GREMLIN Database
YUGU - UPF0047 protein YugU
UniProt: O05243 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 132 (126)
Sequences: 2722 (1759)
Seq/√Len: 156.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_V113_I2.9351.00
46_G118_F2.7931.00
101_E106_I2.7631.00
36_A128_I2.7001.00
4_T125_T2.5651.00
31_I130_M2.1901.00
48_T90_S2.1831.00
5_L128_I2.1791.00
21_E24_A2.1681.00
40_C45_A2.1491.00
63_R76_D2.1481.00
6_Q123_T2.1201.00
59_K76_D2.1181.00
41_P125_T2.0561.00
25_F128_I2.0391.00
38_I128_I2.0211.00
23_E104_R1.8661.00
71_W84_A1.8531.00
10_T14_E1.8131.00
32_T102_N1.7901.00
37_L97_H1.7201.00
33_S101_E1.6401.00
17_D112_G1.5751.00
64_R87_M1.5711.00
65_F92_V1.5671.00
56_D79_M1.5431.00
52_N112_G1.5361.00
6_Q125_T1.4721.00
35_A97_H1.4671.00
24_A28_E1.4061.00
64_R68_V1.3681.00
31_I100_V1.3361.00
37_L129_K1.3331.00
75_L78_H1.3241.00
67_E73_H1.3221.00
46_G92_V1.3161.00
89_S94_A1.2961.00
29_T130_M1.2941.00
15_M116_C1.2881.00
56_D76_D1.2811.00
61_M90_S1.2671.00
62_L66_D1.2541.00
100_V130_M1.2421.00
8_K123_T1.2291.00
22_V36_A1.2201.00
26_L130_M1.2171.00
49_I98_V1.2001.00
39_Y49_I1.2001.00
36_A105_L1.1981.00
4_T41_P1.1941.00
69_Y91_T1.1851.00
23_E105_L1.1741.00
82_N119_D1.1541.00
41_P127_Y1.1501.00
8_K21_E1.1291.00
59_K63_R1.1101.00
5_L126_C1.1061.00
99_I129_K1.0660.99
56_D59_K1.0590.99
13_D62_L1.0560.99
15_M65_F1.0540.99
25_F130_M1.0290.99
41_P106_I1.0200.99
18_I126_C1.0200.99
66_D71_W1.0170.99
13_D66_D1.0160.99
98_V113_I1.0090.99
64_R67_E1.0060.99
74_E78_H1.0000.99
26_L100_V0.9930.99
63_R67_E0.9810.99
18_I22_V0.9570.99
71_W120_G0.9510.98
20_R24_A0.9440.98
45_A115_F0.9330.98
23_E27_Q0.9200.98
26_L29_T0.9200.98
40_C89_S0.9160.98
65_F116_C0.9100.98
64_R69_Y0.9060.98
35_A131_M0.9030.98
92_V118_F0.9020.98
13_D71_W0.8960.98
69_Y75_L0.8930.98
26_L105_L0.8810.98
27_Q104_R0.8760.97
106_I127_Y0.8650.97
48_T116_C0.8590.97
54_D57_V0.8500.97
27_Q30_G0.8480.97
44_T119_D0.8420.97
69_Y87_M0.8390.97
7_I16_I0.8340.97
48_T93_G0.8230.96
40_C115_F0.8150.96
38_I96_Q0.8150.96
49_I94_A0.8140.96
80_E83_T0.8090.96
47_I96_Q0.8020.96
70_P73_H0.7980.96
64_R73_H0.7960.96
20_R23_E0.7920.95
36_A130_M0.7890.95
33_S129_K0.7850.95
24_A27_Q0.7790.95
58_K62_L0.7780.95
25_F29_T0.7730.95
33_S102_N0.7660.94
40_C47_I0.7620.94
36_A100_V0.7610.94
52_N114_Y0.7580.94
10_T21_E0.7580.94
66_D88_K0.7530.94
15_M114_Y0.7470.94
4_T106_I0.7400.93
32_T103_G0.7320.93
39_Y98_V0.7300.93
46_G96_Q0.7280.93
44_T82_N0.7240.93
39_Y99_I0.7240.93
49_I107_L0.7210.93
5_L25_F0.7190.92
51_E110_W0.7160.92
37_L99_I0.7130.92
39_Y95_S0.7050.92
99_I127_Y0.7040.92
13_D84_A0.7010.91
43_T80_E0.6870.91
4_T101_E0.6850.90
71_W75_L0.6840.90
22_V38_I0.6810.90
25_F28_E0.6780.90
35_A129_K0.6780.90
98_V105_L0.6680.89
21_E25_F0.6550.88
14_E117_E0.6540.88
63_R73_H0.6400.87
46_G116_C0.6400.87
71_W88_K0.6390.87
119_D122_R0.6390.87
64_R75_L0.6380.87
52_N58_K0.6360.87
23_E26_L0.6270.86
15_M61_M0.6250.86
42_H50_N0.6220.86
83_T87_M0.6200.86
20_R104_R0.6080.84
75_L87_M0.6010.84
51_E57_V0.5990.84
9_T16_I0.5980.83
7_I21_E0.5980.83
22_V25_F0.5950.83
83_T119_D0.5920.83
78_H88_K0.5840.82
73_H87_M0.5810.82
11_K14_E0.5800.82
98_V107_L0.5740.81
61_M87_M0.5730.81
49_I114_Y0.5720.81
57_V81_G0.5700.80
33_S130_M0.5700.80
25_F36_A0.5520.78
57_V80_E0.5480.78
15_M48_T0.5410.77
37_L95_S0.5380.77
31_I34_G0.5380.77
42_H86_H0.5350.76
50_N114_Y0.5340.76
33_S100_V0.5330.76
15_M50_N0.5320.76
33_S131_M0.5300.76
101_E129_K0.5300.76
65_F70_P0.5290.75
9_T122_R0.5280.75
54_D110_W0.5280.75
61_M114_Y0.5270.75
50_N61_M0.5260.75
51_E124_R0.5250.75
90_S93_G0.5240.75
89_S92_V0.5180.74
45_A81_G0.5160.74
20_R27_Q0.5150.73
17_D20_R0.5100.73
88_K117_E0.5070.72
63_R74_E0.5060.72
88_K116_C0.5050.72
20_R32_T0.5020.72
106_I129_K0.5010.71
58_K69_Y0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p6hA 3 0.9924 100 0.066 Contact Map
1vphA 4 0.9924 100 0.078 Contact Map
2p6cA 3 0.9924 100 0.078 Contact Map
1vmfA 3 0.9924 100 0.081 Contact Map
1vmhA 3 0.9773 100 0.084 Contact Map
1ve0A 3 0.9773 100 0.084 Contact Map
1vmjA 4 0.9924 100 0.086 Contact Map
2cu5A 3 0.9545 100 0.107 Contact Map
4lubA 2 0.6667 20.1 0.941 Contact Map
2qmwA 2 0.7121 15.6 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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