GREMLIN Database
MRPD - Na(+)/H(+) antiporter subunit D
UniProt: O05229 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 493 (457)
Sequences: 20311 (12551)
Seq/√Len: 587.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_D258_R4.7081.00
339_A376_S4.6191.00
122_G135_F4.3921.00
188_N191_D4.0431.00
82_V125_L3.7951.00
148_V159_S3.5721.00
332_H387_S3.2441.00
161_K231_G3.2381.00
295_N354_A3.1711.00
89_G117_L3.1031.00
186_T191_D3.0011.00
329_Y391_G2.9491.00
283_V414_S2.9181.00
15_S36_A2.8421.00
294_S357_H2.8101.00
279_A316_A2.7301.00
374_F426_F2.6621.00
300_V344_A2.6461.00
119_G138_L2.6291.00
176_G211_L2.6121.00
353_T358_K2.5811.00
85_T124_F2.5781.00
82_V121_S2.5461.00
13_L118_A2.5261.00
222_I312_L2.4681.00
355_S358_K2.4421.00
38_A90_L2.3021.00
96_S109_Y2.2851.00
377_A422_V2.2641.00
299_I356_L2.2261.00
73_A127_G2.2201.00
233_Y241_S2.2091.00
86_A121_S2.1951.00
291_L420_Y2.1911.00
233_Y249_T2.0711.00
313_F411_I2.0051.00
314_G395_I1.9981.00
273_Q277_W1.9561.00
303_N421_S1.9391.00
217_G222_I1.9291.00
249_T304_I1.9041.00
294_S355_S1.8911.00
284_I414_S1.8581.00
41_I87_I1.8371.00
75_D78_A1.8131.00
366_Y369_L1.8051.00
191_D194_V1.8021.00
317_V322_S1.7981.00
424_R428_H1.7811.00
287_V306_T1.7581.00
296_V425_I1.7481.00
129_L192_L1.7451.00
276_I316_A1.7451.00
465_G468_W1.7341.00
446_K450_Y1.7311.00
105_E108_F1.7291.00
396_A411_I1.7271.00
221_G229_L1.7141.00
179_F208_I1.7091.00
328_Y391_G1.7051.00
129_L259_V1.6801.00
38_A42_V1.6771.00
132_M255_A1.6741.00
25_N28_L1.6651.00
325_G398_G1.6501.00
213_L217_G1.6501.00
293_Y298_K1.6461.00
127_G190_A1.6421.00
223_F281_L1.6171.00
257_T315_V1.6171.00
363_I370_G1.6001.00
270_F273_Q1.5991.00
78_A254_Y1.5851.00
84_T334_M1.5821.00
335_L458_L1.5791.00
48_V52_F1.5711.00
399_G408_S1.5641.00
80_L331_I1.5441.00
183_V208_I1.5321.00
126_T131_N1.5321.00
280_A410_L1.5251.00
73_A76_Q1.5191.00
44_S86_A1.5191.00
27_M30_R1.5171.00
128_D188_N1.4921.00
191_D195_K1.4921.00
457_L461_L1.4901.00
275_M316_A1.4721.00
397_E401_A1.4701.00
375_I456_L1.4691.00
203_G207_V1.4461.00
369_L443_R1.4451.00
9_I118_A1.4321.00
28_L31_I1.4271.00
287_V414_S1.4151.00
93_G110_Y1.4141.00
42_V46_I1.4141.00
276_I407_I1.4101.00
23_T107_S1.4091.00
26_L30_R1.4081.00
112_G145_M1.4071.00
315_V326_A1.4061.00
373_F377_A1.4061.00
63_G69_G1.3941.00
181_Y187_L1.3901.00
454_I458_L1.3881.00
213_L275_M1.3831.00
128_D187_L1.3821.00
37_S41_I1.3781.00
311_I326_A1.3711.00
58_T61_L1.3691.00
272_H276_I1.3681.00
222_I278_L1.3671.00
176_G215_V1.3551.00
36_A40_G1.3451.00
173_F215_V1.3401.00
216_F255_A1.3341.00
256_I312_L1.3261.00
40_G44_S1.3261.00
340_L376_S1.3231.00
93_G113_V1.3191.00
95_Y342_M1.3171.00
158_E235_A1.3161.00
370_G431_W1.3161.00
176_G212_L1.3151.00
451_P454_I1.3111.00
257_T326_A1.3101.00
250_K254_Y1.3041.00
446_K449_L1.2971.00
370_G426_F1.2941.00
314_G322_S1.2911.00
176_G208_I1.2811.00
336_I379_S1.2781.00
373_F425_I1.2691.00
74_A125_L1.2671.00
445_A448_L1.2621.00
178_G182_A1.2591.00
317_V399_G1.2581.00
123_A251_V1.2581.00
98_R101_G1.2571.00
71_V127_G1.2571.00
165_F227_F1.2511.00
80_L327_I1.2461.00
46_I50_T1.2421.00
314_G326_A1.2401.00
154_I234_Y1.2391.00
20_I23_T1.2301.00
313_F399_G1.2281.00
177_V212_L1.2251.00
231_G298_K1.2191.00
453_A457_L1.2181.00
418_V421_S1.2121.00
37_S40_G1.2111.00
45_G49_Q1.2101.00
377_A426_F1.2071.00
16_A115_F1.2061.00
130_F187_L1.2001.00
467_E471_P1.1971.00
332_H391_G1.1941.00
285_F289_G1.1941.00
31_I35_A1.1931.00
9_I12_P1.1901.00
116_L120_V1.1851.00
279_A309_G1.1841.00
88_I334_M1.1821.00
376_S456_L1.1811.00
133_Y174_V1.1801.00
27_M31_I1.1751.00
41_I86_A1.1741.00
81_L330_L1.1731.00
132_M189_M1.1731.00
322_S398_G1.1661.00
127_G188_N1.1661.00
356_L429_A1.1621.00
179_F204_L1.1571.00
88_I338_G1.1531.00
35_A39_I1.1531.00
16_A19_L1.1451.00
40_G47_L1.1411.00
277_W281_L1.1371.00
16_A20_I1.1361.00
249_T254_Y1.1231.00
343_L373_F1.1211.00
348_I354_A1.1201.00
380_L422_V1.1161.00
157_R161_K1.1161.00
468_W471_P1.1141.00
246_A250_K1.1121.00
129_L177_V1.1121.00
286_G309_G1.1111.00
146_L240_I1.1051.00
60_S63_G1.1051.00
406_T409_M1.1051.00
306_T418_V1.1041.00
249_T253_L1.1001.00
372_M456_L1.0971.00
245_G249_T1.0931.00
325_G394_K1.0891.00
173_F177_V1.0881.00
183_V204_L1.0851.00
91_L454_I1.0831.00
374_F430_F1.0821.00
217_G278_L1.0801.00
169_S218_M1.0771.00
86_A90_L1.0731.00
90_L94_L1.0701.00
49_Q52_F1.0691.00
368_V371_W1.0681.00
333_D337_K1.0651.00
394_K397_E1.0641.00
190_A194_V1.0611.00
152_T155_Q1.0601.00
33_S37_S1.0561.00
350_L366_Y1.0501.00
41_I45_G1.0501.00
409_M413_L1.0461.00
95_Y345_G1.0441.00
218_M225_L1.0401.00
29_M33_S1.0381.00
400_F408_S1.0361.00
458_L462_F1.0361.00
87_I91_L1.0331.00
77_F257_T1.0301.00
78_A258_R1.0261.00
19_L23_T1.0251.00
48_V83_L1.0231.00
61_L69_G1.0211.00
223_F285_F1.0181.00
43_I47_L1.0141.00
208_I212_L1.0121.00
74_A79_S1.0111.00
206_T271_T1.0081.00
343_L452_A1.0011.00
184_T192_L0.9981.00
346_T452_A0.9941.00
44_S47_L0.9881.00
456_L460_L0.9851.00
368_V453_A0.9841.00
26_L29_M0.9831.00
115_F142_A0.9801.00
230_P302_Y0.9801.00
360_G435_K0.9761.00
279_A313_F0.9761.00
85_T117_L0.9741.00
296_V344_A0.9731.00
114_Q118_A0.9711.00
378_I383_I0.9661.00
98_R445_A0.9641.00
373_F430_F0.9631.00
387_S462_F0.9631.00
186_T189_M0.9601.00
37_S93_G0.9591.00
372_M452_A0.9581.00
33_S110_Y0.9551.00
229_L233_Y0.9551.00
8_P43_I0.9521.00
203_G206_T0.9521.00
213_L256_I0.9511.00
368_V372_M0.9511.00
63_G66_A0.9501.00
189_M193_S0.9491.00
172_L211_L0.9491.00
143_S248_L0.9491.00
256_I315_V0.9481.00
339_A455_F0.9471.00
447_G451_P0.9431.00
369_L444_T0.9421.00
77_F327_I0.9421.00
287_V417_L0.9411.00
328_Y332_H0.9391.00
233_Y304_I0.9381.00
29_M32_F0.9371.00
172_L214_L0.9341.00
119_G142_A0.9331.00
181_Y184_T0.9321.00
33_S36_A0.9321.00
238_A297_M0.9321.00
88_I246_A0.9281.00
241_S244_F0.9281.00
414_S417_L0.9251.00
98_R447_G0.9221.00
30_R33_S0.9201.00
206_T270_F0.9201.00
8_P12_P0.9181.00
304_I333_D0.9171.00
370_G430_F0.9151.00
180_L192_L0.9141.00
311_I330_L0.9131.00
314_G325_G0.9101.00
307_A329_Y0.9101.00
290_S421_S0.9081.00
283_V313_F0.9061.00
372_M453_A0.9051.00
180_L208_I0.9041.00
280_A407_I0.8991.00
7_L11_I0.8961.00
46_I49_Q0.8921.00
273_Q276_I0.8901.00
360_G428_H0.8901.00
120_V139_L0.8891.00
346_T369_L0.8881.00
210_V214_L0.8861.00
287_V421_S0.8851.00
207_V211_L0.8851.00
426_F431_W0.8851.00
78_A82_V0.8841.00
11_I15_S0.8831.00
295_N355_S0.8831.00
281_L285_F0.8801.00
206_T210_V0.8791.00
349_A442_H0.8771.00
351_T359_M0.8761.00
283_V309_G0.8761.00
47_L51_V0.8751.00
276_I279_A0.8751.00
288_I417_L0.8731.00
347_L362_L0.8711.00
120_V248_L0.8711.00
393_F397_E0.8701.00
187_L191_D0.8701.00
236_P239_A0.8691.00
119_G135_F0.8691.00
16_A111_S0.8691.00
133_Y177_V0.8681.00
72_L125_L0.8651.00
199_S202_T0.8641.00
201_Q205_I0.8621.00
247_L250_K0.8621.00
350_L448_L0.8591.00
220_G253_L0.8591.00
20_I111_S0.8561.00
121_S125_L0.8551.00
89_G113_V0.8531.00
147_I232_S0.8531.00
154_I235_A0.8501.00
71_V188_N0.8491.00
156_L159_S0.8481.00
450_Y454_I0.8481.00
276_I280_A0.8431.00
253_L311_I0.8351.00
296_V359_M0.8331.00
307_A418_V0.8331.00
202_T206_T0.8331.00
299_I425_I0.8301.00
201_Q204_L0.8271.00
133_Y137_E0.8271.00
15_S19_L0.8271.00
85_T120_V0.8241.00
68_Y130_F0.8241.00
116_L143_S0.8221.00
310_V395_I0.8191.00
92_V342_M0.8191.00
253_L312_L0.8161.00
371_W430_F0.8151.00
233_Y236_P0.8151.00
280_A313_F0.8141.00
307_A421_S0.8121.00
31_I34_T0.8121.00
17_I20_I0.8121.00
16_A118_A0.8121.00
24_K27_M0.8111.00
186_T192_L0.8111.00
39_I43_I0.8061.00
10_L14_L0.8051.00
9_I125_L0.8041.00
422_V425_I0.8041.00
346_T444_T0.8041.00
14_L18_L0.8031.00
237_P240_I0.8031.00
209_G271_T0.8021.00
336_I388_G0.8001.00
51_V79_S0.8001.00
461_L465_G0.7951.00
286_G306_T0.7941.00
179_F183_V0.7941.00
84_T331_I0.7921.00
356_L428_H0.7901.00
371_W375_I0.7891.00
9_I72_L0.7851.00
107_S111_S0.7851.00
253_L330_L0.7841.00
250_K253_L0.7821.00
300_V340_L0.7821.00
387_S459_S0.7791.00
153_K234_Y0.7771.00
242_A342_M0.7721.00
423_L427_I0.7721.00
167_I170_S0.7711.00
370_G374_F0.7711.00
254_Y258_R0.7701.00
381_A419_L0.7681.00
139_L248_L0.7671.00
144_Y159_S0.7671.00
269_A272_H0.7671.00
287_V303_N0.7621.00
279_A312_L0.7611.00
276_I313_F0.7601.00
365_R434_E0.7601.00
50_T54_K0.7591.00
32_F36_A0.7581.00
386_L390_V0.7541.00
364_K367_P0.7521.00
396_A408_S0.7521.00
366_Y443_R0.7521.00
441_N444_T0.7521.00
444_T449_L0.7501.00
83_L86_A0.7481.00
435_K438_P0.7481.00
116_L243_L0.7451.00
33_S40_G0.7451.00
257_T323_I0.7431.00
353_T359_M0.7421.00
136_F173_F0.7421.00
329_Y336_I0.7401.00
154_I157_R0.7401.00
385_P464_L0.7391.00
303_N333_D0.7391.00
456_L459_S0.7391.00
45_G83_L0.7381.00
310_V414_S0.7381.00
336_I459_S0.7371.00
416_L420_Y0.7361.00
342_M451_P0.7351.00
377_A425_I0.7351.00
79_S83_L0.7331.00
97_F447_G0.7311.00
449_L453_A0.7301.00
174_V178_G0.7301.00
91_L451_P0.7271.00
28_L32_F0.7261.00
106_R110_Y0.7251.00
293_Y302_Y0.7231.00
360_G432_G0.7191.00
419_L423_L0.7181.00
205_I208_I0.7171.00
160_L164_V0.7161.00
47_L50_T0.7161.00
365_R441_N0.7161.00
320_P324_Q0.7151.00
372_M376_S0.7121.00
443_R449_L0.7101.00
144_Y166_N0.7091.00
202_T205_I0.7091.00
96_S99_S0.7081.00
379_S386_L0.7071.00
91_L455_F0.7071.00
382_G392_K0.7061.00
236_P240_I0.7051.00
49_Q53_T0.7051.00
147_I244_F0.7051.00
317_V402_E0.7041.00
286_G289_G0.7031.00
284_I288_I0.7001.00
368_V449_L0.6981.00
12_P15_S0.6961.00
30_R34_T0.6921.00
15_S20_I0.6911.00
462_F469_V0.6901.00
234_Y295_N0.6901.00
253_L308_V0.6881.00
83_L87_I0.6881.00
371_W374_F0.6871.00
279_A283_V0.6871.00
274_L277_W0.6841.00
436_E439_K0.6841.00
25_N29_M0.6831.00
59_L71_V0.6821.00
180_L212_L0.6821.00
268_T272_H0.6811.00
62_G65_K0.6791.00
73_A190_A0.6791.00
280_A284_I0.6751.00
375_I460_L0.6731.00
307_A337_K0.6711.00
245_G333_D0.6711.00
322_S326_A0.6701.00
147_I236_P0.6701.00
136_F251_V0.6691.00
259_V263_I0.6691.00
128_D131_N0.6681.00
85_T121_S0.6671.00
113_V243_L0.6671.00
44_S48_V0.6651.00
234_Y298_K0.6641.00
71_V128_D0.6611.00
396_A415_S0.6601.00
41_I48_V0.6591.00
26_L31_I0.6561.00
86_A117_L0.6561.00
233_Y244_F0.6531.00
34_T94_L0.6531.00
51_V55_G0.6531.00
37_S47_L0.6491.00
384_P389_F0.6471.00
11_I36_A0.6471.00
392_K415_S0.6461.00
303_N337_K0.6451.00
15_S40_G0.6451.00
461_L468_W0.6451.00
289_G302_Y0.6421.00
296_V429_A0.6411.00
209_G213_L0.6411.00
343_L376_S0.6361.00
450_Y453_A0.6351.00
287_V418_V0.6331.00
137_E219_K0.6321.00
15_S114_Q0.6311.00
245_G250_K0.6281.00
200_G203_G0.6281.00
410_L414_S0.6281.00
233_Y301_I0.6271.00
150_G153_K0.6271.00
284_I410_L0.6271.00
227_F230_P0.6261.00
77_F81_L0.6251.00
91_L338_G0.6251.00
61_L65_K0.6241.00
34_T38_A0.6241.00
87_I458_L0.6241.00
132_M173_F0.6231.00
92_V113_V0.6231.00
34_T97_F0.6231.00
238_A345_G0.6221.00
9_I16_A0.6221.00
394_K470_S0.6211.00
293_Y299_I0.6211.00
52_F55_G0.6211.00
11_I39_I0.6201.00
192_L195_K0.6201.00
169_S215_V0.6201.00
343_L372_M0.6191.00
230_P305_I0.6191.00
11_I43_I0.6191.00
246_A338_G0.6191.00
53_T56_I0.6131.00
372_M449_L0.6111.00
109_Y239_A0.6101.00
36_A114_Q0.6091.00
124_F254_Y0.6061.00
26_L34_T0.6051.00
51_V54_K0.6051.00
74_A78_A0.6051.00
336_I380_L0.6041.00
129_L180_L0.6041.00
127_G131_N0.6031.00
116_L248_L0.6031.00
303_N307_A0.6011.00
81_L85_T0.6011.00
213_L271_T0.5991.00
362_L366_Y0.5981.00
37_S43_I0.5941.00
207_V210_V0.5941.00
329_Y332_H0.5931.00
43_I46_I0.5921.00
115_F119_G0.5921.00
15_S32_F0.5911.00
229_L249_T0.5911.00
34_T37_S0.5891.00
92_V239_A0.5891.00
363_I430_F0.5881.00
382_G388_G0.5861.00
40_G86_A0.5861.00
204_L208_I0.5851.00
356_L359_M0.5851.00
335_L387_S0.5851.00
289_G293_Y0.5851.00
304_I308_V0.5841.00
390_V464_L0.5841.00
246_A249_T0.5841.00
63_G67_P0.5831.00
462_F466_T0.5821.00
175_I179_F0.5821.00
339_A452_A0.5811.00
193_S261_T0.5801.00
237_P241_S0.5801.00
412_L415_S0.5801.00
294_S303_N0.5771.00
346_T350_L0.5771.00
31_I38_A0.5761.00
229_L232_S0.5761.00
88_I243_L0.5751.00
8_P20_I0.5751.00
382_G386_L0.5731.00
179_F207_V0.5731.00
139_L251_V0.5721.00
426_F430_F0.5721.00
129_L189_M0.5701.00
108_F112_G0.5701.00
211_L215_V0.5691.00
204_L207_V0.5671.00
270_F274_L0.5671.00
25_N30_R0.5661.00
379_S388_G0.5661.00
89_G243_L0.5651.00
283_V310_V0.5651.00
58_T62_G0.5641.00
40_G43_I0.5641.00
346_T448_L0.5631.00
307_A380_L0.5620.99
374_F431_W0.5610.99
50_T53_T0.5580.99
35_A38_A0.5560.99
126_T135_F0.5550.99
199_S203_G0.5550.99
112_G142_A0.5550.99
12_P16_A0.5530.99
143_S146_L0.5530.99
41_I90_L0.5520.99
331_I469_V0.5520.99
390_V394_K0.5510.99
420_Y424_R0.5510.99
28_L36_A0.5470.99
343_L369_L0.5470.99
15_S23_T0.5460.99
256_I263_I0.5460.99
8_P13_L0.5460.99
374_F378_I0.5450.99
401_A404_E0.5440.99
236_P241_S0.5430.99
127_G258_R0.5430.99
277_W280_A0.5420.99
233_Y246_A0.5420.99
34_T41_I0.5420.99
94_L450_Y0.5420.99
120_V247_L0.5420.99
223_F286_G0.5400.99
460_L464_L0.5380.99
38_A41_I0.5370.99
363_I374_F0.5370.99
234_Y245_G0.5370.99
81_L124_F0.5370.99
289_G292_A0.5370.99
181_Y185_G0.5350.99
109_Y149_L0.5350.99
422_V426_F0.5340.99
143_S147_I0.5340.99
12_P118_A0.5330.99
26_L33_S0.5320.99
33_S114_Q0.5320.99
157_R231_G0.5320.99
467_E470_S0.5310.99
333_D341_F0.5310.99
8_P47_L0.5290.99
84_T330_L0.5280.99
85_T89_G0.5280.99
28_L34_T0.5270.99
37_S44_S0.5270.99
249_T308_V0.5270.99
446_K451_P0.5270.99
248_L251_V0.5250.99
45_G87_I0.5230.99
444_T448_L0.5230.99
117_L121_S0.5220.99
356_L425_I0.5210.99
133_Y170_S0.5200.99
44_S82_V0.5190.99
40_G51_V0.5180.99
11_I23_T0.5180.99
367_P370_G0.5180.99
233_Y297_M0.5180.99
378_I423_L0.5170.99
165_F218_M0.5170.99
396_A412_L0.5160.99
140_L166_N0.5160.99
442_H446_K0.5150.99
381_A422_V0.5150.99
322_S325_G0.5150.99
189_M263_I0.5140.99
349_A448_L0.5140.99
288_I292_A0.5130.99
7_L14_L0.5110.99
296_V347_L0.5090.99
40_G121_S0.5080.99
286_G305_I0.5070.99
374_F377_A0.5040.99
33_S93_G0.5040.99
112_G115_F0.5040.99
349_A445_A0.5030.99
213_L278_L0.5030.99
152_T235_A0.5020.99
88_I92_V0.5020.99
398_G402_E0.5020.99
184_T188_N0.5010.99
140_L143_S0.5010.99
328_Y394_K0.5010.99
220_G256_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rkoM 1 0.9736 100 0.168 Contact Map
3rkoL 1 0.9757 100 0.197 Contact Map
3rkoN 1 0.929 100 0.207 Contact Map
4he8L 1 0.9736 100 0.209 Contact Map
4he8M 1 0.931 100 0.21 Contact Map
4he8N 1 0.8621 100 0.28 Contact Map
4he8K 1 0.1866 29.6 0.965 Contact Map
3rkoK 1 0.1947 26.5 0.966 Contact Map
3wu2X 1 0.0751 7.5 0.973 Contact Map
3wdoA 1 0.8438 4.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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