GREMLIN Database
MRPB - Na(+)/H(+) antiporter subunit B
UniProt: O05259 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (135)
Sequences: 1282 (788)
Seq/√Len: 67.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
26_S125_Y7.1891.00
29_L46_I4.6371.00
103_Y111_K4.3921.00
47_T125_Y3.5961.00
101_F113_E3.5911.00
30_F122_L3.4201.00
105_Q111_K2.8871.00
103_Y113_E2.6451.00
88_G116_T2.3971.00
26_S47_T2.3661.00
86_G96_F2.2921.00
94_A98_T2.2651.00
95_P98_T1.9751.00
88_G119_I1.9131.00
116_T119_I1.8801.00
85_T119_I1.7971.00
79_L127_V1.7481.00
104_F114_L1.7121.00
94_A100_T1.6981.00
86_G89_S1.6500.99
77_A126_L1.6300.99
85_T88_G1.5150.99
81_L126_L1.5070.99
101_F117_A1.4930.99
88_G100_T1.4700.99
12_Q16_K1.4000.98
101_F115_A1.3630.98
11_L53_L1.3280.97
23_L47_T1.3160.97
89_S92_F1.3130.97
106_L112_T1.3030.97
77_A93_G1.2980.97
27_F31_L1.2860.97
80_L84_L1.2740.96
59_D62_T1.2540.96
53_L67_L1.2520.96
27_F30_F1.2500.96
31_L66_L1.2230.95
83_V87_V1.2160.95
7_N12_Q1.1930.95
70_N73_Y1.1890.95
12_Q58_Y1.1560.94
14_A80_L1.1180.93
28_Y31_L1.0990.92
35_N113_E1.0830.92
87_V91_V1.0810.91
87_V90_F1.0800.91
71_F138_T1.0580.91
105_Q112_T1.0580.91
35_N42_V1.0550.90
28_Y45_L1.0480.90
118_T122_L1.0390.90
51_I68_P1.0260.89
10_I13_T1.0100.88
80_L87_V1.0100.88
34_H39_G1.0080.88
101_F119_I1.0000.88
99_H117_A0.9980.88
88_G92_F0.9970.88
86_G97_L0.9960.88
63_V68_P0.9880.87
19_S54_L0.9810.87
26_S43_G0.9790.87
89_S94_A0.9720.86
135_I139_I0.9610.86
99_H115_A0.9550.85
43_G49_S0.9510.85
55_L137_Q0.9440.85
11_L74_V0.9430.85
81_L84_L0.9420.85
20_F66_L0.9350.84
75_A79_L0.9330.84
79_L118_T0.9280.84
19_S22_I0.9260.84
121_D125_Y0.9220.83
52_V132_T0.9200.83
26_S60_L0.9190.83
99_H139_I0.9160.83
82_A124_V0.9140.83
44_G127_V0.9020.82
19_S108_I0.8820.81
44_G79_L0.8810.80
64_R141_E0.8770.80
95_P117_A0.8730.80
71_F127_V0.8600.79
106_L109_L0.8450.78
37_P42_V0.8250.76
89_S96_F0.8050.74
16_K58_Y0.8040.74
23_L27_F0.8030.74
15_T57_A0.8020.74
18_V61_K0.7990.74
56_L59_D0.7900.73
69_V74_V0.7870.72
37_P128_V0.7740.71
36_A52_V0.7680.71
20_F116_T0.7650.70
26_S140_G0.7630.70
11_L45_L0.7620.70
24_L131_I0.7600.70
22_I50_S0.7570.70
43_G47_T0.7510.69
15_T53_L0.7490.69
104_F113_E0.7490.69
22_I53_L0.7470.68
84_L89_S0.7420.68
88_G133_M0.7410.68
48_S132_T0.7390.68
50_S58_Y0.7360.67
28_Y46_I0.7340.67
117_A133_M0.7320.67
12_Q57_A0.7300.67
9_L15_T0.7250.66
118_T129_V0.7220.66
109_L112_T0.7200.66
9_L13_T0.7110.65
30_F126_L0.7100.65
137_Q140_G0.7090.64
77_A84_L0.7030.64
105_Q113_E0.7000.63
48_S134_T0.7000.63
120_F128_V0.6950.63
69_V73_Y0.6930.63
19_S42_V0.6930.63
125_Y140_G0.6920.63
59_D141_E0.6890.62
47_T50_S0.6880.62
56_L72_I0.6870.62
86_G115_A0.6850.62
60_L137_Q0.6850.62
26_S121_D0.6810.61
114_L118_T0.6800.61
50_S138_T0.6650.60
9_L18_V0.6640.59
115_A118_T0.6580.59
84_L88_G0.6550.58
52_V139_I0.6530.58
90_F93_G0.6510.58
18_V53_L0.6450.57
76_G124_V0.6450.57
73_Y77_A0.6430.57
9_L67_L0.6410.57
28_Y32_S0.6380.56
11_L57_A0.6370.56
82_A92_F0.6350.56
89_S98_T0.6300.55
64_R137_Q0.6230.55
14_A45_L0.6170.54
21_I96_F0.6150.54
82_A86_G0.6100.53
22_I51_I0.6040.52
77_A91_V0.6010.52
62_T141_E0.5990.52
64_R74_V0.5970.52
18_V31_L0.5940.51
74_V126_L0.5920.51
100_T115_A0.5920.51
43_G74_V0.5910.51
116_T130_G0.5870.50
124_V130_G0.5860.50
102_G113_E0.5830.50
35_N131_I0.5820.50
26_S46_I0.5810.50
32_S45_L0.5790.49
55_L99_H0.5660.48
89_S95_P0.5650.48
107_P110_G0.5630.47
27_F71_F0.5590.47
80_L83_V0.5580.47
131_I135_I0.5560.47
10_I61_K0.5560.47
48_S68_P0.5540.46
80_L102_G0.5540.46
117_A121_D0.5530.46
28_Y87_V0.5520.46
21_I120_F0.5480.46
90_F112_T0.5460.45
23_L73_Y0.5420.45
121_D127_V0.5390.45
25_F36_A0.5390.45
73_Y83_V0.5370.44
80_L136_I0.5370.44
61_K65_S0.5360.44
9_L20_F0.5320.44
94_A116_T0.5250.43
105_Q109_L0.5250.43
85_T101_F0.5240.43
75_A134_T0.5210.42
18_V52_V0.5200.42
69_V106_L0.5180.42
137_Q141_E0.5180.42
124_V134_T0.5170.42
22_I137_Q0.5160.42
90_F110_G0.5150.42
67_L95_P0.5120.41
81_L122_L0.5090.41
8_D20_F0.5090.41
113_E117_A0.5080.41
29_L97_L0.5010.40
65_S91_V0.5010.40
127_V137_Q0.5000.40
15_T92_F0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1q16C 2 0.7622 5.9 0.952 Contact Map
4ev6A 3 0.4266 5.8 0.952 Contact Map
3iyzA 3 0.8392 4.1 0.956 Contact Map
4i0uA 4 0.3986 3.7 0.956 Contact Map
2zz9A 3 0.8392 3.6 0.957 Contact Map
1yfsA 1 0.2238 3.1 0.958 Contact Map
2ks1B 1 0.2308 2.9 0.959 Contact Map
4cadC 1 0.7972 2.6 0.96 Contact Map
2f2bA 4 0.7762 2.1 0.962 Contact Map
4nefA 4 0.9021 2.1 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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