GREMLIN Database
YHAQ - Uncharacterized ABC transporter ATP-binding protein YhaQ
UniProt: C0SPB4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 298 (230)
Sequences: 105120 (62045)
Seq/√Len: 4091.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_Q198_N3.5041.00
72_K149_E3.1101.00
15_K18_D3.0841.00
3_T23_D3.0421.00
6_H19_G2.9751.00
198_N210_Q2.9181.00
5_D57_S2.8731.00
30_F200_C2.8421.00
122_Y125_K2.7131.00
57_S64_P2.6781.00
31_G196_C2.6701.00
25_P28_Q2.6351.00
10_T15_K2.5091.00
3_T59_S2.4551.00
18_D206_K2.3571.00
212_K215_E2.3181.00
211_G215_E2.2851.00
8_T15_K2.2611.00
8_T55_E2.2501.00
5_D59_S2.1921.00
8_T19_G2.1571.00
9_K46_M2.1161.00
200_C210_Q2.0531.00
200_C207_P1.9951.00
4_I7_V1.9661.00
61_K149_E1.9621.00
102_E105_E1.9531.00
26_E149_E1.8411.00
111_G123_E1.7751.00
109_E147_K1.7711.00
111_G119_I1.7611.00
147_K180_V1.7361.00
88_V130_L1.7271.00
116_R178_S1.7091.00
173_I194_E1.6671.00
44_F152_I1.6661.00
89_R93_V1.6481.00
44_F185_S1.6311.00
89_R123_E1.6041.00
186_S192_V1.6011.00
193_E214_K1.5491.00
89_R124_N1.5441.00
11_F42_T1.5311.00
111_G115_E1.5231.00
125_K129_E1.5211.00
22_L200_C1.5101.00
11_F16_A1.5031.00
109_E112_T1.4961.00
107_V111_G1.4621.00
211_G216_I1.4541.00
9_K51_L1.4541.00
6_H21_D1.4481.00
9_K54_T1.4211.00
112_T116_R1.4181.00
28_Q197_E1.4181.00
64_P67_Y1.4001.00
115_E120_T1.3841.00
220_F224_N1.3681.00
61_K72_K1.3661.00
24_I30_F1.3601.00
8_T18_D1.3571.00
114_L123_E1.3561.00
4_I22_L1.3451.00
10_T54_T1.3411.00
93_V106_A1.3381.00
30_F210_Q1.3181.00
49_G52_S1.3021.00
85_K90_D1.2751.00
7_V53_I1.2681.00
59_S64_P1.2621.00
30_F198_N1.2441.00
25_P198_N1.2291.00
87_K90_D1.2121.00
203_Q208_V1.2121.00
20_L43_T1.2041.00
224_N228_H1.1981.00
4_I47_I1.1971.00
31_G192_V1.1961.00
113_W145_L1.1951.00
215_E219_S1.1941.00
17_V46_M1.1811.00
22_L43_T1.1781.00
29_M176_K1.1671.00
175_L180_V1.1591.00
10_T13_D1.1501.00
209_V219_S1.1471.00
5_D23_D1.1461.00
63_R68_H1.1451.00
91_Q142_S1.1171.00
48_L75_Y1.1161.00
32_L43_T1.1161.00
213_L223_K1.1151.00
147_K178_S1.1031.00
222_K225_V1.0971.00
29_M196_C1.0921.00
169_K191_H1.0811.00
93_V110_L1.0741.00
108_K112_T1.0731.00
74_G148_P1.0651.00
103_K107_V1.0631.00
46_M53_I1.0601.00
29_M184_F1.0591.00
166_E170_E1.0501.00
105_E108_K1.0451.00
160_L168_L1.0321.00
26_E61_K1.0301.00
89_R107_V1.0241.00
122_Y130_L1.0211.00
43_T202_L1.0211.00
153_L182_I1.0211.00
92_L145_L1.0201.00
214_K218_R1.0181.00
78_E132_K1.0161.00
93_V107_V1.0131.00
102_E106_A1.0101.00
96_A100_G1.0101.00
223_K226_T1.0091.00
165_V188_R0.9841.00
165_V191_H0.9761.00
104_R108_K0.9751.00
112_T115_E0.9741.00
4_I43_T0.9731.00
29_M182_I0.9721.00
209_V220_F0.9701.00
89_R110_L0.9701.00
86_M90_D0.9671.00
5_D21_D0.9651.00
173_I176_K0.9581.00
45_R51_L0.9561.00
110_L113_W0.9561.00
151_L180_V0.9551.00
76_L153_L0.9431.00
113_W141_I0.9401.00
87_K124_N0.9401.00
199_L213_L0.9381.00
35_A203_Q0.9351.00
6_H55_E0.9321.00
103_K106_A0.9301.00
208_V222_K0.9271.00
106_A110_L0.9261.00
92_L114_L0.9261.00
176_K182_I0.9231.00
116_R174_S0.9181.00
32_L200_C0.9171.00
96_A99_K0.9121.00
47_I183_L0.9111.00
215_E218_R0.9071.00
9_K42_T0.9061.00
209_V221_G0.9051.00
105_E109_E0.8981.00
4_I58_I0.8911.00
90_D93_V0.8871.00
171_A174_S0.8851.00
32_L183_L0.8821.00
109_E113_W0.8751.00
89_R111_G0.8701.00
99_K146_H0.8701.00
74_G143_A0.8681.00
130_L138_I0.8661.00
113_W117_F0.8641.00
153_L172_V0.8631.00
63_R72_K0.8631.00
117_F141_I0.8631.00
151_L182_I0.8601.00
120_T123_E0.8501.00
96_A145_L0.8481.00
176_K197_E0.8451.00
127_V138_I0.8351.00
19_G206_K0.8331.00
155_E187_H0.8291.00
101_M105_E0.8281.00
48_L152_I0.8281.00
46_M58_I0.8271.00
52_S66_N0.8241.00
97_R106_A0.8191.00
118_N167_L0.8141.00
169_K194_E0.8121.00
7_V46_M0.8091.00
106_A111_G0.8081.00
87_K126_K0.7961.00
24_I183_L0.7961.00
88_V138_I0.7961.00
76_L140_F0.7921.00
207_P210_Q0.7871.00
224_N227_I0.7861.00
10_T16_A0.7851.00
122_Y134_N0.7821.00
102_E111_G0.7821.00
118_N121_D0.7791.00
170_E173_I0.7791.00
222_K226_T0.7771.00
82_L135_Q0.7721.00
107_V110_L0.7711.00
167_L170_E0.7711.00
38_A202_L0.7671.00
29_M173_I0.7671.00
17_V20_L0.7551.00
10_T18_D0.7521.00
149_E180_V0.7511.00
209_V216_I0.7501.00
96_A106_A0.7491.00
184_F196_C0.7461.00
193_E213_L0.7461.00
172_V182_I0.7441.00
225_V229_S0.7391.00
226_T230_D0.7361.00
76_L143_A0.7341.00
126_K129_E0.7331.00
24_I181_S0.7321.00
223_K227_I0.7311.00
157_F168_L0.7301.00
225_V228_H0.7271.00
53_I66_N0.7251.00
26_E179_G0.7221.00
57_S66_N0.7191.00
20_L207_P0.7181.00
105_E119_I0.7151.00
93_V97_R0.7151.00
193_E217_K0.7131.00
46_M51_L0.7121.00
51_L54_T0.7111.00
132_K137_K0.7101.00
80_R139_Q0.7101.00
152_I183_L0.7091.00
64_P68_H0.7081.00
86_M91_Q0.7061.00
85_K128_E0.7061.00
28_Q210_Q0.7051.00
213_L217_K0.7051.00
130_L134_N0.7031.00
25_P181_S0.6941.00
29_M195_L0.6931.00
30_F183_L0.6911.00
19_G55_E0.6891.00
2_L47_I0.6861.00
105_E114_L0.6851.00
203_Q227_I0.6831.00
69_I73_I0.6821.00
203_Q222_K0.6821.00
113_W116_R0.6801.00
2_L150_L0.6791.00
170_E174_S0.6761.00
36_N164_N0.6761.00
101_M106_A0.6721.00
95_L142_S0.6711.00
91_Q127_V0.6691.00
95_L99_K0.6681.00
33_L201_I0.6561.00
220_F223_K0.6551.00
47_I58_I0.6541.00
33_L189_M0.6501.00
209_V224_N0.6481.00
189_M217_K0.6431.00
150_L181_S0.6421.00
17_V43_T0.6321.00
115_E121_D0.6321.00
45_R50_L0.6311.00
173_I195_L0.6291.00
33_L192_V0.6271.00
15_K19_G0.6231.00
6_H9_K0.6231.00
114_L119_I0.6221.00
61_K150_L0.6211.00
59_S62_G0.6201.00
108_K111_G0.6161.00
87_K91_Q0.6141.00
89_R120_T0.6121.00
227_I230_D0.6091.00
23_D210_Q0.6081.00
107_V123_E0.6071.00
73_I150_L0.6071.00
2_L60_W0.6061.00
203_Q206_K0.6041.00
12_G15_K0.6001.00
9_K17_V0.5991.00
227_I231_D0.5981.00
170_E194_E0.5961.00
79_E135_Q0.5951.00
36_N155_E0.5941.00
111_G120_T0.5881.00
63_R67_Y0.5871.00
10_T55_E0.5871.00
112_T147_K0.5861.00
186_S191_H0.5841.00
100_G103_K0.5821.00
83_Y91_Q0.5821.00
48_L73_I0.5791.00
15_K55_E0.5771.00
196_C199_L0.5731.00
24_I150_L0.5711.00
96_A101_M0.5671.00
62_G65_V0.5671.00
61_K65_V0.5661.00
11_F51_L0.5661.00
10_T14_Y0.5641.00
74_G146_H0.5631.00
49_G66_N0.5631.00
192_V196_C0.5621.00
60_W150_L0.5621.00
46_M54_T0.5611.00
95_L98_L0.5611.00
101_M109_E0.5591.00
114_L117_F0.5551.00
220_F228_H0.5541.00
80_R135_Q0.5541.00
198_N212_K0.5511.00
164_N167_L0.5511.00
136_Q159_G0.5501.00
174_S178_S0.5471.00
150_L183_L0.5411.00
60_W72_K0.5401.00
113_W144_V0.5391.00
77_P80_R0.5371.00
14_Y204_K0.5361.00
118_N174_S0.5361.00
111_G121_D0.5351.00
191_H195_L0.5341.00
215_E221_G0.5341.00
27_Q181_S0.5271.00
188_R191_H0.5241.00
216_I225_V0.5231.00
18_D204_K0.5211.00
29_M197_E0.5211.00
131_S134_N0.5201.00
16_A42_T0.5201.00
201_I216_I0.5181.00
26_E181_S0.5171.00
47_I152_I0.5171.00
97_R103_K0.5141.00
92_L105_E0.5141.00
86_M94_Y0.5121.00
221_G226_T0.5121.00
57_S67_Y0.5101.00
3_T62_G0.5081.00
76_L139_Q0.5081.00
38_A204_K0.5071.00
41_T45_R0.5071.00
95_L146_H0.5061.00
157_F191_H0.5051.00
82_L127_V0.5041.00
92_L110_L0.5031.00
49_G53_I0.5031.00
190_E194_E0.5011.00
7_V58_I0.5011.00
217_K220_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.9128 100 0.113 Contact Map
3tuiC 2 1 100 0.159 Contact Map
4rvcA 4 0.7919 100 0.181 Contact Map
4u00A 1 0.7852 100 0.182 Contact Map
1v43A 2 0.9497 100 0.182 Contact Map
4ymuJ 2 0.7819 100 0.183 Contact Map
1vplA 2 0.7852 100 0.184 Contact Map
2oljA 2 0.7819 100 0.184 Contact Map
1g291 4 0.9899 100 0.186 Contact Map
1b0uA 2 0.7987 100 0.187 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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