GREMLIN Database
YULB - Uncharacterized HTH-type transcriptional regulator YulB
UniProt: O05261 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 258 (247)
Sequences: 7694 (5630)
Seq/√Len: 358.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_D167_K3.3341.00
85_E88_K3.0421.00
107_M205_M2.9701.00
136_S143_I2.7391.00
168_T199_S2.6101.00
99_D192_K2.4631.00
13_I28_I2.3121.00
208_S231_D2.2461.00
109_K128_E2.2091.00
196_I220_A2.2091.00
227_R250_T2.1541.00
203_I227_R2.0841.00
167_K203_I2.0501.00
91_K94_D2.0501.00
161_E194_R2.0341.00
9_K12_E2.0281.00
13_I17_R2.0041.00
97_I165_V2.0031.00
80_K106_Y1.9651.00
84_H110_I1.9551.00
196_I202_T1.9531.00
218_H221_S1.9501.00
234_L239_V1.9421.00
98_L104_A1.9081.00
158_R161_E1.9031.00
167_K201_Q1.8611.00
92_S114_I1.8401.00
97_I195_M1.8371.00
119_I165_V1.7871.00
201_Q227_R1.7521.00
106_Y109_K1.7511.00
239_V243_E1.7391.00
86_A169_F1.7181.00
165_V195_M1.7071.00
85_E250_T1.6871.00
221_S224_D1.6541.00
158_R162_T1.6411.00
86_A205_M1.6291.00
157_E190_L1.5761.00
139_S151_F1.5761.00
166_N200_D1.5681.00
140_T159_S1.5401.00
194_R197_E1.5401.00
75_N209_S1.5331.00
107_M169_F1.5271.00
126_A139_S1.5231.00
181_M225_V1.5161.00
240_K244_D1.5021.00
161_E197_E1.5001.00
87_A110_I1.4991.00
31_V36_I1.4931.00
181_M204_L1.4821.00
25_L36_I1.4781.00
19_S57_V1.4631.00
83_A110_I1.4501.00
156_A191_L1.4251.00
10_I25_L1.4241.00
7_Q46_E1.4221.00
140_T151_F1.4171.00
40_L56_A1.4161.00
235_D238_S1.4151.00
13_I20_I1.4061.00
8_Q12_E1.4021.00
80_K110_I1.3971.00
118_V129_L1.3911.00
17_R24_E1.3831.00
194_R198_R1.3751.00
50_S59_I1.3731.00
75_N78_E1.3721.00
9_K13_I1.3721.00
204_L225_V1.3611.00
89_Y203_I1.3531.00
100_A150_S1.3471.00
52_S55_G1.3471.00
208_S233_G1.3461.00
94_D166_N1.3441.00
144_L151_F1.3441.00
89_Y229_I1.3261.00
15_N58_S1.3251.00
143_I187_W1.3241.00
78_E231_D1.3231.00
23_S33_E1.3161.00
92_S115_E1.3121.00
76_V106_Y1.2931.00
118_V135_I1.2891.00
7_Q42_K1.2841.00
34_E38_R1.2711.00
93_G115_E1.2681.00
79_K102_T1.2651.00
140_T156_A1.2631.00
90_V111_L1.2601.00
11_V48_K1.2571.00
220_A224_D1.2441.00
21_R24_E1.2421.00
236_P240_K1.2401.00
175_F211_W1.2301.00
85_E89_Y1.2281.00
3_V7_Q1.2261.00
9_K28_I1.2241.00
112_P132_K1.2131.00
201_Q226_S1.2121.00
80_K109_K1.1961.00
117_T138_I1.1951.00
197_E224_D1.1911.00
89_Y250_T1.1821.00
240_K243_E1.1621.00
9_K29_F1.1531.00
172_C206_A1.1521.00
108_A129_L1.1461.00
211_W234_L1.1421.00
176_D179_N1.1351.00
14_V49_L1.1341.00
97_I198_R1.1311.00
169_F203_I1.1301.00
12_E16_M1.1231.00
77_I80_K1.1151.00
14_V58_S1.1111.00
41_E45_K1.1081.00
91_K167_K1.1081.00
11_V14_V1.1061.00
78_E208_S1.0971.00
157_E191_L1.0951.00
76_V80_K1.0921.00
17_R28_I1.0811.00
117_T136_S1.0811.00
174_G182_S1.0771.00
155_L159_S1.0771.00
50_S57_V1.0701.00
227_R248_K1.0691.00
203_I229_I1.0671.00
172_C219_I1.0641.00
202_T225_V1.0611.00
90_V169_F1.0161.00
22_V40_L1.0121.00
138_I143_I1.0111.00
49_L56_A1.0071.00
87_A90_V1.0071.00
42_K46_E1.0041.00
87_A107_M0.9991.00
26_S33_E0.9831.00
140_T160_L0.9831.00
119_I163_Y0.9771.00
86_A107_M0.9761.00
238_S241_A0.9751.00
78_E82_I0.9711.00
3_V42_K0.9701.00
98_L107_M0.9681.00
173_K183_D0.9631.00
155_L163_Y0.9631.00
5_E9_K0.9561.00
108_A128_E0.9541.00
68_F102_T0.9531.00
211_W228_L0.9491.00
175_F206_A0.9491.00
101_S104_A0.9421.00
41_E44_E0.9341.00
103_T207_D0.9341.00
80_K84_H0.9321.00
79_K103_T0.9301.00
104_A125_A0.9291.00
168_T195_M0.9281.00
172_C204_L0.9251.00
107_M110_I0.9221.00
190_L193_K0.9201.00
83_A87_A0.9191.00
89_Y227_R0.9171.00
157_E194_R0.9121.00
13_I16_M0.9101.00
42_K45_K0.9081.00
79_K210_K0.9071.00
239_V249_V0.9071.00
223_Q245_K0.9061.00
162_T193_K0.8971.00
189_A217_S0.8951.00
176_D214_R0.8951.00
164_H200_D0.8901.00
26_S36_I0.8901.00
104_A107_M0.8831.00
24_E28_I0.8831.00
164_H179_N0.8801.00
82_I103_T0.8781.00
103_T210_K0.8781.00
75_N207_D0.8761.00
124_K149_L0.8751.00
83_A107_M0.8621.00
20_I25_L0.8581.00
20_I56_A0.8551.00
43_L48_K0.8551.00
83_A106_Y0.8491.00
137_V144_L0.8471.00
241_A244_D0.8411.00
200_D214_R0.8361.00
122_S125_A0.8361.00
130_S149_L0.8341.00
108_A125_A0.8321.00
163_Y186_E0.8301.00
11_V15_N0.8261.00
160_L195_M0.8211.00
164_H218_H0.8141.00
86_A229_I0.8131.00
155_L162_T0.8091.00
148_S173_K0.8091.00
169_F205_M0.8051.00
183_D189_A0.8031.00
5_E8_Q0.7941.00
112_P128_E0.7921.00
12_E15_N0.7881.00
132_K135_I0.7861.00
202_T226_S0.7811.00
164_H214_R0.7791.00
81_A84_H0.7781.00
24_E27_D0.7781.00
75_N208_S0.7741.00
71_R173_K0.7741.00
186_E217_S0.7691.00
41_E51_R0.7651.00
160_L194_R0.7651.00
179_N214_R0.7641.00
128_E131_N0.7621.00
145_L188_Q0.7591.00
5_E19_S0.7561.00
175_F181_M0.7551.00
115_E134_N0.7531.00
234_L249_V0.7531.00
182_S214_R0.7521.00
97_I160_L0.7511.00
104_A205_M0.7491.00
172_C181_M0.7481.00
98_L108_A0.7401.00
162_T218_H0.7381.00
98_L118_V0.7371.00
234_L238_S0.7321.00
141_G156_A0.7291.00
126_A151_F0.7230.99
105_W128_E0.7200.99
127_I149_L0.7190.99
102_T210_K0.7190.99
164_H198_R0.7140.99
106_Y110_I0.7110.99
77_I81_A0.7090.99
67_H70_E0.7070.99
183_D219_I0.7060.99
183_D188_Q0.7020.99
7_Q11_V0.7010.99
196_I219_I0.6980.99
181_M219_I0.6940.99
18_S58_S0.6920.99
126_A144_L0.6920.99
100_A148_S0.6900.99
121_N195_M0.6880.99
165_V199_S0.6880.99
168_T202_T0.6870.99
31_V34_E0.6800.99
145_L152_A0.6790.99
84_H88_K0.6770.99
175_F222_L0.6770.99
193_K197_E0.6760.99
207_D210_K0.6700.99
206_A228_L0.6690.99
141_G159_S0.6660.99
95_R119_I0.6650.99
23_S27_D0.6630.99
40_L51_R0.6620.99
81_A85_E0.6600.99
153_G156_A0.6590.99
52_S57_V0.6490.99
44_E51_R0.6470.99
11_V43_L0.6460.99
25_L40_L0.6450.99
236_P239_V0.6440.99
22_V36_I0.6410.99
82_I205_M0.6410.99
201_Q248_K0.6410.99
96_I118_V0.6410.99
123_M151_F0.6400.99
131_N149_L0.6390.99
96_I167_K0.6360.99
170_L199_S0.6360.99
34_E122_S0.6340.99
14_V20_I0.6340.99
203_I226_S0.6330.99
161_E198_R0.6330.99
237_A241_A0.6290.99
158_R190_L0.6270.99
65_E71_R0.6270.99
72_E105_W0.6260.99
105_W124_K0.6240.99
154_P158_R0.6220.98
241_A245_K0.6200.98
173_K215_E0.6170.98
44_E49_L0.6170.98
119_I216_F0.6150.98
120_T126_A0.6140.98
163_Y217_S0.6110.98
90_V107_M0.6060.98
154_P190_L0.6060.98
113_D132_K0.6040.98
29_F36_I0.6040.98
115_E136_S0.6020.98
6_R39_D0.6020.98
220_A225_V0.6020.98
4_A7_Q0.6020.98
101_S171_S0.5990.98
199_S202_T0.5960.98
122_S188_Q0.5950.98
189_A219_I0.5860.98
184_S215_E0.5860.98
99_D104_A0.5830.98
78_E233_G0.5830.98
123_M127_I0.5820.98
176_D182_S0.5790.98
173_K188_Q0.5780.98
123_M139_S0.5770.98
114_I132_K0.5760.98
154_P157_E0.5750.97
145_L185_N0.5710.97
81_A232_S0.5710.97
150_S188_Q0.5690.97
72_E106_Y0.5670.97
170_L219_I0.5670.97
34_E173_K0.5660.97
101_S173_K0.5660.97
171_S183_D0.5650.97
238_S242_L0.5640.97
211_W238_S0.5630.97
173_K184_S0.5620.97
79_K207_D0.5610.97
177_V241_A0.5590.97
156_A159_S0.5590.97
124_K127_I0.5560.97
95_R216_F0.5560.97
96_I169_F0.5540.97
38_R175_F0.5530.97
208_S234_L0.5510.97
187_W190_L0.5510.97
192_K219_I0.5500.97
119_I138_I0.5490.97
157_E161_E0.5470.97
183_D192_K0.5460.97
158_R193_K0.5450.97
211_W230_T0.5440.97
177_V238_S0.5440.97
173_K192_K0.5430.96
181_M220_A0.5410.96
27_D30_S0.5410.96
191_L194_R0.5410.96
97_I168_T0.5400.96
101_S122_S0.5400.96
69_S72_E0.5360.96
71_R188_Q0.5360.96
170_L196_I0.5350.96
154_P187_W0.5310.96
10_I29_F0.5280.96
96_I107_M0.5260.96
236_P243_E0.5220.96
100_A188_Q0.5210.96
151_F159_S0.5200.95
78_E81_A0.5190.95
202_T224_D0.5170.95
170_L202_T0.5160.95
65_E145_L0.5140.95
97_I119_I0.5140.95
174_G215_E0.5130.95
233_G239_V0.5120.95
20_I52_S0.5110.95
82_I230_T0.5110.95
26_S32_T0.5100.95
129_L135_I0.5030.95
34_E183_D0.5000.94
22_V26_S0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9419 100 0.521 Contact Map
3rrlB 1 0.6783 100 0.532 Contact Map
2w48A 3 0.9109 100 0.576 Contact Map
3l7oA 2 0.6008 100 0.614 Contact Map
2o0mA 1 0.6822 100 0.618 Contact Map
1o8bA 2 0.593 100 0.623 Contact Map
1uj6A 2 0.6085 100 0.626 Contact Map
1lk5A 4 0.6124 100 0.628 Contact Map
1m0sA 2 0.6163 100 0.63 Contact Map
4io1A 2 0.6163 100 0.634 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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