_P0.6290.99
211_K214_N0.6280.99
297_M301_Q0.6270.99
323_T327_Q0.6250.99
208_E439_A0.6250.99
405_D409_Q0.6240.99
55_I58_G0.6220.99
258_S411_T0.6220.99
84_L155_Y0.6210.99
136_F192_V0.6200.99
33_F46_W0.6190.99
182_G281_E0.6190.99
84_L148_K0.6180.99
154_D164_A0.6180.99
133_Y175_Q0.6170.99
467_D471_I0.6160.99
176_L199_F0.6120.99
437_I442_V0.6110.99
416_G465_D0.6110.99
264_N268_I0.6100.99
153_P170_N0.6080.99
143_L147_D0.6080.99
244_G249_W0.6080.99
136_F143_L0.6070.99
49_D93_E0.6060.99
182_G286_N0.6060.99
29_E65_L0.6060.99
113_L188_L0.6040.99
323_T367_C0.6040.99
303_V307_L0.6040.99
227_V439_A0.6010.99
409_Q412_A0.6010.99
338_L358_I0.6010.99
267_P276_N0.6000.99
77_W97_Y0.6000.99
418_A463_P0.6000.99
76_T152_I0.5980.99
404_N407_L0.5980.99
201_P207_C0.5970.99
331_N353_Q0.5970.99
145_K148_K0.5960.99
233_H236_A0.5960.99
332_L372_N0.5950.99
433_L437_I0.5940.99
320_A370_Y0.5910.99
190_E195_L0.5910.99
476_Q479_V0.5900.99
29_E33_F0.5890.99
339_N343_M0.5880.98
143_L193_S0.5880.98
89_D145_K0.5870.98
320_A323_T0.5860.98
371_S375_I0.5860.98
287_T290_F0.5860.98
20_L70_C0.5850.98
303_V308_Q0.5850.98
194_V199_F0.5840.98
118_I192_V0.5840.98
367_C410_L0.5840.98
128_P347_I0.5830.98
243_P449_R0.5830.98
102_T133_Y0.5810.98
31_H54_Q0.5800.98
69_H222_L0.5800.98
313_F317_A0.5780.98
56_L59_L0.5780.98
81_Y131_T0.5780.98
326_F367_C0.5770.98
190_E193_S0.5770.98
49_D52_L0.5770.98
212_L221_D0.5760.98
241_A426_A0.5750.98
135_L198_Q0.5740.98
116_A119_Y0.5740.98
126_F175_Q0.5710.98
467_D470_T0.5710.98
103_D128_P0.5710.98
416_G467_D0.5710.98
235_T253_S0.5700.98
83_L92_R0.5690.98
474_S478_T0.5690.98
280_N283_G0.5680.98
3_Y442_V0.5680.98
43_H101_R0.5670.98
212_L223_P0.5660.98
60_Q63_K0.5650.98
392_I417_K0.5650.98
408_N421_A0.5650.98
48_I94_A0.5650.98
317_A370_Y0.5630.98
47_D53_K0.5630.98
28_Q425_E0.5620.98
169_T205_P0.5620.98
82_V94_A0.5620.98
88_G148_K0.5600.98
32_R304_K0.5590.98
414_M471_I0.5590.98
260_I380_A0.5590.98
78_A173_T0.5570.98
252_I260_I0.5570.98
45_L92_R0.5560.98
213_R225_C0.5560.98
306_Q361_T0.5560.98
19_E22_E0.5560.98
133_Y136_F0.5550.98
446_K450_Q0.5550.98
143_L195_L0.5540.98
82_V90_R0.5540.98
206_G438_A0.5530.98
329_F360_R0.5520.98
317_A320_A0.5520.98
239_V261_G0.5510.98
373_L407_L0.5510.98
180_S183_N0.5500.98
174_T184_L0.5490.98
10_A97_Y0.5480.98
254_S397_I0.5460.98
461_F465_D0.5460.98
325_P328_Q0.5440.98
285_N288_I0.5430.97
90_R93_E0.5420.97
72_V228_M0.5420.97
163_K211_K0.5420.97
216_W222_L0.5410.97
471_I478_T0.5400.97
24_K28_Q0.5390.97
325_P367_C0.5390.97
240_I433_L0.5380.97
51_L94_A0.5370.97
11_S14_R0.5370.97
188_L192_V0.5370.97
243_P452_V0.5360.97
402_A421_A0.5330.97
429_T433_L0.5330.97
411_T415_S0.5300.97
459_K468_R0.5290.97
412_A419_V0.5280.97
16_M429_T0.5280.97
43_H95_I0.5280.97
54_Q57_Q0.5270.97
109_L133_Y0.5270.97
277_N289_R0.5260.97
300_I316_L0.5250.97
253_S398_I0.5250.97
188_L191_A0.5240.97
470_T473_Q0.5240.97
428_A431_N0.5240.97
332_L335_K0.5230.97
444_D448_A0.5230.97
249_W393_E0.5210.97
287_T445_I0.5200.97
169_T236_A0.5200.97
3_Y70_C0.5200.97
26_D29_E0.5200.97
342_N345_K0.5190.97
68_E223_P0.5190.97
84_L147_D0.5180.97
80_D96_S0.5180.97
38_S44_C0.5180.97
440_K443_K0.5170.97
44_C96_S0.5170.97
445_I449_R0.5170.97
472_I479_V0.5160.97
150_M158_Y0.5160.97
262_V392_I0.5160.97
168_I205_P0.5150.97
162_G215_E0.5150.97
319_E323_T0.5140.97
77_W94_A0.5120.96
123_G134_Q0.5100.96
327_Q364_E0.5100.96
234_D400_G0.5090.96
75_D431_N0.5080.96
393_E418_A0.5080.96
316_L404_N0.5070.96
151_M170_N0.5060.96
324_E364_E0.5050.96
230_V237_S0.5050.96
118_I191_A0.5030.96
79_V97_Y0.5030.96
240_I445_I0.5020.96
249_W449_R0.5020.96
437_I440_K0.5020.96
24_K423_P0.5000.96
253_S259_L0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ll3A 2 0.9814 100 0.13 Contact Map
3hz6A 1 0.9753 100 0.143 Contact Map
2itmA 2 0.9546 100 0.147 Contact Map
3ifrA 2 0.9711 100 0.151 Contact Map
3qdkA 2 0.9856 100 0.155 Contact Map
3wxlA 2 0.9897 100 0.158 Contact Map
3ezwA 3 0.9753 100 0.168 Contact Map
2w40A 3 0.9753 100 0.173 Contact Map
3h3nX 3 0.9753 100 0.174 Contact Map
2d4wA 2 0.9732 100 0.175 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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