GREMLIN Database
YWRF - Uncharacterized protein YwrF
UniProt: O05220 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 205 (169)
Sequences: 3701 (2656)
Seq/√Len: 204.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_H128_E3.8341.00
120_A160_V3.3471.00
81_F157_G3.3341.00
136_K158_R3.1601.00
34_S38_A3.0771.00
88_E182_K2.9841.00
35_S77_E2.7331.00
136_K160_V2.7151.00
106_S109_T2.4361.00
138_E158_R2.4301.00
116_V127_K2.4051.00
31_T82_V2.2881.00
39_V115_P2.2731.00
170_D173_K2.2301.00
76_V140_H2.1431.00
101_L110_R2.0911.00
86_S94_I2.0891.00
41_A126_I2.0561.00
33_L39_V2.0501.00
80_E136_K1.9951.00
88_E194_K1.9021.00
114_H127_K1.8931.00
82_V121_V1.8711.00
33_L122_S1.7961.00
108_L115_P1.7661.00
118_S125_G1.7441.00
125_G132_R1.6911.00
80_E122_S1.6121.00
73_R103_P1.5851.00
101_L105_E1.5831.00
58_S154_L1.5501.00
50_V58_S1.5351.00
39_V124_P1.5281.00
170_D177_L1.5101.00
18_L49_V1.4931.00
119_K161_C1.4891.00
118_S134_E1.4851.00
57_L83_V1.4821.00
121_V134_E1.4401.00
140_H153_D1.4261.00
118_S123_V1.4151.00
29_F41_A1.4101.00
185_S193_A1.4081.00
81_F135_C1.4061.00
56_L156_I1.3821.00
31_T41_A1.3621.00
87_D90_I1.3531.00
75_A137_L1.3521.00
106_S115_P1.3291.00
29_F97_T1.2841.00
118_S121_V1.2841.00
75_A81_F1.2781.00
177_L180_E1.2711.00
73_R77_E1.2621.00
133_F162_F1.2491.00
120_A161_C1.2451.00
170_D180_E1.2401.00
86_S184_A1.2301.00
56_L138_E1.2271.00
21_T131_V1.2191.00
68_Q76_V1.1951.00
125_G163_H1.1921.00
50_V156_I1.1761.00
91_I184_A1.1501.00
90_I128_E1.1481.00
86_S129_A1.1471.00
116_V125_G1.1361.00
194_K197_E1.1331.00
42_A71_T1.1271.00
41_A108_L1.1221.00
84_H132_R1.1151.00
80_E121_V1.1071.00
72_A76_V1.1031.00
39_V106_S1.0661.00
89_A182_K1.0621.00
68_Q72_A1.0451.00
135_C157_G1.0381.00
32_T75_A1.0211.00
29_F90_I1.0191.00
93_D111_T1.0101.00
82_V125_G1.0081.00
137_L140_H1.0071.00
168_V181_L1.0021.00
137_L155_L0.9971.00
72_A153_D0.9861.00
28_A47_Y0.9721.00
72_A155_L0.9711.00
97_T111_T0.9681.00
70_D73_R0.9580.99
57_L133_F0.9540.99
32_T74_N0.9530.99
78_N122_S0.9500.99
33_L123_V0.9440.99
51_S143_F0.9100.99
87_D130_R0.9100.99
32_T71_T0.9060.99
93_D113_L0.9010.99
140_H155_L0.9000.99
105_E110_R0.8970.99
82_V118_S0.8960.99
164_L168_V0.8940.99
187_L193_A0.8920.99
142_T153_D0.8610.99
70_D103_P0.8580.99
51_S152_A0.8550.99
133_F159_V0.8530.99
141_I156_I0.8440.99
165_D168_V0.8370.99
96_E101_L0.8360.99
88_E91_I0.8300.98
58_S156_I0.8290.98
116_V132_R0.8290.98
33_L117_E0.8250.98
83_V135_C0.8230.98
33_L78_N0.8140.98
31_T123_V0.8140.98
31_T126_I0.8130.98
44_F61_V0.8070.98
48_N58_S0.8000.98
130_R165_D0.7970.98
191_H198_E0.7930.98
96_E110_R0.7920.98
34_S77_E0.7870.98
168_V176_I0.7860.98
38_A104_D0.7850.98
185_S195_L0.7840.98
94_I184_A0.7830.98
38_A103_P0.7830.98
50_V56_L0.7820.98
182_K194_K0.7820.98
34_S74_N0.7770.98
117_E122_S0.7690.98
67_R142_T0.7690.98
168_V180_E0.7670.97
80_E123_V0.7640.97
85_V181_L0.7580.97
131_V181_L0.7570.97
30_V59_I0.7490.97
178_T183_P0.7480.97
50_V60_S0.7470.97
44_F59_I0.7450.97
143_F156_I0.7450.97
76_V79_G0.7440.97
31_T84_H0.7420.97
94_I129_A0.7420.97
82_V132_R0.7410.97
85_V183_P0.7390.97
70_D74_N0.7360.97
39_V108_L0.7340.97
90_I129_A0.7280.97
170_D175_Y0.7260.97
84_H126_I0.7240.96
79_G137_L0.7240.96
22_V49_V0.7230.96
76_V142_T0.7210.96
31_T108_L0.7190.96
79_G136_K0.7160.96
183_P195_L0.7090.96
50_V154_L0.6960.96
46_F49_V0.6920.95
139_R142_T0.6900.95
29_F126_I0.6850.95
120_A134_E0.6850.95
89_A130_R0.6840.95
176_I181_L0.6830.95
132_R163_H0.6820.95
93_D128_E0.6770.95
57_L159_V0.6750.95
20_G188_A0.6750.95
92_E96_E0.6740.95
29_F94_I0.6680.94
29_F129_A0.6670.94
33_L37_G0.6640.94
23_I183_P0.6630.94
19_S52_S0.6620.94
47_Y85_V0.6600.94
28_A83_V0.6550.94
102_R105_E0.6540.94
80_E134_E0.6500.94
116_V119_K0.6490.94
72_A140_H0.6480.94
70_D107_E0.6450.93
109_T112_S0.6420.93
47_Y58_S0.6360.93
56_L143_F0.6360.93
39_V123_V0.6350.93
21_T133_F0.6350.93
111_T126_I0.6310.93
187_L191_H0.6280.92
71_T74_N0.6280.92
85_V131_V0.6240.92
74_N78_N0.6240.92
27_I43_P0.6220.92
59_I155_L0.6220.92
75_A157_G0.6220.92
191_H195_L0.6200.92
53_D145_N0.6180.92
96_E99_A0.6170.92
115_P128_E0.6160.92
30_V44_F0.6140.92
118_S132_R0.6140.92
167_K180_E0.6130.92
61_V155_L0.6090.91
67_R153_D0.6080.91
68_Q73_R0.6070.91
75_A155_L0.6060.91
96_E105_E0.6060.91
59_I75_A0.6050.91
44_F71_T0.6040.91
138_E156_I0.6020.91
96_E111_T0.6020.91
168_V178_T0.6000.91
90_I113_L0.5960.90
82_V123_V0.5950.90
131_V164_L0.5920.90
113_L126_I0.5910.90
60_S152_A0.5900.90
178_T187_L0.5840.89
43_P86_S0.5750.89
29_F113_L0.5740.89
57_L157_G0.5710.88
23_I178_T0.5690.88
36_G77_E0.5630.88
84_H123_V0.5600.87
27_I86_S0.5590.87
138_E141_I0.5540.87
193_A196_G0.5520.87
109_T115_P0.5490.86
169_Y176_I0.5480.86
33_L118_S0.5400.86
164_L176_I0.5360.85
108_L126_I0.5290.84
93_D96_E0.5270.84
75_A79_G0.5270.84
22_V57_L0.5260.84
29_F42_A0.5260.84
91_I94_I0.5260.84
56_L60_S0.5250.84
48_N60_S0.5250.84
98_A101_L0.5230.84
61_V72_A0.5190.83
79_G139_R0.5190.83
117_E124_P0.5170.83
108_L111_T0.5170.83
61_V66_G0.5130.83
179_D198_E0.5130.83
30_V81_F0.5120.82
115_P124_P0.5110.82
87_D129_A0.5090.82
145_N161_C0.5070.82
66_G152_A0.5020.81
114_H126_I0.5020.81
187_L195_L0.5010.81
120_A136_K0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bpkA 2 0.9707 100 0.23 Contact Map
3fgeA 2 0.9317 100 0.266 Contact Map
1ejeA 2 0.9073 100 0.339 Contact Map
3hmzA 2 0.8878 100 0.369 Contact Map
2r6vA 2 0.8878 100 0.378 Contact Map
2d5mA 2 0.8683 100 0.381 Contact Map
3bnkA 2 0.878 100 0.401 Contact Map
3e4vA 2 0.8537 100 0.409 Contact Map
1uscA 2 0.8683 100 0.416 Contact Map
3cb0A 2 0.7805 100 0.491 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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