GREMLIN Database
YKON - Uncharacterized glycosyltransferase YkoN
UniProt: C0SPB9 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (329)
Sequences: 18842 (15588)
Seq/√Len: 859.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
306_L312_V2.9971.00
339_E342_K2.9941.00
26_E29_S2.8751.00
274_P291_I2.8641.00
337_M341_K2.7101.00
96_R124_E2.6051.00
290_F330_F2.5491.00
26_E30_Q2.4801.00
329_A336_Q2.4681.00
291_I303_L2.4401.00
307_H314_D2.3741.00
304_N308_E2.3491.00
313_T329_A2.3041.00
324_E328_A2.2661.00
270_I282_C2.2571.00
26_E354_R2.2431.00
339_E343_H2.1391.00
35_E102_K2.0901.00
329_A333_S2.0781.00
282_C289_V2.0621.00
97_H101_E2.0591.00
343_H346_G2.0561.00
237_Y241_K2.0561.00
338_K342_K2.0181.00
213_K217_E2.0041.00
293_H296_P1.9911.00
109_C130_V1.9731.00
216_Q219_S1.9651.00
213_K216_Q1.9451.00
344_V348_L1.9361.00
328_A332_Q1.9221.00
313_T326_Y1.8651.00
351_M355_K1.8461.00
196_P225_L1.8181.00
322_K326_Y1.8081.00
272_T289_V1.8071.00
279_I306_L1.7821.00
198_T225_L1.7721.00
100_Q126_P1.7311.00
316_R319_D1.7041.00
215_V218_L1.7031.00
154_P159_K1.6971.00
47_L51_S1.6971.00
187_S190_T1.6921.00
336_Q339_E1.6801.00
236_L239_Y1.6741.00
340_Y343_H1.6691.00
259_E262_R1.6651.00
215_V219_S1.6601.00
265_E285_K1.6531.00
270_I278_T1.6411.00
217_E220_P1.6331.00
341_K344_V1.6261.00
236_L240_V1.6201.00
254_L257_K1.6101.00
194_H225_L1.5921.00
217_E320_M1.5821.00
155_S159_K1.5691.00
154_P158_V1.5591.00
342_K346_G1.5551.00
199_I271_M1.5401.00
96_R126_P1.5081.00
156_T159_K1.5021.00
216_Q220_P1.5011.00
270_I287_L1.4991.00
304_N307_H1.4981.00
26_E353_D1.4961.00
212_L216_Q1.4951.00
333_S336_Q1.4821.00
40_F43_S1.4791.00
320_M324_E1.4691.00
211_I217_E1.4641.00
94_Q97_H1.4631.00
290_F326_Y1.4501.00
154_P160_K1.4451.00
335_E338_K1.4441.00
153_V159_K1.4361.00
313_T336_Q1.4341.00
269_G330_F1.4141.00
227_K263_L1.3941.00
211_I215_V1.3921.00
351_M354_R1.3921.00
269_G327_I1.3901.00
188_A192_Q1.3741.00
7_F24_Q1.3651.00
84_Y88_E1.3641.00
188_A191_L1.3621.00
336_Q340_Y1.3621.00
222_G328_A1.3541.00
200_I267_A1.3381.00
107_A122_K1.3281.00
81_D85_F1.3271.00
156_T160_K1.3221.00
35_E58_W1.3211.00
153_V158_V1.3071.00
225_L252_P1.2981.00
147_N150_Y1.2911.00
334_N338_K1.2831.00
214_W218_L1.2761.00
153_V156_T1.2751.00
96_R100_Q1.2681.00
68_G72_L1.2651.00
15_G19_V1.2591.00
187_S191_L1.2501.00
305_L308_E1.2471.00
196_P223_K1.2351.00
335_E339_E1.2321.00
155_S160_K1.2291.00
49_K54_A1.2271.00
211_I214_W1.2261.00
155_S158_V1.2261.00
286_R345_N1.2211.00
240_V244_H1.2191.00
307_H313_T1.2161.00
87_Y91_F1.2121.00
67_S70_Y1.2031.00
150_Y173_Y1.2031.00
326_Y329_A1.2001.00
70_Y73_L1.1991.00
313_T330_F1.1961.00
115_S118_L1.1941.00
306_L311_L1.1931.00
148_I152_F1.1811.00
42_H46_R1.1661.00
212_L217_E1.1651.00
180_H183_F1.1651.00
42_H45_R1.1561.00
211_I216_Q1.1511.00
343_H347_Y1.1481.00
35_E56_L1.1461.00
138_F141_Q1.1401.00
336_Q343_H1.1401.00
240_V243_L1.1371.00
334_N337_M1.1351.00
229_L257_K1.1321.00
197_Y268_T1.1281.00
300_E304_N1.1241.00
97_H100_Q1.1191.00
200_I229_L1.1191.00
122_K130_V1.1181.00
224_I328_A1.1171.00
322_K325_E1.1161.00
214_W219_S1.1141.00
189_D193_H1.1101.00
300_E316_R1.1071.00
220_P324_E1.1071.00
84_Y87_Y1.1041.00
174_L177_I1.1011.00
50_L55_Y1.1001.00
67_S71_R1.0961.00
238_S241_K1.0871.00
310_K339_E1.0841.00
325_E329_A1.0801.00
83_R87_Y1.0791.00
83_R86_M1.0781.00
239_Y243_L1.0771.00
121_L126_P1.0751.00
69_I73_L1.0721.00
25_A55_Y1.0701.00
66_Y70_Y1.0691.00
341_K345_N1.0671.00
32_L37_I1.0611.00
7_F20_A1.0611.00
14_T18_H1.0601.00
345_N348_L1.0541.00
70_Y74_A1.0461.00
185_M189_D1.0451.00
82_K85_F1.0431.00
6_I24_Q1.0391.00
68_G71_R1.0371.00
106_I131_V1.0361.00
330_F336_Q1.0271.00
48_E52_S1.0241.00
41_S44_Y1.0221.00
228_I231_G1.0201.00
237_Y244_H1.0201.00
32_L35_E1.0161.00
93_Q97_H1.0151.00
175_T178_P1.0131.00
342_K345_N1.0121.00
199_I269_G1.0111.00
232_R255_H1.0081.00
173_Y176_G1.0061.00
85_F89_W1.0051.00
43_S46_R1.0021.00
60_Q63_P0.9981.00
147_N151_H0.9921.00
198_T227_K0.9921.00
186_E190_T0.9911.00
49_K52_S0.9911.00
214_W217_E0.9911.00
286_R344_V0.9911.00
237_Y240_V0.9901.00
44_Y47_L0.9891.00
290_F313_T0.9891.00
185_M188_A0.9881.00
345_N349_G0.9841.00
18_H256_S0.9841.00
216_Q320_M0.9831.00
30_Q354_R0.9771.00
311_L343_H0.9771.00
291_I306_L0.9701.00
200_I263_L0.9591.00
50_L53_V0.9541.00
338_K341_K0.9481.00
40_F46_R0.9441.00
186_E189_D0.9431.00
337_M343_H0.9421.00
200_I259_E0.9411.00
150_Y154_P0.9411.00
283_L311_L0.9401.00
218_L324_E0.9401.00
131_V152_F0.9361.00
349_G355_K0.9331.00
315_M326_Y0.9301.00
40_F45_R0.9301.00
209_G213_K0.9281.00
219_S226_Y0.9261.00
25_A28_E0.9261.00
188_A193_H0.9251.00
211_I219_S0.9211.00
304_N314_D0.9211.00
198_T267_A0.9201.00
305_L309_R0.9201.00
71_R74_A0.9151.00
291_I312_V0.9141.00
43_S47_L0.9111.00
171_N175_T0.9111.00
143_W147_N0.9111.00
197_Y331_F0.9101.00
20_A36_K0.9071.00
51_S56_L0.9041.00
143_W146_K0.9031.00
173_Y177_I0.9021.00
157_E160_K0.8991.00
41_S47_L0.8961.00
51_S54_A0.8961.00
213_K218_L0.8941.00
151_H154_P0.8921.00
227_K252_P0.8891.00
193_H225_L0.8871.00
54_A58_W0.8871.00
212_L218_L0.8851.00
25_A29_S0.8851.00
271_M292_Y0.8841.00
49_K53_V0.8821.00
44_Y48_E0.8821.00
91_F94_Q0.8801.00
188_A266_Q0.8761.00
289_V312_V0.8761.00
40_F44_Y0.8701.00
69_I72_L0.8701.00
321_Q325_E0.8691.00
13_S206_M0.8681.00
154_P157_E0.8651.00
55_Y58_W0.8601.00
24_Q55_Y0.8581.00
303_L314_D0.8571.00
66_Y69_I0.8541.00
33_A56_L0.8541.00
107_A128_L0.8491.00
5_L27_L0.8491.00
143_W151_H0.8491.00
25_A53_V0.8471.00
50_L54_A0.8461.00
53_V57_K0.8461.00
279_I302_N0.8411.00
271_M323_A0.8371.00
123_P147_N0.8331.00
68_G73_L0.8331.00
114_P117_L0.8301.00
16_H110_T0.8291.00
51_S57_K0.8291.00
319_D322_K0.8281.00
189_D192_Q0.8281.00
336_Q344_V0.8251.00
168_D171_N0.8251.00
149_D152_F0.8201.00
212_L215_V0.8181.00
190_T193_H0.8171.00
279_I289_V0.8161.00
21_D25_A0.8161.00
152_F175_T0.8141.00
6_I37_I0.8131.00
5_L32_L0.8131.00
58_W101_E0.8111.00
211_I218_L0.8091.00
27_L34_A0.8081.00
47_L57_K0.8061.00
179_V182_N0.8021.00
85_F88_E0.7991.00
313_T316_R0.7931.00
244_H248_I0.7901.00
340_Y344_V0.7881.00
210_G317_N0.7851.00
28_E34_A0.7801.00
188_A194_H0.7791.00
75_C78_F0.7791.00
41_S45_R0.7771.00
54_A60_Q0.7771.00
147_N152_F0.7751.00
5_L8_P0.7741.00
299_E302_N0.7741.00
98_I101_E0.7711.00
19_V277_V0.7681.00
145_R148_I0.7681.00
199_I224_I0.7671.00
274_P303_L0.7631.00
236_L244_H0.7631.00
95_M99_L0.7621.00
257_K263_L0.7611.00
337_M340_Y0.7601.00
81_D84_Y0.7591.00
239_Y242_S0.7591.00
25_A182_N0.7561.00
236_L243_L0.7561.00
236_L241_K0.7511.00
67_S73_L0.7491.00
27_L32_L0.7451.00
6_I104_P0.7441.00
148_I151_H0.7421.00
32_L105_D0.7411.00
286_R340_Y0.7391.00
173_Y355_K0.7371.00
32_L36_K0.7351.00
198_T266_Q0.7351.00
212_L219_S0.7351.00
144_G151_H0.7341.00
301_M304_N0.7311.00
284_Q348_L0.7291.00
41_S48_E0.7271.00
310_K343_H0.7271.00
184_E190_T0.7251.00
107_A110_T0.7251.00
22_A25_A0.7201.00
179_V284_Q0.7171.00
272_T278_T0.7171.00
202_T278_T0.7161.00
92_T96_R0.7151.00
28_E55_Y0.7141.00
350_E355_K0.7141.00
52_S55_Y0.7131.00
337_M344_V0.7111.00
248_I251_I0.7091.00
51_S55_Y0.6981.00
251_I254_L0.6961.00
68_G74_A0.6961.00
22_A180_H0.6951.00
235_K240_V0.6911.00
61_Y64_K0.6901.00
264_Y270_I0.6901.00
65_T69_I0.6901.00
212_L220_P0.6901.00
199_I226_Y0.6891.00
144_G147_N0.6851.00
31_G34_A0.6831.00
267_A287_L0.6821.00
289_V306_L0.6821.00
86_M90_L0.6811.00
211_I220_P0.6811.00
52_S58_W0.6791.00
150_Y153_V0.6761.00
49_K57_K0.6761.00
145_R149_D0.6751.00
241_K244_H0.6701.00
54_A57_K0.6681.00
93_Q96_R0.6681.00
5_L106_I0.6681.00
41_S46_R0.6671.00
59_I62_F0.6641.00
200_I264_Y0.6631.00
325_E328_A0.6601.00
50_L57_K0.6601.00
55_Y59_I0.6581.00
201_I226_Y0.6561.00
83_R88_E0.6541.00
82_K87_Y0.6541.00
223_K328_A0.6511.00
264_Y287_L0.6501.00
224_I331_F0.6431.00
50_L56_L0.6421.00
259_E281_E0.6391.00
178_P182_N0.6381.00
53_V58_W0.6371.00
48_E51_S0.6361.00
153_V160_K0.6351.00
146_K149_D0.6341.00
53_V56_L0.6241.00
213_K320_M0.6221.00
273_K299_E0.6201.00
216_Q243_L0.6181.00
29_S181_Q0.6171.00
82_K86_M0.6171.00
171_N177_I0.6171.00
65_T73_L0.6161.00
37_I98_I0.6151.00
77_E81_D0.6151.00
282_C291_I0.6141.00
86_M89_W0.6141.00
224_I332_Q0.6121.00
24_Q34_A0.6111.00
6_I99_L0.6091.00
153_V157_E0.6081.00
283_L306_L0.6071.00
262_R266_Q0.6061.00
92_T98_I0.6051.00
143_W152_F0.6001.00
66_Y73_L0.5991.00
344_V347_Y0.5961.00
22_A26_E0.5931.00
94_Q99_L0.5931.00
202_T229_L0.5921.00
151_H156_T0.5921.00
149_D155_S0.5911.00
92_T124_E0.5911.00
150_Y155_S0.5911.00
197_Y334_N0.5901.00
184_E188_A0.5891.00
146_K150_Y0.5861.00
149_D153_V0.5851.00
200_I257_K0.5831.00
51_S58_W0.5811.00
87_Y90_L0.5801.00
226_Y229_L0.5741.00
35_E104_P0.5731.00
98_I102_K0.5721.00
212_L239_Y0.5701.00
237_Y255_H0.5691.00
58_W102_K0.5651.00
33_A102_K0.5631.00
142_L145_R0.5611.00
66_Y74_A0.5611.00
64_K68_G0.5571.00
69_I74_A0.5571.00
193_H198_T0.5561.00
23_L110_T0.5541.00
7_F27_L0.5531.00
94_Q98_I0.5531.00
144_G150_Y0.5521.00
95_M98_I0.5511.00
7_F108_F0.5501.00
143_W150_Y0.5501.00
238_S242_S0.5491.00
283_L344_V0.5481.00
237_Y243_L0.5471.00
192_Q266_Q0.5471.00
290_F315_M0.5461.00
88_E94_Q0.5431.00
10_L20_A0.5431.00
23_L178_P0.5371.00
42_H47_L0.5371.00
174_L178_P0.5351.00
276_G280_S0.5341.00
190_T225_L0.5341.00
92_T95_M0.5331.00
283_L340_Y0.5321.00
201_I271_M0.5311.00
272_T291_I0.5301.00
145_R151_H0.5291.00
277_V281_E0.5291.00
184_E187_S0.5291.00
272_T282_C0.5281.00
100_Q124_E0.5281.00
179_V183_F0.5281.00
59_I63_P0.5281.00
269_G290_F0.5271.00
286_R341_K0.5261.00
131_V150_Y0.5251.00
89_W93_Q0.5241.00
37_I95_M0.5241.00
269_G337_M0.5221.00
133_V137_F0.5211.00
42_H48_E0.5211.00
55_Y60_Q0.5211.00
66_Y72_L0.5191.00
187_S193_H0.5191.00
239_Y244_H0.5161.00
222_G226_Y0.5151.00
67_S74_A0.5141.00
196_P250_A0.5121.00
90_L94_Q0.5111.00
131_V134_Y0.5101.00
113_L116_Y0.5101.00
213_K219_S0.5101.00
272_T279_I0.5081.00
287_L337_M0.5081.00
59_I64_K0.5071.00
213_K220_P0.5051.00
46_R50_L0.5051.00
77_E82_K0.5041.00
143_W149_D0.5011.00
20_A110_T0.5011.00
93_Q99_L0.5001.00
195_P198_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iyaA 1 0.9142 100 0.384 Contact Map
2vchA 1 0.9517 100 0.386 Contact Map
3rscA 1 0.9223 100 0.39 Contact Map
2pq6A 1 0.8874 100 0.391 Contact Map
2iyfA 1 0.9169 100 0.397 Contact Map
3ia7A 2 0.9142 100 0.401 Contact Map
2p6pA 2 0.9142 100 0.406 Contact Map
2c1xA 1 0.9303 100 0.408 Contact Map
1rrvA 1 0.8981 100 0.415 Contact Map
3hbfA 1 0.9303 100 0.417 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0107 seconds.