GREMLIN Database
YUFP - Uncharacterized ABC transporter permease protein YufP
UniProt: O05254 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 348 (285)
Sequences: 30944 (20014)
Seq/√Len: 1185.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
115_A246_A4.0271.00
119_G242_L3.6861.00
119_G246_A3.2271.00
123_F242_L2.9971.00
223_Q237_I2.9501.00
91_A117_A2.9421.00
95_V113_T2.7511.00
216_L240_S2.6091.00
62_I196_A2.5591.00
69_A290_V2.5441.00
131_R234_R2.5171.00
232_S235_K2.4961.00
235_K239_T2.3801.00
206_I212_K2.3531.00
204_W208_N2.3521.00
122_G245_G2.3461.00
118_G249_G2.3281.00
215_E236_N2.2071.00
123_F238_M2.1901.00
125_P143_M2.1871.00
205_F209_K2.1781.00
212_K239_T2.1691.00
275_D301_K2.1561.00
127_I131_R2.1471.00
202_I206_I2.0801.00
92_A114_A2.0481.00
115_A250_L1.9771.00
86_L151_T1.9661.00
64_S276_G1.9551.00
219_V236_N1.8701.00
118_G245_G1.8591.00
108_P112_I1.8521.00
58_I298_G1.8341.00
201_V205_F1.7961.00
92_A253_A1.7861.00
111_L253_A1.7741.00
65_G290_V1.7591.00
102_P109_L1.7531.00
71_A244_S1.7241.00
70_F203_M1.7041.00
126_G238_M1.6961.00
218_A226_S1.6961.00
145_Y148_L1.6921.00
180_L183_I1.6571.00
73_R217_R1.6321.00
211_T215_E1.6191.00
94_W98_A1.6171.00
121_W147_A1.6141.00
62_I294_A1.5861.00
212_K216_L1.5651.00
275_D322_I1.5591.00
96_G110_A1.5291.00
58_I295_C1.5181.00
224_H227_Q1.5141.00
115_A253_A1.5081.00
95_V99_F1.5071.00
83_G148_L1.4921.00
87_V121_W1.4741.00
94_W154_I1.4601.00
223_Q227_Q1.4521.00
131_R238_M1.4521.00
178_P181_E1.4511.00
200_A291_V1.4441.00
85_L255_E1.4261.00
143_M147_A1.4201.00
102_P108_P1.4201.00
239_T242_L1.4121.00
64_S85_L1.4071.00
179_F182_Q1.4051.00
169_I172_S1.3951.00
179_F183_I1.3931.00
215_E231_M1.3921.00
283_G289_G1.3841.00
172_S175_L1.3731.00
102_P107_L1.3661.00
109_L112_I1.3571.00
215_E226_S1.3521.00
63_L251_A1.3361.00
70_F240_S1.3121.00
63_L254_M1.3101.00
238_M242_L1.2851.00
226_S231_M1.2801.00
67_A247_F1.2731.00
231_M236_N1.2721.00
81_V248_A1.2651.00
127_I238_M1.2641.00
54_T298_G1.2501.00
66_L203_M1.2491.00
110_A114_A1.2451.00
76_L136_E1.2441.00
68_V276_G1.2411.00
62_I291_V1.2401.00
76_L237_I1.2401.00
219_V233_V1.2381.00
114_A118_G1.2341.00
283_G293_A1.2271.00
130_A234_R1.2191.00
68_V280_A1.2121.00
112_I116_A1.2061.00
76_L241_M1.2031.00
95_V101_G1.1951.00
38_S303_G1.1931.00
116_A119_G1.1901.00
50_Y302_I1.1881.00
101_G109_L1.1821.00
219_V226_S1.1771.00
208_N217_R1.1681.00
84_Q121_W1.1561.00
175_L179_F1.1481.00
242_L246_A1.1421.00
199_A247_F1.1401.00
91_A95_V1.1351.00
239_T243_I1.1311.00
39_A42_N1.1251.00
204_W209_K1.1211.00
83_G147_A1.1201.00
38_S42_N1.1181.00
54_T299_G1.1161.00
227_Q234_R1.1101.00
65_G279_V1.0941.00
58_I294_A1.0911.00
302_I305_L1.0881.00
130_A140_T1.0801.00
216_L236_N1.0761.00
286_T289_G1.0691.00
120_L123_F1.0661.00
92_A257_L1.0631.00
67_A81_V1.0481.00
65_G280_A1.0471.00
101_G113_T1.0451.00
194_I198_L1.0431.00
243_I247_F1.0411.00
128_L139_V1.0401.00
114_A253_A1.0391.00
94_W155_I1.0371.00
119_G249_G1.0361.00
236_N239_T1.0311.00
317_V320_I1.0291.00
245_G249_G1.0271.00
90_T151_T1.0271.00
125_P139_V1.0261.00
201_V204_W1.0251.00
37_Y41_W1.0161.00
95_V98_A1.0141.00
301_K322_I1.0081.00
227_Q233_V1.0051.00
95_V110_A0.9991.00
252_G256_G0.9981.00
69_A280_A0.9981.00
59_T193_I0.9971.00
272_V275_D0.9941.00
171_E174_S0.9941.00
203_M243_I0.9931.00
144_N148_L0.9931.00
178_P183_I0.9911.00
112_I115_A0.9841.00
72_F280_A0.9781.00
198_L202_I0.9721.00
52_G56_R0.9711.00
82_E273_G0.9711.00
148_L152_N0.9701.00
200_A247_F0.9681.00
64_S251_A0.9621.00
285_N290_V0.9611.00
279_V293_A0.9571.00
212_K236_N0.9561.00
36_G40_L0.9481.00
170_H173_A0.9471.00
177_S180_L0.9461.00
90_T155_I0.9451.00
319_D322_I0.9451.00
60_P251_A0.9451.00
279_V294_A0.9451.00
93_V97_T0.9421.00
74_T240_S0.9391.00
178_P182_Q0.9381.00
83_G144_N0.9371.00
127_I132_F0.9341.00
66_L199_A0.9301.00
244_S248_A0.9281.00
129_K139_V0.9241.00
187_S194_I0.9221.00
288_V292_L0.9141.00
175_L178_P0.9061.00
303_G307_M0.9041.00
168_K171_E0.8991.00
84_Q248_A0.8991.00
116_A120_L0.8991.00
235_K238_M0.8961.00
214_F217_R0.8941.00
192_G254_M0.8931.00
297_L322_I0.8911.00
42_N46_G0.8911.00
196_A200_A0.8881.00
87_V91_A0.8801.00
191_L194_I0.8791.00
88_G114_A0.8791.00
115_A249_G0.8771.00
78_N81_V0.8771.00
88_G118_G0.8721.00
304_A321_V0.8711.00
92_A96_G0.8651.00
65_G294_A0.8641.00
68_V81_V0.8621.00
271_G275_D0.8621.00
219_V240_S0.8611.00
222_N225_A0.8561.00
71_A78_N0.8551.00
255_E259_T0.8551.00
233_V237_I0.8531.00
62_I200_A0.8501.00
128_L132_F0.8481.00
225_A229_A0.8461.00
89_W256_G0.8461.00
328_F332_S0.8441.00
154_I157_N0.8391.00
120_L124_I0.8391.00
57_Q61_Y0.8391.00
89_W268_A0.8371.00
197_L201_V0.8361.00
153_Y317_V0.8351.00
234_R237_I0.8341.00
85_L272_V0.8331.00
88_G252_G0.8281.00
39_A43_G0.8281.00
133_Y223_Q0.8251.00
70_F207_I0.8201.00
91_A94_W0.8191.00
63_L196_A0.8191.00
184_T187_S0.8181.00
150_M154_I0.8071.00
73_R207_I0.8071.00
159_L162_H0.8071.00
35_S39_A0.8061.00
190_H194_I0.8061.00
51_V303_G0.8041.00
248_A252_G0.8031.00
49_Y52_G0.8031.00
40_L43_G0.8021.00
70_F243_I0.8021.00
193_I197_L0.8011.00
124_I128_L0.7911.00
234_R238_M0.7901.00
204_W288_V0.7901.00
69_A285_N0.7901.00
246_A249_G0.7861.00
280_A285_N0.7811.00
109_L113_T0.7811.00
126_G131_R0.7801.00
43_G47_E0.7751.00
85_L269_F0.7741.00
84_Q118_G0.7731.00
286_T290_V0.7721.00
149_H152_N0.7711.00
82_E271_G0.7691.00
53_E57_Q0.7681.00
191_L195_V0.7681.00
207_I216_L0.7661.00
302_I306_N0.7661.00
44_I47_E0.7651.00
223_Q233_V0.7631.00
219_V237_I0.7621.00
123_F127_I0.7581.00
290_V294_A0.7561.00
66_L290_V0.7561.00
64_S81_V0.7551.00
90_T266_K0.7531.00
79_I277_I0.7511.00
126_G130_A0.7431.00
246_A250_L0.7371.00
295_C299_G0.7331.00
156_S160_T0.7301.00
101_G107_L0.7261.00
160_T164_D0.7261.00
115_A119_G0.7251.00
39_A46_G0.7241.00
92_A110_A0.7171.00
67_A248_A0.7161.00
130_A238_M0.7141.00
316_E319_D0.7121.00
38_S43_G0.7101.00
87_V118_G0.7051.00
58_I62_I0.7041.00
111_L115_A0.7031.00
181_E184_T0.7021.00
136_E241_M0.7001.00
88_G117_A0.7001.00
206_I209_K0.6941.00
278_A326_I0.6911.00
146_I150_M0.6911.00
215_E232_S0.6901.00
324_I328_F0.6901.00
61_Y275_D0.6861.00
189_L258_G0.6861.00
202_I205_F0.6851.00
63_L199_A0.6841.00
85_L251_A0.6761.00
148_L273_G0.6751.00
249_G253_A0.6741.00
203_M247_F0.6731.00
40_L44_I0.6681.00
64_S67_A0.6661.00
84_Q125_P0.6621.00
205_F208_N0.6591.00
183_I186_Y0.6581.00
71_A241_M0.6571.00
34_A38_S0.6561.00
55_I59_T0.6511.00
69_A73_R0.6511.00
175_L180_L0.6481.00
35_S38_S0.6441.00
294_A298_G0.6431.00
76_L223_Q0.6421.00
118_G122_G0.6421.00
200_A204_W0.6391.00
157_N160_T0.6361.00
61_Y279_V0.6361.00
119_G122_G0.6331.00
206_I210_S0.6331.00
158_V162_H0.6311.00
53_E302_I0.6311.00
158_V161_D0.6291.00
199_A250_L0.6291.00
72_F277_I0.6281.00
61_Y272_V0.6261.00
122_G242_L0.6241.00
301_K318_V0.6241.00
54_T302_I0.6231.00
203_M207_I0.6211.00
212_K243_I0.6211.00
177_S181_E0.6181.00
133_Y136_E0.6151.00
129_K241_M0.6141.00
56_R258_G0.6131.00
129_K136_E0.6121.00
84_Q147_A0.6121.00
84_Q88_G0.6111.00
96_G257_L0.6071.00
84_Q245_G0.6071.00
35_S299_G0.6071.00
50_Y306_N0.6071.00
87_V147_A0.6031.00
160_T163_Q0.6031.00
133_Y234_R0.6031.00
69_A287_A0.6001.00
59_T196_A0.5981.00
177_S183_I0.5981.00
48_I51_V0.5971.00
66_L200_A0.5951.00
243_I246_A0.5951.00
80_G125_P0.5941.00
204_W286_T0.5921.00
70_F206_I0.5921.00
93_V160_T0.5911.00
41_W44_I0.5891.00
72_F285_N0.5861.00
170_H174_S0.5861.00
145_Y149_H0.5841.00
233_V236_N0.5791.00
282_L293_A0.5791.00
119_G245_G0.5751.00
107_L257_L0.5741.00
255_E272_V0.5741.00
158_V164_D0.5731.00
237_I240_S0.5731.00
101_G108_P0.5691.00
206_I239_T0.5661.00
171_E175_L0.5651.00
88_G248_A0.5641.00
92_A252_G0.5631.00
322_I326_I0.5621.00
91_A113_T0.5621.00
155_I158_V0.5611.00
35_S42_N0.5591.00
91_A114_A0.5581.00
89_W264_A0.5561.00
242_L245_G0.5561.00
57_Q302_I0.5551.00
61_Y294_A0.5551.00
282_L329_V0.5551.00
67_A71_A0.5521.00
132_F331_S0.5471.00
115_A118_G0.5461.00
71_A76_L0.5431.00
226_S233_V0.5411.00
189_L192_G0.5401.00
187_S191_L0.5401.00
279_V290_V0.5401.00
56_R193_I0.5401.00
144_N273_G0.5391.00
48_I52_G0.5391.00
198_L201_V0.5391.00
62_I66_L0.5381.00
87_V117_A0.5361.00
141_I145_Y0.5361.00
158_V163_Q0.5351.00
275_D319_D0.5341.00
95_V117_A0.5321.00
94_W97_T0.5311.00
97_T164_D0.5281.00
38_S41_W0.5281.00
267_G270_T0.5271.00
270_T273_G0.5251.00
195_V199_A0.5241.00
84_Q122_G0.5241.00
245_G248_A0.5221.00
36_G39_A0.5211.00
140_T144_N0.5211.00
208_N211_T0.5201.00
147_A151_T0.5191.00
189_L194_I0.5191.00
55_I58_I0.5181.00
62_I197_L0.5181.00
182_Q186_Y0.5171.00
60_P258_G0.5171.00
304_A313_V0.5171.00
86_L268_A0.5161.00
151_T155_I0.5151.00
159_L265_V0.5141.00
75_G223_Q0.5141.00
224_H228_Y0.5121.00
81_V244_S0.5081.00
78_N244_S0.5071.00
276_G280_A0.5071.00
151_T154_I0.5041.00
54_T58_I0.5041.00
37_Y43_G0.5001.00
60_P255_E0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.8075 96.7 0.88 Contact Map
4g1uA 2 0.7874 95.7 0.891 Contact Map
2qi9A 2 0.8247 95.3 0.894 Contact Map
2rddB 1 0.092 29.7 0.945 Contact Map
2m20A 2 0.1063 27.8 0.946 Contact Map
2l2tA 2 0.1207 21.2 0.949 Contact Map
2kluA 1 0.1264 19 0.95 Contact Map
2gfpA 2 0.5345 18.8 0.95 Contact Map
2ksfA 1 0.3075 13.7 0.953 Contact Map
2ks1B 1 0.1264 12.6 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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