GREMLIN Database
YUGK - Probable NADH-dependent butanol dehydrogenase 2
UniProt: O05240 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 390 (368)
Sequences: 10276 (7076)
Seq/√Len: 368.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
360_D379_K4.0401.00
356_E383_L3.9751.00
229_P338_S3.6831.00
352_E387_R3.3381.00
82_G86_E3.2811.00
294_R333_S3.2481.00
75_A155_W3.1911.00
80_G107_I2.8061.00
234_D237_N2.8011.00
378_N381_D2.7011.00
227_T243_T2.6791.00
181_F238_Y2.6481.00
230_K237_N2.6371.00
49_D53_G2.5841.00
16_K178_E2.5011.00
67_G79_K2.4811.00
351_G354_K2.4141.00
269_M386_L2.4021.00
21_Q24_K2.3531.00
355_L383_L2.3521.00
219_A222_Q2.3241.00
383_L387_R2.3221.00
344_R347_D2.2621.00
199_V220_V2.2531.00
18_Q21_Q2.2091.00
334_A338_S2.1711.00
17_G178_E2.1211.00
214_D303_R2.0681.00
175_L245_L2.0611.00
195_M224_V2.0111.00
196_M221_L2.0071.00
84_C131_L2.0071.00
379_K383_L1.9661.00
101_I135_T1.9471.00
92_L104_T1.9401.00
63_H87_H1.9371.00
359_A383_L1.8981.00
331_K334_A1.8591.00
41_S45_N1.8471.00
78_E116_D1.8381.00
190_Y283_G1.8341.00
296_T373_N1.8331.00
52_T56_K1.8211.00
294_R388_A1.8161.00
69_E76_T1.8091.00
188_T241_R1.8071.00
358_I386_L1.7791.00
359_A379_K1.7711.00
384_A388_A1.7701.00
287_I348_Y1.7341.00
225_I312_F1.7301.00
49_D52_T1.7281.00
229_P233_E1.7091.00
270_E284_G1.7061.00
356_E379_K1.7011.00
43_K66_S1.6951.00
233_E338_S1.6821.00
308_M328_G1.6661.00
239_E243_T1.6621.00
16_K238_Y1.6571.00
31_K91_F1.6411.00
76_T79_K1.6341.00
337_T343_S1.6021.00
221_L307_L1.6011.00
63_H83_L1.6001.00
94_A133_F1.5961.00
192_M228_A1.5891.00
293_M332_L1.5811.00
79_K82_G1.5611.00
84_C111_V1.5551.00
32_N61_V1.5541.00
185_E189_V1.5521.00
154_N157_T1.5431.00
384_A387_R1.5411.00
40_G44_R1.5411.00
83_L87_H1.5381.00
53_G57_E1.5301.00
11_K25_E1.5271.00
276_V357_L1.5211.00
20_E50_Q1.5171.00
180_T241_R1.5141.00
33_V38_G1.4901.00
16_K242_E1.4811.00
77_V152_I1.4761.00
186_N283_G1.4741.00
63_H89_I1.4681.00
23_R54_I1.4591.00
330_D334_A1.4581.00
25_E28_R1.4571.00
56_K62_V1.4551.00
357_L361_I1.4541.00
354_K357_L1.4511.00
26_F91_F1.4411.00
94_A104_T1.4371.00
52_T62_V1.4331.00
192_M244_I1.4111.00
294_R326_L1.4081.00
74_L78_E1.3771.00
193_V336_W1.3681.00
279_I284_G1.3651.00
269_M288_L1.3641.00
83_L86_E1.3621.00
178_E238_Y1.3341.00
218_F306_N1.3321.00
297_L326_L1.3321.00
227_T230_K1.3251.00
360_D364_K1.3201.00
34_L91_F1.3201.00
50_Q178_E1.3151.00
25_E172_F1.3141.00
180_T245_L1.3101.00
78_E82_G1.3091.00
13_I25_E1.3071.00
108_A130_A1.3061.00
185_E232_L1.3011.00
81_I110_G1.2961.00
33_V37_Y1.2951.00
237_N240_L1.2891.00
116_D119_D1.2831.00
84_C89_I1.2761.00
202_Q257_Q1.2711.00
134_G172_F1.2661.00
381_D384_A1.2601.00
33_V61_V1.2571.00
92_L108_A1.2551.00
188_T235_L1.2521.00
193_V341_A1.2501.00
84_C107_I1.2451.00
77_V103_C1.2441.00
326_L330_D1.2441.00
32_N90_D1.2411.00
69_E73_R1.2341.00
295_Y381_D1.2321.00
380_D383_L1.2311.00
82_G85_R1.2271.00
115_G119_D1.2251.00
230_K234_D1.2241.00
178_E181_F1.2231.00
305_K324_I1.2231.00
291_N388_A1.2221.00
38_G41_S1.2211.00
112_K129_D1.2151.00
115_G120_I1.2151.00
91_F134_G1.2141.00
12_L249_T1.2101.00
306_N310_N1.1921.00
227_T240_L1.1871.00
140_A188_T1.1821.00
31_K34_L1.1811.00
13_I21_Q1.1761.00
218_F222_Q1.1761.00
226_E243_T1.1761.00
357_L360_D1.1741.00
73_R76_T1.1681.00
224_V244_I1.1641.00
265_A377_L1.1581.00
215_R219_A1.1571.00
53_G56_K1.1501.00
18_Q174_I1.1471.00
104_T133_F1.1421.00
218_F311_M1.1381.00
297_L325_A1.1351.00
15_G18_Q1.1281.00
363_A379_K1.1271.00
17_G20_E1.1211.00
188_T231_L1.1181.00
219_A223_T1.1171.00
81_I85_R1.1081.00
19_L136_V1.1051.00
183_V187_Q1.1021.00
307_L328_G1.1001.00
177_P242_E1.0961.00
380_D384_A1.0851.00
298_D375_Q1.0821.00
146_M249_T1.0731.00
269_M382_V1.0621.00
16_K181_F1.0601.00
31_K90_D1.0591.00
299_T375_Q1.0551.00
266_S289_F1.0521.00
149_D164_G1.0511.00
51_V95_V1.0471.00
230_K240_L1.0471.00
185_E233_E1.0451.00
355_L387_R1.0411.00
327_E330_D1.0391.00
27_K58_E1.0391.00
189_V232_L1.0341.00
22_L51_V1.0331.00
19_L50_Q1.0311.00
268_T370_G1.0231.00
74_L155_W1.0171.00
222_Q310_N1.0061.00
193_V286_A1.0021.00
73_R155_W1.0001.00
75_A156_E1.0001.00
276_V361_I0.9941.00
295_Y375_Q0.9941.00
135_T170_P0.9801.00
186_N190_Y0.9661.00
34_L37_Y0.9651.00
11_K28_R0.9651.00
225_I331_K0.9611.00
266_S285_L0.9611.00
356_E360_D0.9601.00
39_G42_I0.9591.00
181_F236_E0.9581.00
24_K58_E0.9581.00
214_D217_C0.9541.00
81_I107_I0.9511.00
305_K325_A0.9491.00
68_V103_C0.9481.00
196_M224_V0.9451.00
224_V247_A0.9431.00
40_G43_K0.9401.00
343_S347_D0.9381.00
230_K239_E0.9371.00
94_A135_T0.9361.00
40_G66_S0.9321.00
220_V251_A0.9321.00
146_M173_S0.9311.00
33_V39_G0.9271.00
202_Q214_D0.9211.00
270_E274_S0.9181.00
203_Y306_N0.9141.00
65_L80_G0.9141.00
323_E327_E0.9131.00
26_F134_G0.9121.00
232_L339_L0.9071.00
222_Q226_E0.9031.00
265_A292_W0.9031.00
71_N278_D0.8981.00
235_L241_R0.8951.00
199_V251_A0.8921.00
42_I45_N0.8901.00
56_K61_V0.8861.00
20_E54_I0.8841.00
223_T243_T0.8831.00
69_E79_K0.8801.00
101_I137_L0.8791.00
132_P171_R0.8771.00
231_L235_L0.8761.00
48_Y52_T0.8751.00
200_F221_L0.8691.00
43_K49_D0.8691.00
17_G176_D0.8631.00
43_K48_Y0.8611.00
197_S289_F0.8611.00
277_Y354_K0.8601.00
19_L178_E0.8581.00
333_S337_T0.8541.00
42_I48_Y0.8521.00
190_Y280_P0.8521.00
310_N324_I0.8491.00
361_I364_K0.8451.00
246_Y250_I0.8381.00
23_R57_E0.8371.00
272_A386_L0.8371.00
314_I327_E0.8361.00
204_F293_M0.8351.00
342_P347_D0.8341.00
38_G42_I0.8331.00
103_C107_I0.8321.00
15_G21_Q0.8311.00
73_R278_D0.8301.00
231_L240_L0.8281.00
19_L179_N0.8281.00
363_A382_V0.8261.00
232_L340_G0.8241.00
50_Q54_I0.8241.00
50_Q179_N0.8211.00
108_A131_L0.8211.00
223_T247_A0.8201.00
94_A101_I0.8201.00
200_F307_L0.8191.00
272_A361_I0.8091.00
148_P166_N0.8091.00
291_N294_R0.8091.00
295_Y377_L0.8081.00
37_Y40_G0.8051.00
22_L136_V0.8031.00
77_V106_A0.8021.00
37_Y42_I0.8001.00
108_A133_F0.7981.00
109_A168_T0.7941.00
135_T173_S0.7931.00
52_T64_E0.7931.00
75_A79_K0.7901.00
185_E235_L0.7901.00
199_V217_C0.7891.00
50_Q53_G0.7871.00
327_E331_K0.7871.00
196_M200_F0.7841.00
209_N303_R0.7811.00
36_V68_V0.7781.00
43_K52_T0.7781.00
189_V341_A0.7771.00
46_G49_D0.7771.00
227_T244_I0.7761.00
273_V284_G0.7751.00
110_G114_D0.7731.00
101_I144_S0.7731.00
158_N278_D0.7721.00
307_L332_L0.7711.00
40_G67_G0.7681.00
206_N376_K0.7681.00
65_L79_K0.7671.00
202_Q217_C0.7661.00
185_E340_G0.7631.00
19_L176_D0.7611.00
301_V325_A0.7601.00
226_E229_P0.7581.00
215_R222_Q0.7541.00
133_F171_R0.7541.00
111_V131_L0.7511.00
334_A337_T0.7471.00
13_I18_Q0.7461.00
140_A245_L0.7451.00
183_V191_G0.7441.00
194_D281_H0.7431.00
230_K233_E0.7431.00
239_E242_E0.7421.00
216_M250_I0.7401.00
203_Y303_R0.7401.00
203_Y218_F0.7391.00
79_K83_L0.7391.00
288_L385_I0.7361.00
359_A363_A0.7361.00
209_N214_D0.7351.00
14_F242_E0.7341.00
113_Y128_E0.7311.00
293_M304_F0.7311.00
267_H281_H0.7291.00
314_I331_K0.7271.00
78_E81_I0.7241.00
54_I57_E0.7211.00
225_I229_P0.7151.00
19_L51_V0.7141.00
192_M339_L0.7110.99
21_Q25_E0.7110.99
227_T239_E0.7080.99
293_M328_G0.7060.99
265_A382_V0.7050.99
290_P336_W0.7050.99
36_V104_T0.6980.99
342_P348_Y0.6970.99
24_K28_R0.6960.99
226_E230_K0.6960.99
35_L83_L0.6930.99
77_V107_I0.6860.99
229_P232_L0.6860.99
209_N213_Q0.6850.99
356_E359_A0.6850.99
34_L93_L0.6840.99
283_G342_P0.6830.99
375_Q381_D0.6830.99
140_A180_T0.6820.99
112_K131_L0.6810.99
180_T188_T0.6800.99
297_L301_V0.6780.99
23_R58_E0.6750.99
355_L386_L0.6750.99
218_F310_N0.6740.99
270_E285_L0.6670.99
377_L382_V0.6630.99
273_V386_L0.6620.99
20_E57_E0.6620.99
335_F339_L0.6600.99
337_T347_D0.6600.99
193_V339_L0.6590.99
26_F93_L0.6580.99
345_L350_I0.6580.99
106_A152_I0.6540.99
19_L54_I0.6540.99
20_E178_E0.6530.99
301_V304_F0.6530.99
49_D56_K0.6530.99
286_A336_W0.6520.99
219_A250_I0.6520.99
293_M329_I0.6510.99
41_S46_G0.6510.99
47_L95_V0.6490.99
41_S44_R0.6490.99
194_D267_H0.6470.99
332_L336_W0.6470.99
311_M314_I0.6460.99
33_V63_H0.6440.99
294_R329_I0.6440.99
106_A150_S0.6410.99
262_G372_G0.6410.99
26_F60_A0.6410.99
211_P243_T0.6410.99
324_I327_E0.6380.99
200_F289_F0.6370.99
137_L248_G0.6360.99
71_N99_S0.6340.99
25_E29_Y0.6340.99
34_L38_G0.6330.99
315_D324_I0.6330.99
231_L244_I0.6320.99
222_Q311_M0.6310.99
247_A251_A0.6290.99
295_Y378_N0.6280.99
38_G66_S0.6270.99
94_A100_V0.6270.99
56_K59_G0.6270.99
227_T231_L0.6260.99
350_I355_L0.6250.99
238_Y242_E0.6240.99
134_G174_I0.6230.99
294_R297_L0.6230.99
352_E355_L0.6200.99
175_L249_T0.6200.99
84_C92_L0.6200.99
365_E369_G0.6190.99
268_T369_G0.6150.99
246_Y249_T0.6140.99
377_L381_D0.6130.98
271_H365_E0.6130.98
13_I172_F0.6130.98
197_S285_L0.6130.98
23_R27_K0.6110.98
150_S163_W0.6080.98
14_F246_Y0.6060.98
42_I47_L0.6040.98
273_V345_L0.6020.98
205_H372_G0.5980.98
113_Y130_A0.5980.98
30_G90_D0.5960.98
229_P331_K0.5950.98
81_I111_V0.5940.98
222_Q306_N0.5940.98
330_D333_S0.5920.98
333_S343_S0.5910.98
304_F308_M0.5900.98
294_R330_D0.5890.98
181_F241_R0.5880.98
280_P283_G0.5880.98
177_P238_Y0.5870.98
197_S266_S0.5870.98
38_G100_V0.5860.98
221_L225_I0.5860.98
206_N372_G0.5840.98
258_M263_D0.5840.98
279_I348_Y0.5830.98
245_L248_G0.5820.98
23_R26_F0.5820.98
47_L179_N0.5800.98
112_K130_A0.5800.98
211_P226_E0.5800.98
306_N311_M0.5800.98
109_A126_T0.5800.98
265_A268_T0.5790.98
16_K239_E0.5780.98
110_G117_A0.5780.98
12_L173_S0.5770.98
37_Y107_I0.5730.98
377_L385_I0.5730.98
78_E117_A0.5730.98
314_I328_G0.5730.98
307_L312_F0.5710.98
24_K27_K0.5710.98
37_Y100_V0.5700.98
285_L288_L0.5690.98
204_F304_F0.5690.98
197_S264_W0.5680.98
26_F55_L0.5680.98
22_L54_I0.5680.98
136_V174_I0.5630.97
29_Y134_G0.5610.97
33_V91_F0.5600.97
305_K310_N0.5600.97
93_L134_G0.5600.97
276_V358_I0.5590.97
33_V93_L0.5590.97
192_M224_V0.5580.97
78_E118_W0.5580.97
200_F293_M0.5550.97
290_P333_S0.5540.97
38_G43_K0.5520.97
274_S284_G0.5520.97
69_E278_D0.5520.97
35_L38_G0.5520.97
33_V87_H0.5490.97
55_L62_V0.5480.97
287_I345_L0.5470.97
137_L175_L0.5440.97
283_G341_A0.5440.97
301_V305_K0.5430.97
27_K60_A0.5430.97
308_M314_I0.5420.97
149_D162_V0.5420.97
359_A382_V0.5390.97
200_F328_G0.5380.97
120_I124_K0.5370.97
255_T258_M0.5370.97
310_N313_D0.5350.96
225_I335_F0.5340.96
160_K281_H0.5340.96
122_S125_V0.5330.96
43_K46_G0.5330.96
47_L50_Q0.5320.96
59_G62_V0.5320.96
32_N88_D0.5310.96
114_D120_I0.5300.96
45_N48_Y0.5270.96
162_V369_G0.5260.96
203_Y214_D0.5250.96
106_A163_W0.5250.96
244_I248_G0.5240.96
269_M362_A0.5220.96
130_A171_R0.5210.96
325_A328_G0.5200.96
210_T213_Q0.5190.96
295_Y385_I0.5180.96
303_R306_N0.5180.96
51_V54_I0.5180.96
198_H251_A0.5170.96
34_L60_A0.5170.96
117_A120_I0.5160.96
304_F328_G0.5160.96
146_M256_L0.5150.96
212_L215_R0.5140.96
336_W341_A0.5140.96
198_H281_H0.5140.96
35_L89_I0.5140.96
182_T236_E0.5130.96
361_I365_E0.5130.96
148_P259_G0.5130.96
48_Y95_V0.5110.95
273_V358_I0.5100.95
43_K64_E0.5100.95
352_E356_E0.5090.95
315_D327_E0.5090.95
221_L311_M0.5080.95
74_L154_N0.5060.95
223_T227_T0.5060.95
242_E246_Y0.5050.95
35_L48_Y0.5050.95
71_N274_S0.5040.95
61_V87_H0.5030.95
185_E236_E0.5030.95
208_E262_G0.5030.95
177_P245_L0.5020.95
76_T103_C0.5020.95
223_T250_I0.5020.95
297_L304_F0.5010.95
41_S100_V0.5010.95
221_L224_V0.5010.95
248_G251_A0.5010.95
118_W154_N0.5000.95
91_F132_P0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9795 100 0.089 Contact Map
3bfjA 5 0.9769 100 0.09 Contact Map
1vljA 2 0.9769 100 0.113 Contact Map
1rrmA 2 0.9744 100 0.113 Contact Map
4fr2A 2 0.9769 100 0.118 Contact Map
4qgsA 2 0.9538 100 0.144 Contact Map
3zdrA 2 0.9641 100 0.151 Contact Map
1o2dA 1 0.9179 100 0.173 Contact Map
3w5sA 2 0.8795 100 0.203 Contact Map
3iv7A 2 0.8769 100 0.204 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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