GREMLIN Database
MRPC - Na(+)/H(+) antiporter subunit C
UniProt: O05260 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 113 (104)
Sequences: 1647 (979)
Seq/√Len: 96.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_F38_G5.3731.00
19_L31_G4.5111.00
23_K102_D2.8771.00
24_S101_D2.7451.00
33_A84_T2.4331.00
40_H73_I2.4101.00
86_F90_M2.3741.00
94_A106_M2.3221.00
69_P72_L2.1651.00
102_D105_Q2.0791.00
36_S76_A2.0251.00
100_S105_Q1.9301.00
43_L47_G1.9101.00
84_T88_L1.8651.00
94_A98_L1.8461.00
43_L73_I1.8421.00
13_F39_V1.8291.00
10_G14_M1.8001.00
16_A35_L1.7961.00
29_I84_T1.7421.00
22_S27_R1.5141.00
90_M93_R1.4831.00
25_L102_D1.4761.00
39_V56_I1.4411.00
31_G34_L1.3890.99
40_H79_I1.3840.99
16_A89_V1.3370.99
19_L22_S1.3140.99
65_V70_Q1.2940.99
36_S79_I1.2860.99
93_R96_Q1.2760.99
14_M18_Y1.2740.99
13_F35_L1.2550.99
71_A79_I1.2520.99
11_I65_V1.2380.99
29_I91_A1.1580.98
26_L91_A1.1510.98
40_H47_G1.1330.98
20_L32_T1.1280.97
15_A34_L1.1210.97
66_D84_T1.1200.97
32_T41_L1.0960.97
20_L33_A1.0890.97
66_D70_Q1.0850.97
28_V79_I1.0720.97
83_V90_M1.0310.96
29_I87_I1.0230.95
12_I35_L1.0110.95
58_S63_S0.9890.95
86_F89_V0.9830.94
20_L99_K0.9740.94
26_L73_I0.9720.94
29_I43_L0.9670.94
20_L85_S0.9530.93
40_H43_L0.9500.93
35_L71_A0.9410.93
71_A81_F0.9360.93
99_K103_M0.9240.92
40_H76_A0.9040.92
44_L73_I0.8950.91
8_L20_L0.8850.91
28_V103_M0.8830.91
44_L51_K0.8640.90
36_S80_S0.8560.89
66_D79_I0.8440.88
24_S94_A0.8410.88
37_H42_M0.8310.88
17_T21_L0.8260.87
18_Y90_M0.8180.87
94_A101_D0.8110.86
36_S64_F0.7980.85
47_G69_P0.7940.85
54_A83_V0.7910.85
23_K93_R0.7810.84
29_I93_R0.7760.84
44_L81_F0.7570.82
53_A63_S0.7540.82
74_L77_I0.7400.81
36_S90_M0.7370.81
87_I94_A0.7350.80
6_A14_M0.7330.80
41_L65_V0.7320.80
27_R42_M0.7310.80
48_G81_F0.7280.80
51_K55_P0.7240.79
28_V98_L0.7130.78
86_F93_R0.7080.78
5_M45_T0.7050.78
81_F89_V0.6970.77
50_K60_H0.6960.77
11_I15_A0.6880.76
82_G93_R0.6780.75
96_Q101_D0.6760.75
20_L65_V0.6730.74
16_A67_P0.6720.74
56_I85_S0.6700.74
7_V10_G0.6680.74
13_F45_T0.6670.74
51_K63_S0.6640.73
99_K102_D0.6620.73
70_Q79_I0.6600.73
5_M8_L0.6580.73
53_A62_K0.6570.73
48_G52_G0.6490.72
29_I61_A0.6450.71
19_L30_I0.6280.69
27_R88_L0.6250.69
80_S89_V0.6250.69
13_F26_L0.6230.69
36_S85_S0.6220.68
23_K30_I0.6170.68
10_G47_G0.6170.68
7_V102_D0.6150.68
68_L84_T0.6150.68
61_A83_V0.6140.67
21_L95_Y0.6120.67
3_I16_A0.6050.66
66_D101_D0.5970.65
47_G70_Q0.5950.65
29_I37_H0.5950.65
6_A25_L0.5920.65
7_V14_M0.5910.65
66_D83_V0.5890.64
76_A80_S0.5880.64
91_A101_D0.5860.64
23_K89_V0.5850.64
23_K105_Q0.5780.63
46_M84_T0.5770.63
3_I7_V0.5760.63
58_S64_F0.5750.62
56_I72_L0.5690.62
22_S25_L0.5680.61
37_H84_T0.5630.61
50_K65_V0.5600.60
37_H86_F0.5590.60
16_A20_L0.5560.60
21_L28_V0.5540.60
56_I67_P0.5510.59
21_L103_M0.5510.59
37_H92_F0.5500.59
31_G74_L0.5490.59
19_L47_G0.5480.59
19_L34_L0.5470.59
49_L52_G0.5430.58
36_S40_H0.5420.58
50_K62_K0.5400.58
48_G92_F0.5370.57
23_K50_K0.5290.56
56_I61_A0.5260.56
90_M100_S0.5170.54
7_V11_I0.5140.54
20_L35_L0.5100.53
54_A85_S0.5030.52
57_L60_H0.5020.52
51_K83_V0.5000.52
8_L51_K0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoK 1 0.8584 99.6 0.595 Contact Map
4he8K 1 0.8319 99.5 0.611 Contact Map
3pjsK 4 0.885 29.6 0.919 Contact Map
1lnqA 6 0.6903 21.6 0.923 Contact Map
2a9hA 4 0.7699 21 0.924 Contact Map
2kluA 1 0.4248 19.4 0.925 Contact Map
3ukmA 2 0.7965 17.9 0.926 Contact Map
4bw5A 2 0.7788 17.6 0.927 Contact Map
3effK 4 0.885 16.1 0.928 Contact Map
3vouA 4 0.823 16 0.928 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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