GREMLIN Database
MRPG - Na(+)/H(+) antiporter subunit G
UniProt: O05227 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 124 (101)
Sequences: 1701 (1170)
Seq/√Len: 116.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_L25_F3.5481.00
9_V54_G3.1661.00
9_V58_Y2.9741.00
18_L22_I2.8321.00
41_S85_G2.7291.00
33_V92_A2.4761.00
7_V11_V2.4631.00
12_F53_L2.4351.00
31_P35_T2.4251.00
15_L50_M2.1801.00
93_Y106_D2.0391.00
26_G39_A2.0331.00
16_G51_I2.0271.00
32_D35_T1.9661.00
12_F50_M1.9521.00
56_F67_S1.7051.00
10_A14_L1.6871.00
30_L39_A1.6421.00
90_R94_N1.6041.00
5_A57_F1.5781.00
34_F92_A1.5751.00
53_L56_F1.5231.00
17_A24_S1.5191.00
96_G99_L1.4661.00
99_L103_S1.4131.00
54_G70_I1.4111.00
8_V12_F1.3361.00
9_V57_F1.3281.00
13_I54_G1.3211.00
9_V59_L1.3051.00
23_A37_A1.2790.99
23_A43_G1.2700.99
30_L38_H1.2670.99
16_G54_G1.2590.99
19_I46_L1.2420.99
9_V13_I1.2320.99
33_V88_I1.2160.99
76_F80_T1.2050.99
45_T82_P1.1870.99
34_F96_G1.1860.99
76_F82_P1.1790.99
100_D103_S1.1550.99
14_L18_L1.1490.99
42_K85_G1.1450.99
8_V57_F1.1160.99
55_V70_I1.0830.98
81_S85_G1.0640.98
7_V10_A1.0470.98
10_A13_I1.0400.98
19_I42_K1.0370.98
49_N89_C1.0200.97
68_A89_C1.0110.97
32_D42_K0.9730.97
22_I25_F0.9510.96
6_K58_Y0.9340.96
34_F97_V0.9300.96
48_V77_I0.9050.95
30_L64_G0.8750.94
8_V50_M0.8640.93
90_R95_S0.8640.93
44_S69_K0.8610.93
49_N74_I0.8570.93
28_L52_L0.8480.93
64_G67_S0.8310.92
12_F57_F0.8300.92
42_K48_V0.8250.92
98_K103_S0.8230.92
86_H90_R0.8180.91
56_F71_L0.8130.91
24_S83_I0.8100.91
52_L70_I0.8090.91
40_A81_S0.8050.91
84_G88_I0.7930.90
48_V78_F0.7900.90
53_L74_I0.7860.90
54_G72_L0.7810.89
42_K46_L0.7800.89
103_S106_D0.7790.89
51_I98_K0.7690.89
99_L102_R0.7650.89
35_T79_I0.7590.88
51_I62_V0.7580.88
30_L43_G0.7570.88
78_F90_R0.7320.86
12_F71_L0.7320.86
37_A81_S0.7280.86
48_V91_A0.7230.86
43_G77_I0.7210.85
40_A82_P0.7120.85
28_L76_F0.7080.84
19_I45_T0.7040.84
20_C77_I0.7030.84
52_L74_I0.7010.84
35_T86_H0.6880.83
17_A21_L0.6880.83
56_F98_K0.6850.82
20_C47_G0.6800.82
33_V97_V0.6730.81
10_A17_A0.6720.81
55_V66_L0.6580.80
87_L91_A0.6580.80
20_C48_V0.6570.80
28_L39_A0.6570.80
44_S77_I0.6540.79
54_G58_Y0.6390.78
67_S86_H0.6330.77
34_F88_I0.6270.76
7_V29_R0.6270.76
104_V107_D0.6210.76
55_V84_G0.6200.76
40_A84_G0.6170.75
10_A81_S0.6150.75
101_E104_V0.6120.75
45_T77_I0.6090.74
45_T92_A0.6070.74
23_A44_S0.6070.74
56_F73_G0.5980.73
11_V15_L0.5910.72
27_V39_A0.5830.71
23_A27_V0.5740.70
43_G49_N0.5720.70
82_P86_H0.5700.69
26_G30_L0.5520.67
21_L24_S0.5520.67
73_G93_Y0.5500.67
23_A41_S0.5470.66
37_A89_C0.5470.66
27_V48_V0.5460.66
59_L67_S0.5460.66
52_L76_F0.5450.66
45_T81_S0.5410.65
49_N78_F0.5410.65
33_V96_G0.5390.65
80_T100_D0.5320.64
24_S43_G0.5290.64
43_G48_V0.5270.63
50_M71_L0.5230.63
22_I74_I0.5220.63
29_R79_I0.5210.63
34_F68_A0.5200.62
21_L104_V0.5180.62
84_G91_A0.5170.62
67_S94_N0.5100.61
46_L50_M0.5080.61
35_T41_S0.5070.61
18_L21_L0.5040.60
5_A104_V0.5040.60
48_V74_I0.5040.60
14_L26_G0.5020.60
49_N85_G0.5020.60
8_V90_R0.5010.60
22_I26_G0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hkrA 3 0.7097 19.2 0.928 Contact Map
3j8eG 3 0.7984 12.9 0.933 Contact Map
3wdoA 1 0.9919 11.9 0.934 Contact Map
4pyzA 1 0.2661 9 0.938 Contact Map
4c7rA 3 0.8952 8.8 0.938 Contact Map
4cbcA 3 0.5968 8.7 0.938 Contact Map
4ui9G 1 0.2016 7.8 0.939 Contact Map
3rvyA 3 0.6855 7.4 0.94 Contact Map
4zw9A 1 0.8548 7.1 0.94 Contact Map
4ltoA 3 0.879 7.1 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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