GREMLIN Database
YUGJ - Probable NADH-dependent butanol dehydrogenase 1
UniProt: O05239 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 387 (367)
Sequences: 10222 (7015)
Seq/√Len: 366.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
356_D380_L4.0081.00
360_D376_K3.9971.00
229_P338_S3.5891.00
294_R333_S3.3631.00
82_A86_E3.2701.00
352_D384_K3.1481.00
230_K237_N3.0541.00
75_S155_W3.0031.00
234_D237_N2.8921.00
80_G107_I2.8701.00
227_T243_T2.6281.00
375_N378_D2.5701.00
49_D53_E2.5611.00
181_F238_Y2.5211.00
355_L380_L2.4841.00
351_N354_Q2.4521.00
269_I383_L2.4371.00
16_R178_V2.4101.00
67_G79_K2.3941.00
219_S222_R2.3541.00
199_V220_L2.3111.00
21_R24_E2.2971.00
344_R347_D2.2581.00
380_L384_K2.2321.00
175_L245_L2.1641.00
17_G178_V2.1501.00
334_A338_S2.1261.00
18_E21_R2.1151.00
195_M224_V2.0731.00
196_M221_L2.0191.00
101_I135_T1.9931.00
214_D303_R1.9921.00
84_C131_L1.9691.00
359_A380_L1.9421.00
296_T370_Q1.9381.00
188_T241_R1.8961.00
92_L104_T1.8931.00
63_H87_Q1.8801.00
270_E284_G1.8791.00
190_Y283_G1.8781.00
31_K91_F1.8631.00
376_K380_L1.8501.00
69_E76_T1.8431.00
78_N116_D1.8371.00
358_I383_L1.8221.00
331_K334_A1.8201.00
52_I56_N1.8201.00
84_C111_A1.7641.00
41_S45_S1.7481.00
225_I312_F1.7371.00
294_R385_A1.7361.00
49_D52_I1.7301.00
359_A376_K1.7151.00
308_A328_G1.7151.00
229_P233_N1.7071.00
287_I348_Y1.7051.00
221_L307_L1.6781.00
356_D376_K1.6571.00
233_N338_S1.6561.00
40_G44_R1.6441.00
43_K66_A1.6361.00
76_T79_K1.6201.00
192_M228_A1.6121.00
381_S385_A1.6081.00
180_T241_R1.5921.00
16_R238_Y1.5791.00
23_P54_Q1.5781.00
94_A133_F1.5731.00
185_K189_I1.5711.00
239_E243_T1.5671.00
63_H83_I1.5491.00
20_E50_Q1.5411.00
337_T343_N1.5401.00
63_H89_I1.5381.00
237_N240_L1.5371.00
79_K82_A1.5351.00
293_M332_L1.5321.00
186_N283_G1.5121.00
381_S384_K1.4931.00
53_E57_K1.4911.00
83_I87_Q1.4881.00
330_D334_A1.4841.00
11_K25_E1.4831.00
77_V152_I1.4821.00
34_L91_F1.4651.00
294_R326_L1.4541.00
33_V38_G1.4401.00
26_L91_F1.4271.00
16_R242_E1.4241.00
192_M244_I1.4151.00
269_I288_L1.4151.00
25_E28_P1.4121.00
276_V357_T1.4041.00
52_I62_V1.4021.00
188_T235_L1.3971.00
279_I284_G1.3921.00
56_N62_V1.3791.00
180_T245_L1.3591.00
94_A104_T1.3551.00
230_K234_D1.3431.00
81_V110_G1.3381.00
83_I86_E1.3351.00
357_T361_K1.3331.00
354_Q357_T1.3321.00
84_C89_I1.3241.00
108_A130_A1.3151.00
74_V78_N1.3151.00
50_Q178_V1.3021.00
193_V336_W1.2991.00
78_N82_A1.2971.00
115_G119_D1.2921.00
178_V238_Y1.2901.00
218_E306_Q1.2881.00
33_V61_T1.2851.00
112_K129_D1.2831.00
185_K232_I1.2821.00
115_G120_I1.2801.00
297_L326_L1.2781.00
360_D364_A1.2741.00
77_V103_C1.2721.00
13_I25_E1.2701.00
134_G172_F1.2691.00
378_D381_S1.2681.00
32_N61_T1.2671.00
227_T230_K1.2651.00
69_E73_R1.2531.00
91_F134_G1.2491.00
84_C107_I1.2451.00
32_N90_D1.2321.00
25_E172_F1.2291.00
202_Q257_S1.2171.00
116_D119_D1.2151.00
326_L330_D1.2141.00
33_V37_Y1.2071.00
226_E243_T1.2071.00
377_E380_L1.2031.00
12_L249_T1.2011.00
82_A85_K1.1991.00
295_H378_D1.1981.00
265_A374_L1.1921.00
193_V341_A1.1881.00
355_L384_K1.1881.00
140_A188_T1.1751.00
104_T133_F1.1681.00
92_L108_A1.1651.00
227_T240_L1.1641.00
297_L325_A1.1621.00
218_E311_V1.1591.00
18_E174_I1.1581.00
178_V181_F1.1571.00
224_V244_I1.1541.00
73_R76_T1.1481.00
53_E56_N1.1431.00
307_L328_G1.1361.00
305_K324_I1.1361.00
31_K34_L1.1341.00
357_T360_D1.1341.00
41_S44_R1.1301.00
219_S223_T1.1291.00
19_V136_V1.1221.00
183_V187_H1.1151.00
188_T231_L1.1081.00
13_I21_R1.1051.00
15_G18_E1.1041.00
146_M249_T1.1001.00
218_E222_R1.0981.00
154_N157_T1.0981.00
269_I379_V1.0941.00
51_V95_V1.0911.00
298_S372_K1.0911.00
291_N385_A1.0851.00
363_M376_K1.0771.00
185_K233_N1.0741.00
266_T289_F1.0681.00
177_P242_E1.0671.00
215_R219_S1.0641.00
75_S156_E1.0601.00
81_V85_K1.0601.00
306_Q310_R1.0581.00
17_G20_E1.0571.00
22_L51_V1.0491.00
305_K325_A1.0461.00
74_V155_W1.0391.00
266_T285_L1.0371.00
299_E372_K1.0351.00
377_E381_S1.0301.00
135_T170_P1.0291.00
16_R181_F1.0271.00
189_I232_I1.0181.00
222_R310_R1.0181.00
268_N368_F1.0091.00
39_G42_I1.0081.00
203_Y306_Q1.0001.00
149_G164_G1.0001.00
38_G41_S0.9971.00
40_G66_A0.9901.00
193_V286_A0.9871.00
214_D217_C0.9871.00
220_L251_A0.9851.00
71_N278_D0.9851.00
68_V103_C0.9841.00
26_L134_G0.9781.00
327_E330_D0.9741.00
202_Q214_D0.9731.00
94_A135_T0.9701.00
146_M173_S0.9691.00
196_M224_V0.9651.00
199_V251_A0.9641.00
230_K239_E0.9611.00
24_E58_A0.9601.00
27_K58_A0.9531.00
19_V50_Q0.9521.00
186_N190_Y0.9521.00
73_R155_W0.9501.00
295_H372_K0.9491.00
224_V247_T0.9481.00
235_L241_R0.9461.00
276_V361_K0.9421.00
56_N61_T0.9411.00
314_V327_E0.9411.00
17_G176_D0.9391.00
225_I331_K0.9321.00
69_E79_K0.9311.00
40_G43_K0.9251.00
43_K49_D0.9241.00
190_Y280_P0.9241.00
270_E274_S0.9211.00
232_I340_G0.9201.00
42_I45_S0.9131.00
81_V107_I0.9111.00
265_A292_W0.9111.00
231_L235_L0.9101.00
42_I48_Y0.9071.00
200_F221_L0.9061.00
132_P171_K0.9031.00
108_A131_L0.9001.00
230_K240_L0.8961.00
356_D360_D0.8941.00
181_F236_E0.8891.00
359_A363_M0.8861.00
101_I137_L0.8841.00
343_N347_D0.8801.00
232_I339_L0.8781.00
222_R226_E0.8771.00
103_C107_I0.8741.00
223_T243_T0.8731.00
135_T173_S0.8711.00
43_K48_Y0.8711.00
272_A383_L0.8711.00
31_K90_D0.8651.00
11_K28_P0.8631.00
34_L93_L0.8601.00
81_V111_A0.8591.00
19_V178_V0.8531.00
197_S289_F0.8461.00
15_G21_R0.8461.00
73_R278_D0.8431.00
19_V179_N0.8381.00
277_Y354_Q0.8361.00
48_Y52_I0.8341.00
113_Y128_K0.8301.00
111_A131_L0.8301.00
50_Q179_N0.8251.00
204_F293_M0.8241.00
361_K364_A0.8241.00
310_R324_I0.8231.00
246_Y250_I0.8211.00
215_R222_R0.8211.00
65_L80_G0.8201.00
109_A168_V0.8181.00
158_K278_D0.8171.00
34_L37_Y0.8161.00
291_N294_R0.8151.00
101_I144_S0.8081.00
43_K52_I0.8081.00
50_Q54_Q0.8081.00
94_A101_I0.8071.00
108_A133_F0.8051.00
180_T188_T0.8031.00
65_L79_K0.8021.00
316_E324_I0.8021.00
196_M200_F0.8001.00
363_M379_V0.7991.00
333_S337_T0.7981.00
33_V39_G0.7971.00
23_P57_K0.7961.00
133_F171_K0.7961.00
77_V106_A0.7921.00
140_A245_L0.7921.00
295_H374_L0.7911.00
148_S166_P0.7901.00
36_V68_V0.7891.00
307_L332_L0.7891.00
216_M250_I0.7861.00
227_T244_I0.7861.00
21_R25_E0.7801.00
218_E310_R0.7781.00
19_V176_D0.7781.00
227_T239_E0.7771.00
223_T247_T0.7761.00
189_I341_A0.7761.00
271_H365_N0.7681.00
273_V284_G0.7681.00
267_H281_H0.7671.00
200_F307_L0.7671.00
231_L240_L0.7651.00
327_E331_K0.7641.00
230_K233_N0.7641.00
342_P347_D0.7611.00
272_A361_K0.7601.00
183_V191_G0.7551.00
226_E229_P0.7541.00
203_Y218_E0.7541.00
199_V217_C0.7531.00
20_E54_Q0.7521.00
334_A337_T0.7491.00
202_Q217_C0.7491.00
288_L382_I0.7491.00
265_A379_V0.7431.00
50_Q53_E0.7391.00
229_P232_I0.7351.00
356_D359_A0.7341.00
301_P325_A0.7341.00
24_E28_P0.7321.00
22_L136_V0.7321.00
239_E242_E0.7321.00
194_D281_H0.7311.00
185_K340_G0.7291.00
297_L301_P0.7231.00
37_Y42_I0.7211.00
293_M328_G0.7181.00
293_M304_M0.7150.99
13_I18_E0.7150.99
342_P348_Y0.7130.99
290_P336_W0.7130.99
270_E285_L0.7120.99
40_G67_G0.7110.99
75_S79_K0.7100.99
19_V51_V0.7080.99
23_P26_L0.7080.99
225_I229_P0.7060.99
52_I64_E0.7050.99
185_K235_L0.7040.99
14_F242_E0.7010.99
293_M329_I0.7000.99
19_V54_Q0.6970.99
54_Q57_K0.6940.99
295_H375_N0.6940.99
37_Y107_I0.6910.99
140_A180_T0.6910.99
78_N81_V0.6890.99
38_G66_A0.6890.99
203_Y303_R0.6890.99
77_V107_I0.6860.99
42_I47_L0.6860.99
283_G342_P0.6850.99
94_A100_V0.6840.99
26_L93_L0.6830.99
222_R306_Q0.6800.99
150_S163_W0.6780.99
337_T347_D0.6780.99
35_L83_I0.6770.99
79_K83_I0.6730.99
332_L336_W0.6730.99
197_S285_L0.6720.99
46_G49_D0.6700.99
335_F339_L0.6650.99
26_L60_A0.6640.99
219_S250_I0.6640.99
273_V383_L0.6600.99
206_H373_S0.6590.99
355_L383_L0.6590.99
49_D56_N0.6580.99
315_E324_I0.6570.99
56_N59_G0.6560.99
47_L95_V0.6560.99
33_V63_H0.6540.99
279_I348_Y0.6520.99
84_C92_L0.6500.99
23_P58_A0.6500.99
209_N303_R0.6500.99
294_R329_I0.6490.99
106_A150_S0.6480.99
197_S266_T0.6480.99
238_Y242_E0.6470.99
30_G90_D0.6470.99
314_V328_G0.6440.99
226_E230_K0.6430.99
207_V262_G0.6420.99
192_M339_L0.6420.99
137_L248_G0.6400.99
38_G43_K0.6380.99
34_L38_G0.6380.99
333_S343_N0.6360.99
227_T231_L0.6340.99
39_G44_R0.6340.99
374_L382_I0.6310.99
106_A152_I0.6310.99
112_K131_L0.6300.99
372_K378_D0.6290.99
37_Y100_V0.6270.99
330_D333_S0.6270.99
35_L89_I0.6230.99
248_G251_A0.6230.99
137_L175_L0.6200.99
209_N214_D0.6200.99
305_K310_R0.6160.98
314_V331_K0.6160.98
286_A336_W0.6160.98
271_H367_T0.6150.98
294_R297_L0.6150.98
134_G174_I0.6140.98
20_E178_V0.6140.98
294_R330_D0.6130.98
22_L54_Q0.6130.98
205_H369_G0.6120.98
175_L249_T0.6110.98
71_N99_S0.6100.98
374_L379_V0.6100.98
280_P283_G0.6100.98
222_R311_V0.6090.98
34_L90_D0.6090.98
311_V314_V0.6060.98
221_L225_I0.6050.98
200_F289_F0.6050.98
345_L350_I0.6040.98
14_F246_Y0.6020.98
13_I172_F0.6020.98
197_S264_W0.6020.98
258_M263_D0.6000.98
113_Y130_A0.5990.98
374_L378_D0.5990.98
206_H369_G0.5970.98
45_S48_Y0.5970.98
262_G369_G0.5970.98
37_Y40_G0.5950.98
276_V358_I0.5940.98
130_A171_K0.5920.98
324_I327_E0.5910.98
38_G100_V0.5900.98
38_G42_I0.5900.98
26_L31_K0.5900.98
69_E278_D0.5890.98
194_D267_H0.5890.98
204_F304_M0.5880.98
209_N213_Q0.5880.98
55_L62_V0.5870.98
20_E57_K0.5860.98
148_S259_G0.5860.98
25_E29_Y0.5860.98
177_P238_Y0.5860.98
109_A126_Q0.5850.98
200_F328_G0.5850.98
307_L312_F0.5830.98
237_N241_R0.5830.98
78_N110_G0.5830.98
12_L173_S0.5820.98
265_A268_N0.5820.98
300_N304_M0.5750.98
231_L244_I0.5740.98
287_I345_L0.5720.98
274_S284_G0.5720.98
301_P304_M0.5690.97
16_R239_E0.5680.97
273_V345_L0.5680.97
84_C87_Q0.5670.97
34_L60_A0.5660.97
160_K281_H0.5650.97
112_K130_A0.5650.97
36_V48_Y0.5650.97
26_L55_L0.5640.97
71_N274_S0.5640.97
106_A163_W0.5640.97
192_M224_V0.5640.97
110_G114_D0.5630.97
38_G64_E0.5600.97
83_I89_I0.5600.97
265_A370_Q0.5600.97
193_V339_L0.5600.97
198_H281_H0.5600.97
36_V62_V0.5600.97
304_M308_A0.5580.97
51_V54_Q0.5570.97
33_V88_N0.5570.97
301_P305_K0.5560.97
228_A335_F0.5560.97
37_Y104_T0.5540.97
151_V194_D0.5530.97
285_L288_L0.5530.97
47_L179_N0.5530.97
78_N117_A0.5530.97
149_G162_G0.5520.97
346_A352_D0.5520.97
362_A383_L0.5510.97
136_V174_I0.5500.97
325_A328_G0.5490.97
271_H274_S0.5490.97
118_W156_E0.5480.97
93_L134_G0.5470.97
221_L311_V0.5440.97
78_N118_W0.5440.97
368_F379_V0.5440.97
114_D120_I0.5420.97
283_G341_A0.5410.97
203_Y214_D0.5400.97
359_A379_V0.5390.97
33_V90_D0.5380.97
181_F241_R0.5380.97
227_T247_T0.5370.96
200_F293_M0.5360.96
352_D355_L0.5350.96
129_D167_L0.5350.96
23_P27_K0.5350.96
43_K64_E0.5330.96
350_I355_L0.5300.96
336_W339_L0.5300.96
118_W154_N0.5290.96
306_Q311_V0.5290.96
247_T251_A0.5280.96
264_W369_G0.5280.96
204_F264_W0.5270.96
29_Y134_G0.5260.96
92_L107_I0.5250.96
229_P335_F0.5250.96
198_H251_A0.5240.96
269_I362_A0.5230.96
13_I174_I0.5230.96
268_N367_T0.5220.96
336_W341_A0.5200.96
41_S100_V0.5170.96
273_V358_I0.5170.96
80_G103_C0.5160.96
65_L76_T0.5160.96
264_W271_H0.5150.96
216_M256_L0.5140.95
24_E27_K0.5140.95
76_T103_C0.5140.95
47_L50_Q0.5130.95
59_G62_V0.5130.95
34_L62_V0.5110.95
288_L292_W0.5110.95
120_I124_K0.5100.95
41_S46_G0.5090.95
223_T250_I0.5060.95
33_V93_L0.5040.95
328_G332_L0.5030.95
108_A132_P0.5030.95
308_A314_V0.5020.95
350_I358_I0.5000.95
287_I290_P0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ox4A 2 0.9845 100 0.072 Contact Map
3bfjA 5 0.9819 100 0.073 Contact Map
1vljA 2 0.9819 100 0.091 Contact Map
1rrmA 2 0.9793 100 0.094 Contact Map
4fr2A 2 0.9819 100 0.103 Contact Map
4qgsA 2 0.9561 100 0.122 Contact Map
3zdrA 2 0.969 100 0.137 Contact Map
1o2dA 1 0.9199 100 0.166 Contact Map
3w5sA 2 0.8863 100 0.178 Contact Map
3iv7A 2 0.8837 100 0.181 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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