GREMLIN Database
YUGS - UPF0053 protein YugS
UniProt: O05241 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 429 (406)
Sequences: 8294 (5340)
Seq/√Len: 265.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
226_I324_L4.1891.00
395_E400_D3.8061.00
360_M424_I3.6171.00
403_H408_E3.3781.00
401_V408_E3.3301.00
401_V410_K3.2801.00
291_V300_L3.2241.00
254_K259_H3.1621.00
234_S237_E3.1291.00
389_L422_V2.9971.00
233_Q237_E2.9611.00
268_D286_R2.9271.00
359_V412_L2.9131.00
280_K283_Q2.9101.00
228_V253_I2.8021.00
252_V285_M2.7441.00
354_G357_H2.7421.00
254_K282_N2.6421.00
143_I147_K2.5541.00
216_A300_L2.5511.00
130_K133_A2.5391.00
231_L254_K2.5241.00
154_K158_G2.5121.00
359_V421_F2.4541.00
313_I324_L2.3401.00
113_F159_S2.3301.00
295_I303_R2.3091.00
226_I321_T2.2861.00
16_T70_A2.2581.00
228_V257_K2.2231.00
369_V373_L2.1851.00
34_I48_A2.1771.00
162_F166_L2.1731.00
47_A143_I2.1611.00
388_W404_A2.1281.00
18_V141_P2.1051.00
231_L282_N2.0831.00
229_I238_A2.0771.00
353_K357_H2.0611.00
57_E150_Y2.0571.00
231_L261_L2.0561.00
263_I288_V2.0321.00
38_I49_H2.0261.00
219_I325_V1.9951.00
47_A140_K1.9911.00
412_L423_E1.9731.00
33_K132_E1.9651.00
300_L325_V1.9591.00
313_I321_T1.9511.00
369_V424_I1.9391.00
385_I422_V1.9271.00
413_D421_F1.9241.00
357_H423_E1.9181.00
240_H244_N1.8731.00
229_I252_V1.8601.00
37_L136_L1.8481.00
253_I260_I1.8471.00
364_A369_V1.8401.00
219_I297_V1.8281.00
137_W141_P1.8191.00
328_E332_E1.8061.00
415_E420_R1.8031.00
42_D136_L1.7971.00
350_I364_A1.7411.00
188_L205_V1.7401.00
50_K143_I1.7181.00
248_T265_N1.7121.00
214_R218_E1.7051.00
233_Q238_A1.6971.00
208_I334_I1.6771.00
352_K358_Y1.6731.00
413_D420_R1.6351.00
158_G162_F1.6091.00
311_M324_L1.6061.00
232_E254_K1.6021.00
204_Y208_I1.6001.00
364_A385_I1.5911.00
410_K423_E1.5881.00
230_S233_Q1.5841.00
360_M385_I1.5781.00
293_E322_A1.5571.00
133_A137_W1.5561.00
22_A138_I1.5481.00
105_V109_I1.5251.00
370_N375_I1.5251.00
227_A241_H1.5021.00
297_V330_I1.4991.00
359_V423_E1.4991.00
47_A139_A1.4921.00
370_N377_I1.4891.00
389_L409_F1.4841.00
256_D259_H1.4811.00
352_K355_E1.4801.00
61_A145_F1.4741.00
369_V385_I1.4741.00
41_G45_A1.4631.00
6_L10_F1.4581.00
295_I300_L1.4571.00
224_T320_G1.4501.00
340_D343_D1.4381.00
302_I305_Q1.4361.00
7_I11_V1.4361.00
16_T66_I1.4341.00
8_A76_L1.4341.00
227_A247_Y1.4261.00
390_L419_I1.4211.00
279_I283_Q1.4191.00
353_K423_E1.3991.00
35_N39_E1.3981.00
263_I311_M1.3971.00
254_K261_L1.3971.00
409_F422_V1.3941.00
353_K356_H1.3901.00
353_K359_V1.3871.00
389_L411_I1.3791.00
48_A135_S1.3691.00
404_A409_F1.3491.00
150_Y154_K1.3351.00
48_A139_A1.3321.00
227_A250_Y1.3271.00
249_R310_H1.3251.00
389_L402_I1.3251.00
147_K150_Y1.3241.00
15_I69_T1.3201.00
19_F65_G1.3191.00
35_N49_H1.3181.00
223_R258_D1.3061.00
382_I391_T1.3051.00
38_I46_L1.2991.00
360_M369_V1.2941.00
71_L74_G1.2891.00
237_E240_H1.2861.00
49_H53_S1.2831.00
245_E250_Y1.2771.00
331_I335_V1.2751.00
21_A134_V1.2671.00
204_Y334_I1.2631.00
311_M326_T1.2601.00
44_R136_L1.2571.00
412_L421_F1.2561.00
303_R307_E1.2471.00
46_L50_K1.2461.00
392_Q404_A1.2431.00
61_A153_I1.2391.00
77_G111_V1.2251.00
258_D320_G1.2241.00
223_R320_G1.2241.00
101_I105_V1.2241.00
138_I141_P1.2221.00
288_V313_I1.2121.00
9_I73_L1.2121.00
389_L393_K1.2081.00
258_D321_T1.2071.00
141_P144_W1.2041.00
42_D45_A1.2031.00
37_L42_D1.2021.00
227_A245_E1.2011.00
140_K144_W1.1951.00
44_R140_K1.1761.00
407_C424_I1.1641.00
366_I370_N1.1611.00
272_A284_I1.1531.00
216_A291_V1.1521.00
11_V15_I1.1501.00
158_G161_S1.1501.00
261_L285_M1.1491.00
233_Q241_H1.1451.00
216_A314_L1.1391.00
24_F27_V1.1391.00
260_I313_I1.1321.00
292_I295_I1.1301.00
122_A163_L1.1241.00
63_Q66_I1.1191.00
338_I343_D1.1181.00
19_F145_F1.1161.00
66_I70_A1.1151.00
43_S46_L1.1151.00
350_I372_L1.1141.00
86_H90_T1.0941.00
217_R293_E1.0941.00
144_W147_K1.0781.00
70_A115_H1.0731.00
349_H361_D1.0721.00
236_E240_H1.0711.00
402_I409_F1.0571.00
373_L407_C1.0491.00
328_E338_I1.0451.00
13_I114_L1.0441.00
291_V314_L1.0391.00
390_L396_L1.0391.00
264_I284_I1.0351.00
403_H406_G1.0311.00
351_L359_V1.0291.00
386_A390_L1.0281.00
34_I49_H1.0271.00
18_V138_I1.0191.00
50_K54_N1.0101.00
291_V312_A1.0061.00
249_R328_E1.0031.00
44_R48_A1.0021.00
36_Q40_S1.0011.00
255_D259_H0.9981.00
21_A127_S0.9961.00
229_I281_L0.9961.00
289_I303_R0.9951.00
16_T20_V0.9901.00
231_L285_M0.9881.00
304_M312_A0.9871.00
228_V321_T0.9871.00
393_K402_I0.9861.00
61_A146_Y0.9861.00
179_I187_I0.9821.00
23_E124_K0.9811.00
51_I58_Y0.9801.00
9_I111_V0.9791.00
45_A136_L0.9791.00
230_S255_D0.9651.00
388_W409_F0.9551.00
192_Y202_F0.9431.00
191_S195_G0.9421.00
119_G124_K0.9381.00
162_F165_K0.9381.00
51_I139_A0.9351.00
20_V24_F0.9341.00
240_H243_I0.9321.00
409_F424_I0.9291.00
361_D421_F0.9281.00
362_G385_I0.9271.00
225_E418_H0.9251.00
219_I330_I0.9251.00
54_N57_E0.9221.00
370_N376_A0.9221.00
184_L191_S0.9201.00
230_S253_I0.9201.00
339_R346_E0.9111.00
350_I360_M0.9101.00
29_I131_A0.9091.00
211_F301_L0.9091.00
211_F298_Q0.9071.00
398_A413_D0.9071.00
155_A158_G0.9031.00
239_I243_I0.9031.00
350_I358_Y0.9021.00
34_I52_I0.8991.00
77_G81_F0.8981.00
392_Q402_I0.8911.00
295_I299_Q0.8911.00
232_E282_N0.8901.00
292_I317_E0.8901.00
316_D319_G0.8871.00
226_I257_K0.8861.00
109_I113_F0.8821.00
365_L368_E0.8771.00
22_A142_L0.8771.00
146_Y150_Y0.8761.00
103_T107_A0.8751.00
223_R316_D0.8701.00
38_I42_D0.8701.00
151_P155_A0.8691.00
137_W140_K0.8691.00
242_I250_Y0.8671.00
289_I312_A0.8661.00
211_F330_I0.8661.00
165_K170_H0.8631.00
328_E343_D0.8631.00
47_A50_K0.8601.00
161_S165_K0.8571.00
393_K397_K0.8571.00
120_E124_K0.8491.00
251_P260_I0.8430.99
216_A325_V0.8350.99
388_W392_Q0.8350.99
328_E341_E0.8340.99
332_E337_E0.8300.99
362_G386_A0.8300.99
386_A418_H0.8280.99
12_L72_G0.8260.99
328_E340_D0.8260.99
75_W108_F0.8260.99
235_L238_A0.8250.99
78_E107_A0.8240.99
73_L111_V0.8230.99
18_V65_G0.8210.99
9_I80_T0.8210.99
71_L112_T0.8210.99
215_V218_E0.8170.99
62_C142_L0.8170.99
67_T112_T0.8160.99
75_W78_E0.8160.99
185_R210_E0.8120.99
279_I284_I0.8110.99
29_I34_I0.8050.99
251_P313_I0.8020.99
24_F127_S0.8000.99
268_D342_Y0.7950.99
74_G78_E0.7910.99
316_D322_A0.7900.99
21_A25_A0.7890.99
140_K143_I0.7880.99
8_A11_V0.7880.99
64_L152_F0.7870.99
332_E340_D0.7860.99
17_A21_A0.7830.99
170_H173_K0.7770.99
352_K356_H0.7770.99
67_T124_K0.7740.99
235_L279_I0.7730.99
238_A281_L0.7720.99
55_L58_Y0.7710.99
328_E333_E0.7710.99
63_Q70_A0.7700.99
260_I321_T0.7690.99
382_I388_W0.7580.99
242_I269_M0.7580.99
71_L108_F0.7580.99
316_D320_G0.7550.99
164_V168_G0.7540.99
56_D161_S0.7540.99
33_K37_L0.7530.99
328_E337_E0.7520.99
99_N103_T0.7520.99
229_I241_H0.7510.99
248_T267_K0.7490.99
87_P90_T0.7460.99
225_E363_K0.7440.99
241_H244_N0.7420.99
310_H331_I0.7410.99
229_I250_Y0.7410.99
361_D364_A0.7390.99
31_G53_S0.7380.99
66_I115_H0.7360.99
66_I69_T0.7340.99
16_T115_H0.7330.99
351_L421_F0.7310.99
282_N285_M0.7290.99
350_I369_V0.7290.99
366_I382_I0.7260.98
249_R265_N0.7260.98
265_N268_D0.7250.98
242_I266_S0.7240.98
66_I120_E0.7230.98
393_K400_D0.7220.98
289_I307_E0.7210.98
13_I73_L0.7210.98
332_E343_D0.7200.98
300_L330_I0.7150.98
38_I41_G0.7150.98
135_S139_A0.7150.98
42_D46_L0.7150.98
231_L238_A0.7130.98
16_T69_T0.7130.98
102_V106_V0.7120.98
14_G17_A0.7110.98
8_A12_L0.7070.98
44_R139_A0.7050.98
419_I422_V0.7020.98
303_R306_K0.7020.98
290_R315_V0.7010.98
392_Q405_E0.7000.98
253_I256_D0.6950.98
375_I407_C0.6930.98
25_A135_S0.6930.98
73_L115_H0.6920.98
181_E213_N0.6910.98
315_V321_T0.6910.98
386_A419_I0.6900.98
396_L414_A0.6890.98
10_F14_G0.6860.98
63_Q74_G0.6850.98
214_R333_E0.6840.98
223_R319_G0.6830.98
243_I271_K0.6830.98
310_H328_E0.6810.98
56_D125_T0.6800.98
333_E337_E0.6800.98
184_L197_I0.6800.98
223_R318_Y0.6790.98
301_L330_I0.6780.98
377_I388_W0.6770.98
221_I339_R0.6770.98
134_V138_I0.6750.98
229_I242_I0.6740.98
37_L41_G0.6730.98
376_A405_E0.6730.98
44_R47_A0.6710.97
251_P263_I0.6700.97
59_L119_G0.6700.97
398_A414_A0.6700.97
48_A52_I0.6700.97
249_R341_E0.6690.97
66_I121_L0.6690.97
33_K36_Q0.6690.97
236_E278_P0.6680.97
288_V311_M0.6650.97
362_G419_I0.6640.97
202_F206_N0.6640.97
104_F108_F0.6640.97
370_N380_E0.6630.97
352_K357_H0.6620.97
216_A295_I0.6610.97
317_E387_G0.6600.97
217_R322_A0.6600.97
243_I275_L0.6580.97
152_F156_L0.6560.97
13_I119_G0.6550.97
369_V372_L0.6540.97
353_K413_D0.6540.97
67_T115_H0.6530.97
381_E391_T0.6530.97
240_H274_F0.6530.97
67_T108_F0.6530.97
35_N38_I0.6510.97
229_I233_Q0.6490.97
29_I132_E0.6490.97
181_E185_R0.6470.97
181_E212_D0.6460.97
71_L107_A0.6390.97
71_L78_E0.6390.97
274_F277_Q0.6390.97
63_Q67_T0.6390.97
145_F149_T0.6380.97
63_Q115_H0.6380.97
189_S206_N0.6370.97
327_V338_I0.6370.97
69_T73_L0.6360.97
181_E209_F0.6350.96
66_I119_G0.6340.96
29_I48_A0.6340.96
57_E146_Y0.6260.96
37_L40_S0.6250.96
207_K334_I0.6240.96
74_G112_T0.6230.96
20_V115_H0.6220.96
212_D298_Q0.6200.96
300_L304_M0.6200.96
86_H100_H0.6200.96
372_L375_I0.6170.96
170_H174_E0.6170.96
204_Y211_F0.6160.96
249_R311_M0.6150.96
366_I377_I0.6130.96
74_G79_P0.6120.96
44_R137_W0.6110.96
420_R423_E0.6110.96
51_I146_Y0.6110.96
23_E120_E0.6100.96
46_L49_H0.6090.96
252_V262_G0.6090.96
20_V120_E0.6080.96
54_N146_Y0.6070.95
349_H364_A0.6070.95
71_L75_W0.6050.95
16_T67_T0.6050.95
291_V295_I0.6050.95
289_I309_I0.6040.95
37_L45_A0.6040.95
69_T112_T0.6040.95
261_L282_N0.6040.95
121_L156_L0.6030.95
86_H103_T0.6030.95
292_I315_V0.6020.95
388_W402_I0.5990.95
74_G77_G0.5990.95
265_N286_R0.5980.95
205_V209_F0.5970.95
238_A280_K0.5960.95
339_R345_D0.5960.95
12_L69_T0.5950.95
185_R206_N0.5950.95
180_S184_L0.5930.95
302_I306_K0.5930.95
157_N161_S0.5930.95
253_I257_K0.5910.95
238_A242_I0.5900.95
98_F101_I0.5900.95
75_W104_F0.5890.95
15_I19_F0.5850.95
231_L234_S0.5840.94
148_I151_P0.5830.94
414_A417_H0.5830.94
227_A244_N0.5820.94
5_Q9_I0.5810.94
34_I45_A0.5810.94
20_V62_C0.5810.94
13_I16_T0.5800.94
149_T152_F0.5790.94
98_F102_V0.5770.94
265_N310_H0.5770.94
133_A136_L0.5760.94
20_V66_I0.5760.94
16_T63_Q0.5750.94
126_V134_V0.5750.94
257_K321_T0.5750.94
408_E412_L0.5740.94
75_W111_V0.5740.94
358_Y372_L0.5730.94
338_I341_E0.5730.94
30_R183_E0.5720.94
373_L424_I0.5670.94
276_G279_I0.5670.94
131_A134_V0.5630.93
203_R207_K0.5630.93
64_L112_T0.5630.93
263_I285_M0.5630.93
230_S259_H0.5610.93
180_S183_E0.5600.93
28_K128_I0.5600.93
211_F296_P0.5600.93
328_E335_V0.5590.93
163_L167_F0.5580.93
273_Y276_G0.5580.93
75_W79_P0.5570.93
52_I55_L0.5570.93
23_E67_T0.5550.93
223_R322_A0.5540.93
332_E336_G0.5540.93
360_M422_V0.5520.93
81_F107_A0.5510.93
310_H338_I0.5510.93
78_E116_V0.5500.93
26_I135_S0.5490.92
223_R317_E0.5480.92
118_M163_L0.5480.92
51_I55_L0.5470.92
301_L335_V0.5460.92
72_G104_F0.5460.92
185_R205_V0.5420.92
179_I184_L0.5420.92
242_I270_F0.5410.92
67_T71_L0.5400.92
286_R309_I0.5400.92
157_N160_A0.5390.92
301_L304_M0.5380.92
216_A296_P0.5370.92
21_A138_I0.5360.92
185_R188_L0.5350.91
370_N379_N0.5350.91
112_T124_K0.5350.91
312_A325_V0.5340.91
70_A73_L0.5340.91
70_A121_L0.5340.91
248_T341_E0.5330.91
31_G49_H0.5320.91
248_T340_D0.5310.91
220_M322_A0.5310.91
310_H327_V0.5300.91
251_P383_D0.5300.91
328_E342_Y0.5300.91
283_Q287_P0.5290.91
144_W148_I0.5290.91
79_P104_F0.5280.91
69_T119_G0.5270.91
278_P283_Q0.5270.91
241_H245_E0.5270.91
274_F279_I0.5270.91
50_K147_K0.5270.91
6_L80_T0.5270.91
364_A368_E0.5270.91
25_A134_V0.5260.91
317_E320_G0.5260.91
301_L327_V0.5260.91
27_V128_I0.5260.91
290_R313_I0.5250.91
237_E241_H0.5250.91
59_L63_Q0.5240.91
253_I259_H0.5220.90
348_P351_L0.5220.90
78_E104_F0.5210.90
393_K401_V0.5210.90
29_I37_L0.5200.90
191_S197_I0.5200.90
366_I369_V0.5180.90
112_T116_V0.5180.90
360_M372_L0.5180.90
188_L192_Y0.5180.90
126_V130_K0.5180.90
29_I136_L0.5170.90
217_R383_D0.5170.90
367_D371_D0.5170.90
156_L160_A0.5170.90
366_I385_I0.5150.90
350_I354_G0.5150.90
368_E372_L0.5150.90
122_A159_S0.5140.90
90_T99_N0.5130.90
262_G285_M0.5130.90
295_I314_L0.5130.90
218_E383_D0.5130.90
29_I52_I0.5120.90
223_R226_I0.5110.90
38_I44_R0.5110.90
360_M373_L0.5110.90
43_S140_K0.5100.89
32_S186_L0.5090.89
327_V335_V0.5090.89
151_P154_K0.5090.89
249_R263_I0.5090.89
72_G76_L0.5080.89
260_I290_R0.5080.89
390_L400_D0.5080.89
188_L197_I0.5070.89
62_C108_F0.5070.89
249_R340_D0.5070.89
210_E213_N0.5070.89
71_L115_H0.5040.89
67_T70_A0.5020.89
20_V67_T0.5010.89
296_P299_Q0.5000.89
108_F111_V0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hg0A 2 0.5361 100 0.506 Contact Map
3lhhA 1 0.2914 100 0.759 Contact Map
3ocoA 2 0.3147 99.9 0.776 Contact Map
3oi8A 2 0.3636 99.9 0.777 Contact Map
3ocmA 5 0.3473 99.9 0.783 Contact Map
2v8qE 1 0.5082 99.9 0.786 Contact Map
3kxrA 3 0.3753 99.9 0.789 Contact Map
3lv9A 2 0.303 99.9 0.792 Contact Map
4iysA 2 0.331 99.9 0.802 Contact Map
3t4nC 1 0.5221 99.9 0.806 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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