GREMLIN Database
YUFQ - Uncharacterized ABC transporter permease protein YufQ
UniProt: O05255 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (270)
Sequences: 30639 (19659)
Seq/√Len: 1196.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_M211_L4.0351.00
80_A207_M3.6561.00
80_A211_L3.1391.00
51_T78_A3.0371.00
84_L207_M2.9721.00
188_P202_R2.9181.00
55_F74_A2.7031.00
181_I205_G2.6011.00
22_I161_A2.5831.00
29_V254_A2.5771.00
197_N200_K2.5071.00
92_S199_Y2.4661.00
79_G214_G2.3841.00
200_K204_I2.3811.00
171_I177_F2.3611.00
83_S210_G2.3451.00
169_W173_F2.3011.00
170_F174_K2.2821.00
86_H104_I2.2791.00
180_R201_M2.2261.00
84_L203_Y2.2251.00
239_I265_Q2.1671.00
88_A92_S2.1481.00
177_F204_I2.0921.00
67_A70_L2.0851.00
167_I171_I2.0481.00
24_T240_A2.0261.00
52_S75_A1.9681.00
46_I112_T1.9621.00
76_M215_L1.9541.00
69_W73_L1.9141.00
55_F59_F1.8901.00
79_G210_G1.8681.00
52_S218_G1.8431.00
166_F170_F1.7961.00
72_L218_G1.7771.00
18_A262_G1.7651.00
87_A203_Y1.7401.00
184_V201_M1.7401.00
25_A254_A1.7331.00
183_S191_A1.6981.00
31_S209_S1.6951.00
106_M109_L1.6891.00
33_R182_R1.6441.00
30_F168_S1.6261.00
54_L58_F1.6111.00
176_P180_R1.6091.00
22_I258_A1.6091.00
82_F108_A1.5851.00
239_I289_P1.5511.00
56_N71_S1.5391.00
76_M218_G1.5371.00
177_F181_I1.5181.00
18_A259_L1.5161.00
189_M192_D1.5121.00
47_I82_F1.4761.00
165_A255_L1.4521.00
144_P147_G1.4491.00
43_G109_L1.4361.00
104_I108_A1.4291.00
188_P192_D1.4231.00
204_I207_M1.4201.00
45_M220_Y1.4181.00
92_S203_Y1.4141.00
54_L115_I1.4091.00
24_T45_M1.3761.00
180_R196_I1.3721.00
70_L73_L1.3451.00
23_L216_G1.3431.00
180_R191_A1.3341.00
34_S205_G1.3321.00
247_G253_G1.3311.00
23_L219_V1.3081.00
75_A79_G1.3071.00
88_A203_Y1.2971.00
191_A196_I1.2931.00
30_F205_G1.2931.00
27_G212_F1.2921.00
66_A70_L1.2841.00
29_V249_W1.2761.00
22_I255_L1.2741.00
247_G257_A1.2631.00
184_V198_V1.2541.00
196_I201_M1.2521.00
203_Y207_M1.2521.00
59_F66_A1.2481.00
28_G244_L1.2371.00
91_I199_Y1.2361.00
71_S75_A1.2321.00
41_L213_G1.2101.00
36_V202_R1.2081.00
14_T262_G1.2061.00
26_L168_S1.2041.00
73_L77_A1.1981.00
14_T263_F1.1961.00
60_G67_A1.1851.00
184_V191_A1.1801.00
51_T55_F1.1771.00
28_G240_A1.1751.00
36_V206_V1.1701.00
173_F182_R1.1611.00
169_W174_K1.1561.00
10_I266_S1.1541.00
77_A80_A1.1531.00
207_M211_L1.1491.00
164_L212_F1.1361.00
250_H253_G1.1331.00
25_A243_A1.1301.00
36_V97_Q1.1291.00
44_L82_F1.1231.00
210_G214_G1.1071.00
43_G108_A1.1061.00
266_S269_I1.1001.00
192_D199_Y1.0931.00
145_V148_K1.0851.00
12_P16_V1.0731.00
139_G142_D1.0691.00
52_S222_S1.0691.00
18_A258_A1.0691.00
204_I208_I1.0641.00
201_M204_I1.0611.00
25_A244_L1.0561.00
89_A100_S1.0551.00
295_L299_G1.0541.00
181_I201_M1.0501.00
27_G41_L1.0491.00
192_D198_V1.0481.00
163_A167_I1.0461.00
80_A214_G1.0421.00
146_L149_I1.0361.00
265_Q289_P1.0331.00
165_A212_F1.0261.00
75_A218_G1.0231.00
166_F169_W1.0221.00
29_V244_L1.0221.00
243_A257_A1.0201.00
105_N109_L1.0091.00
50_F112_T1.0081.00
236_Q239_I1.0081.00
168_S208_I1.0011.00
159_I163_A1.0001.00
208_I212_F0.9921.00
217_G221_A0.9921.00
141_G144_P0.9921.00
81_L84_L0.9911.00
177_F201_M0.9911.00
88_A93_F0.9891.00
73_L76_M0.9821.00
24_T216_G0.9811.00
91_I101_G0.9801.00
42_E237_G0.9751.00
47_I51_T0.9721.00
54_L116_V0.9691.00
109_L113_L0.9661.00
55_F58_F0.9651.00
66_A69_W0.9601.00
268_S288_A0.9531.00
19_A158_S0.9501.00
140_L143_I0.9491.00
53_V57_L0.9441.00
243_A258_A0.9431.00
209_S213_G0.9351.00
60_G66_A0.9331.00
115_I118_L0.9291.00
55_F71_S0.9291.00
86_H100_S0.9261.00
32_E244_L0.9251.00
38_N41_L0.9221.00
20_P216_G0.9191.00
44_L213_G0.9161.00
284_Y287_M0.9141.00
43_G105_N0.9141.00
152_S159_I0.9111.00
66_A74_A0.9081.00
156_Y159_I0.9031.00
49_A232_T0.8981.00
252_I256_G0.8971.00
179_L182_R0.8961.00
261_F289_P0.8891.00
50_F116_V0.8851.00
11_V267_L0.8811.00
94_R97_Q0.8771.00
235_G239_I0.8771.00
90_A100_S0.8761.00
161_A165_A0.8751.00
25_A258_A0.8741.00
111_A115_I0.8671.00
48_G75_A0.8651.00
200_K203_Y0.8641.00
22_I165_A0.8611.00
157_T219_V0.8601.00
34_S181_I0.8571.00
114_F284_Y0.8571.00
146_L150_F0.8561.00
162_I166_F0.8541.00
76_M214_G0.8521.00
48_G79_G0.8511.00
190_A194_M0.8471.00
45_M236_Q0.8461.00
220_Y224_I0.8451.00
94_R188_P0.8401.00
52_S56_N0.8401.00
144_P148_K0.8371.00
17_Y21_L0.8351.00
28_G41_L0.8331.00
143_I146_L0.8321.00
286_L289_P0.8311.00
31_S38_N0.8291.00
49_A221_A0.8291.00
70_L74_A0.8231.00
172_L181_I0.8231.00
199_Y202_R0.8221.00
26_L164_L0.8211.00
77_A81_L0.8191.00
30_F208_I0.8181.00
169_W252_I0.8181.00
184_V205_G0.8171.00
266_S270_I0.8141.00
89_A93_F0.7981.00
187_H190_A0.7971.00
188_P198_V0.7961.00
51_T54_L0.7941.00
301_I304_A0.7941.00
42_E235_G0.7901.00
45_M233_I0.7901.00
198_V202_R0.7891.00
23_L161_A0.7871.00
184_V202_R0.7861.00
48_G217_G0.7811.00
158_S162_I0.7801.00
213_G217_G0.7791.00
211_L214_G0.7761.00
171_I174_K0.7691.00
26_L254_A0.7691.00
155_Y159_I0.7651.00
250_H254_A0.7641.00
148_K151_F0.7611.00
291_I295_L0.7601.00
30_F172_L0.7591.00
23_L164_L0.7591.00
84_L88_A0.7561.00
85_I89_A0.7551.00
199_Y203_Y0.7511.00
156_Y160_L0.7501.00
254_A258_A0.7471.00
52_S71_S0.7471.00
24_T41_L0.7461.00
147_G150_F0.7441.00
87_A91_I0.7441.00
44_L79_G0.7411.00
81_L85_I0.7381.00
27_G213_G0.7371.00
110_G113_L0.7361.00
87_A92_S0.7301.00
59_F67_A0.7301.00
24_T27_G0.7241.00
211_L215_L0.7141.00
10_I270_I0.7081.00
76_M80_A0.7061.00
33_R172_L0.7041.00
180_R197_N0.7041.00
72_L76_M0.7021.00
283_V286_L0.7011.00
91_I203_Y0.6991.00
21_L239_I0.6991.00
120_Y123_A0.6971.00
151_F159_I0.6931.00
39_I241_L0.6921.00
50_F230_H0.6921.00
138_P141_G0.6851.00
167_I170_F0.6811.00
170_F173_F0.6811.00
265_Q285_M0.6791.00
242_A293_T0.6791.00
259_L263_F0.6781.00
90_A97_Q0.6771.00
47_I79_G0.6771.00
18_A22_I0.6721.00
13_A17_Y0.6711.00
168_S212_F0.6691.00
31_S206_V0.6681.00
258_A262_G0.6621.00
83_S207_M0.6561.00
107_L111_A0.6561.00
29_V33_R0.6521.00
117_K121_G0.6491.00
45_M216_G0.6461.00
97_Q206_V0.6461.00
214_G218_G0.6411.00
32_E241_L0.6371.00
48_G78_A0.6361.00
79_G83_S0.6341.00
44_L86_H0.6341.00
121_G125_T0.6331.00
44_L48_G0.6331.00
56_N222_S0.6311.00
14_T266_S0.6281.00
36_V188_P0.6271.00
21_L243_A0.6261.00
168_S172_L0.6251.00
67_A71_S0.6251.00
109_L237_G0.6231.00
177_F208_I0.6231.00
112_T116_V0.6221.00
15_L19_A0.6201.00
154_V223_T0.6191.00
21_L258_A0.6181.00
150_F153_D0.6181.00
149_I152_S0.6171.00
164_L215_L0.6151.00
44_L210_G0.6141.00
14_T18_A0.6101.00
53_V121_G0.6101.00
165_A169_W0.6081.00
239_I286_L0.6061.00
55_F60_G0.6061.00
282_N285_M0.6031.00
246_F296_A0.6011.00
34_S184_V0.6001.00
198_V201_M0.6001.00
19_A161_A0.6001.00
253_G257_A0.5991.00
80_A83_S0.5991.00
142_D145_V0.5981.00
51_T74_A0.5981.00
144_P149_I0.5951.00
90_A206_V0.5941.00
231_S234_S0.5921.00
68_P222_S0.5911.00
243_A254_A0.5911.00
55_F78_A0.5901.00
44_L108_A0.5891.00
287_M291_I0.5861.00
47_I108_A0.5841.00
29_V251_P0.5821.00
102_V106_M0.5801.00
118_L121_G0.5771.00
51_T79_G0.5761.00
210_G213_G0.5761.00
171_I204_I0.5721.00
280_I284_Y0.5721.00
30_F171_I0.5711.00
26_L169_W0.5691.00
16_V158_S0.5681.00
16_V223_T0.5671.00
191_A198_V0.5661.00
268_S280_I0.5661.00
246_F257_A0.5651.00
106_M110_G0.5641.00
171_I175_T0.5621.00
26_L165_A0.5611.00
51_T75_A0.5601.00
220_Y236_Q0.5581.00
13_A266_S0.5571.00
55_F66_A0.5541.00
208_I211_L0.5531.00
21_L236_Q0.5531.00
27_G31_S0.5521.00
40_G86_H0.5521.00
145_V150_F0.5501.00
202_R205_G0.5491.00
31_S36_V0.5481.00
247_G254_A0.5471.00
160_L164_L0.5471.00
105_N237_G0.5461.00
117_K120_Y0.5451.00
152_S156_Y0.5411.00
34_S202_R0.5411.00
207_M210_G0.5401.00
44_L83_S0.5381.00
94_R199_Y0.5381.00
116_V119_I0.5371.00
173_F176_P0.5371.00
243_A261_F0.5361.00
55_F67_A0.5341.00
242_A289_P0.5341.00
20_P220_Y0.5331.00
119_I122_K0.5331.00
26_L166_F0.5321.00
112_T115_I0.5311.00
9_I12_P0.5311.00
76_M79_G0.5281.00
296_A300_F0.5271.00
11_V15_L0.5251.00
234_S237_G0.5231.00
48_G213_G0.5221.00
163_A166_F0.5211.00
15_L18_A0.5201.00
169_W250_H0.5181.00
119_I123_A0.5151.00
249_W254_A0.5141.00
138_P142_D0.5141.00
293_T297_L0.5121.00
60_G71_S0.5121.00
17_Y266_S0.5081.00
68_P72_L0.5081.00
143_I147_G0.5071.00
33_R249_W0.5071.00
227_D230_H0.5051.00
54_L57_L0.5051.00
49_A228_F0.5041.00
57_L125_T0.5041.00
108_A112_T0.5031.00
57_L60_G0.5011.00
189_M193_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g1uA 2 0.7868 96.8 0.881 Contact Map
2nq2A 2 0.7962 96.8 0.881 Contact Map
2qi9A 2 0.8213 95.9 0.892 Contact Map
2gfpA 2 0.6019 42.3 0.941 Contact Map
2cfqA 1 0.6332 26.7 0.947 Contact Map
4m64A 1 0.6426 20.1 0.95 Contact Map
4tphA 2 0.6144 17.7 0.952 Contact Map
4xnjA 1 0.652 15.3 0.953 Contact Map
1u7gA 3 0.511 14.6 0.953 Contact Map
2m20A 2 0.1348 10.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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