GREMLIN Database
YTEP - Uncharacterized multiple-sugar transport system permease YteP
UniProt: C0SPB3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 321 (257)
Sequences: 68795 (43271)
Seq/√Len: 2699.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_R229_H4.0941.00
94_K98_V3.1101.00
202_L206_T2.9341.00
217_K226_Q2.9101.00
59_A80_F2.8031.00
91_L94_K2.5851.00
92_L276_Y2.5801.00
120_E213_Y2.5681.00
222_G225_R2.5321.00
213_Y231_T2.5301.00
216_A226_Q2.4811.00
102_L186_I2.4801.00
106_I190_I2.4311.00
78_K81_I2.3821.00
204_A238_V2.3721.00
90_F94_K2.3431.00
81_I85_T2.3291.00
104_L243_L2.3201.00
271_E279_T2.3191.00
224_L228_W2.2581.00
201_Y239_I2.2551.00
223_R226_Q2.2261.00
78_K82_R2.2241.00
112_I227_M2.0931.00
221_A225_R2.0631.00
225_R228_W2.0181.00
286_Q289_Y1.9991.00
205_I235_I1.9601.00
197_S242_L1.9331.00
119_N206_T1.9131.00
212_L234_A1.8701.00
216_A221_A1.8701.00
57_V61_Q1.8681.00
98_V182_R1.8411.00
112_I235_I1.7741.00
108_F243_L1.7671.00
217_K223_R1.7311.00
131_Q202_L1.7211.00
91_L95_N1.7191.00
100_F247_I1.7091.00
123_I126_F1.7021.00
111_P197_S1.6931.00
306_M310_R1.6801.00
213_Y226_Q1.6531.00
82_R289_Y1.6061.00
98_V102_L1.6031.00
182_R270_A1.6011.00
112_I201_Y1.5981.00
103_N250_T1.5871.00
118_L198_T1.5851.00
56_I295_V1.5831.00
114_L198_T1.5771.00
213_Y217_K1.5181.00
39_L43_I1.4741.00
210_P213_Y1.4491.00
264_A269_V1.4441.00
126_F129_F1.4191.00
76_G79_H1.3971.00
99_L272_I1.3961.00
82_R85_T1.3921.00
232_L239_I1.3871.00
197_S246_K1.3791.00
241_V245_L1.3781.00
115_A201_Y1.3761.00
77_L81_I1.3721.00
119_N202_L1.3661.00
205_I231_T1.3531.00
276_Y280_A1.3511.00
54_W58_I1.3381.00
123_I127_K1.3251.00
181_F270_A1.3181.00
51_V54_W1.3091.00
120_E210_P1.3071.00
255_F278_Y1.3051.00
107_F246_K1.2991.00
88_T91_L1.2961.00
201_Y242_L1.2851.00
216_A230_I1.2781.00
109_P113_L1.2671.00
122_R127_K1.2561.00
255_F259_Y1.2471.00
188_Q261_L1.2461.00
96_T273_F1.2331.00
262_L270_A1.2191.00
210_P214_E1.2181.00
153_L184_L1.2171.00
31_Q34_L1.2151.00
257_H261_L1.2141.00
112_I239_I1.2141.00
280_A286_Q1.1941.00
32_K36_L1.1941.00
280_A284_Q1.1911.00
116_L205_I1.1841.00
80_F295_V1.1801.00
222_G226_Q1.1791.00
265_T269_V1.1761.00
211_Q214_E1.1731.00
33_Y37_M1.1651.00
34_L38_I1.1641.00
102_L105_A1.1591.00
208_V234_A1.1581.00
43_I47_L1.1371.00
105_A109_P1.1351.00
281_G290_S1.1191.00
129_F132_T1.1121.00
201_Y238_V1.1061.00
65_P74_W1.1021.00
36_L40_P1.1021.00
108_F239_I1.0941.00
271_E276_Y1.0831.00
55_G295_V1.0801.00
95_N98_V1.0711.00
310_R313_K1.0671.00
236_K240_V1.0651.00
84_F90_F1.0621.00
129_F133_L1.0501.00
272_I275_T1.0481.00
234_A237_S1.0471.00
307_L311_L1.0451.00
62_D65_P1.0421.00
106_I186_I1.0371.00
154_T157_G1.0361.00
116_L227_M1.0341.00
213_Y223_R1.0301.00
183_P187_L1.0241.00
194_A198_T1.0241.00
103_N107_F1.0231.00
271_E275_T1.0221.00
182_R186_I1.0171.00
97_L101_A1.0151.00
93_L273_F1.0141.00
116_L223_R1.0121.00
186_I190_I1.0111.00
279_T283_K1.0061.00
102_L106_I1.0041.00
103_N189_V1.0031.00
200_I242_L1.0021.00
258_V272_I0.9941.00
276_Y293_V0.9861.00
221_A226_Q0.9801.00
119_N205_I0.9771.00
151_V155_V0.9701.00
226_Q229_H0.9671.00
185_Y258_V0.9661.00
30_Q34_L0.9591.00
54_W57_V0.9531.00
113_L117_L0.9501.00
33_Y36_L0.9491.00
89_F293_V0.9461.00
79_H288_S0.9461.00
127_K206_T0.9451.00
35_Y39_L0.9351.00
259_Y275_T0.9331.00
189_V250_T0.9291.00
204_A235_I0.9251.00
125_L128_K0.9201.00
83_L296_F0.9141.00
253_L257_H0.9111.00
36_L39_L0.9091.00
159_L183_P0.9091.00
101_A105_A0.9071.00
253_L258_V0.9061.00
31_Q35_Y0.9051.00
103_N186_I0.9041.00
98_V183_P0.9011.00
58_I291_T0.9001.00
82_R86_E0.8971.00
38_I42_C0.8971.00
46_L50_Y0.8941.00
95_N182_R0.8901.00
236_K239_I0.8871.00
71_G74_W0.8851.00
115_A119_N0.8841.00
149_S261_L0.8821.00
93_L97_L0.8791.00
227_M232_L0.8781.00
264_A270_A0.8761.00
99_L182_R0.8751.00
197_S201_Y0.8751.00
98_V101_A0.8751.00
105_A243_L0.8561.00
106_I109_P0.8541.00
307_L310_R0.8531.00
228_W232_L0.8521.00
118_L131_Q0.8521.00
235_I238_V0.8501.00
188_Q257_H0.8431.00
201_Y235_I0.8421.00
61_Q65_P0.8311.00
246_K250_T0.8311.00
111_P198_T0.8301.00
55_G294_G0.8291.00
58_I61_Q0.8281.00
115_A205_I0.8231.00
59_A63_Y0.8221.00
107_F111_P0.8221.00
289_Y293_V0.8141.00
60_F75_V0.8081.00
149_S188_Q0.8061.00
146_V260_L0.8061.00
276_Y279_T0.8041.00
128_K131_Q0.8031.00
280_A293_V0.8031.00
94_K97_L0.8021.00
135_Y199_I0.7991.00
99_L189_V0.7961.00
142_W192_R0.7951.00
208_V235_I0.7951.00
280_A289_Y0.7941.00
212_L230_I0.7911.00
303_I307_L0.7851.00
102_L190_I0.7811.00
86_E90_F0.7801.00
150_F154_T0.7741.00
82_R286_Q0.7721.00
226_Q231_T0.7661.00
60_F76_G0.7651.00
55_G291_T0.7641.00
115_A198_T0.7631.00
107_F193_E0.7591.00
223_R227_M0.7581.00
183_P186_I0.7571.00
96_T274_D0.7471.00
277_V293_V0.7451.00
118_L130_V0.7441.00
107_F197_S0.7381.00
92_L95_N0.7381.00
40_P43_I0.7301.00
108_F201_Y0.7291.00
210_P217_K0.7281.00
158_G161_N0.7281.00
308_A311_L0.7251.00
181_F184_L0.7251.00
227_M231_T0.7241.00
92_L273_F0.7241.00
81_I84_F0.7221.00
161_N264_A0.7211.00
253_L272_I0.7201.00
100_F104_L0.7171.00
201_Y205_I0.7171.00
184_L188_Q0.7141.00
104_L247_I0.7131.00
58_I62_D0.7081.00
265_T271_E0.7021.00
239_I242_L0.7021.00
291_T295_V0.7021.00
301_G305_V0.6981.00
114_L194_A0.6981.00
62_D73_E0.6981.00
118_L202_L0.6981.00
62_D74_W0.6971.00
273_F297_K0.6971.00
135_Y138_H0.6961.00
236_K311_L0.6941.00
75_V78_K0.6941.00
262_L271_E0.6901.00
142_W256_E0.6841.00
221_A229_H0.6841.00
65_P73_E0.6831.00
37_M40_P0.6821.00
104_L108_F0.6751.00
37_M41_G0.6751.00
256_E260_L0.6751.00
110_V194_A0.6751.00
193_E246_K0.6691.00
99_L185_Y0.6681.00
61_Q72_S0.6681.00
45_F49_K0.6671.00
80_F292_A0.6671.00
61_Q74_W0.6661.00
287_F291_T0.6641.00
215_A219_D0.6571.00
83_L289_Y0.6571.00
145_V191_W0.6571.00
35_Y38_I0.6541.00
90_F93_L0.6531.00
107_F250_T0.6521.00
87_P91_L0.6511.00
146_V256_E0.6511.00
42_C46_L0.6501.00
274_D297_K0.6491.00
288_S291_T0.6481.00
99_L186_I0.6481.00
278_Y282_L0.6471.00
287_F290_S0.6471.00
59_A292_A0.6461.00
193_E249_D0.6461.00
111_P201_Y0.6431.00
184_L261_L0.6421.00
200_I238_V0.6411.00
239_I243_L0.6391.00
238_V242_L0.6391.00
32_K35_Y0.6381.00
30_Q33_Y0.6361.00
231_T234_A0.6341.00
46_L49_K0.6311.00
126_F130_V0.6301.00
66_F69_I0.6301.00
258_V275_T0.6291.00
121_V127_K0.6281.00
117_L123_I0.6281.00
110_V190_I0.6241.00
79_H82_R0.6211.00
95_N270_A0.6211.00
185_Y262_L0.6161.00
114_L134_I0.6151.00
275_T279_T0.6131.00
87_P90_F0.6111.00
117_L121_V0.6081.00
153_L160_I0.6061.00
83_L293_V0.6031.00
149_S152_L0.6031.00
96_T251_L0.6021.00
138_H195_G0.6021.00
215_A218_M0.5971.00
122_R125_L0.5961.00
151_V154_T0.5961.00
138_H196_W0.5951.00
222_G228_W0.5941.00
143_V260_L0.5921.00
107_F190_I0.5911.00
154_T160_I0.5911.00
282_L285_G0.5891.00
88_T276_Y0.5881.00
56_I60_F0.5811.00
134_I195_G0.5801.00
100_F250_T0.5801.00
249_D252_E0.5771.00
108_F112_I0.5771.00
131_Q199_I0.5751.00
41_G45_F0.5751.00
265_T270_A0.5741.00
74_W78_K0.5721.00
59_A295_V0.5721.00
63_Y72_S0.5721.00
226_Q230_I0.5681.00
70_L73_E0.5641.00
99_L103_N0.5631.00
77_L80_F0.5621.00
152_L160_I0.5621.00
128_K132_T0.5621.00
185_Y189_V0.5611.00
302_L306_M0.5581.00
115_A202_L0.5561.00
74_W77_L0.5551.00
130_V134_I0.5511.00
240_V243_L0.5511.00
192_R257_H0.5491.00
86_E289_Y0.5481.00
189_V253_L0.5481.00
72_S75_V0.5461.00
100_F251_L0.5461.00
125_L129_F0.5461.00
61_Q73_E0.5451.00
291_T294_G0.5441.00
248_G252_E0.5421.00
297_K301_G0.5421.00
103_N190_I0.5411.00
104_L250_T0.5391.00
208_V213_Y0.5381.00
243_L246_K0.5381.00
142_W146_V0.5371.00
122_R210_P0.5361.00
277_V294_G0.5361.00
57_V60_F0.5351.00
132_T136_I0.5351.00
192_R195_G0.5321.00
137_P195_G0.5261.00
140_M144_I0.5251.00
116_L231_T0.5181.00
275_T278_Y0.5151.00
80_F84_F0.5141.00
256_E259_Y0.5131.00
60_F77_L0.5111.00
131_Q206_T0.5071.00
114_L117_L0.5071.00
89_F276_Y0.5061.00
228_W231_T0.5051.00
84_F296_F0.5031.00
95_N272_I0.5031.00
93_L296_F0.5021.00
58_I63_Y0.5011.00
44_Y48_F0.5011.00
88_T271_E0.5001.00
246_K249_D0.5001.00
109_P112_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.8847 100 0.31 Contact Map
2onkC 2 0.7819 100 0.365 Contact Map
3d31C 2 0.7726 100 0.372 Contact Map
3rlfF 1 0.9346 100 0.381 Contact Map
3rlfG 1 0.838 100 0.415 Contact Map
4tquN 1 0.8224 100 0.427 Contact Map
4ymuD 2 0.6667 99.9 0.547 Contact Map
3tuiA 2 0.6542 99.9 0.559 Contact Map
4ytpC 1 0.4081 12.8 0.952 Contact Map
1zoyC 1 0.3489 12.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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