GREMLIN Database
YTMP - Putative phosphotransferase YtmP
UniProt: C0SPC1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (197)
Sequences: 262 (200)
Seq/√Len: 14.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_M50_K3.8121.00
33_R37_T3.5920.99
63_K84_E3.2630.99
107_W129_A3.0920.98
17_E118_I2.7860.96
76_I138_H2.6740.95
32_L107_W2.4950.93
133_G164_M2.4330.92
29_A160_L2.3750.91
132_L156_L2.3240.90
3_N121_D2.3090.89
42_L125_I2.3030.89
27_P113_N2.2140.87
45_L50_K2.1470.85
17_E105_N2.1390.85
164_M195_L2.1050.84
96_V121_D2.0570.83
44_M97_V1.9300.79
35_I98_C1.8940.77
146_E150_S1.8200.74
67_F188_F1.8140.74
125_I164_M1.8120.74
47_R121_D1.7870.73
7_I105_N1.7830.73
17_E164_M1.7820.73
135_L162_L1.7580.72
35_I105_N1.7460.71
121_D136_L1.7410.71
45_L124_M1.7360.71
138_H191_A1.7340.70
16_R47_R1.6960.69
116_Y174_T1.6810.68
50_K108_L1.6560.67
76_I178_W1.6480.66
40_A43_D1.6280.65
33_R40_A1.5530.62
22_D48_L1.5410.61
4_G9_A1.5370.61
17_E35_I1.5330.61
82_Y133_G1.4970.59
13_M45_L1.4720.57
102_V133_G1.4690.57
63_K80_I1.4610.57
47_R136_L1.4560.56
135_L194_E1.4450.56
58_L100_C1.4430.56
62_L76_I1.4270.55
31_L35_I1.4240.55
165_A171_E1.4140.54
50_K100_C1.3850.53
108_L111_E1.3750.52
17_E125_I1.3720.52
64_Q173_I1.3530.51
73_S192_M1.3240.49
46_K95_K1.3050.48
21_K197_I1.3020.48
27_P154_I1.2940.48
17_E40_A1.2710.46
66_V177_A1.2690.46
35_I47_R1.2670.46
58_L132_L1.2640.46
40_A47_R1.2460.45
146_E156_L1.2350.44
8_T28_V1.2350.44
85_E183_G1.2320.44
54_N68_A1.2200.44
6_V123_A1.2110.43
21_K24_S1.2000.43
187_E191_A1.2000.43
35_I42_L1.1910.42
63_K100_C1.1900.42
11_H164_M1.1880.42
91_H140_V1.1860.42
108_L188_F1.1830.42
5_D9_A1.1790.41
105_N160_L1.1750.41
43_D116_Y1.1710.41
142_K161_R1.1660.41
70_Q189_H1.1620.41
48_L105_N1.1610.41
138_H171_E1.1460.40
68_A76_I1.1350.39
24_S37_T1.1130.38
47_R169_L1.1110.38
102_V122_G1.1070.38
8_T47_R1.0960.37
3_N63_K1.0960.37
3_N16_R1.0900.37
111_E114_Q1.0860.37
43_D125_I1.0790.36
137_Y171_E1.0790.36
3_N112_D1.0780.36
125_I163_R1.0770.36
45_L184_N1.0720.36
42_L164_M1.0490.35
50_K125_I1.0480.35
7_I177_A1.0480.35
77_Q84_E1.0380.34
174_T192_M1.0370.34
79_G173_I1.0340.34
123_A126_A1.0340.34
176_I192_M1.0290.34
17_E52_P1.0260.34
128_P163_R1.0200.33
39_K91_H1.0180.33
182_K191_A1.0170.33
22_D89_E1.0160.33
102_V113_N1.0000.32
34_K123_A0.9950.32
74_P188_F0.9950.32
2_E7_I0.9850.32
189_H193_E0.9780.31
11_H45_L0.9760.31
50_K105_N0.9620.31
74_P186_K0.9550.30
50_K62_L0.9470.30
70_Q177_A0.9450.30
48_L125_I0.9360.29
79_G161_R0.9240.29
68_A80_I0.9160.28
4_G10_Q0.9110.28
57_A69_V0.9060.28
95_K126_A0.9020.28
6_V80_I0.8940.28
66_V173_I0.8920.27
178_W182_K0.8900.27
42_L128_P0.8860.27
40_A184_N0.8830.27
20_P48_L0.8810.27
14_T25_G0.8780.27
46_K122_G0.8730.27
31_L123_A0.8720.27
80_I155_E0.8710.27
23_M197_I0.8650.26
100_C149_L0.8550.26
62_L146_E0.8540.26
2_E35_I0.8540.26
172_T191_A0.8440.25
82_Y86_H0.8430.25
126_A129_A0.8400.25
17_E42_L0.8370.25
123_A160_L0.8350.25
14_T168_V0.8340.25
100_C170_S0.8320.25
191_A194_E0.8260.25
75_L144_A0.8230.25
176_I189_H0.8230.25
133_G165_A0.8210.24
49_G62_L0.8200.24
6_V182_K0.8200.24
129_A163_R0.8200.24
117_L139_Y0.8170.24
93_G157_T0.8150.24
58_L107_W0.8120.24
134_P160_L0.8090.24
138_H198_L0.8080.24
55_P135_L0.8010.24
55_P132_L0.7980.24
173_I192_M0.7970.23
57_A62_L0.7970.23
112_D128_P0.7960.23
32_L141_E0.7960.23
102_V165_A0.7940.23
35_I52_P0.7920.23
114_Q143_P0.7890.23
8_T12_W0.7840.23
28_V134_P0.7840.23
81_K197_I0.7790.23
45_L108_L0.7710.22
126_A167_Y0.7630.22
44_M115_L0.7590.22
105_N137_Y0.7530.22
28_V114_Q0.7520.22
15_G189_H0.7520.22
127_D163_R0.7520.22
14_T111_E0.7490.22
129_A132_L0.7480.22
59_L129_A0.7420.21
11_H125_I0.7420.21
3_N72_S0.7420.21
3_N28_V0.7350.21
109_L183_G0.7290.21
72_S77_Q0.7230.21
173_I191_A0.7230.21
6_V136_L0.7230.21
37_T194_E0.7190.21
5_D16_R0.7180.21
118_I182_K0.7130.20
45_L100_C0.7120.20
3_N98_C0.7110.20
62_L100_C0.7110.20
35_I40_A0.7070.20
87_L158_E0.7060.20
110_S134_P0.7030.20
82_Y109_L0.7030.20
42_L105_N0.7020.20
40_A182_K0.7010.20
55_P90_V0.7010.20
17_E163_R0.6960.20
54_N88_H0.6940.20
19_K150_S0.6930.20
135_L168_V0.6900.20
12_W100_C0.6880.19
10_Q36_H0.6880.19
185_D188_F0.6860.19
174_T177_A0.6800.19
16_R42_L0.6780.19
11_H116_Y0.6770.19
52_P125_I0.6620.19
27_P116_Y0.6530.18
31_L98_C0.6510.18
96_V105_N0.6480.18
3_N96_V0.6470.18
39_K88_H0.6440.18
13_M108_L0.6440.18
14_T95_K0.6370.18
29_A146_E0.6340.18
11_H189_H0.6340.18
97_V103_N0.6320.18
49_G170_S0.6310.18
29_A35_I0.6290.18
51_E181_A0.6280.18
92_F185_D0.6280.18
53_L100_C0.6270.17
133_G168_V0.6270.17
7_I35_I0.6260.17
65_A177_A0.6240.17
48_L52_P0.6230.17
76_I171_E0.6200.17
118_I164_M0.6200.17
96_V132_L0.6170.17
78_E146_E0.6160.17
73_S189_H0.6150.17
27_P59_L0.6140.17
100_C198_L0.6130.17
147_S170_S0.6120.17
21_K146_E0.6050.17
86_H165_A0.6020.17
40_A82_Y0.6020.17
72_S181_A0.6010.17
65_A102_V0.5970.17
11_H137_Y0.5970.17
39_K58_L0.5940.16
172_T181_A0.5930.16
25_G147_S0.5900.16
2_E8_T0.5890.16
2_E47_R0.5880.16
84_E133_G0.5880.16
42_L118_I0.5860.16
79_G169_L0.5830.16
35_I102_V0.5800.16
91_H169_L0.5790.16
53_L187_E0.5780.16
29_A123_A0.5770.16
29_A107_W0.5740.16
2_E105_N0.5730.16
16_R140_V0.5730.16
58_L90_V0.5720.16
41_L169_L0.5710.16
35_I123_A0.5700.16
62_L177_A0.5670.16
171_E187_E0.5630.16
51_E68_A0.5610.15
77_Q198_L0.5610.15
43_D46_K0.5600.15
20_P179_H0.5600.15
159_S198_L0.5590.15
47_R178_W0.5560.15
84_E132_L0.5540.15
33_R109_L0.5500.15
141_E152_Y0.5450.15
16_R22_D0.5430.15
122_G191_A0.5420.15
90_V170_S0.5400.15
63_K183_G0.5380.15
47_R179_H0.5360.15
66_V70_Q0.5340.15
84_E186_K0.5320.15
180_K189_H0.5310.15
46_K65_A0.5250.14
59_L76_I0.5250.14
30_E74_P0.5240.14
70_Q176_I0.5210.14
59_L80_I0.5210.14
132_L163_R0.5180.14
21_K26_R0.5170.14
46_K61_Q0.5160.14
78_E158_E0.5160.14
179_H184_N0.5120.14
78_E150_S0.5060.14
140_V178_W0.5060.14
11_H65_A0.5050.14
59_L71_Q0.5040.14
171_E191_A0.5020.14
23_M48_L0.5010.14
80_I111_E0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3i1aA 1 0.9902 99.9 0.746 Contact Map
3tdwA 1 0.9706 99.8 0.763 Contact Map
4dcaA 1 0.9902 99.8 0.765 Contact Map
3dxqA 1 0.9559 99.8 0.765 Contact Map
2qg7A 2 0.9755 99.8 0.777 Contact Map
4ocvA 1 0.9755 99.8 0.777 Contact Map
1nw1A 2 0.9363 99.7 0.788 Contact Map
4orkA 1 0.951 99.7 0.79 Contact Map
4pdyA 1 0.9461 99.7 0.793 Contact Map
1nd4A 2 0.7941 99.7 0.794 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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