GREMLIN Database
YUGP - Putative membrane protease YugP
UniProt: O05248 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (217)
Sequences: 1176 (821)
Seq/√Len: 55.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_E76_R5.0091.00
59_P79_E4.0031.00
44_R48_D3.8921.00
48_D52_L3.3801.00
166_N169_S3.2531.00
73_R103_H2.7731.00
69_D72_R2.5681.00
144_G218_F2.4351.00
59_P83_Y2.3111.00
172_K189_V2.2681.00
75_V97_V2.2171.00
44_R52_L2.2071.00
181_I189_V2.1661.00
172_K190_N2.0981.00
147_I218_F2.0611.00
80_P84_G2.0241.00
16_W20_K1.9811.00
69_D76_R1.9781.00
123_A152_A1.9781.00
147_I215_V1.9171.00
67_H76_R1.8801.00
154_V208_L1.8711.00
42_T90_I1.8690.99
94_S175_I1.8570.99
40_A44_R1.8270.99
46_I174_I1.8140.99
103_H111_V1.8070.99
143_I218_F1.7470.99
33_A90_I1.7200.99
45_R49_I1.6800.99
132_L136_L1.6780.99
165_F201_V1.6460.99
120_V123_A1.6330.99
54_D73_R1.6270.99
129_L133_G1.6240.99
75_V100_A1.6200.99
46_I97_V1.6150.99
57_V75_V1.5810.98
54_D103_H1.5800.98
50_N174_I1.5780.98
117_F121_N1.5770.98
63_T80_P1.5460.98
12_G16_W1.5410.98
58_E74_V1.5390.98
127_A131_F1.5160.98
147_I211_L1.4940.97
190_N194_S1.4860.97
154_V207_S1.4840.97
116_I159_I1.4830.97
165_F198_L1.4740.97
143_I147_I1.4630.97
154_V204_A1.4590.97
20_K194_S1.4540.97
22_K26_E1.4500.97
106_S111_V1.4490.97
73_R110_L1.4400.97
25_F92_V1.4270.97
46_I94_S1.4270.97
112_L115_K1.4000.96
10_A209_F1.4000.96
154_V211_L1.4000.96
48_D53_Y1.3970.96
17_A21_V1.3760.96
135_M143_I1.3730.96
133_G137_L1.3700.96
62_G65_T1.3700.96
68_Y73_R1.3560.96
25_F81_V1.3520.95
8_I12_G1.3480.95
111_V115_K1.3250.95
181_I186_E1.3110.95
119_V152_A1.3000.94
34_S184_N1.2900.94
22_K63_T1.2790.94
65_T80_P1.2790.94
103_H110_L1.2790.94
84_G89_A1.2710.94
13_L209_F1.2700.94
56_P74_V1.2640.94
133_G136_L1.2530.93
79_E83_Y1.2490.93
101_L174_I1.2460.93
34_S182_R1.2460.93
6_L10_A1.2400.93
72_R76_R1.2380.93
122_F126_V1.2300.93
120_V153_A1.2300.93
39_G43_A1.2240.92
60_V65_T1.2090.92
176_V186_E1.1920.91
25_F88_S1.1800.91
37_R42_T1.1610.90
204_A207_S1.1590.90
107_Y170_R1.1370.89
69_D74_V1.1330.89
150_F153_A1.1310.89
58_E69_D1.1310.89
42_T94_S1.1210.89
148_I151_S1.1070.88
158_L204_A1.1030.88
169_S173_Q1.1000.88
60_V67_H1.0880.87
25_F80_P1.0860.87
56_P76_R1.0860.87
60_V63_T1.0800.87
101_L105_E1.0730.86
38_T85_R1.0730.86
68_Y103_H1.0670.86
134_G146_G1.0590.86
57_V94_S1.0550.85
158_L208_L1.0510.85
52_L104_Q1.0470.85
39_G90_I1.0460.85
61_R79_E1.0430.85
108_G112_L1.0300.84
100_A110_L1.0200.83
60_V79_E1.0120.83
41_E44_R1.0050.82
116_I120_V0.9690.80
15_F18_Q0.9560.79
213_R217_I0.9530.79
130_L149_L0.9460.78
9_A12_G0.9420.78
210_E214_F0.9410.78
80_P92_V0.9410.78
55_V104_Q0.9230.77
56_P72_R0.9160.76
9_A13_L0.9150.76
52_L55_V0.9050.75
58_E67_H0.9030.75
15_F19_F0.9020.75
79_E84_G0.9020.75
178_E181_I0.8910.74
50_N101_L0.8880.74
175_I186_E0.8850.74
64_L88_S0.8820.73
131_F218_F0.8810.73
145_L148_I0.8740.73
137_L214_F0.8710.72
9_A16_W0.8700.72
33_A85_R0.8630.72
127_A146_G0.8500.71
194_S198_L0.8470.70
92_V196_A0.8410.70
8_I11_L0.8380.69
144_G148_I0.8370.69
87_I120_V0.8350.69
114_H153_A0.8320.69
4_I7_T0.8290.69
42_T180_F0.8260.68
144_G147_I0.8250.68
10_A13_L0.8210.68
24_N191_K0.8190.68
215_V218_F0.8170.68
60_V76_R0.8130.67
206_V213_R0.8070.67
176_V183_N0.8070.67
91_S189_V0.8060.66
109_A112_L0.8020.66
18_Q22_K0.7990.66
150_F210_E0.7970.66
187_N190_N0.7960.65
52_L73_R0.7960.65
37_R45_R0.7870.65
117_F120_V0.7840.64
123_A153_A0.7800.64
141_N145_L0.7760.63
151_S155_F0.7760.63
57_V97_V0.7760.63
97_V101_L0.7740.63
172_K186_E0.7720.63
14_S206_V0.7710.63
103_H114_H0.7640.62
25_F196_A0.7640.62
129_L136_L0.7510.61
116_I155_F0.7470.61
24_N92_V0.7450.60
172_K176_V0.7440.60
14_S203_A0.7440.60
97_V206_V0.7430.60
45_R180_F0.7390.60
10_A14_S0.7390.60
25_F29_S0.7380.60
16_W198_L0.7350.59
155_F158_L0.7340.59
101_L104_Q0.7290.59
49_I178_E0.7280.59
215_V219_L0.7240.58
176_V190_N0.7230.58
173_Q177_S0.7230.58
13_L16_W0.7220.58
88_S190_N0.7220.58
72_R75_V0.7210.58
116_I153_A0.7200.58
35_S45_R0.7190.58
68_Y110_L0.7160.57
133_G142_L0.7140.57
27_K148_I0.7130.57
70_P82_Y0.7110.57
118_P156_F0.7060.56
13_L205_L0.7060.56
165_F185_E0.7010.56
119_V141_N0.7000.56
21_V165_F0.6980.55
176_V181_I0.6970.55
52_L100_A0.6950.55
131_F206_V0.6940.55
14_S25_F0.6940.55
130_L153_A0.6890.54
191_K195_A0.6870.54
214_F219_L0.6860.54
124_S134_G0.6820.54
119_V136_L0.6810.54
146_G150_F0.6780.53
174_I178_E0.6770.53
45_R178_E0.6740.53
176_V179_G0.6730.53
50_N91_S0.6660.52
137_L146_G0.6660.52
175_I178_E0.6640.52
204_A208_L0.6610.51
29_S89_A0.6610.51
6_L9_A0.6560.51
212_L215_V0.6520.50
9_A18_Q0.6480.50
126_V129_L0.6470.50
154_V157_Q0.6430.49
117_F204_A0.6370.49
112_L116_I0.6370.49
203_A207_S0.6360.49
64_L78_S0.6310.48
49_I177_S0.6310.48
11_L15_F0.6310.48
14_S18_Q0.6270.48
157_Q210_E0.6260.48
198_L201_V0.6260.48
40_A82_Y0.6230.47
38_T41_E0.6220.47
42_T46_I0.6200.47
63_T79_E0.6180.47
42_T97_V0.6140.46
175_I181_I0.6140.46
7_T213_R0.6130.46
216_M219_L0.6130.46
131_F143_I0.6110.46
80_P83_Y0.6110.46
214_F218_F0.6090.46
110_L114_H0.6080.46
59_P101_L0.6050.45
100_A104_Q0.6050.45
132_L143_I0.6030.45
71_T115_K0.6030.45
26_E30_K0.6000.45
131_F146_G0.5990.45
109_A166_N0.5930.44
71_T119_V0.5890.44
94_S97_V0.5890.44
125_G151_S0.5890.44
108_G115_K0.5880.44
32_E36_G0.5880.44
21_V25_F0.5870.43
7_T129_L0.5870.43
47_L100_A0.5840.43
90_I180_F0.5810.43
20_K23_S0.5800.43
138_G145_L0.5750.42
145_L149_L0.5730.42
112_L159_I0.5720.42
117_F180_F0.5710.42
109_A170_R0.5700.42
154_V214_F0.5690.42
130_L207_S0.5660.41
91_S192_V0.5640.41
19_F26_E0.5640.41
142_L145_L0.5610.41
9_A209_F0.5590.40
58_E72_R0.5570.40
112_L155_F0.5570.40
151_S154_V0.5560.40
4_I8_I0.5540.40
46_I204_A0.5540.40
130_L145_L0.5540.40
128_P214_F0.5520.40
120_V127_A0.5500.40
35_S182_R0.5490.39
91_S109_A0.5490.39
105_E109_A0.5440.39
16_W158_L0.5440.39
166_N173_Q0.5420.39
60_V69_D0.5410.39
186_E190_N0.5390.38
75_V91_S0.5380.38
25_F64_L0.5370.38
176_V189_V0.5360.38
17_A202_A0.5360.38
150_F201_V0.5360.38
114_H159_I0.5350.38
28_Y190_N0.5350.38
110_L159_I0.5350.38
26_E172_K0.5340.38
75_V117_F0.5320.38
127_A153_A0.5290.37
169_S194_S0.5280.37
97_V174_I0.5270.37
7_T127_A0.5260.37
137_L142_L0.5250.37
55_V75_V0.5250.37
7_T11_L0.5240.37
59_P80_P0.5240.37
140_L143_I0.5230.37
20_K24_N0.5220.37
109_A116_I0.5220.37
165_F169_S0.5170.36
14_S213_R0.5120.36
41_E45_R0.5100.35
157_Q203_A0.5100.35
15_F145_L0.5100.35
91_S186_E0.5090.35
120_V157_Q0.5090.35
105_E108_G0.5080.35
132_L141_N0.5060.35
82_Y103_H0.5060.35
26_E148_I0.5050.35
152_A217_I0.5040.35
172_K194_S0.5030.35
151_S211_L0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4aw6A 2 0.8933 95.5 0.93 Contact Map
4il3A 1 0.8844 94.8 0.933 Contact Map
3cqbA 4 0.44 54 0.958 Contact Map
3c37A 1 0.8356 43.9 0.961 Contact Map
4jixA 2 0.4356 33.4 0.963 Contact Map
1hv5A 2 0.5733 25.6 0.965 Contact Map
1c7kA 1 0.5644 19.7 0.967 Contact Map
4jiuA 1 0.4267 17.6 0.968 Contact Map
1cgeA 1 0.5689 17 0.968 Contact Map
4xctA 1 0.5556 14.3 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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