GREMLIN Database
YWRK - Putative arsenical pump membrane protein
UniProt: O05224 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (398)
Sequences: 4799 (3157)
Seq/√Len: 158.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
86_S89_K3.7721.00
237_L241_A3.7231.00
78_K82_Q3.6541.00
118_L139_G3.6231.00
389_P399_M3.5491.00
57_L295_F3.0291.00
41_D310_N2.9311.00
413_E416_K2.8561.00
111_I143_A2.6931.00
68_S285_D2.6691.00
74_W78_K2.6521.00
418_T422_I2.6151.00
12_F15_P2.5851.00
6_V9_I2.5401.00
230_R234_K2.5171.00
98_C114_T2.4931.00
128_K132_K2.4911.00
146_S183_L2.4491.00
111_I398_W2.4271.00
315_E319_S2.3531.00
341_S426_V2.3471.00
136_L398_W2.2901.00
6_V13_W2.2811.00
415_I419_I2.2251.00
232_Q236_M2.2031.00
159_I357_T2.1691.00
431_T435_F2.1411.00
4_F8_M2.1281.00
7_T14_R2.1221.00
167_D170_L2.1071.00
119_L407_E2.1061.00
151_G161_L2.1021.00
233_T236_M2.0901.00
345_N387_L2.0771.00
10_F14_R2.0451.00
376_A380_G2.0221.00
7_T11_I2.0141.00
147_S154_N2.0131.00
39_L43_G1.9901.00
235_I239_V1.9781.00
247_R251_F1.9661.00
338_I430_L1.9591.00
7_T15_P1.9401.00
271_L275_R1.9331.00
96_L183_L1.9161.00
83_S93_L1.9121.00
170_L173_A1.9021.00
8_M15_P1.8791.00
10_F13_W1.8571.00
6_V10_F1.8461.00
181_M432_C1.8401.00
221_H225_A1.8281.00
419_I422_I1.8241.00
10_F16_K1.8081.00
38_S41_D1.7721.00
88_I191_F1.7691.00
40_A44_E1.7691.00
238_F242_F1.7551.00
237_L240_L1.7331.00
9_I13_W1.7321.00
238_F241_A1.7291.00
236_M239_V1.7021.00
169_Y173_A1.6981.00
234_K237_L1.6871.00
260_V263_V1.6861.00
123_K405_H1.6851.00
284_R288_Y1.6201.00
246_V250_L1.6061.00
128_K197_R1.5991.00
39_L42_L1.5971.00
4_F13_W1.5971.00
115_T136_L1.5911.00
267_G271_L1.5871.00
316_L319_S1.5831.00
334_F430_L1.5711.00
231_N234_K1.5651.00
4_F12_F1.5631.00
30_M34_C1.5611.00
7_T13_W1.5441.00
395_T398_W1.5271.00
10_F15_P1.5241.00
173_A177_V1.5211.00
342_V346_L1.5181.00
12_F16_K1.5111.00
11_I15_P1.5021.00
194_F417_T1.4981.00
42_L45_I1.4981.00
106_N109_G1.4911.00
58_A268_S1.4861.00
188_C192_M1.4801.00
6_V12_F1.4681.00
32_L35_G1.4651.00
185_F428_F1.4491.00
148_A179_S1.4441.00
4_F14_R1.4401.00
100_L104_F1.4331.00
11_I14_R1.4211.00
74_W77_A1.4161.00
403_K408_S1.4051.00
40_A43_G1.4021.00
8_M13_W1.3951.00
133_A413_E1.3921.00
233_T237_L1.3871.00
339_S343_F1.3871.00
61_I287_L1.3811.00
45_I306_Y1.3801.00
92_W191_F1.3781.00
8_M12_F1.3721.00
270_I274_W1.3721.00
68_S289_K1.3651.00
340_T381_S1.3551.00
24_A33_L1.3521.00
6_V14_R1.3481.00
78_K81_Q1.3441.00
264_A271_L1.3441.00
427_L431_T1.3301.00
330_A434_Y1.3291.00
234_K238_F1.3251.00
228_P231_N1.3151.00
95_N138_S1.3001.00
338_I342_V1.2951.00
182_G425_T1.2931.00
227_L231_N1.2921.00
224_S230_R1.2891.00
92_W187_T1.2881.00
234_K241_A1.2801.00
231_N235_I1.2621.00
31_V35_G1.2561.00
134_P190_L1.2541.00
410_S413_E1.2511.00
422_I426_V1.2481.00
232_Q235_I1.2451.00
6_V11_I1.2451.00
412_G416_K1.2441.00
376_A433_L1.2441.00
137_L141_L1.2431.00
176_F180_M1.2401.00
140_V398_W1.2371.00
77_A81_Q1.2351.00
13_W16_K1.2351.00
29_L33_L1.2341.00
228_P234_K1.2301.00
5_F14_R1.2301.00
66_L71_F1.2281.00
189_L424_L1.2211.00
7_T16_K1.2201.00
57_L61_I1.2151.00
396_L399_M1.2131.00
316_L320_Y1.2131.00
325_V332_A1.2091.00
32_L37_V1.2081.00
228_P232_Q1.2031.00
96_L100_L1.2021.00
414_Y418_T1.2011.00
84_K89_K1.2011.00
41_D44_E1.2001.00
232_Q239_V1.1961.00
389_P396_L1.1871.00
285_D288_Y1.1861.00
353_L381_S1.1831.00
142_I183_L1.1741.00
115_T398_W1.1701.00
6_V15_P1.1701.00
298_A385_S1.1691.00
94_T118_L1.1661.00
4_F15_P1.1651.00
67_E289_K1.1561.00
21_A24_A1.1541.00
9_I14_R1.1541.00
9_I16_K1.1491.00
242_F246_V1.1491.00
192_M195_Y1.1401.00
241_A248_M1.1321.00
340_T377_N1.1311.00
229_E232_Q1.1181.00
188_C191_F1.1161.00
73_Y77_A1.1101.00
150_I153_S1.1101.00
261_P275_R1.1091.00
122_L135_Y1.1041.00
156_V382_D1.0970.99
4_F7_T1.0930.99
171_H175_M1.0930.99
252_A255_Y1.0880.99
246_V267_G1.0840.99
108_D147_S1.0770.99
272_L276_W1.0760.99
9_I15_P1.0700.99
191_F195_Y1.0690.99
418_T421_I1.0680.99
32_L36_S1.0670.99
239_V242_F1.0670.99
168_L172_T1.0630.99
236_M240_L1.0590.99
5_F15_P1.0540.99
268_S272_L1.0520.99
192_M196_K1.0440.99
419_I423_P1.0420.99
341_S422_I1.0370.99
155_I302_Y1.0360.99
39_L45_I1.0340.99
181_M428_F1.0310.99
20_E348_N1.0290.99
268_S271_L1.0290.99
177_V432_C1.0150.99
344_S381_S1.0140.99
146_S298_A1.0120.99
320_Y324_V1.0100.99
248_M251_F1.0010.99
12_F23_P1.0010.99
48_K53_S1.0010.99
9_I12_F0.9950.99
24_A27_G0.9930.99
27_G32_L0.9920.99
82_Q85_G0.9900.99
410_S416_K0.9810.99
260_V268_S0.9710.99
41_D45_I0.9690.99
247_R250_L0.9680.99
236_M242_F0.9680.99
172_T176_F0.9670.99
249_S253_A0.9670.99
247_R253_A0.9660.99
320_Y323_P0.9660.99
23_P26_F0.9610.99
270_I275_R0.9610.99
38_S42_L0.9600.99
306_Y310_N0.9600.99
329_L333_T0.9560.99
178_P379_I0.9550.99
81_Q223_P0.9540.99
8_M16_K0.9530.99
108_D154_N0.9470.99
97_L143_A0.9440.98
248_M252_A0.9420.98
229_E233_T0.9410.98
136_L402_L0.9400.98
156_V350_H0.9390.98
62_M246_V0.9380.98
109_G297_F0.9370.98
312_G315_E0.9370.98
148_A175_M0.9350.98
261_P271_L0.9350.98
260_V264_A0.9330.98
23_P27_G0.9320.98
260_V271_L0.9320.98
11_I16_K0.9260.98
8_M14_R0.9250.98
230_R233_T0.9170.98
225_A229_E0.9140.98
418_T429_T0.9140.98
221_H224_S0.9130.98
184_I188_C0.9130.98
127_L135_Y0.9110.98
411_W418_T0.9080.98
264_A267_G0.9070.98
106_N147_S0.9060.98
251_F255_Y0.9060.98
19_N23_P0.9040.98
387_L422_I0.9030.98
5_F30_M0.9020.98
220_L223_P0.8990.98
149_P179_S0.8970.98
398_W402_L0.8960.98
25_T33_L0.8950.98
305_I394_A0.8900.98
28_A300_T0.8890.98
154_N157_N0.8870.98
26_F30_M0.8870.98
146_S153_S0.8780.98
415_I418_T0.8750.98
21_A25_T0.8730.97
170_L174_M0.8710.97
178_P182_G0.8670.97
7_T12_F0.8670.97
70_G73_Y0.8670.97
97_L101_M0.8670.97
26_F269_F0.8640.97
345_N348_N0.8610.97
51_G162_K0.8610.97
102_T350_H0.8610.97
250_L253_A0.8600.97
79_L82_Q0.8600.97
200_K203_P0.8580.97
49_V52_A0.8540.97
352_A356_S0.8460.97
159_I350_H0.8450.97
5_F13_W0.8440.97
175_M179_S0.8410.97
102_T107_N0.8380.97
4_F177_V0.8370.97
378_I381_S0.8370.97
235_I238_F0.8370.97
261_P264_A0.8360.97
25_T29_L0.8360.97
137_L417_T0.8340.97
51_G261_P0.8330.97
128_K133_A0.8320.97
79_L83_S0.8300.97
98_C139_G0.8270.96
361_T364_T0.8240.96
415_I422_I0.8240.96
269_F273_S0.8190.96
180_M184_I0.8190.96
29_L32_L0.8160.96
159_I354_M0.8160.96
24_A32_L0.8140.96
73_Y124_Y0.8090.96
336_S377_N0.8080.96
64_I286_L0.8070.96
24_A29_L0.8070.96
93_L97_L0.8060.96
382_D385_S0.8050.96
70_G74_W0.8040.96
30_M33_L0.8000.96
337_G430_L0.7990.96
24_A31_V0.7980.96
31_V307_G0.7970.96
4_F16_K0.7970.96
387_L419_I0.7960.96
225_A228_P0.7920.96
386_L395_T0.7900.95
340_T356_S0.7790.95
55_T59_T0.7780.95
416_K419_I0.7760.95
141_L145_A0.7760.95
22_I26_F0.7700.95
254_S257_G0.7690.95
153_S395_T0.7690.95
298_A349_N0.7640.95
160_S378_I0.7600.94
79_L85_G0.7590.94
256_T259_S0.7550.94
261_P268_S0.7550.94
350_H353_L0.7550.94
420_I423_P0.7540.94
34_C37_V0.7520.94
307_G311_I0.7490.94
348_N385_S0.7410.94
59_T109_G0.7400.94
340_T380_G0.7390.94
37_V42_L0.7380.93
385_S395_T0.7360.93
141_L421_I0.7350.93
333_T376_A0.7340.93
6_V16_K0.7330.93
372_I434_Y0.7330.93
272_L275_R0.7290.93
423_P427_L0.7280.93
220_L224_S0.7280.93
308_L311_I0.7260.93
28_A303_V0.7230.93
175_M178_P0.7230.93
153_S350_H0.7210.93
422_I425_T0.7170.92
185_F189_L0.7170.92
392_T395_T0.7160.92
33_L36_S0.7120.92
408_S412_G0.7060.92
155_I160_S0.7060.92
102_T146_S0.7050.92
416_K420_I0.7050.92
63_A150_I0.6960.91
233_T240_L0.6960.91
5_F12_F0.6930.91
170_L371_K0.6930.91
330_A431_T0.6920.91
23_P33_L0.6910.91
68_S71_F0.6910.91
352_A355_I0.6900.91
156_V345_N0.6860.91
61_I268_S0.6860.91
349_N385_S0.6860.91
250_L271_L0.6850.91
259_S262_L0.6840.91
52_A352_A0.6800.90
27_G37_V0.6800.90
64_I67_E0.6790.90
298_A350_H0.6780.90
250_L267_G0.6740.90
259_S263_V0.6740.90
99_F386_L0.6740.90
97_L114_T0.6710.90
9_I304_L0.6710.90
382_D392_T0.6700.90
285_D289_K0.6700.90
350_H393_L0.6680.90
27_G31_V0.6650.89
67_E73_Y0.6650.89
144_T394_A0.6650.89
343_F352_A0.6640.89
4_F252_A0.6640.89
260_V275_R0.6640.89
172_T175_M0.6630.89
107_N155_I0.6620.89
227_L230_R0.6610.89
157_N351_P0.6600.89
319_S323_P0.6580.89
378_I395_T0.6580.89
115_T401_I0.6570.89
19_N22_I0.6570.89
107_N351_P0.6570.89
382_D395_T0.6560.89
20_E23_P0.6560.89
172_T179_S0.6540.89
270_I273_S0.6520.88
143_A394_A0.6510.88
148_A382_D0.6510.88
190_L417_T0.6500.88
101_M110_S0.6470.88
349_N382_D0.6470.88
48_K299_F0.6460.88
155_I385_S0.6440.88
24_A28_A0.6430.88
247_R255_Y0.6410.88
227_L233_T0.6400.88
175_M378_I0.6390.87
380_G384_G0.6390.87
4_F10_F0.6390.87
153_S385_S0.6380.87
179_S183_L0.6380.87
154_N351_P0.6360.87
107_N394_A0.6360.87
195_Y198_L0.6350.87
161_L168_L0.6350.87
59_T106_N0.6350.87
261_P272_L0.6340.87
246_V249_S0.6330.87
108_D157_N0.6320.87
107_N154_N0.6320.87
309_H312_G0.6310.87
383_I425_T0.6300.87
9_I23_P0.6290.87
265_V269_F0.6290.87
107_N349_N0.6290.87
59_T264_A0.6260.86
118_L122_L0.6240.86
145_A148_A0.6230.86
232_Q241_A0.6220.86
315_E322_E0.6210.86
58_A264_A0.6210.86
57_L292_W0.6200.86
353_L357_T0.6180.86
379_I429_T0.6160.85
52_A60_M0.6160.85
8_M11_I0.6140.85
302_Y354_M0.6140.85
77_A124_Y0.6110.85
108_D116_P0.6110.85
58_A62_M0.6090.85
147_S352_A0.6080.85
4_F11_I0.6080.85
76_A79_L0.6060.85
140_V418_T0.6040.84
79_L93_L0.6040.84
158_L380_G0.6030.84
199_P202_L0.6020.84
122_L132_K0.6020.84
431_T434_Y0.6020.84
391_G396_L0.6010.84
234_K242_F0.6000.84
178_P181_M0.6000.84
354_M393_L0.6000.84
321_F335_A0.5980.84
274_W286_L0.5980.84
232_Q242_F0.5970.84
282_S286_L0.5970.84
102_T110_S0.5970.84
412_G415_I0.5970.84
260_V276_W0.5960.84
107_N144_T0.5950.83
315_E362_E0.5950.83
186_M190_L0.5950.83
348_N355_I0.5950.83
342_V435_F0.5930.83
342_V423_P0.5910.83
156_V397_I0.5910.83
62_M271_L0.5880.83
5_F10_F0.5870.83
107_N392_T0.5850.82
39_L262_L0.5840.82
6_V308_L0.5830.82
242_F319_S0.5830.82
144_T392_T0.5820.82
191_F196_K0.5810.82
108_D393_L0.5800.82
163_I357_T0.5790.82
106_N348_N0.5790.82
108_D397_I0.5780.82
347_F352_A0.5780.82
59_T63_A0.5770.82
425_T429_T0.5760.81
150_I177_V0.5750.81
187_T191_F0.5710.81
153_S302_Y0.5710.81
133_A137_L0.5700.81
55_T151_G0.5690.81
52_A62_M0.5680.81
81_Q85_G0.5680.81
79_L84_K0.5660.80
148_A383_I0.5660.80
57_L290_S0.5620.80
360_L363_M0.5620.80
67_E120_L0.5610.80
411_W422_I0.5610.80
29_L37_V0.5610.80
391_G414_Y0.5600.80
185_F424_L0.5600.80
7_T221_H0.5570.79
109_G386_L0.5570.79
297_F301_M0.5570.79
348_N351_P0.5570.79
53_S299_F0.5570.79
324_V335_A0.5560.79
235_I240_L0.5550.79
132_K407_E0.5540.79
321_F373_I0.5530.79
422_I429_T0.5530.79
95_N142_I0.5530.79
410_S414_Y0.5530.79
54_V58_A0.5520.79
53_S57_L0.5520.79
108_D115_T0.5510.79
235_I242_F0.5500.78
156_V348_N0.5490.78
233_T242_F0.5490.78
265_V275_R0.5490.78
399_M403_K0.5490.78
5_F16_K0.5470.78
16_K20_E0.5470.78
410_S422_I0.5460.78
233_T239_V0.5460.78
102_T156_V0.5460.78
389_P415_I0.5450.78
147_S156_V0.5450.78
152_V168_L0.5450.78
251_F254_S0.5430.78
430_L434_Y0.5430.78
395_T399_M0.5420.77
387_L391_G0.5390.77
5_F34_C0.5380.77
260_V270_I0.5350.77
235_I274_W0.5350.77
59_T140_V0.5330.76
76_A83_S0.5330.76
108_D156_V0.5310.76
11_I329_L0.5310.76
95_N190_L0.5310.76
60_M291_P0.5300.76
111_I114_T0.5290.76
356_S392_T0.5290.76
385_S390_M0.5270.75
74_W81_Q0.5270.75
224_S228_P0.5260.75
99_F141_L0.5250.75
91_F135_Y0.5240.75
284_R287_L0.5230.75
171_H375_L0.5230.75
65_A286_L0.5220.75
140_V391_G0.5220.75
391_G395_T0.5220.75
113_I343_F0.5210.75
40_A45_I0.5210.75
194_F197_R0.5210.75
9_I27_G0.5210.75
269_F274_W0.5200.75
293_H396_L0.5190.74
114_T388_L0.5180.74
160_S298_A0.5170.74
317_L320_Y0.5170.74
322_E346_L0.5170.74
19_N293_H0.5160.74
344_S348_N0.5150.74
336_S358_F0.5140.74
69_F72_F0.5130.74
118_L135_Y0.5130.74
321_F339_S0.5120.73
355_I373_I0.5120.73
87_G198_L0.5120.73
350_H395_T0.5110.73
344_S353_L0.5100.73
87_G134_P0.5100.73
234_K240_L0.5080.73
177_V181_M0.5070.73
175_M375_L0.5070.73
219_P226_P0.5070.73
260_V265_V0.5060.73
106_N110_S0.5060.73
147_S348_N0.5050.72
199_P435_F0.5050.72
189_L193_F0.5050.72
231_N237_L0.5040.72
26_F29_L0.5030.72
142_I146_S0.5020.72
105_L136_L0.5000.72
319_S322_E0.5000.72
384_G392_T0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f35D 2 0.8959 100 0.439 Contact Map
4r1iA 2 0.9502 99.9 0.703 Contact Map
4r0cA 3 0.9389 99.9 0.723 Contact Map
3tdsE 3 0.509 36.5 0.957 Contact Map
3kcuA 3 0.4593 32.9 0.958 Contact Map
1j4nA 4 0.4118 26.3 0.96 Contact Map
3klyA 3 0.4729 22.4 0.961 Contact Map
2b6oA 6 0.414 22.4 0.961 Contact Map
3d9sA 3 0.4208 21.1 0.962 Contact Map
4oj2X 3 0.4367 18.1 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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