GREMLIN Database
YOAI - Probable 4-hydroxyphenylacetate 3-monooxygenase
UniProt: C0SPC0 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (471)
Sequences: 814 (515)
Seq/√Len: 23.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_H262_H8.5391.00
140_Q144_H5.8971.00
10_I41_I5.4951.00
406_R410_D5.1161.00
25_E34_H4.7411.00
351_A359_M4.5461.00
185_I219_F4.5121.00
12_R199_D4.3981.00
183_L270_V3.8741.00
30_N33_E3.8551.00
175_V273_Y3.8121.00
401_F424_V3.7841.00
267_W270_V3.6511.00
14_N30_N3.5871.00
6_G49_E3.5861.00
179_T264_L3.5341.00
200_E269_R3.4371.00
179_T184_M3.4321.00
401_F409_L3.2871.00
63_C70_R3.2801.00
57_I70_R3.2381.00
136_D139_E3.2371.00
181_K264_L3.1201.00
326_I387_I3.0991.00
231_I259_V3.0781.00
220_S271_F3.0621.00
178_R274_D3.0431.00
14_N32_S3.0211.00
15_K18_N3.0061.00
183_L217_Y2.9231.00
315_V330_L2.9091.00
178_R273_Y2.8991.00
379_R382_E2.6400.99
73_L86_K2.6010.99
184_M264_L2.6010.99
311_A333_I2.5090.99
19_E229_K2.4650.98
5_N52_T2.4620.98
332_E379_R2.4570.98
177_D262_H2.3800.98
64_L67_D2.3760.98
8_E11_D2.3580.98
173_A185_I2.3160.98
259_V408_D2.2790.97
64_L71_I2.2720.97
25_E399_N2.2660.97
177_D181_K2.2520.97
5_N8_E2.2430.97
193_T233_R2.2230.97
4_I12_R2.1340.96
80_T359_M2.0540.95
419_N422_E2.0520.95
132_E136_D2.0500.95
120_A135_L2.0380.95
124_K355_E2.0350.95
177_D184_M2.0200.94
320_V326_I2.0190.94
65_P71_I2.0110.94
4_I199_D2.0070.94
214_D274_D1.9780.94
79_K83_D1.9770.94
69_N143_K1.9730.94
173_A260_F1.9710.94
61_T70_R1.9700.94
137_M200_E1.9540.93
7_K11_D1.9420.93
352_Q362_C1.9370.93
305_E341_K1.8820.92
288_F292_T1.8790.92
60_M90_M1.8630.92
316_D470_L1.8480.91
63_C67_D1.8250.91
98_T102_M1.7870.90
82_N86_K1.7600.89
310_V433_L1.7540.89
156_Q391_G1.7090.88
289_H292_T1.6900.87
19_E26_K1.6810.87
473_I477_L1.6700.86
298_I344_I1.6700.86
154_T189_R1.6320.85
270_V273_Y1.6220.85
123_L286_S1.6160.84
92_E96_R1.5900.83
175_V217_Y1.5690.83
183_L264_L1.5680.83
176_I184_M1.5610.82
316_D321_S1.5490.82
267_W273_Y1.5480.82
325_H329_K1.5330.81
275_N278_A1.4980.79
129_C132_E1.4950.79
125_D277_E1.4950.79
56_L93_H1.4820.79
289_H293_F1.4750.78
6_G45_S1.4510.77
66_G139_E1.4430.77
88_R348_E1.4300.76
402_D405_I1.4190.76
304_I380_F1.4100.75
203_V260_F1.4040.75
140_Q146_L1.4030.75
132_E135_L1.3910.74
96_R302_I1.3870.74
136_D140_Q1.3760.73
137_M269_R1.3710.73
415_A418_T1.3650.73
315_V320_V1.3540.72
47_L94_W1.3520.72
161_Q165_G1.3520.72
409_L424_V1.3490.72
231_I408_D1.3450.72
81_K359_M1.3260.70
232_T254_M1.3250.70
98_T374_P1.3240.70
137_M140_Q1.3200.70
137_M220_S1.3130.70
229_K408_D1.3100.69
234_E245_H1.3060.69
379_R383_I1.3050.69
421_E425_K1.3010.69
288_F293_F1.2950.69
313_L474_K1.2730.67
66_G71_I1.2720.67
294_H348_E1.2710.67
17_E224_N1.2630.67
51_Q72_G1.2610.66
307_L430_A1.2600.66
190_L390_S1.2580.66
308_L333_I1.2570.66
178_R267_W1.2520.66
24_G400_A1.2500.66
362_C365_P1.2490.66
184_M217_Y1.2400.65
222_P265_V1.2340.65
49_E52_T1.2290.64
176_I186_H1.2280.64
402_D406_R1.2270.64
329_K383_I1.2240.64
395_L424_V1.2210.64
382_E447_R1.2210.64
259_V412_Y1.2190.64
124_K131_P1.2190.64
205_S215_E1.2070.63
314_L430_A1.2010.63
26_K404_E1.1990.62
134_I138_Y1.1960.62
221_I225_T1.1870.62
133_H270_V1.1850.62
219_F265_V1.1840.61
133_H268_N1.1780.61
471_N475_T1.1740.61
20_I180_E1.1730.61
385_Q447_R1.1660.60
317_T418_T1.1530.59
201_I223_S1.1510.59
106_P150_H1.1490.59
64_L143_K1.1440.59
170_P174_K1.1420.59
122_L126_K1.1360.58
407_E410_D1.1290.58
174_K214_D1.1260.57
147_S194_Q1.1220.57
202_L337_L1.1190.57
195_G230_F1.1170.57
11_D14_N1.1120.57
265_V269_R1.1090.56
20_I279_A1.1070.56
184_M262_H1.1040.56
151_T192_A1.1030.56
165_G211_F1.1010.56
39_G42_K1.0950.55
146_L200_E1.0920.55
54_D57_I1.0910.55
139_E183_L1.0880.55
203_V219_F1.0860.55
378_P382_E1.0840.55
216_A390_S1.0720.54
185_I357_G1.0640.53
158_N161_Q1.0610.53
14_N33_E1.0590.53
221_I265_V1.0560.53
201_I258_V1.0520.52
428_R449_F1.0450.52
181_K184_M1.0440.52
329_K387_I1.0400.51
9_F140_Q1.0330.51
133_H185_I1.0320.51
288_F291_F1.0270.51
431_W435_M1.0210.50
40_I197_L1.0200.50
43_T99_H1.0080.49
14_N31_I1.0010.49
441_R445_Y0.9970.48
345_D350_D0.9950.48
228_V263_V0.9950.48
429_L473_I0.9940.48
126_K277_E0.9930.48
63_C68_H0.9930.48
164_F212_E0.9890.48
162_S165_G0.9820.47
71_I142_A0.9750.47
281_D285_K0.9740.47
168_E411_Q0.9740.47
68_H316_D0.9690.46
81_K351_A0.9640.46
168_E215_E0.9620.46
304_I373_I0.9600.46
81_K349_N0.9590.46
157_V414_Q0.9540.45
140_Q200_E0.9530.45
312_Q330_L0.9530.45
339_T372_I0.9510.45
186_H203_V0.9470.45
467_Q470_L0.9450.45
140_Q143_K0.9440.45
255_D303_K0.9440.45
137_M148_F0.9440.45
14_N224_N0.9420.45
233_R253_E0.9400.44
303_K446_E0.9350.44
80_T336_G0.9300.44
132_E270_V0.9300.44
318_I390_S0.9300.44
172_S207_P0.9270.44
27_I38_K0.9270.44
76_L86_K0.9250.43
244_N247_L0.9210.43
113_M141_A0.9150.43
350_D362_C0.9130.43
452_D455_R0.9120.42
291_F294_H0.9100.42
441_R446_E0.9070.42
181_K268_N0.9060.42
108_Y292_T0.9050.42
62_Y76_L0.9050.42
25_E262_H0.9040.42
225_T405_I0.9040.42
272_F279_A0.8990.42
140_Q148_F0.8970.41
45_S403_S0.8970.41
342_A365_P0.8900.41
9_F144_H0.8850.41
291_F296_V0.8840.41
78_P87_R0.8820.40
53_K56_L0.8820.40
23_D404_E0.8770.40
329_K386_L0.8760.40
257_I413_L0.8710.40
261_D347_S0.8710.40
141_A148_F0.8710.40
324_Q454_I0.8690.40
20_I53_K0.8660.39
170_P186_H0.8600.39
243_F246_P0.8590.39
163_Y166_L0.8590.39
259_V426_I0.8500.38
10_I409_L0.8490.38
7_K321_S0.8480.38
164_F179_T0.8430.38
67_D143_K0.8410.38
148_F220_S0.8400.38
21_W423_R0.8360.37
43_T46_S0.8350.37
189_R373_I0.8320.37
145_D219_F0.8320.37
8_E19_E0.8310.37
195_G223_S0.8300.37
143_K259_V0.8290.37
54_D61_T0.8260.37
189_R476_F0.8240.37
442_Q449_F0.8230.36
465_P468_E0.8220.36
96_R472_M0.8200.36
80_T260_F0.8180.36
73_L76_L0.8170.36
332_E383_I0.8130.36
153_I197_L0.8130.36
25_E28_K0.8120.36
448_Y452_D0.8110.36
38_K42_K0.8100.36
19_E404_E0.8090.36
99_H476_F0.8080.36
253_E441_R0.8080.36
378_P447_R0.8010.35
250_R425_K0.8010.35
100_G253_E0.7980.35
124_K129_C0.7980.35
314_L427_F0.7960.35
334_I464_Y0.7940.35
213_T274_D0.7920.34
92_E302_I0.7910.34
19_E139_E0.7900.34
148_F202_L0.7890.34
7_K228_V0.7880.34
71_I143_K0.7870.34
8_E274_D0.7850.34
129_C179_T0.7850.34
245_H248_S0.7820.34
10_I32_S0.7820.34
203_V225_T0.7810.34
314_L388_G0.7790.34
83_D216_A0.7750.33
7_K58_H0.7740.33
67_D139_E0.7740.33
161_Q174_K0.7730.33
112_V137_M0.7730.33
310_V319_N0.7720.33
240_D245_H0.7720.33
159_R319_N0.7710.33
33_E184_M0.7690.33
79_K136_D0.7690.33
39_G237_V0.7690.33
11_D20_I0.7690.33
21_W447_R0.7670.33
272_F275_N0.7660.33
428_R442_Q0.7660.33
85_K348_E0.7660.33
176_I262_H0.7650.33
328_E375_K0.7640.33
58_H86_K0.7630.33
13_L18_N0.7590.32
76_L294_H0.7560.32
77_Q114_M0.7550.32
410_D419_N0.7530.32
72_G145_D0.7520.32
329_K453_P0.7520.32
213_T276_V0.7490.32
108_Y150_H0.7490.32
229_K259_V0.7440.31
67_D71_I0.7430.31
310_V430_A0.7410.31
20_I85_K0.7400.31
190_L428_R0.7400.31
293_F370_S0.7380.31
85_K349_N0.7380.31
157_V163_Y0.7380.31
317_T426_I0.7370.31
20_I175_V0.7370.31
154_T286_S0.7360.31
92_E305_E0.7350.31
166_L172_S0.7300.31
188_A412_Y0.7290.31
259_V420_A0.7290.31
356_F362_C0.7270.30
304_I337_L0.7240.30
58_H70_R0.7220.30
265_V317_T0.7210.30
314_L426_I0.7210.30
320_V414_Q0.7150.30
415_A423_R0.7130.30
264_L267_W0.7130.30
253_E303_K0.7120.30
255_D432_D0.7120.30
181_K412_Y0.7100.29
467_Q471_N0.7090.29
19_E405_I0.7070.29
225_T263_V0.7050.29
64_L142_A0.7010.29
316_D416_T0.7010.29
228_V258_V0.7000.29
66_G268_N0.6960.29
246_P432_D0.6960.29
256_S288_F0.6940.29
297_V369_I0.6930.28
43_T251_Y0.6930.28
123_L128_N0.6920.28
129_C133_H0.6900.28
132_E224_N0.6890.28
193_T253_E0.6890.28
243_F247_L0.6890.28
319_N347_S0.6890.28
130_F133_H0.6890.28
327_Q458_S0.6880.28
374_P456_I0.6870.28
261_D346_K0.6870.28
82_N85_K0.6860.28
226_K262_H0.6860.28
139_E143_K0.6830.28
190_L193_T0.6830.28
40_I274_D0.6820.28
140_Q269_R0.6820.28
63_C66_G0.6810.28
21_W116_F0.6810.28
344_I348_E0.6810.28
342_A346_K0.6810.28
337_L439_G0.6800.28
100_G246_P0.6800.28
37_F40_I0.6790.28
137_M196_G0.6770.28
26_K181_K0.6760.27
102_M183_L0.6750.27
208_K387_I0.6740.27
212_E228_V0.6740.27
318_I427_F0.6740.27
20_I409_L0.6740.27
180_E267_W0.6740.27
58_H136_D0.6730.27
372_I376_L0.6690.27
258_V271_F0.6690.27
10_I45_S0.6690.27
34_H45_S0.6690.27
193_T251_Y0.6680.27
6_G52_T0.6680.27
389_A452_D0.6670.27
46_S97_H0.6660.27
200_E265_V0.6660.27
25_E402_D0.6650.27
75_Y78_P0.6650.27
402_D409_L0.6640.27
119_S131_P0.6630.27
226_K358_Y0.6620.27
286_S290_A0.6620.27
113_M134_I0.6620.27
104_R193_T0.6610.27
289_H294_H0.6610.27
27_I353_L0.6600.27
260_F271_F0.6600.27
221_I269_R0.6600.27
257_I390_S0.6580.26
15_K30_N0.6580.26
385_Q443_T0.6570.26
183_L273_Y0.6560.26
230_F256_S0.6550.26
254_M433_L0.6540.26
17_E28_K0.6540.26
288_F344_I0.6530.26
15_K224_N0.6530.26
99_H251_Y0.6520.26
153_I456_I0.6520.26
223_S230_F0.6520.26
469_Q472_M0.6480.26
13_L290_A0.6470.26
120_A124_K0.6430.26
82_N433_L0.6430.26
28_K55_E0.6420.26
54_D70_R0.6410.26
305_E469_Q0.6400.26
175_V406_R0.6390.25
155_P188_A0.6390.25
175_V467_Q0.6360.25
95_A303_K0.6340.25
408_D412_Y0.6320.25
190_L257_I0.6320.25
265_V285_K0.6300.25
95_A98_T0.6300.25
184_M471_N0.6300.25
54_D277_E0.6290.25
92_E298_I0.6290.25
58_H465_P0.6280.25
22_Y309_G0.6270.25
331_S335_V0.6260.25
194_Q442_Q0.6260.25
166_L215_E0.6260.25
345_D401_F0.6250.25
373_I442_Q0.6250.25
339_T368_V0.6240.25
10_I42_K0.6240.25
318_I389_A0.6230.25
100_G233_R0.6220.25
72_G90_M0.6210.25
228_V403_S0.6210.25
313_L426_I0.6200.24
80_T322_E0.6190.24
103_G150_H0.6180.24
190_L235_S0.6180.24
225_T250_R0.6170.24
149_T192_A0.6150.24
26_K48_Y0.6140.24
229_K404_E0.6140.24
26_K402_D0.6140.24
106_P255_D0.6110.24
160_S319_N0.6110.24
292_T296_V0.6110.24
288_F452_D0.6100.24
196_G256_S0.6100.24
22_Y27_I0.6100.24
400_A429_L0.6100.24
37_F207_P0.6090.24
339_T342_A0.6090.24
50_L93_H0.6060.24
21_W229_K0.6060.24
25_E82_N0.6060.24
134_I458_S0.6050.24
349_N407_E0.6040.24
103_G445_Y0.6040.24
192_A195_G0.6020.24
8_E417_N0.6020.24
135_L471_N0.6020.24
19_E467_Q0.6000.23
88_R342_A0.6000.23
268_N475_T0.6000.23
13_L434_T0.6000.23
201_I230_F0.6000.23
339_T343_L0.6000.23
12_R15_K0.5990.23
104_R253_E0.5980.23
186_H215_E0.5970.23
406_R420_A0.5970.23
183_L274_D0.5970.23
214_D378_P0.5960.23
115_S119_S0.5960.23
445_Y449_F0.5950.23
19_E31_I0.5940.23
44_K424_V0.5940.23
5_N17_E0.5920.23
103_G255_D0.5920.23
222_P271_F0.5910.23
95_A295_Q0.5910.23
72_G271_F0.5900.23
243_F249_S0.5900.23
109_M150_H0.5880.23
431_W441_R0.5880.23
33_E410_D0.5880.23
189_R449_F0.5880.23
62_Y73_L0.5880.23
5_N12_R0.5870.23
122_L272_F0.5860.23
75_Y138_Y0.5860.23
77_Q112_V0.5850.23
253_E446_E0.5840.23
58_H405_I0.5830.23
98_T177_D0.5830.23
127_E275_N0.5830.23
224_N316_D0.5820.23
311_A342_A0.5820.23
237_V428_R0.5810.22
11_D180_E0.5810.22
312_Q315_V0.5800.22
323_Y452_D0.5800.22
234_E473_I0.5790.22
183_L262_H0.5790.22
145_D200_E0.5760.22
294_H361_P0.5760.22
141_A146_L0.5750.22
173_A217_Y0.5750.22
78_P380_F0.5750.22
50_L422_E0.5750.22
8_E261_D0.5750.22
379_R411_Q0.5740.22
179_T186_H0.5740.22
13_L250_R0.5740.22
455_R459_R0.5730.22
38_K235_S0.5730.22
250_R424_V0.5720.22
104_R107_D0.5720.22
43_T409_L0.5720.22
156_Q159_R0.5710.22
137_M203_V0.5710.22
262_H383_I0.5700.22
57_I86_K0.5700.22
221_I263_V0.5700.22
27_I322_E0.5690.22
327_Q331_S0.5680.22
143_K384_I0.5680.22
27_I33_E0.5680.22
127_E409_L0.5670.22
155_P233_R0.5670.22
14_N38_K0.5670.22
10_I467_Q0.5660.22
137_M345_D0.5650.22
303_K445_Y0.5650.22
190_L409_L0.5640.22
188_A265_V0.5640.22
242_S265_V0.5630.22
397_T400_A0.5620.22
80_T121_E0.5620.22
59_E89_T0.5610.22
320_V380_F0.5610.22
370_S374_P0.5610.22
48_Y147_S0.5610.22
428_R450_F0.5610.22
179_T407_E0.5610.22
345_D349_N0.5600.21
244_N432_D0.5600.21
292_T295_Q0.5590.21
96_R305_E0.5590.21
107_D232_T0.5580.21
192_A258_V0.5580.21
74_S110_N0.5580.21
356_F477_L0.5580.21
311_A384_I0.5570.21
106_P431_W0.5570.21
35_P214_D0.5560.21
255_D441_R0.5560.21
64_L69_N0.5550.21
88_R298_I0.5540.21
79_K177_D0.5540.21
368_V458_S0.5530.21
115_S202_L0.5520.21
434_T443_T0.5520.21
177_D264_L0.5520.21
377_Y440_T0.5520.21
151_T203_V0.5510.21
188_A259_V0.5500.21
156_Q160_S0.5500.21
21_W26_K0.5500.21
121_E229_K0.5490.21
12_R194_Q0.5490.21
83_D419_N0.5490.21
26_K175_V0.5480.21
253_E445_Y0.5470.21
365_P382_E0.5470.21
402_D407_E0.5460.21
352_Q363_L0.5440.21
311_A330_L0.5430.21
173_A430_A0.5430.21
20_I135_L0.5420.21
75_Y412_Y0.5420.21
27_I471_N0.5420.21
59_E93_H0.5420.21
43_T97_H0.5420.21
38_K53_K0.5410.21
313_L331_S0.5390.20
258_V408_D0.5390.20
203_V427_F0.5380.20
18_N223_S0.5380.20
215_E268_N0.5380.20
122_L439_G0.5370.20
58_H124_K0.5370.20
22_Y43_T0.5370.20
9_F265_V0.5360.20
103_G106_P0.5360.20
243_F425_K0.5350.20
106_P110_N0.5350.20
277_E335_V0.5340.20
179_T267_W0.5340.20
390_S413_L0.5340.20
318_I413_L0.5340.20
268_N285_K0.5340.20
119_S291_F0.5330.20
32_S316_D0.5330.20
268_N351_A0.5320.20
135_L139_E0.5310.20
143_K327_Q0.5310.20
23_D400_A0.5310.20
333_I380_F0.5300.20
330_L395_L0.5300.20
82_N259_V0.5300.20
174_K416_T0.5290.20
174_K419_N0.5290.20
350_D365_P0.5280.20
31_I41_I0.5270.20
103_G191_L0.5260.20
5_N32_S0.5260.20
41_I254_M0.5240.20
330_L470_L0.5240.20
231_I261_D0.5230.20
334_I466_K0.5230.20
186_H229_K0.5220.20
158_N165_G0.5220.20
163_Y170_P0.5220.20
221_I407_E0.5220.20
229_K261_D0.5210.20
60_M474_K0.5210.20
23_D330_L0.5210.20
235_S261_D0.5200.20
34_H50_L0.5200.20
365_P388_G0.5200.20
82_N404_E0.5190.20
104_R233_R0.5190.20
26_K177_D0.5190.20
179_T226_K0.5190.20
70_R86_K0.5190.20
228_V260_F0.5180.20
195_G258_V0.5180.20
104_R446_E0.5170.19
341_K344_I0.5160.19
426_I475_T0.5150.19
208_K293_F0.5150.19
25_E35_P0.5140.19
213_T474_K0.5140.19
37_F254_M0.5140.19
352_Q355_E0.5130.19
11_D89_T0.5130.19
27_I46_S0.5120.19
260_F277_E0.5110.19
100_G432_D0.5110.19
377_Y385_Q0.5100.19
82_N353_L0.5090.19
50_L97_H0.5090.19
428_R431_W0.5090.19
37_F80_T0.5090.19
146_L269_R0.5080.19
287_S291_F0.5080.19
163_Y172_S0.5080.19
228_V347_S0.5060.19
174_K422_E0.5060.19
180_E268_N0.5060.19
325_H388_G0.5060.19
145_D396_P0.5050.19
8_E82_N0.5050.19
222_P263_V0.5040.19
59_E73_L0.5040.19
330_L355_E0.5030.19
311_A315_V0.5030.19
94_W383_I0.5030.19
330_L362_C0.5030.19
321_S474_K0.5020.19
178_R268_N0.5020.19
313_L429_L0.5010.19
381_T388_G0.5010.19
435_M444_H0.5010.19
129_C267_W0.5010.19
282_F288_F0.5000.19
63_C143_K0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3hwcA 4 0.9752 100 0.482 Contact Map
4g5eA 4 0.9524 100 0.485 Contact Map
4oo2A 4 0.9814 100 0.504 Contact Map
2yykA 3 0.971 100 0.505 Contact Map
1u8vA 3 0.9731 100 0.515 Contact Map
1ukwA 4 0.7308 99.8 0.893 Contact Map
4l1fA 4 0.7329 99.7 0.896 Contact Map
3r7kA 4 0.7391 99.7 0.896 Contact Map
5af7A 4 0.735 99.7 0.897 Contact Map
2pg0A 4 0.7495 99.7 0.897 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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