GREMLIN Database
SSBB - Single-stranded DNA-binding protein B
UniProt: C0SPB6 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 113 (106)
Sequences: 4973 (2678)
Seq/√Len: 260.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_N88_V2.6081.00
19_Y25_A2.6081.00
83_E89_N2.5541.00
12_T48_Y2.3591.00
51_C97_A2.3071.00
80_R94_E2.2631.00
24_A55_R2.1981.00
81_S89_N2.1701.00
80_R92_V2.1031.00
4_Q74_S2.0721.00
84_N90_V2.0571.00
70_L104_D1.7791.00
11_L65_C1.7761.00
33_V49_V1.7501.00
53_L61_T1.7091.00
14_D66_Q1.6951.00
29_V51_C1.6751.00
20_T54_W1.6401.00
10_R70_L1.6101.00
82_Y92_V1.5921.00
2_F6_M1.5821.00
29_V53_L1.5601.00
13_K30_T1.5481.00
61_T65_C1.5021.00
56_K59_E1.3461.00
17_L62_A1.3271.00
65_C71_V1.3081.00
30_T50_N1.3041.00
2_F72_G1.3021.00
17_L27_A1.2821.00
52_T94_E1.2811.00
35_R76_R1.2741.00
35_R47_D1.2581.00
8_V72_G1.2491.00
69_S104_D1.2451.00
20_T26_V1.2451.00
53_L97_A1.2421.00
8_V103_M1.2361.00
74_S99_T1.2361.00
76_R98_D1.2201.00
78_Q96_L1.2011.00
34_N44_I1.1781.00
7_L31_L1.1741.00
79_T93_T1.1721.00
25_A59_E1.1291.00
83_E87_G1.1271.00
97_A100_V1.1221.00
10_R34_N1.1061.00
50_N92_V1.1021.00
45_E78_Q1.0921.00
39_N43_E1.0861.00
66_Q69_S1.0701.00
60_N102_F1.0681.00
35_R45_E1.0551.00
12_T30_T1.0381.00
15_P61_T1.0381.00
15_P27_A1.0291.00
47_D79_T1.0241.00
61_T100_V1.0211.00
49_V95_V1.0191.00
7_L95_V1.0161.00
76_R96_L0.9981.00
64_Y102_F0.9921.00
5_V77_I0.9851.00
70_L101_R0.9831.00
77_I95_V0.9791.00
5_V95_V0.9691.00
53_L57_T0.9591.00
79_T91_Y0.9501.00
11_L15_P0.9171.00
18_R26_V0.9151.00
60_N100_V0.9141.00
26_V54_W0.9141.00
34_N46_A0.8911.00
2_F101_R0.8901.00
2_F8_V0.8801.00
57_T60_N0.8741.00
18_R28_H0.8721.00
38_K42_G0.8561.00
31_L71_V0.8551.00
20_T24_A0.8551.00
13_K50_N0.8350.99
25_A62_A0.8240.99
69_S102_F0.8160.99
50_N91_Y0.8160.99
49_V93_T0.8060.99
28_H80_R0.8000.99
53_L100_V0.7990.99
49_V79_T0.7980.99
52_T80_R0.7930.99
13_K16_D0.7850.99
82_Y91_Y0.7730.99
32_A46_A0.7690.99
6_M72_G0.7680.99
59_E63_L0.7570.99
4_Q98_D0.7520.99
82_Y90_V0.7480.99
36_S44_I0.7470.99
38_K44_I0.7400.99
60_N64_Y0.7390.99
56_K60_N0.7250.98
37_F44_I0.7240.98
24_A54_W0.7150.98
17_L25_A0.7150.98
70_L103_M0.7080.98
40_A43_E0.6990.98
61_T71_V0.6980.98
28_H50_N0.6950.98
14_D67_K0.6890.98
20_T23_G0.6880.98
57_T100_V0.6870.98
39_N44_I0.6810.98
72_G103_M0.6790.98
47_D78_Q0.6760.97
54_W96_L0.6720.97
82_Y85_E0.6670.97
27_A62_A0.6640.97
39_N45_E0.6620.97
33_V47_D0.6560.97
28_H52_T0.6510.97
65_C102_F0.6490.97
6_M74_S0.6400.96
7_L33_V0.6390.96
19_Y63_L0.6380.96
25_A58_A0.6220.96
104_D107_P0.6210.96
8_V70_L0.6200.96
53_L58_A0.6190.96
77_I93_T0.6060.95
29_V97_A0.6010.95
39_N42_G0.6010.95
5_V93_T0.5920.95
69_S107_P0.5870.94
29_V61_T0.5780.94
52_T78_Q0.5770.94
37_F45_E0.5760.94
35_R98_D0.5700.93
37_F42_G0.5640.93
82_Y94_E0.5610.93
51_C73_V0.5590.93
4_Q99_T0.5540.92
16_D28_H0.5500.92
65_C69_S0.5490.92
27_A61_T0.5470.92
85_E88_V0.5450.92
28_H94_E0.5390.91
59_E62_A0.5280.91
57_T97_A0.5280.91
7_L49_V0.5250.90
81_S91_Y0.5190.90
74_S98_D0.5180.90
21_S24_A0.5170.90
4_Q72_G0.5130.89
2_F70_L0.5120.89
31_L73_V0.5110.89
70_L105_P0.5060.89
52_T96_L0.5040.88
34_N45_E0.5030.88
32_A48_Y0.5000.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z9fA 4 0.7611 100 0.136 Contact Map
3vdyA 3 0.8938 100 0.141 Contact Map
2vw9A 3 0.9381 100 0.146 Contact Map
3lgjA 2 0.7965 100 0.167 Contact Map
4mz9A 4 0.9292 100 0.168 Contact Map
1se8A 2 0.9027 100 0.17 Contact Map
3tqyA 4 0.9204 100 0.177 Contact Map
3ullA 3 0.8938 100 0.182 Contact Map
3pgzA 2 0.9204 100 0.185 Contact Map
3ulpA 4 0.9204 100 0.194 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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