GREMLIN Database
YUFN - Uncharacterized lipoprotein YufN
UniProt: O05252 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 359 (315)
Sequences: 3738 (2764)
Seq/√Len: 155.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
152_F191_A3.8851.00
338_K342_D3.6721.00
107_G116_I3.5991.00
327_D331_K3.5061.00
189_V196_A3.5041.00
335_K339_K3.4931.00
294_K298_D3.4171.00
220_Y254_V3.0651.00
165_G193_N2.8211.00
91_T118_E2.7521.00
156_V336_W2.7501.00
167_I189_V2.6941.00
337_K341_I2.6571.00
95_N122_Q2.6541.00
160_L332_A2.6361.00
166_K197_V2.6351.00
57_Q61_E2.5791.00
69_E290_E2.5761.00
203_A234_T2.5631.00
162_S165_G2.5401.00
187_A347_P2.5381.00
166_K199_E2.4561.00
51_D57_Q2.3511.00
65_A290_E2.3021.00
310_G313_Q2.2321.00
332_A335_K2.2191.00
326_S329_V2.1571.00
174_E179_K2.1391.00
162_S225_D2.1271.00
98_A128_F2.1011.00
334_D337_K2.0991.00
161_S326_S2.0811.00
64_Q67_G2.0521.00
170_V238_V1.9971.00
334_D338_K1.9901.00
330_I334_D1.9741.00
154_V318_I1.9711.00
150_G281_M1.9691.00
166_K224_V1.9371.00
95_N123_R1.9341.00
156_V192_V1.9301.00
98_A123_R1.9231.00
291_D295_K1.8891.00
339_K342_D1.8461.00
205_G208_K1.8121.00
145_F288_V1.8011.00
65_A69_E1.7781.00
331_K335_K1.7611.00
157_A333_V1.7601.00
60_W64_Q1.7521.00
317_G337_K1.7421.00
327_D330_I1.7371.00
156_V191_A1.7281.00
191_A336_W1.7211.00
64_Q68_K1.7121.00
338_K341_I1.6981.00
147_E180_K1.6931.00
66_F293_T1.6861.00
42_A97_L1.6861.00
212_G234_T1.6811.00
105_I126_T1.6791.00
146_K310_G1.6771.00
154_V257_I1.6391.00
186_R190_Q1.6391.00
339_K344_L1.5881.00
182_E186_R1.5731.00
221_K252_R1.5621.00
311_L341_I1.5481.00
161_S329_V1.5361.00
213_K244_N1.5321.00
159_A162_S1.5241.00
295_K300_K1.5061.00
209_A234_T1.4721.00
159_A196_A1.4481.00
213_K217_E1.4351.00
42_A102_F1.4261.00
332_A336_W1.4161.00
220_Y242_A1.4151.00
199_E224_V1.4071.00
216_A227_I1.4061.00
66_F70_N1.4021.00
70_N290_E1.3751.00
258_G263_Q1.3701.00
39_F296_A1.3621.00
331_K334_D1.3481.00
314_D317_G1.3431.00
94_L107_G1.3401.00
70_N294_K1.3341.00
213_K240_T1.3091.00
164_S225_D1.3011.00
149_E312_D1.2881.00
146_K149_E1.2851.00
135_V142_S1.2851.00
59_A289_V1.2551.00
153_L337_K1.2471.00
162_S226_V1.2391.00
336_W339_K1.2381.00
217_E221_K1.2291.00
203_A215_T1.2261.00
113_E133_A1.2261.00
69_E294_K1.2151.00
284_K287_T1.2001.00
95_N99_R1.1961.00
152_F336_W1.1911.00
16_A19_I1.1881.00
65_A286_D1.1821.00
153_L333_V1.1771.00
154_V281_M1.1761.00
89_D92_T1.1691.00
40_S102_F1.1641.00
19_I22_A1.1531.00
95_N119_I1.1421.00
82_L97_L1.1391.00
15_A18_T1.1351.00
104_L293_T1.1301.00
50_V81_Y1.1261.00
117_S121_D1.1241.00
99_R123_R1.1231.00
159_A192_V1.1221.00
171_G178_I1.1191.00
160_L329_V1.1181.00
290_E294_K1.1181.00
61_E64_Q1.1141.00
157_A279_T1.1131.00
48_G56_N1.1101.00
168_G224_V1.1091.00
101_N126_T1.1091.00
150_G316_V1.1091.00
166_K223_G1.0900.99
20_L23_C1.0860.99
253_D276_V1.0740.99
141_A301_F1.0740.99
91_T95_N1.0730.99
214_A217_E1.0650.99
255_W324_N1.0640.99
162_S189_V1.0620.99
130_I133_A1.0600.99
239_F277_T1.0560.99
243_K275_N1.0550.99
41_V104_L1.0500.99
39_F297_S1.0480.99
108_V131_I1.0410.99
291_D294_K1.0370.99
97_L102_F1.0360.99
279_T319_S1.0290.99
94_L119_I1.0270.99
50_V60_W1.0270.99
279_T320_P1.0190.99
284_K317_G1.0130.99
255_W278_L1.0050.99
220_Y227_I0.9980.99
168_G219_M0.9860.99
217_E241_E0.9860.99
241_E244_N0.9840.99
226_V257_I0.9760.99
256_V276_V0.9730.99
91_T119_I0.9720.99
95_N98_A0.9620.99
94_L116_I0.9610.99
238_V256_V0.9610.99
199_E222_S0.9510.98
201_K219_M0.9500.98
208_K211_V0.9490.98
67_G73_K0.9490.98
203_A212_G0.9480.98
62_G286_D0.9450.98
239_F256_V0.9450.98
239_F273_D0.9430.98
141_A307_L0.9430.98
282_V317_G0.9380.98
156_V332_A0.9340.98
287_T291_D0.9340.98
127_N301_F0.9290.98
193_N196_A0.9280.98
211_V214_A0.9270.98
242_A256_V0.9240.98
146_K308_T0.9160.98
12_L15_A0.9120.98
239_F276_V0.9090.98
104_L296_A0.9080.98
117_S140_V0.9060.98
23_C26_S0.9050.98
14_I17_G0.9030.98
82_L85_K0.9020.98
157_A325_L0.9000.98
186_R198_V0.8990.98
151_S181_F0.8940.98
113_E117_S0.8910.98
106_Y129_A0.8820.97
84_S93_N0.8810.97
228_Y281_M0.8790.97
103_D126_T0.8730.97
12_L16_A0.8700.97
336_W344_L0.8690.97
129_A143_I0.8680.97
41_V293_T0.8630.97
104_L129_A0.8620.97
22_A25_N0.8610.97
335_K338_K0.8600.97
136_D142_S0.8590.97
146_K313_Q0.8480.97
264_Y319_S0.8450.97
98_A126_T0.8430.97
81_Y84_S0.8410.97
86_S89_D0.8380.97
309_Y313_Q0.8350.97
151_S281_M0.8340.96
201_K215_T0.8320.96
219_M224_V0.8310.96
256_V277_T0.8290.96
328_D331_K0.8270.96
48_G52_D0.8260.96
80_D102_F0.8240.96
258_G280_S0.8230.96
156_V160_L0.8190.96
50_V57_Q0.8160.96
16_A20_L0.8120.96
98_A119_I0.8120.96
43_M59_A0.8110.96
45_T50_V0.8100.96
159_A193_N0.8040.96
117_S137_K0.8040.96
63_I67_G0.8020.96
273_D276_V0.8000.96
158_A257_I0.7950.95
295_K298_D0.7900.95
294_K297_S0.7890.95
18_T22_A0.7870.95
161_S278_L0.7850.95
181_F230_S0.7850.95
114_D117_S0.7830.95
186_R200_V0.7830.95
152_F188_G0.7810.95
161_S226_V0.7780.95
116_I140_V0.7760.95
157_A161_S0.7740.95
94_L112_M0.7720.95
264_Y274_D0.7710.95
39_F103_D0.7680.94
43_M63_I0.7650.94
240_T243_K0.7650.94
169_F230_S0.7610.94
260_D283_K0.7600.94
165_G225_D0.7590.94
65_A287_T0.7560.94
127_N296_A0.7530.94
45_T60_W0.7530.94
149_E310_G0.7500.94
162_S196_A0.7470.94
217_E252_R0.7470.94
157_A257_I0.7450.94
188_G191_A0.7440.93
172_G232_G0.7430.93
314_D341_I0.7400.93
19_I23_C0.7390.93
145_F283_K0.7360.93
45_T81_Y0.7350.93
164_S223_G0.7330.93
66_F72_L0.7320.93
59_A285_V0.7320.93
66_F290_E0.7300.93
132_D283_K0.7290.93
62_G66_F0.7270.93
131_I285_V0.7250.93
160_L192_V0.7210.92
189_V198_V0.7200.92
58_S286_D0.7200.92
63_I79_Y0.7170.92
328_D332_A0.7170.92
13_V19_I0.7160.92
230_S259_V0.7140.92
65_A68_K0.7130.92
94_L98_A0.7110.92
340_I344_L0.7100.92
113_E135_V0.7050.92
169_F182_E0.7020.91
181_F259_V0.7010.91
156_V189_V0.7010.91
141_A292_V0.6990.91
37_N103_D0.6980.91
53_K266_E0.6950.91
259_V283_K0.6930.91
47_V207_D0.6930.91
152_F156_V0.6920.91
216_A220_Y0.6910.91
257_I279_T0.6910.91
70_N297_S0.6880.91
181_F260_D0.6880.91
125_N138_D0.6880.91
96_K100_E0.6880.91
99_R122_Q0.6880.91
102_F126_T0.6870.90
231_A235_G0.6850.90
311_L340_I0.6850.90
211_V215_T0.6850.90
106_Y293_T0.6840.90
187_A190_Q0.6840.90
118_E122_Q0.6830.90
177_L180_K0.6830.90
12_L18_T0.6830.90
182_E200_V0.6810.90
182_E202_Y0.6780.90
59_A108_V0.6780.90
91_T115_S0.6770.90
156_V333_V0.6760.90
148_Q346_I0.6760.90
40_S103_D0.6740.90
10_M13_V0.6740.90
210_D213_K0.6730.90
147_E281_M0.6720.89
199_E219_M0.6710.89
262_D320_P0.6700.89
18_T21_G0.6700.89
243_K276_V0.6690.89
174_E204_G0.6680.89
229_H238_V0.6680.89
11_S15_A0.6670.89
153_L311_L0.6660.89
11_S14_I0.6660.89
137_K140_V0.6650.89
142_S305_E0.6650.89
282_V319_S0.6630.89
143_I292_V0.6630.89
166_K222_S0.6620.89
214_A218_S0.6620.89
61_E261_K0.6620.89
147_E283_K0.6620.89
264_Y321_S0.6590.89
226_V278_L0.6570.88
11_S18_T0.6570.88
151_S230_S0.6570.88
159_A165_G0.6550.88
170_V216_A0.6520.88
242_A253_D0.6520.88
141_A302_P0.6500.88
217_E244_N0.6480.88
23_C27_E0.6460.88
163_K195_K0.6460.88
325_L329_V0.6440.87
231_A237_G0.6430.87
277_T280_S0.6420.87
190_Q194_P0.6410.87
191_A194_P0.6400.87
215_T219_M0.6400.87
113_E130_I0.6390.87
148_Q180_K0.6390.87
314_D337_K0.6390.87
329_V333_V0.6340.87
60_W63_I0.6330.87
235_G259_V0.6320.86
161_S255_W0.6280.86
292_V295_K0.6280.86
119_I122_Q0.6260.86
13_V17_G0.6260.86
87_D111_L0.6230.86
311_L344_L0.6210.85
52_D57_Q0.6190.85
134_V142_S0.6180.85
220_Y241_E0.6180.85
151_S228_Y0.6170.85
165_G195_K0.6160.85
52_D56_N0.6150.85
129_A292_V0.6140.85
275_N323_Q0.6130.85
121_D137_K0.6130.85
212_G235_G0.6120.85
10_M17_G0.6110.85
134_V144_T0.6070.84
167_I185_F0.6070.84
143_I309_Y0.6020.84
60_W81_Y0.6020.84
173_M206_F0.6000.83
17_G20_L0.6000.83
244_N252_R0.6000.83
81_Y85_K0.5990.83
310_G315_G0.5990.83
40_S73_K0.5980.83
103_D125_N0.5970.83
212_G237_G0.5950.83
191_A339_K0.5920.83
67_G72_L0.5910.83
168_G216_A0.5890.82
302_P305_E0.5880.82
151_S177_L0.5870.82
171_G182_E0.5860.82
192_V196_A0.5850.82
154_V279_T0.5850.82
84_S89_D0.5840.82
325_L330_I0.5840.82
47_V111_L0.5840.82
291_D313_Q0.5810.82
296_A301_F0.5810.82
130_I135_V0.5800.81
287_T290_E0.5800.81
108_V143_I0.5790.81
233_A236_T0.5790.81
15_A19_I0.5780.81
295_K302_P0.5760.81
157_A329_V0.5760.81
68_K125_N0.5750.81
311_L337_K0.5750.81
89_D93_N0.5740.81
82_L93_N0.5710.80
279_T321_S0.5680.80
119_I128_F0.5670.80
68_K300_K0.5620.79
144_T180_K0.5610.79
10_M16_A0.5600.79
50_V64_Q0.5580.79
20_L27_E0.5560.79
157_A160_L0.5550.79
20_L25_N0.5530.78
213_K241_E0.5520.78
170_V229_H0.5520.78
318_I333_V0.5510.78
262_D280_S0.5490.78
187_A191_A0.5480.78
66_F297_S0.5480.78
295_K307_L0.5460.77
167_I196_A0.5460.77
266_E274_D0.5460.77
55_F181_F0.5450.77
55_F132_D0.5450.77
14_I18_T0.5450.77
275_N324_N0.5420.77
171_G202_Y0.5420.77
131_I289_V0.5420.77
144_T308_T0.5380.76
179_K202_Y0.5370.76
13_V16_A0.5370.76
189_V192_V0.5350.76
185_F188_G0.5350.76
10_M14_I0.5330.76
177_L228_Y0.5300.75
61_E286_D0.5290.75
160_L328_D0.5290.75
262_D319_S0.5260.75
169_F178_I0.5260.75
18_T23_C0.5260.75
127_N141_A0.5250.75
12_L22_A0.5230.74
90_Y112_M0.5230.74
58_S261_K0.5230.74
183_V349_T0.5210.74
185_F228_Y0.5210.74
97_L105_I0.5200.74
263_Q266_E0.5200.74
207_D234_T0.5190.74
162_S167_I0.5190.74
184_G283_K0.5180.74
291_D309_Y0.5180.74
240_T244_N0.5180.74
60_W67_G0.5170.74
38_K73_K0.5160.73
67_G70_N0.5140.73
173_M204_G0.5140.73
161_S325_L0.5130.73
318_I337_K0.5120.73
105_I128_F0.5110.73
54_S263_Q0.5110.73
66_F79_Y0.5110.73
141_A295_K0.5100.73
132_D232_G0.5100.73
181_F283_K0.5090.72
231_A234_T0.5080.72
44_V93_N0.5070.72
190_Q197_V0.5070.72
154_V157_A0.5050.72
229_H235_G0.5010.71
153_L318_I0.5010.71
53_K57_Q0.5010.71
62_G287_T0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pevA 1 0.8579 100 0.418 Contact Map
4iilA 1 0.8134 100 0.449 Contact Map
3s99A 1 0.8329 100 0.45 Contact Map
4p98A 1 0.805 100 0.46 Contact Map
2fqxA 1 0.8663 100 0.472 Contact Map
2hqbA 1 0.7827 100 0.487 Contact Map
4ycsA 1 0.337 100 0.646 Contact Map
4wzzA 1 0.7967 99.9 0.713 Contact Map
4yv7A 1 0.7772 99.8 0.753 Contact Map
4z0nA 1 0.7716 99.8 0.759 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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