GREMLIN Database
YWRB - Uncharacterized transporter YwrB
UniProt: O05216 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 197 (170)
Sequences: 6612 (4608)
Seq/√Len: 353.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_R44_D4.8011.00
10_T85_A4.3751.00
33_H37_N3.9611.00
43_D46_E3.7481.00
46_E72_K3.7111.00
67_A83_I2.9191.00
6_Y81_V2.8331.00
15_R34_E2.6921.00
8_D39_Y2.5361.00
34_E38_K2.4791.00
11_A15_R2.1921.00
32_R37_N2.1801.00
71_F79_A2.1251.00
162_N165_L2.1121.00
81_V85_A1.9861.00
33_H38_K1.9731.00
42_I69_L1.9671.00
34_E39_Y1.8391.00
10_T88_L1.8341.00
154_I159_L1.8221.00
50_I68_Y1.8211.00
154_I158_T1.8171.00
123_V127_I1.8081.00
7_R11_A1.7541.00
9_M74_K1.7511.00
12_A34_E1.6981.00
155_G159_L1.6971.00
153_F157_Q1.6971.00
133_G137_L1.6891.00
9_M82_A1.6851.00
19_L30_L1.5561.00
170_F174_G1.5351.00
156_L166_V1.5271.00
14_V18_I1.5191.00
146_I150_I1.4251.00
44_D135_K1.4031.00
169_I173_Y1.3821.00
75_G78_G1.3691.00
111_A115_G1.3681.00
147_L151_I1.3621.00
35_A41_W1.3411.00
13_M35_A1.3161.00
32_R131_E1.3151.00
9_M73_L1.3091.00
12_A39_Y1.2991.00
143_V147_L1.2941.00
68_Y72_K1.2861.00
171_L174_G1.2861.00
70_G78_G1.2701.00
9_M13_M1.2501.00
173_Y177_H1.2451.00
45_D49_E1.2391.00
16_T31_I1.2311.00
144_T147_L1.2251.00
128_M132_F1.2221.00
13_M82_A1.1951.00
149_F153_F1.1791.00
144_T177_H1.1781.00
24_G27_V1.1701.00
36_V47_F1.1591.00
168_I171_L1.1461.00
27_V62_A1.1331.00
6_Y74_K1.1301.00
137_L146_I1.1251.00
161_I165_L1.1241.00
10_T81_V1.1161.00
139_G145_G1.1141.00
133_G136_A1.0981.00
139_G143_V1.0941.00
76_T80_I1.0921.00
137_L149_F1.0851.00
15_R19_L1.0841.00
67_A79_A1.0791.00
164_G168_I1.0671.00
73_L77_L1.0671.00
17_G90_T1.0511.00
145_G149_F1.0401.00
152_A170_F1.0331.00
166_V170_F1.0331.00
94_M97_L1.0251.00
143_V146_I1.0141.00
12_A41_W1.0031.00
46_E49_E1.0031.00
144_T173_Y0.9951.00
78_G82_A0.9951.00
109_I113_M0.9891.00
80_I84_L0.9871.00
127_I131_E0.9841.00
152_A166_V0.9831.00
31_I35_A0.9831.00
35_A69_L0.9781.00
20_G47_F0.9761.00
171_L175_A0.9721.00
105_S111_A0.9701.00
92_L96_G0.9591.00
6_Y77_L0.9561.00
37_N40_K0.9471.00
130_Y134_Q0.9451.00
78_G85_A0.9411.00
20_G27_V0.9371.00
57_L67_A0.9291.00
47_F51_L0.9221.00
11_A14_V0.9211.00
16_T90_T0.9001.00
9_M81_V0.8921.00
16_T27_V0.8861.00
108_A112_G0.8841.00
114_I117_V0.8791.00
18_I93_A0.8771.00
172_A176_F0.8771.00
54_A57_L0.8711.00
168_I172_A0.8711.00
77_L80_I0.8681.00
50_I65_M0.8681.00
110_V113_M0.8661.00
125_L128_M0.8611.00
26_S128_M0.8591.00
165_L169_I0.8551.00
94_M98_F0.8511.00
74_K78_G0.8491.00
88_L92_L0.8391.00
69_L73_L0.8241.00
119_P127_I0.8161.00
14_V88_L0.8151.00
162_N166_V0.8141.00
31_I66_A0.8121.00
77_L81_V0.8101.00
35_A42_I0.8041.00
116_A120_V0.8011.00
112_G116_A0.8011.00
54_A65_M0.7991.00
37_N44_D0.7861.00
31_I62_A0.7781.00
53_I57_L0.7781.00
149_F152_A0.7781.00
100_A104_L0.7771.00
113_M117_V0.7771.00
6_Y10_T0.7771.00
63_T83_I0.7761.00
8_D12_A0.7761.00
161_I166_V0.7741.00
51_L65_M0.7691.00
66_A86_H0.7671.00
129_A133_G0.7671.00
104_L110_V0.7591.00
35_A73_L0.7551.00
47_F65_M0.7471.00
12_A16_T0.7411.00
24_G64_K0.7411.00
84_L88_L0.7401.00
28_I47_F0.7341.00
61_I65_M0.7301.00
12_A15_R0.7220.99
139_G168_I0.7100.99
149_F156_L0.6980.99
57_L63_T0.6890.99
99_A102_N0.6830.99
119_P123_V0.6820.99
16_T57_L0.6790.99
42_I46_E0.6770.99
164_G171_L0.6720.99
30_L124_M0.6700.99
132_F136_A0.6680.99
21_F27_V0.6680.99
63_T87_I0.6610.99
25_P64_K0.6600.99
61_I64_K0.6590.99
13_M17_G0.6580.99
151_I155_G0.6560.99
173_Y178_F0.6550.99
154_I169_I0.6540.99
104_L107_S0.6530.99
102_N105_S0.6500.99
91_C95_V0.6460.99
10_T14_V0.6450.99
163_P167_I0.6400.99
57_L83_I0.6290.99
131_E135_K0.6290.99
48_G136_A0.6270.98
27_V86_H0.6270.98
102_N106_H0.6260.98
115_G119_P0.6250.98
136_A139_G0.6240.98
17_G30_L0.6140.98
106_H109_I0.6140.98
49_E52_A0.6110.98
83_I87_I0.6100.98
97_L100_A0.6040.98
53_I64_K0.6020.98
90_T119_P0.6000.98
169_I172_A0.5980.98
20_G26_S0.5970.98
101_V110_V0.5960.98
21_F121_I0.5940.98
88_L91_C0.5920.98
8_D11_A0.5870.98
82_A85_A0.5870.98
91_C94_M0.5860.98
148_F152_A0.5840.98
44_D48_G0.5800.98
45_D135_K0.5760.97
14_V17_G0.5760.97
101_V104_L0.5760.97
103_V107_S0.5710.97
24_G62_A0.5690.97
62_A86_H0.5690.97
95_V99_A0.5680.97
74_K77_L0.5670.97
167_I174_G0.5670.97
25_P57_L0.5650.97
103_V158_T0.5640.97
90_T94_M0.5640.97
108_A111_A0.5630.97
6_Y9_M0.5630.97
16_T29_P0.5610.97
25_P121_I0.5610.97
9_M78_G0.5610.97
168_I178_F0.5600.97
17_G86_H0.5530.97
52_A89_P0.5520.97
25_P61_I0.5520.97
155_G161_I0.5450.96
63_T67_A0.5420.96
151_I173_Y0.5400.96
98_F102_N0.5400.96
130_Y133_G0.5390.96
129_A132_F0.5380.96
131_E134_Q0.5370.96
175_A178_F0.5370.96
144_T148_F0.5360.96
173_Y176_F0.5350.96
147_L150_I0.5320.96
146_I158_T0.5320.96
52_A167_I0.5320.96
31_I47_F0.5300.96
42_I72_K0.5260.96
163_P172_A0.5260.96
154_I175_A0.5250.96
24_G128_M0.5230.95
81_V84_L0.5220.95
42_I50_I0.5220.95
16_T19_L0.5210.95
24_G61_I0.5180.95
54_A61_I0.5170.95
25_P125_L0.5170.95
47_F60_P0.5160.95
41_W121_I0.5090.95
174_G178_F0.5080.95
66_A83_I0.5070.95
31_I86_H0.5070.95
25_P28_I0.5060.95
25_P29_P0.5040.94
164_G167_I0.5010.94
109_I175_A0.5000.94
152_A159_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rp9A 2 0.9188 37.7 0.929 Contact Map
4pypA 1 0.8782 19.8 0.938 Contact Map
3qe7A 2 0.8629 19 0.939 Contact Map
2cfqA 1 0.9188 17.8 0.939 Contact Map
4q65A 1 0.9086 13.1 0.943 Contact Map
2xq2A 2 0.8731 12.3 0.944 Contact Map
4ikvA 1 0.9086 10.7 0.945 Contact Map
2h3oA 1 0.2234 10.7 0.945 Contact Map
2mnsA 1 0.1015 10.4 0.945 Contact Map
2kncA 1 0.2183 8.9 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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