MALK - BACSU - GREMLIN Contacts

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MALK - Sensor histidine kinase MalK

UniProt:	O05250	Sequences: MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKATALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPDPSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVNEIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAMLESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKKPLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALRAQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLGKQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMSMRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMILTSEKNEGTTFSIRIPYEPKEENHD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	533 (499)
Sequences:	9978 (8691)
Seq/√Len:	389.0

ECOLI - DCUS DPIB ATOS RCSC RCSD BARA ARCB NARX NARQ EVGS TORS ZRAS PHOR CREC PHOQ CUSS BAES GLRK QSEC NTRB ENVZ YEDV CPXA RSTB
BACSU - MALK DCTS CITS YYCG RESE PHOR KINE KINA KIND KINC YCLK YVRG CSSS YKOH
HALSA - Q9HQ16 O51970 Q9HR10 Q9HRE4 Q9HQG5 Q9HRG1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
512_E	515_E	4.223	1.00
463_T	518_T	4.161	1.00
351_V	363_I	3.849	1.00
474_Q	509_L	3.630	1.00
497_Q	501_E	3.467	1.00
223_E	311_R	3.342	1.00
405_D	446_Q	3.341	1.00
407_E	450_S	3.279	1.00
508_I	520_S	3.217	1.00
439_V	465_T	3.214	1.00
457_I	522_R	3.006	1.00
211_L	215_S	2.989	1.00
427_I	499_S	2.917	1.00
448_T	463_T	2.911	1.00
500_I	521_I	2.897	1.00
450_S	461_E	2.844	1.00
229_D	233_K	2.812	1.00
470_S	473_D	2.808	1.00
496_T	507_M	2.807	1.00
419_S	503_L	2.724	1.00
461_E	518_T	2.701	1.00
509_L	519_F	2.699	1.00
405_D	448_T	2.679	1.00
240_E	243_R	2.636	1.00
460_I	521_I	2.624	1.00
407_E	448_T	2.598	1.00
326_V	329_Y	2.531	1.00
464_D	468_G	2.524	1.00
469_M	473_D	2.517	1.00
446_Q	465_T	2.502	1.00
459_D	522_R	2.472	1.00
454_H	459_D	2.460	1.00
210_L	213_E	2.444	1.00
461_E	520_S	2.414	1.00
452_R	459_D	2.412	1.00
282_D	285_I	2.390	1.00
450_S	463_T	2.376	1.00
499_S	503_L	2.373	1.00
439_V	445_K	2.312	1.00
316_V	320_A	2.305	1.00
403_N	446_Q	2.284	1.00
453_F	525_Y	2.261	1.00
500_I	505_G	2.255	1.00
511_S	517_T	2.234	1.00
439_V	447_I	2.222	1.00
427_I	500_I	2.207	1.00
428_I	460_I	2.189	1.00
257_Q	261_D	2.148	1.00
510_T	518_T	2.130	1.00
226_L	241_A	2.108	1.00
381_V	384_S	2.095	1.00
459_D	520_S	2.072	1.00
474_Q	511_S	2.049	1.00
478_F	507_M	2.023	1.00
427_I	496_T	2.022	1.00
224_G	310_F	1.992	1.00
445_K	465_T	1.983	1.00
438_A	483_S	1.973	1.00
92_D	96_I	1.971	1.00
348_L	367_A	1.930	1.00
383_S	451_M	1.927	1.00
388_G	425_I	1.906	1.00
317_K	320_A	1.892	1.00
393_K	429_G	1.890	1.00
208_A	211_L	1.886	1.00
506_Q	522_R	1.884	1.00
226_L	308_A	1.880	1.00
476_K	479_E	1.871	1.00
394_Q	398_R	1.849	1.00
324_S	327_K	1.832	1.00
350_L	359_L	1.819	1.00
420_V	423_E	1.819	1.00
221_T	225_I	1.810	1.00
224_G	244_L	1.800	1.00
452_R	461_E	1.787	1.00
511_S	515_E	1.777	1.00
510_T	520_S	1.752	1.00
210_L	215_S	1.751	1.00
206_E	210_L	1.740	1.00
469_M	477_V	1.712	1.00
423_E	426_T	1.711	1.00
408_C	451_M	1.705	1.00
419_S	424_L	1.704	1.00
258_D	261_D	1.692	1.00
423_E	499_S	1.688	1.00
471_E	474_Q	1.671	1.00
195_V	198_I	1.668	1.00
205_Y	208_A	1.649	1.00
324_S	328_M	1.643	1.00
348_L	368_I	1.623	1.00
188_A	192_A	1.616	1.00
214_R	218_L	1.614	1.00
215_S	219_E	1.601	1.00
501_E	506_Q	1.600	1.00
505_G	523_I	1.587	1.00
511_S	514_N	1.584	1.00
242_K	251_N	1.575	1.00
428_I	432_I	1.568	1.00
320_A	324_S	1.566	1.00
207_I	210_L	1.548	1.00
437_D	485_K	1.532	1.00
42_E	46_A	1.522	1.00
270_K	274_T	1.496	1.00
226_L	234_I	1.477	1.00
239_A	243_R	1.472	1.00
473_D	476_K	1.461	1.00
473_D	482_Y	1.457	1.00
210_L	214_R	1.447	1.00
386_L	451_M	1.443	1.00
372_S	422_H	1.440	1.00
397_I	436_L	1.430	1.00
315_E	318_H	1.429	1.00
198_I	202_L	1.428	1.00
508_I	522_R	1.425	1.00
427_I	521_I	1.406	1.00
433_N	437_D	1.401	1.00
337_S	342_N	1.400	1.00
141_P	151_G	1.399	1.00
435_G	447_I	1.396	1.00
247_K	253_N	1.394	1.00
39_R	43_K	1.392	1.00
28_F	32_A	1.384	1.00
470_S	513_K	1.380	1.00
381_V	414_N	1.375	1.00
214_R	217_M	1.374	1.00
224_G	238_N	1.372	1.00
397_I	404_L	1.370	1.00
323_L	326_V	1.366	1.00
371_K	375_S	1.361	1.00
458_L	525_Y	1.359	1.00
239_A	242_K	1.350	1.00
318_H	322_Q	1.349	1.00
115_E	119_L	1.347	1.00
319_L	323_L	1.341	1.00
227_A	305_G	1.341	1.00
431_L	521_I	1.337	1.00
477_V	509_L	1.337	1.00
264_P	267_R	1.333	1.00
428_I	462_I	1.331	1.00
479_E	482_Y	1.330	1.00
478_F	509_L	1.319	1.00
440_A	444_K	1.319	1.00
318_H	321_E	1.303	1.00
250_I	253_N	1.296	1.00
346_V	350_L	1.285	1.00
448_T	465_T	1.273	1.00
87_F	156_G	1.267	1.00
476_K	482_Y	1.258	1.00
412_I	451_M	1.256	1.00
77_K	80_Q	1.253	1.00
320_A	323_L	1.252	1.00
357_D	361_D	1.250	1.00
237_A	241_A	1.246	1.00
424_L	503_L	1.244	1.00
388_G	421_I	1.239	1.00
211_L	214_R	1.233	1.00
413_P	453_F	1.231	1.00
237_A	242_K	1.226	1.00
108_K	112_G	1.222	1.00
500_I	507_M	1.220	1.00
49_T	52_M	1.218	1.00
217_M	221_T	1.218	1.00
349_G	353_L	1.212	1.00
347_I	363_I	1.211	1.00
364_K	368_I	1.210	1.00
351_V	364_K	1.209	1.00
46_A	49_T	1.209	1.00
383_S	387_A	1.205	1.00
423_E	502_N	1.202	1.00
291_V	294_E	1.198	1.00
389_F	425_I	1.197	1.00
237_A	254_P	1.192	1.00
193_R	197_N	1.188	1.00
457_I	506_Q	1.186	1.00
432_I	449_M	1.179	1.00
389_F	432_I	1.177	1.00
50_A	54_A	1.166	1.00
269_K	273_E	1.160	1.00
46_A	50_A	1.158	1.00
473_D	484_T	1.156	1.00
313_K	317_K	1.151	1.00
208_A	212_E	1.149	1.00
469_M	517_T	1.148	1.00
346_V	366_I	1.139	1.00
382_K	460_I	1.138	1.00
339_E	342_N	1.138	1.00
241_A	245_F	1.138	1.00
409_N	452_R	1.136	1.00
509_L	517_T	1.129	1.00
469_M	509_L	1.127	1.00
228_V	308_A	1.127	1.00
87_F	100_H	1.125	1.00
279_Q	282_D	1.125	1.00
296_P	305_G	1.124	1.00
478_F	519_F	1.121	1.00
296_P	303_T	1.118	1.00
113_G	117_E	1.111	1.00
387_A	406_I	1.109	1.00
218_L	236_L	1.109	1.00
224_G	241_A	1.105	1.00
426_T	499_S	1.102	1.00
471_E	512_E	1.100	1.00
361_D	365_D	1.094	1.00
454_H	522_R	1.086	1.00
78_R	82_I	1.082	1.00
477_V	519_F	1.082	1.00
41_Q	44_A	1.081	1.00
281_R	284_R	1.076	1.00
350_L	362_Y	1.074	1.00
392_G	429_G	1.074	1.00
32_A	35_T	1.073	1.00
151_G	155_V	1.065	1.00
227_A	307_I	1.063	1.00
390_L	406_I	1.056	1.00
351_V	360_G	1.055	1.00
383_S	408_C	1.053	1.00
26_T	30_V	1.048	1.00
336_Q	377_I	1.046	1.00
431_L	462_I	1.044	1.00
334_R	339_E	1.040	1.00
109_K	112_G	1.037	1.00
346_V	362_Y	1.037	1.00
431_L	519_F	1.036	1.00
242_K	250_I	1.036	1.00
227_A	236_L	1.036	1.00
397_I	447_I	1.031	1.00
317_K	321_E	1.031	1.00
340_F	343_K	1.026	1.00
384_S	421_I	1.022	1.00
217_M	220_S	1.019	1.00
68_K	71_E	1.018	1.00
393_K	436_L	1.017	1.00
242_K	254_P	1.016	1.00
192_A	196_K	1.011	1.00
413_P	416_A	1.008	1.00
431_L	496_T	1.004	1.00
151_G	158_T	1.004	1.00
228_V	234_I	1.004	1.00
71_E	74_S	1.002	1.00
298_Q	303_T	0.999	1.00
38_I	41_Q	0.998	1.00
205_Y	210_L	0.996	1.00
385_V	389_F	0.994	1.00
330_A	334_R	0.992	1.00
47_L	51_E	0.992	1.00
508_I	521_I	0.991	1.00
42_E	45_T	0.990	1.00
386_L	449_M	0.989	1.00
358_D	362_Y	0.988	1.00
491_F	495_F	0.982	1.00
115_E	118_V	0.976	1.00
454_H	457_I	0.974	1.00
396_F	399_E	0.974	1.00
449_M	462_I	0.973	1.00
339_E	343_K	0.969	1.00
184_G	188_A	0.969	1.00
35_T	39_R	0.967	1.00
316_V	319_L	0.966	1.00
30_V	34_T	0.966	1.00
27_F	31_G	0.964	1.00
469_M	474_Q	0.962	1.00
451_M	460_I	0.959	1.00
341_M	370_Q	0.958	1.00
425_I	429_G	0.955	1.00
245_F	290_L	0.955	1.00
218_L	225_I	0.954	1.00
206_E	211_L	0.954	1.00
50_A	53_V	0.952	1.00
363_I	367_A	0.951	1.00
500_I	523_I	0.951	1.00
362_Y	366_I	0.950	1.00
390_L	394_Q	0.948	1.00
456_S	525_Y	0.947	1.00
432_I	447_I	0.946	1.00
323_L	329_Y	0.945	1.00
45_T	48_Q	0.942	1.00
324_S	329_Y	0.941	1.00
350_L	363_I	0.939	1.00
278_L	281_R	0.939	1.00
218_L	238_N	0.937	1.00
116_S	120_K	0.937	1.00
293_N	316_V	0.935	1.00
288_L	291_V	0.933	1.00
219_E	239_A	0.931	1.00
38_I	42_E	0.929	1.00
427_I	503_L	0.929	1.00
351_V	367_A	0.927	1.00
117_E	121_G	0.925	1.00
106_I	110_F	0.923	1.00
342_N	438_A	0.922	1.00
457_I	524_P	0.917	1.00
469_M	511_S	0.908	1.00
238_N	241_A	0.902	1.00
282_D	317_K	0.902	1.00
45_T	49_T	0.901	1.00
97_R	100_H	0.901	1.00
49_T	54_A	0.898	1.00
128_A	131_T	0.898	1.00
439_V	444_K	0.896	1.00
348_L	351_V	0.895	1.00
186_I	190_I	0.894	1.00
143_Y	149_Q	0.890	1.00
387_A	391_L	0.890	1.00
218_L	221_T	0.888	1.00
91_M	97_R	0.887	1.00
341_M	378_I	0.883	1.00
470_S	477_V	0.883	1.00
411_V	453_F	0.882	1.00
480_Q	498_Q	0.882	1.00
36_K	39_R	0.881	1.00
347_I	367_A	0.880	1.00
340_F	374_T	0.878	1.00
331_N	335_A	0.878	1.00
334_R	373_E	0.876	1.00
170_L	174_Y	0.874	1.00
293_N	311_R	0.873	1.00
133_G	137_R	0.873	1.00
32_A	36_K	0.873	1.00
75_Y	79_V	0.870	1.00
114_D	117_E	0.869	1.00
147_G	151_G	0.869	1.00
437_D	483_S	0.869	1.00
321_E	324_S	0.869	1.00
386_L	428_I	0.868	1.00
467_A	517_T	0.865	1.00
316_V	323_L	0.865	1.00
139_F	152_A	0.864	1.00
229_D	235_K	0.856	1.00
464_D	516_G	0.855	1.00
74_S	77_K	0.854	1.00
426_T	495_F	0.854	1.00
43_K	46_A	0.854	1.00
340_F	370_Q	0.846	1.00
409_N	412_I	0.846	1.00
498_Q	501_E	0.846	1.00
348_L	352_Q	0.842	1.00
159_V	163_D	0.842	1.00
332_A	337_S	0.842	1.00
424_L	521_I	0.841	1.00
117_E	122_H	0.841	1.00
223_E	240_E	0.839	1.00
402_A	439_V	0.839	1.00
40_D	43_K	0.839	1.00
132_L	135_S	0.838	1.00
72_L	76_T	0.836	1.00
158_T	161_E	0.834	1.00
359_L	362_Y	0.834	1.00
194_T	198_I	0.834	1.00
407_E	452_R	0.833	1.00
379_N	423_E	0.832	1.00
340_F	344_L	0.830	1.00
213_E	217_M	0.828	1.00
384_S	388_G	0.826	1.00
340_F	373_E	0.823	1.00
395_S	398_R	0.822	1.00
421_I	425_I	0.821	1.00
366_I	369_Q	0.820	1.00
41_Q	45_T	0.819	1.00
225_I	238_N	0.819	1.00
388_G	392_G	0.819	1.00
226_L	238_N	0.816	1.00
428_I	521_I	0.815	1.00
31_G	35_T	0.815	1.00
235_K	305_G	0.814	1.00
131_T	135_S	0.812	1.00
216_A	220_S	0.812	1.00
339_E	495_F	0.810	1.00
438_A	485_K	0.809	1.00
225_I	309_T	0.807	1.00
382_K	458_L	0.807	1.00
345_H	348_L	0.807	1.00
89_V	97_R	0.806	1.00
343_K	370_Q	0.804	1.00
288_L	312_D	0.803	1.00
338_H	430_N	0.803	1.00
401_G	441_D	0.803	1.00
341_M	371_K	0.801	1.00
138_A	141_P	0.801	1.00
135_S	138_A	0.799	1.00
319_L	322_Q	0.799	1.00
171_R	175_F	0.795	1.00
128_A	139_F	0.794	1.00
437_D	484_T	0.791	1.00
393_K	432_I	0.791	1.00
469_M	475_A	0.790	1.00
496_T	500_I	0.789	1.00
53_V	56_A	0.788	1.00
342_N	349_G	0.787	1.00
148_K	151_G	0.786	1.00
226_L	310_F	0.784	1.00
396_F	400_Q	0.784	1.00
233_K	258_D	0.783	1.00
335_A	480_Q	0.782	1.00
367_A	371_K	0.782	1.00
333_L	336_Q	0.775	1.00
224_G	312_D	0.775	1.00
71_E	75_Y	0.774	1.00
483_S	489_R	0.774	1.00
87_F	101_P	0.773	1.00
281_R	285_I	0.772	1.00
292_F	295_V	0.771	1.00
353_L	359_L	0.770	1.00
72_L	99_T	0.765	1.00
339_E	426_T	0.765	1.00
469_M	493_L	0.765	1.00
208_A	213_E	0.765	1.00
395_S	399_E	0.764	1.00
240_E	244_L	0.764	1.00
116_S	119_L	0.763	1.00
136_Q	140_V	0.763	1.00
376_E	423_E	0.760	1.00
298_Q	304_V	0.760	1.00
402_A	447_I	0.757	1.00
43_K	47_L	0.756	1.00
113_G	116_S	0.756	1.00
341_M	375_S	0.754	1.00
368_I	372_S	0.751	1.00
402_A	436_L	0.748	1.00
114_D	118_V	0.748	1.00
358_D	361_D	0.747	1.00
385_V	419_S	0.746	1.00
352_Q	364_K	0.745	1.00
97_R	101_P	0.744	1.00
227_A	235_K	0.744	1.00
305_G	310_F	0.743	1.00
348_L	371_K	0.743	1.00
280_D	285_I	0.737	1.00
365_D	388_G	0.733	1.00
372_S	375_S	0.733	1.00
137_R	140_V	0.729	1.00
272_I	275_K	0.729	1.00
334_R	340_F	0.729	1.00
323_L	327_K	0.728	1.00
359_L	363_I	0.728	1.00
332_A	378_I	0.728	1.00
195_V	202_L	0.728	1.00
337_S	438_A	0.726	1.00
291_V	311_R	0.725	1.00
44_A	48_Q	0.725	1.00
333_L	342_N	0.723	1.00
271_V	274_T	0.723	1.00
227_A	238_N	0.722	1.00
40_D	44_A	0.722	1.00
24_L	28_F	0.721	1.00
213_E	236_L	0.721	1.00
372_S	376_E	0.719	1.00
110_F	115_E	0.715	1.00
376_E	489_R	0.714	1.00
73_Q	77_K	0.713	1.00
29_T	33_Q	0.710	1.00
107_G	110_F	0.710	1.00
228_V	232_G	0.709	1.00
82_I	85_T	0.709	1.00
426_T	429_G	0.709	1.00
51_E	54_A	0.708	1.00
197_N	200_Y	0.707	1.00
401_G	444_K	0.705	1.00
238_N	314_T	0.704	1.00
89_V	100_H	0.704	1.00
234_I	238_N	0.702	1.00
97_R	102_D	0.702	1.00
75_Y	78_R	0.700	1.00
396_F	433_N	0.699	1.00
92_D	95_G	0.698	1.00
205_Y	211_L	0.697	1.00
507_M	521_I	0.697	1.00
230_E	304_V	0.696	1.00
323_L	328_M	0.695	1.00
438_A	467_A	0.692	0.99
423_E	427_I	0.692	0.99
332_A	336_Q	0.692	0.99
274_T	277_P	0.691	0.99
102_D	105_K	0.691	0.99
332_A	342_N	0.690	0.99
290_L	293_N	0.689	0.99
389_F	393_K	0.687	0.99
386_L	406_I	0.686	0.99
366_I	378_I	0.686	0.99
151_G	157_I	0.685	0.99
39_R	42_E	0.684	0.99
141_P	150_V	0.681	0.99
468_G	516_G	0.680	0.99
160_N	164_E	0.678	0.99
224_G	245_F	0.678	0.99
285_I	288_L	0.677	0.99
287_G	291_V	0.677	0.99
380_D	480_Q	0.676	0.99
72_L	75_Y	0.676	0.99
398_R	401_G	0.675	0.99
289_E	295_V	0.675	0.99
342_N	437_D	0.674	0.99
337_S	341_M	0.674	0.99
505_G	524_P	0.674	0.99
49_T	53_V	0.671	0.99
208_A	215_S	0.670	0.99
521_I	524_P	0.669	0.99
140_V	143_Y	0.668	0.99
331_N	480_Q	0.668	0.99
208_A	214_R	0.667	0.99
416_A	419_S	0.664	0.99
48_Q	52_M	0.662	0.99
221_T	309_T	0.660	0.99
388_G	391_L	0.659	0.99
332_A	483_S	0.658	0.99
244_L	290_L	0.657	0.99
342_N	353_L	0.656	0.99
177_I	181_I	0.656	0.99
137_R	156_G	0.655	0.99
336_Q	340_F	0.655	0.99
478_F	497_Q	0.654	0.99
172_P	175_F	0.653	0.99
392_G	425_I	0.652	0.99
294_E	308_A	0.651	0.99
213_E	218_L	0.650	0.99
272_I	276_K	0.649	0.99
233_K	256_D	0.647	0.99
230_E	303_T	0.647	0.99
434_N	492_G	0.644	0.99
350_L	366_I	0.644	0.99
378_I	489_R	0.641	0.99
247_K	250_I	0.641	0.99
37_R	40_D	0.641	0.99
227_A	308_A	0.641	0.99
369_Q	373_E	0.641	0.99
343_K	481_G	0.640	0.99
385_V	390_L	0.640	0.99
358_D	391_L	0.639	0.99
339_E	373_E	0.638	0.99
106_I	109_K	0.638	0.99
218_L	227_A	0.637	0.99
402_A	483_S	0.637	0.99
241_A	310_F	0.636	0.99
342_N	485_K	0.636	0.99
333_L	345_H	0.633	0.99
500_I	503_L	0.632	0.99
269_K	275_K	0.632	0.99
270_K	277_P	0.632	0.99
342_N	346_V	0.632	0.99
91_M	154_A	0.631	0.99
289_E	294_E	0.629	0.99
209_T	213_E	0.628	0.99
280_D	284_R	0.627	0.99
366_I	370_Q	0.625	0.99
370_Q	376_E	0.624	0.99
335_A	485_K	0.624	0.99
424_L	500_I	0.624	0.99
471_E	475_A	0.622	0.99
152_A	156_G	0.621	0.99
205_Y	209_T	0.621	0.99
338_H	342_N	0.621	0.99
128_A	132_L	0.619	0.99
438_A	484_T	0.619	0.99
343_K	374_T	0.618	0.99
453_F	458_L	0.617	0.99
238_N	312_D	0.617	0.99
162_I	166_I	0.617	0.99
322_Q	326_V	0.615	0.99
480_Q	491_F	0.613	0.99
469_M	519_F	0.612	0.99
493_L	519_F	0.609	0.99
408_C	413_P	0.608	0.99
28_F	31_G	0.608	0.99
344_L	350_L	0.608	0.99
403_N	444_K	0.608	0.99
207_I	211_L	0.607	0.99
268_L	271_V	0.607	0.99
77_K	81_K	0.606	0.99
336_Q	374_T	0.606	0.99
453_F	456_S	0.604	0.99
213_E	227_A	0.604	0.99
390_L	404_L	0.603	0.99
15_V	20_L	0.603	0.99
339_E	430_N	0.600	0.99
335_A	380_D	0.600	0.99
314_T	318_H	0.599	0.99
335_A	342_N	0.598	0.99
154_A	158_T	0.597	0.98
343_K	495_F	0.595	0.98
439_V	483_S	0.595	0.98
430_N	433_N	0.595	0.98
139_F	154_A	0.594	0.98
185_V	189_V	0.594	0.98
396_F	436_L	0.593	0.98
330_A	337_S	0.593	0.98
152_A	155_V	0.592	0.98
380_D	498_Q	0.592	0.98
217_M	307_I	0.590	0.98
270_K	275_K	0.590	0.98
168_H	171_R	0.590	0.98
402_A	465_T	0.590	0.98
354_K	357_D	0.587	0.98
143_Y	151_G	0.585	0.98
366_I	371_K	0.583	0.98
481_G	491_F	0.582	0.98
50_A	155_V	0.582	0.98
336_Q	345_H	0.582	0.98
340_F	350_L	0.581	0.98
369_Q	425_I	0.579	0.98
171_R	174_Y	0.579	0.98
344_L	374_T	0.579	0.98
435_G	462_I	0.578	0.98
339_E	366_I	0.577	0.98
480_Q	494_Y	0.577	0.98
217_M	224_G	0.575	0.98
76_T	80_Q	0.574	0.98
375_S	379_N	0.574	0.98
200_Y	204_P	0.574	0.98
334_R	342_N	0.574	0.98
409_N	451_M	0.574	0.98
130_G	133_G	0.573	0.98
391_L	394_Q	0.573	0.98
404_L	447_I	0.573	0.98
257_Q	262_I	0.573	0.98
167_S	171_R	0.572	0.98
316_V	322_Q	0.572	0.98
206_E	214_R	0.572	0.98
247_K	254_P	0.570	0.98
151_G	156_G	0.570	0.98
342_N	374_T	0.569	0.98
296_P	306_A	0.568	0.98
342_N	370_Q	0.568	0.98
345_H	350_L	0.568	0.98
500_I	506_Q	0.567	0.98
341_M	376_E	0.567	0.98
205_Y	213_E	0.566	0.98
190_I	194_T	0.566	0.98
426_T	489_R	0.566	0.98
132_L	137_R	0.566	0.98
367_A	370_Q	0.564	0.98
44_A	47_L	0.564	0.98
342_N	439_V	0.564	0.98
85_T	89_V	0.563	0.98
423_E	503_L	0.559	0.98
92_D	98_K	0.558	0.98
135_S	140_V	0.558	0.98
432_I	436_L	0.557	0.98
430_N	438_A	0.556	0.98
360_G	363_I	0.555	0.98
278_L	284_R	0.554	0.98
41_Q	50_A	0.554	0.98
135_S	139_F	0.553	0.98
105_K	108_K	0.552	0.98
16_C	19_V	0.550	0.97
366_I	480_Q	0.550	0.97
400_Q	440_A	0.550	0.97
424_L	523_I	0.549	0.97
90_V	153_V	0.549	0.97
37_R	41_Q	0.549	0.97
460_I	523_I	0.549	0.97
173_L	176_I	0.548	0.97
386_L	389_F	0.548	0.97
389_F	429_G	0.548	0.97
498_Q	502_N	0.548	0.97
135_S	143_Y	0.547	0.97
135_S	141_P	0.546	0.97
342_N	483_S	0.546	0.97
214_R	220_S	0.544	0.97
334_R	337_S	0.544	0.97
345_H	366_I	0.544	0.97
313_K	316_V	0.544	0.97
397_I	402_A	0.543	0.97
291_V	316_V	0.543	0.97
189_V	193_R	0.542	0.97
387_A	390_L	0.542	0.97
473_D	477_V	0.542	0.97
220_S	307_I	0.541	0.97
46_A	54_A	0.541	0.97
136_Q	139_F	0.541	0.97
473_D	485_K	0.540	0.97
213_E	216_A	0.539	0.97
210_L	221_T	0.539	0.97
141_P	149_Q	0.538	0.97
226_L	237_A	0.538	0.97
341_M	366_I	0.538	0.97
330_A	335_A	0.537	0.97
128_A	137_R	0.537	0.97
130_G	137_R	0.537	0.97
437_D	489_R	0.537	0.97
184_G	187_G	0.535	0.97
241_A	308_A	0.533	0.97
27_F	30_V	0.532	0.97
72_L	79_V	0.532	0.97
229_D	305_G	0.531	0.97
334_R	491_F	0.531	0.97
268_L	272_I	0.531	0.97
217_M	222_K	0.530	0.97
259_V	262_I	0.530	0.97
141_P	152_A	0.530	0.97
227_A	241_A	0.529	0.97
225_I	236_L	0.528	0.97
342_N	445_K	0.527	0.97
107_G	111_R	0.526	0.97
362_Y	369_Q	0.525	0.97
457_I	525_Y	0.525	0.97
378_I	437_D	0.525	0.97
335_A	483_S	0.524	0.97
294_E	310_F	0.523	0.97
332_A	433_N	0.522	0.97
224_G	228_V	0.522	0.97
381_V	385_V	0.522	0.97
342_N	489_R	0.521	0.96
461_E	510_T	0.520	0.96
470_S	484_T	0.519	0.96
105_K	111_R	0.519	0.96
223_E	309_T	0.519	0.96
76_T	79_V	0.519	0.96
330_A	480_Q	0.518	0.96
221_T	307_I	0.518	0.96
350_L	483_S	0.518	0.96
288_L	292_F	0.517	0.96
349_G	426_T	0.516	0.96
366_I	373_E	0.516	0.96
291_V	295_V	0.516	0.96
279_Q	284_R	0.516	0.96
383_S	414_N	0.515	0.96
341_M	426_T	0.515	0.96
409_N	450_S	0.514	0.96
390_L	393_K	0.514	0.96
330_A	438_A	0.513	0.96
468_G	517_T	0.513	0.96
393_K	396_F	0.513	0.96
507_M	519_F	0.512	0.96
385_V	393_K	0.512	0.96
456_S	524_P	0.512	0.96
298_Q	301_G	0.511	0.96
237_A	255_I	0.511	0.96
151_G	154_A	0.510	0.96
400_Q	436_L	0.509	0.96
346_V	349_G	0.508	0.96
320_A	327_K	0.507	0.96
80_Q	83_T	0.507	0.96
125_I	138_A	0.506	0.96
127_T	131_T	0.506	0.96
345_H	491_F	0.506	0.96
161_E	164_E	0.506	0.96
117_E	120_K	0.506	0.96
225_I	241_A	0.504	0.96
342_N	378_I	0.504	0.96
172_P	180_S	0.503	0.96
127_T	130_G	0.503	0.96
47_L	50_A	0.503	0.96
294_E	306_A	0.503	0.96
89_V	154_A	0.502	0.96
131_T	138_A	0.501	0.96
369_Q	429_G	0.501	0.96
253_N	257_Q	0.501	0.96
211_L	217_M	0.500	0.96
241_A	244_L	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.606	100	0.45	Contact Map
4gczA	2	0.6135	100	0.455	Contact Map
3a0rA	2	0.5722	100	0.462	Contact Map
4r3aA	1	0.5516	100	0.56	Contact Map
2c2aA	2	0.4015	100	0.602	Contact Map
4q20A	2	0.379	100	0.613	Contact Map
4e01A	3	0.5047	100	0.614	Contact Map
2q8gA	2	0.5366	100	0.617	Contact Map
4mpcA	2	0.5385	100	0.618	Contact Map
3jz3A	2	0.2608	100	0.62	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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