GREMLIN Database
YJHB - Putative ADP-ribose pyrophosphatase YjhB
UniProt: C0SPC3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 208 (169)
Sequences: 2672 (1822)
Seq/√Len: 140.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_K123_D5.0391.00
80_R83_Q3.8831.00
95_W169_H3.4951.00
108_P150_I3.1371.00
126_P155_S2.8761.00
77_A84_I2.7991.00
125_E155_S2.7641.00
83_Q174_P2.6951.00
108_P152_I2.6221.00
88_R169_H2.4991.00
123_D157_T2.4361.00
188_P192_S2.4091.00
88_R168_N2.3801.00
78_V116_I2.3661.00
125_E157_T2.3651.00
42_S45_M2.3171.00
47_A60_L2.2371.00
174_P177_R2.2131.00
110_E113_V2.0771.00
122_Y156_M2.0061.00
106_L114_K1.9441.00
82_N175_E1.8991.00
87_V98_P1.8761.00
50_S60_L1.8591.00
42_S59_D1.8461.00
19_A22_G1.7901.00
113_V127_S1.7681.00
86_L173_F1.7621.00
102_C108_P1.7371.00
59_D62_Q1.7101.00
113_V125_E1.6961.00
116_I124_T1.6881.00
82_N174_P1.6821.00
45_M59_D1.6561.00
45_M62_Q1.6511.00
90_K168_N1.6351.00
76_G116_I1.6091.00
38_L44_E1.4991.00
89_E96_S1.4771.00
123_D158_D1.4751.00
120_S170_A1.4221.00
47_A61_W1.4131.00
161_G170_A1.3831.00
189_S193_M1.3551.00
102_C111_N1.3551.00
42_S62_Q1.3251.00
98_P120_S1.3181.00
78_V154_C1.3171.00
79_F155_S1.3141.00
76_G154_C1.2961.00
76_G112_V1.2951.00
80_R159_G1.2941.00
89_E92_D1.2891.00
133_L193_M1.2801.00
128_R153_A1.2771.00
129_L132_V1.2611.00
82_N176_D1.2431.00
111_N114_K1.2291.00
76_G98_P1.2191.00
132_V150_I1.1971.00
73_D149_K1.1851.00
171_A177_R1.1841.00
130_L153_A1.1841.00
108_P148_Y1.1831.00
156_M159_G1.1811.00
79_F153_A1.1751.00
113_V126_P1.1560.99
39_M43_A1.1550.99
74_V111_N1.1540.99
173_F179_P1.1310.99
83_Q177_R1.1040.99
36_E57_I1.1030.99
189_S192_S1.0710.99
34_R38_L1.0650.99
26_S35_Y1.0640.99
30_Y34_R1.0470.99
120_S167_T1.0450.99
127_S155_S1.0440.99
70_P104_I1.0440.99
124_T154_C1.0370.99
97_L151_F1.0070.98
85_L122_Y0.9990.98
26_S32_R0.9960.98
84_I97_L0.9870.98
113_V124_T0.9820.98
40_K48_D0.9760.98
183_P188_P0.9750.98
45_M49_Y0.9640.98
108_P129_L0.9490.98
113_V117_K0.9200.97
92_D96_S0.9180.97
39_M66_G0.9150.97
129_L150_I0.9140.97
75_R112_V0.9090.97
49_Y57_I0.9020.97
102_C148_Y0.8960.97
106_L111_N0.8890.97
52_K58_T0.8860.97
43_A62_Q0.8750.96
128_R155_S0.8700.96
106_L110_E0.8670.96
87_V167_T0.8650.96
164_G167_T0.8610.96
24_A110_E0.8510.96
24_A27_K0.8470.96
112_V116_I0.8470.96
187_T191_L0.8360.95
156_M172_F0.8210.95
135_S149_K0.8170.95
112_V124_T0.8160.95
73_D152_I0.8120.95
95_W173_F0.8100.94
28_D56_V0.8040.94
46_M49_Y0.7920.94
89_E168_N0.7900.94
89_E167_T0.7880.94
187_T190_Q0.7870.94
185_R190_Q0.7760.93
122_Y161_G0.7760.93
31_D139_S0.7750.93
20_Q24_A0.7740.93
76_G124_T0.7710.93
21_A26_S0.7590.92
27_K31_D0.7500.92
43_A49_Y0.7490.92
158_D161_G0.7430.91
73_D140_H0.7410.91
32_R36_E0.7380.91
121_G162_E0.7360.91
185_R191_L0.7340.91
74_V102_C0.7330.91
98_P167_T0.7320.91
163_T166_E0.7290.91
41_L48_D0.7270.91
78_V97_L0.7270.91
49_Y66_G0.7250.90
77_A97_L0.7250.90
21_A24_A0.7230.90
159_G179_P0.7220.90
48_D60_L0.7150.90
120_S164_G0.7150.90
71_K139_S0.7060.89
74_V112_V0.7050.89
53_D65_K0.7030.89
18_I22_G0.6950.89
101_F135_S0.6920.88
113_V123_D0.6880.88
93_E168_N0.6790.87
99_G149_K0.6770.87
182_S185_R0.6760.87
34_R37_E0.6740.87
68_P133_L0.6690.87
161_G164_G0.6660.86
126_P152_I0.6650.86
87_V120_S0.6630.86
36_E51_E0.6580.86
96_S186_N0.6560.85
76_G79_F0.6540.85
95_W98_P0.6530.85
108_P134_D0.6470.85
21_A25_F0.6460.85
28_D34_R0.6460.85
167_T170_A0.6440.84
109_A129_L0.6410.84
35_Y38_L0.6410.84
186_N190_Q0.6390.84
186_N191_L0.6390.84
78_V122_Y0.6370.84
135_S151_F0.6350.84
18_I37_E0.6320.83
101_F138_H0.6290.83
75_R187_T0.6210.82
133_L151_F0.6200.82
44_E64_E0.6200.82
72_A102_C0.6190.82
31_D34_R0.6170.82
66_G71_K0.6150.82
87_V170_A0.6150.82
88_R93_E0.6140.82
71_K104_I0.6130.81
41_L46_M0.6110.81
126_P154_C0.6050.81
66_G69_T0.6040.80
94_L184_K0.6020.80
74_V108_P0.6010.80
104_I139_S0.6000.80
75_R151_F0.5950.79
39_M49_Y0.5930.79
53_D56_V0.5930.79
88_R92_D0.5920.79
182_S187_T0.5890.79
69_T75_R0.5870.79
32_R35_Y0.5860.78
104_I134_D0.5840.78
95_W171_A0.5840.78
109_A132_V0.5780.78
56_V65_K0.5770.77
37_E44_E0.5760.77
109_A133_L0.5740.77
42_S106_L0.5720.77
43_A66_G0.5710.77
33_E36_E0.5710.77
122_Y170_A0.5710.77
190_Q193_M0.5700.77
67_Y101_F0.5690.76
106_L109_A0.5670.76
97_L173_F0.5660.76
115_E119_E0.5640.76
79_F84_I0.5630.76
73_D102_C0.5620.76
105_G135_S0.5600.75
20_Q23_L0.5570.75
37_E61_W0.5560.75
27_K110_E0.5560.75
133_L149_K0.5560.75
164_G168_N0.5540.75
43_A57_I0.5530.74
75_R149_K0.5490.74
28_D32_R0.5470.74
135_S140_H0.5450.73
120_S166_E0.5420.73
80_R155_S0.5420.73
187_T192_S0.5420.73
86_L178_L0.5400.73
21_A68_P0.5400.73
99_G103_E0.5380.72
23_L27_K0.5360.72
52_K56_V0.5350.72
87_V96_S0.5340.72
138_H149_K0.5320.72
178_L182_S0.5300.71
108_P132_V0.5300.71
178_L181_L0.5290.71
131_A193_M0.5270.71
64_E104_I0.5260.71
41_L45_M0.5240.70
52_K59_D0.5240.70
30_Y37_E0.5230.70
72_A148_Y0.5220.70
129_L152_I0.5200.70
182_S189_S0.5160.69
77_A151_F0.5150.69
27_K30_Y0.5150.69
50_S53_D0.5140.69
39_M139_S0.5140.69
112_V154_C0.5120.69
48_D58_T0.5110.69
182_S186_N0.5110.69
176_D179_P0.5110.69
74_V77_A0.5090.68
106_L133_L0.5030.67
33_E37_E0.5020.67
21_A82_N0.5010.67
99_G151_F0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hfqA 2 0.976 100 0.366 Contact Map
3q1pA 2 0.9663 100 0.372 Contact Map
1vk6A 2 0.9327 100 0.395 Contact Map
3o8sA 2 0.6442 100 0.396 Contact Map
3cngA 4 0.7837 100 0.463 Contact Map
2qjtB 2 0.9231 100 0.511 Contact Map
3gz5A 2 0.6538 99.9 0.538 Contact Map
2qjoA 3 0.9183 99.9 0.547 Contact Map
2fmlA 2 0.8221 99.9 0.555 Contact Map
4ktbA 4 0.6538 99.9 0.568 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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