GREMLIN Database
YWRA - Uncharacterized transporter YwrA
UniProt: O05215 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 178 (167)
Sequences: 6558 (4548)
Seq/√Len: 352.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_F41_N4.6201.00
7_F82_A4.1781.00
30_E34_N3.8061.00
40_S43_Q3.6881.00
43_Q69_S3.5951.00
64_A80_L2.9171.00
12_I31_E2.5831.00
31_E35_R2.4881.00
5_Y36_Y2.4691.00
68_Y76_F2.2261.00
8_M12_I2.1371.00
30_E35_R2.0961.00
29_F34_N2.0781.00
159_H162_F2.0671.00
78_I82_A2.0311.00
150_L154_T2.0221.00
39_L66_V1.9851.00
6_L71_G1.8801.00
7_F85_V1.8561.00
47_M65_Y1.8431.00
151_L155_K1.8371.00
151_L156_F1.8341.00
31_E36_Y1.7751.00
9_A31_E1.7651.00
120_V124_I1.7541.00
153_M163_L1.7331.00
130_G134_I1.7011.00
152_A156_F1.6651.00
170_Y174_V1.6261.00
4_I8_M1.6251.00
6_L79_A1.5591.00
16_L27_L1.5481.00
143_I147_G1.4831.00
9_A36_Y1.4691.00
11_F15_L1.4561.00
166_A170_Y1.4411.00
32_V38_W1.3951.00
167_A171_G1.3941.00
136_A142_S1.3751.00
10_F32_V1.3531.00
108_K112_L1.3521.00
140_V144_V1.3381.00
134_I143_I1.3021.00
7_F78_I1.3011.00
21_G24_S1.2991.00
141_Q144_V1.2991.00
146_T150_L1.2961.00
29_F128_Q1.2861.00
67_G75_G1.2781.00
41_N132_D1.2711.00
144_V148_I1.2701.00
165_I168_F1.2511.00
125_L129_I1.2501.00
65_Y69_S1.2401.00
158_M162_F1.2311.00
33_V44_F1.2231.00
140_V143_I1.1901.00
10_F79_A1.1811.00
149_S167_A1.1711.00
127_W131_A1.1671.00
13_A28_M1.1481.00
24_S59_A1.1471.00
42_D46_N1.1291.00
130_G133_G1.1121.00
161_A165_I1.1091.00
73_W77_L1.1071.00
162_F166_A1.1011.00
64_A76_F1.0851.00
6_L10_F1.0701.00
91_L94_L1.0641.00
12_I16_L1.0491.00
102_R108_K1.0361.00
77_L81_I1.0321.00
124_I128_Q1.0301.00
163_L167_A1.0301.00
149_S163_L1.0301.00
142_S146_T1.0171.00
168_F171_G1.0161.00
6_L78_I1.0131.00
105_P109_G1.0051.00
14_N87_S1.0041.00
9_A38_W1.0011.00
43_Q46_N0.9971.00
44_F48_L0.9881.00
17_G44_F0.9821.00
168_F172_G0.9631.00
72_G75_G0.9601.00
17_G24_S0.9581.00
32_V66_V0.9531.00
75_G79_A0.9501.00
128_Q132_D0.9461.00
165_I169_L0.9431.00
34_N37_S0.9301.00
141_Q170_Y0.9291.00
75_G82_A0.9281.00
28_M32_V0.9181.00
70_A74_P0.9161.00
74_P77_L0.9131.00
159_H163_L0.9101.00
54_L64_A0.9061.00
13_A87_S0.9021.00
111_T114_V0.9021.00
32_V39_L0.8951.00
106_V110_M0.8891.00
13_A24_S0.8871.00
169_L173_L0.8861.00
23_A125_L0.8771.00
89_L93_V0.8771.00
71_G75_G0.8651.00
8_M11_F0.8631.00
6_L70_A0.8541.00
85_V89_L0.8461.00
91_L95_L0.8461.00
81_I85_V0.8421.00
5_Y9_A0.8381.00
109_G113_S0.8381.00
15_L90_A0.8371.00
63_A83_T0.8361.00
47_M62_I0.8341.00
122_M125_L0.8321.00
158_M163_L0.8241.00
74_P78_I0.8191.00
51_A54_L0.8181.00
148_I152_A0.8161.00
101_F107_I0.8161.00
11_F85_V0.8141.00
134_I146_T0.8111.00
50_L54_L0.8061.00
141_Q174_V0.8051.00
116_P124_I0.8041.00
110_M114_V0.7951.00
107_I110_M0.7941.00
51_A62_I0.7901.00
66_V70_A0.7871.00
97_I101_F0.7851.00
60_T80_L0.7841.00
101_F104_S0.7771.00
28_M63_A0.7741.00
113_S117_V0.7731.00
48_L62_I0.7711.00
9_A12_I0.7681.00
44_F62_I0.7661.00
136_A165_I0.7571.00
96_R99_Q0.7561.00
9_A13_A0.7521.00
149_S156_F0.7451.00
105_P108_K0.7451.00
58_I62_I0.7441.00
54_L60_T0.7331.00
7_F11_F0.7240.99
126_T130_G0.7200.99
136_A140_V0.7000.99
28_M59_A0.6970.99
25_I44_F0.6930.99
146_T153_M0.6930.99
140_V155_K0.6910.99
99_Q102_R0.6880.99
60_T84_V0.6850.99
27_L121_M0.6840.99
18_Y24_S0.6830.99
13_A54_L0.6750.99
54_L80_L0.6740.99
14_N27_L0.6730.99
39_L43_Q0.6730.99
131_A136_A0.6720.99
79_A82_A0.6720.99
88_A91_L0.6710.99
46_N49_A0.6710.99
95_L99_Q0.6670.99
151_L172_G0.6630.99
147_G155_K0.6610.99
21_G59_A0.6610.99
100_R104_S0.6580.99
17_G23_A0.6550.99
141_Q145_I0.6550.99
42_D132_D0.6520.99
32_V36_Y0.6460.99
94_L97_I0.6400.99
151_L154_T0.6390.99
87_S116_P0.6370.99
41_N45_S0.6330.99
22_P118_I0.6280.98
24_S83_T0.6280.98
146_T149_S0.6260.98
45_S133_G0.6260.98
5_Y8_M0.6250.98
116_P120_V0.6230.98
122_M129_I0.6210.98
71_G74_P0.6180.98
92_I96_R0.6160.98
80_L84_V0.6120.98
11_F14_N0.6100.98
10_F14_N0.6090.98
33_V38_W0.6070.98
160_P164_I0.6030.98
152_A158_M0.6020.98
143_I155_K0.5990.98
88_A92_I0.5980.98
18_Y118_I0.5960.98
59_A83_T0.5960.98
98_I107_I0.5890.98
4_I7_F0.5860.98
22_P54_L0.5860.98
22_P58_I0.5840.98
141_Q148_I0.5840.98
34_N41_N0.5830.98
51_A58_I0.5790.97
131_A135_K0.5770.97
90_A94_L0.5760.97
49_A86_P0.5740.97
122_M126_T0.5690.97
29_F33_V0.5670.97
78_I81_I0.5640.97
24_S121_M0.5640.97
87_S91_L0.5620.97
164_I167_A0.5540.97
124_I127_W0.5520.97
13_A26_P0.5510.97
45_S129_I0.5480.96
112_L116_P0.5440.96
145_I148_I0.5400.96
144_V147_G0.5380.96
6_L75_G0.5360.96
126_T129_I0.5350.96
28_M44_F0.5340.96
10_F82_A0.5330.96
13_A16_L0.5330.96
14_N83_T0.5320.96
152_A163_L0.5300.96
133_G136_A0.5290.96
14_N125_L0.5280.96
11_F48_L0.5260.96
104_S107_I0.5250.96
44_F57_P0.5250.96
25_I62_I0.5230.95
76_F79_A0.5210.95
22_P122_M0.5200.95
94_L101_F0.5180.95
100_R157_K0.5170.95
39_L47_M0.5130.95
161_A164_I0.5110.95
164_I171_G0.5100.95
147_G150_L0.5100.95
18_Y57_P0.5070.95
103_Q106_V0.5070.95
99_Q103_Q0.5040.94
18_Y114_V0.5020.94
22_P26_P0.5010.94
38_W118_I0.5000.94
60_T64_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mnsA 1 0.1124 9.2 0.942 Contact Map
2h3oA 1 0.2472 8.3 0.943 Contact Map
3qnqA 2 0.7753 3.5 0.953 Contact Map
3izxA 3 0.4663 3.4 0.953 Contact Map
2l8sA 1 0.1461 2.4 0.956 Contact Map
4wrtB 1 0.3034 2.4 0.956 Contact Map
4wsbB 1 0.3146 1.9 0.959 Contact Map
4fibA 1 0.2191 1.9 0.959 Contact Map
1afoA 2 0.2247 1.8 0.959 Contact Map
2micA 2 0.2303 1.7 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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