GREMLIN Database
YUGF - Uncharacterized hydrolase YugF
UniProt: O05235 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 273 (249)
Sequences: 63217 (51883)
Seq/√Len: 3287.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_H55_D4.6901.00
97_V121_K4.3661.00
62_P83_L3.5961.00
46_V265_S3.0181.00
85_I111_A2.9081.00
260_R263_L2.7961.00
224_E250_G2.6891.00
97_V120_S2.6821.00
95_Q120_S2.6121.00
247_Y267_H2.5951.00
126_C226_D2.5641.00
125_L264_I2.4041.00
249_L267_H2.3331.00
16_N68_E2.2091.00
85_I118_L2.1351.00
85_I89_E2.1291.00
20_E40_A2.1191.00
111_A115_K2.1051.00
85_I115_K2.0661.00
98_L108_S2.0591.00
88_L96_A2.0431.00
224_E248_S2.0391.00
238_H244_S2.0341.00
89_E118_L1.9811.00
105_G127_S1.9211.00
18_Y66_Q1.9191.00
19_Y87_I1.8751.00
49_L265_S1.8501.00
28_Q97_V1.8491.00
110_S114_Q1.8461.00
53_K269_A1.8211.00
29_T57_I1.8161.00
252_T260_R1.8071.00
82_K114_Q1.7921.00
231_M248_S1.7761.00
112_A122_V1.7681.00
29_T55_D1.7441.00
21_H57_I1.7401.00
28_Q120_S1.7251.00
97_V123_V1.7201.00
29_T93_V1.7191.00
22_Y58_A1.6881.00
219_L247_Y1.6501.00
54_Y97_V1.6311.00
78_Q114_Q1.5911.00
34_H64_F1.5911.00
34_H61_L1.5841.00
18_Y40_A1.5811.00
218_A241_L1.5701.00
38_S42_S1.5521.00
108_S122_V1.5521.00
236_R240_D1.5461.00
267_H270_D1.5171.00
61_L107_I1.5161.00
59_L84_V1.5111.00
13_D86_G1.4951.00
81_A110_S1.4891.00
33_V84_V1.4621.00
33_V61_L1.4591.00
76_T79_N1.4561.00
115_K118_L1.4481.00
84_V111_A1.4351.00
111_A119_F1.4161.00
266_E270_D1.3871.00
40_A60_D1.3851.00
210_Q213_K1.3771.00
18_Y60_D1.3621.00
52_D269_A1.3341.00
231_M235_K1.3311.00
49_L269_A1.3241.00
123_V268_I1.3131.00
33_V108_S1.3101.00
222_W234_G1.3081.00
110_S113_L1.3031.00
263_L267_H1.2861.00
111_A118_L1.2851.00
109_L124_L1.2791.00
124_L127_S1.2771.00
89_E115_K1.2761.00
37_L64_F1.2741.00
57_I87_I1.2571.00
101_H257_P1.2411.00
32_C99_V1.2281.00
49_L52_D1.2261.00
219_L271_F1.2211.00
175_D178_M1.2191.00
15_V62_P1.2181.00
24_N27_R1.2181.00
40_A66_Q1.2081.00
99_V125_L1.2051.00
28_Q54_Y1.2001.00
47_I58_A1.1911.00
123_V219_L1.1851.00
17_V83_L1.1811.00
32_C56_I1.1781.00
102_S254_H1.1731.00
263_L266_E1.1651.00
93_V96_A1.1641.00
235_K239_A1.1561.00
30_L54_Y1.1551.00
87_I91_L1.1401.00
22_Y47_I1.1261.00
238_H246_L1.1091.00
35_G102_S1.0921.00
222_W248_S1.0861.00
221_I249_L1.0811.00
193_K197_R1.0801.00
212_K240_D1.0741.00
59_L87_I1.0731.00
40_A58_A1.0671.00
28_Q95_Q1.0661.00
249_L252_T1.0661.00
241_L244_S1.0661.00
31_V88_L1.0651.00
113_L210_Q1.0601.00
60_D65_G1.0511.00
222_W246_L1.0481.00
224_E251_Q1.0421.00
49_L262_E1.0411.00
191_I194_A1.0391.00
33_V98_L1.0331.00
236_R239_A1.0321.00
19_Y91_L1.0261.00
219_L245_V1.0231.00
48_P51_R1.0211.00
37_L102_S1.0191.00
96_A119_F1.0171.00
78_Q110_S1.0131.00
24_N55_D1.0111.00
264_I268_I1.0021.00
197_R200_R1.0001.00
262_E266_E0.9991.00
245_V267_H0.9781.00
121_K217_P0.9751.00
235_K248_S0.9691.00
222_W231_M0.9661.00
235_K246_L0.9621.00
101_H255_L0.9611.00
88_L93_V0.9611.00
81_A107_I0.9591.00
85_I114_Q0.9591.00
42_S257_P0.9571.00
199_I202_R0.9521.00
88_L111_A0.9521.00
15_V68_E0.9471.00
125_L257_P0.9461.00
249_L263_L0.9391.00
195_M198_F0.9381.00
253_G259_E0.9311.00
85_I88_L0.9221.00
51_R56_I0.9201.00
100_G108_S0.9201.00
31_V96_A0.9191.00
17_V67_S0.9101.00
99_V268_I0.9101.00
252_T256_V0.9071.00
198_F201_H0.9071.00
86_G90_H0.9031.00
96_A118_L0.8971.00
44_R58_A0.8921.00
196_T199_I0.8911.00
221_I267_H0.8881.00
79_N82_K0.8861.00
235_K238_H0.8851.00
28_Q121_K0.8841.00
247_Y270_D0.8831.00
86_G89_E0.8801.00
57_I91_L0.8761.00
122_V218_A0.8741.00
45_K48_P0.8721.00
196_T200_R0.8641.00
22_Y51_R0.8641.00
27_R55_D0.8631.00
30_L56_I0.8591.00
252_T259_E0.8531.00
159_G163_N0.8471.00
125_L256_V0.8421.00
61_L103_M0.8411.00
81_A114_Q0.8361.00
33_V59_L0.8271.00
247_Y263_L0.8151.00
112_A119_F0.8101.00
185_P188_D0.8061.00
100_G105_G0.8061.00
30_L99_V0.8031.00
220_L244_S0.8021.00
82_K85_I0.7991.00
183_G187_Q0.7881.00
110_S210_Q0.7871.00
194_A197_R0.7871.00
232_E235_K0.7771.00
176_E180_D0.7761.00
197_R201_H0.7701.00
44_R48_P0.7681.00
149_L153_R0.7631.00
82_K86_G0.7611.00
223_G256_V0.7601.00
41_F44_R0.7591.00
29_T54_Y0.7591.00
234_G246_L0.7571.00
195_M199_I0.7531.00
31_V84_V0.7531.00
98_L111_A0.7521.00
36_F103_M0.7521.00
163_N167_V0.7501.00
233_I236_R0.7481.00
60_D66_Q0.7481.00
47_I56_I0.7471.00
249_L260_R0.7461.00
181_G185_P0.7451.00
98_L119_F0.7441.00
177_E181_G0.7421.00
32_C43_F0.7411.00
81_A111_A0.7401.00
149_L152_K0.7401.00
29_T96_A0.7391.00
47_I51_R0.7391.00
181_G184_R0.7381.00
80_L103_M0.7381.00
74_I79_N0.7361.00
20_E44_R0.7351.00
161_M165_L0.7321.00
251_Q260_R0.7301.00
225_E251_Q0.7261.00
40_A59_L0.7261.00
164_L167_V0.7251.00
193_K196_T0.7241.00
265_S269_A0.7211.00
157_K161_M0.7161.00
126_C256_V0.7101.00
261_P265_S0.7091.00
54_Y269_A0.7091.00
148_H152_K0.7081.00
37_L103_M0.7061.00
215_N242_P0.7051.00
34_H59_L0.7051.00
30_L97_V0.7041.00
158_E161_M0.7011.00
224_E231_M0.6981.00
162_K165_L0.6961.00
101_H126_C0.6951.00
94_K118_L0.6881.00
92_Q95_Q0.6831.00
126_C222_W0.6831.00
160_V164_L0.6821.00
101_H125_L0.6771.00
178_M181_G0.6761.00
180_D184_R0.6761.00
61_L80_L0.6731.00
207_E210_Q0.6721.00
112_A216_K0.6701.00
158_E162_K0.6701.00
150_Y154_W0.6701.00
159_G162_K0.6681.00
144_I147_F0.6681.00
25_P55_D0.6671.00
155_L159_G0.6651.00
198_F202_R0.6651.00
99_V123_V0.6641.00
126_C223_G0.6611.00
17_V62_P0.6601.00
151_I154_W0.6591.00
119_F216_K0.6591.00
192_F195_M0.6591.00
109_L129_G0.6591.00
221_I264_I0.6561.00
46_V49_L0.6501.00
172_S175_D0.6501.00
27_R53_K0.6471.00
57_I93_V0.6471.00
113_L213_K0.6461.00
192_F196_T0.6461.00
96_A120_S0.6451.00
78_Q82_K0.6441.00
105_G124_L0.6431.00
43_F46_V0.6421.00
160_V163_N0.6391.00
209_E212_K0.6391.00
266_E269_A0.6361.00
180_D183_G0.6351.00
194_A198_F0.6321.00
226_D254_H0.6301.00
55_D93_V0.6281.00
164_L168_V0.6271.00
80_L107_I0.6271.00
171_K175_D0.6251.00
220_L234_G0.6241.00
43_F47_I0.6241.00
62_P80_L0.6221.00
61_L64_F0.6181.00
100_G104_G0.6171.00
162_K166_N0.6101.00
22_Y48_P0.6091.00
106_Q128_S0.6061.00
161_M164_L0.6051.00
156_S159_G0.6031.00
157_K160_V0.6011.00
46_V264_I0.6011.00
185_P189_E0.5951.00
96_A111_A0.5941.00
77_Y110_S0.5901.00
13_D79_N0.5901.00
184_R188_D0.5891.00
192_F199_I0.5891.00
31_V98_L0.5891.00
102_S255_L0.5871.00
158_E164_L0.5861.00
18_Y67_S0.5861.00
182_Y186_F0.5851.00
31_V59_L0.5851.00
170_D173_L0.5841.00
21_H91_L0.5821.00
124_L220_L0.5811.00
144_I148_H0.5801.00
123_V221_I0.5801.00
32_C58_A0.5781.00
13_D82_K0.5771.00
221_I247_Y0.5741.00
191_I195_M0.5731.00
114_Q210_Q0.5711.00
109_L127_S0.5681.00
158_E163_N0.5631.00
234_G238_H0.5591.00
145_P148_H0.5581.00
87_I90_H0.5581.00
81_A85_I0.5571.00
237_L241_L0.5571.00
220_L246_L0.5561.00
245_V270_D0.5531.00
182_Y185_P0.5531.00
88_L118_L0.5511.00
82_K115_K0.5491.00
20_E58_A0.5461.00
61_L84_V0.5461.00
179_I182_Y0.5441.00
184_R187_Q0.5441.00
147_F151_I0.5431.00
190_Q193_K0.5421.00
165_L168_V0.5421.00
256_V264_I0.5421.00
152_K155_L0.5371.00
42_S101_H0.5321.00
220_L238_H0.5301.00
20_E41_F0.5301.00
32_C50_L0.5281.00
121_K271_F0.5281.00
50_L56_I0.5271.00
163_N166_N0.5261.00
30_L50_L0.5241.00
84_V107_I0.5221.00
203_E206_L0.5211.00
151_I155_L0.5201.00
205_D208_P0.5201.00
214_M241_L0.5191.00
130_Y236_R0.5151.00
95_Q118_L0.5151.00
161_M167_V0.5121.00
222_W229_V0.5121.00
79_N83_L0.5121.00
208_P240_D0.5111.00
125_L221_I0.5111.00
208_P236_R0.5091.00
238_H241_L0.5071.00
160_V165_L0.5071.00
191_I202_R0.5061.00
152_K156_S0.5051.00
38_S255_L0.5031.00
108_S124_L0.5031.00
160_V167_V0.5021.00
33_V107_I0.5011.00
36_F102_S0.5011.00
171_K174_I0.5011.00
191_I199_I0.5011.00
225_E252_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ehyA 1 0.9744 100 0.134 Contact Map
4inzA 1 0.9707 100 0.15 Contact Map
3oosA 1 0.978 100 0.166 Contact Map
3om8A 4 0.9634 100 0.169 Contact Map
1iupA 2 0.9524 100 0.17 Contact Map
2pujA 4 0.9853 100 0.171 Contact Map
4psuA 1 0.978 100 0.171 Contact Map
3bwxA 1 0.9744 100 0.18 Contact Map
2wueA 4 0.9853 100 0.184 Contact Map
2xuaA 2 0.9414 100 0.188 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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