GREMLIN Database
YUKJ - Uncharacterized protein YukJ
UniProt: C0SPB1 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (202)
Sequences: 238 (186)
Seq/√Len: 13.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_N213_N5.2571.00
29_V43_I5.2071.00
3_V139_S4.4001.00
77_Y159_M3.8620.99
178_N214_P3.7600.99
40_R141_F3.3840.98
55_L200_A3.1860.98
7_G77_Y2.9390.96
92_V207_C2.7500.94
89_L185_G2.7090.94
55_L102_M2.6730.94
13_V128_Q2.6650.93
111_G115_D2.4970.91
137_F186_I2.3520.88
30_K38_Y2.2880.87
136_I161_N2.2130.85
140_K157_N2.1800.84
41_C136_I2.0650.80
31_M41_C2.0280.79
116_L202_L1.9560.76
11_G31_M1.8410.72
208_T212_G1.7620.68
199_L213_N1.7570.68
9_L116_L1.7470.67
62_F196_A1.7470.67
58_A196_A1.7400.67
123_Y197_V1.7220.66
168_N177_D1.7070.66
161_N177_D1.6590.63
80_I87_V1.6310.62
172_T178_N1.6280.62
69_I73_M1.6260.62
37_T157_N1.6200.61
121_E125_K1.6070.61
51_E161_N1.5990.60
28_Q40_R1.5510.58
75_Y133_P1.5000.55
41_C141_F1.4860.55
175_K178_N1.4830.54
41_C161_N1.4560.53
80_I84_N1.4540.53
41_C162_I1.4430.52
127_A132_T1.4330.52
188_I197_V1.4240.51
27_F117_N1.4200.51
139_S161_N1.4130.51
41_C159_M1.4050.50
42_A160_H1.4010.50
26_H47_S1.4010.50
136_I141_F1.3960.50
22_D78_T1.3740.49
56_Y164_M1.3510.48
55_L206_W1.3380.47
51_E203_S1.3080.45
141_F161_N1.2920.44
1_M179_G1.2910.44
143_P156_T1.2810.44
16_M27_F1.2680.43
134_V188_I1.2540.42
11_G161_N1.2110.40
124_M215_V1.2050.40
60_D214_P1.1870.39
9_L202_L1.1830.39
95_N207_C1.1810.39
50_E98_D1.1810.39
45_V64_S1.1790.39
52_S105_L1.1660.38
3_V181_W1.1630.38
10_K135_Y1.1400.37
9_L57_L1.1240.36
158_G163_H1.1230.36
59_D75_Y1.1230.36
140_K178_N1.1180.36
25_P44_N1.1130.35
169_A214_P1.1110.35
92_V210_E1.0970.35
5_Q43_I1.0920.34
19_E118_D1.0840.34
91_Y137_F1.0800.34
25_P106_P1.0800.34
97_F207_C1.0790.34
54_V111_G1.0790.34
2_A14_L1.0750.34
9_L31_M1.0740.34
26_H158_G1.0690.33
44_N168_N1.0680.33
43_I173_R1.0650.33
10_K133_P1.0650.33
46_M108_E1.0550.33
175_K180_S1.0530.33
90_D184_G1.0320.32
90_D183_D1.0320.32
44_N164_M1.0240.31
135_Y189_Q1.0160.31
40_R143_P1.0160.31
102_M202_L1.0080.31
14_L92_V0.9850.30
187_L195_A0.9830.30
63_D134_V0.9800.29
72_N84_N0.9710.29
34_E39_Y0.9670.29
90_D138_G0.9530.28
168_N181_W0.9380.28
169_A178_N0.9360.27
27_F97_F0.9270.27
18_R45_V0.9260.27
2_A58_A0.9250.27
13_V124_M0.9200.27
42_A156_T0.9190.27
90_D201_F0.9180.27
194_W198_F0.9100.26
54_V70_L0.9080.26
22_D168_N0.9060.26
20_T185_G0.9040.26
57_L116_L0.9030.26
116_L136_I0.8940.26
184_G201_F0.8920.26
183_D201_F0.8920.26
199_L214_P0.8860.25
175_K196_A0.8820.25
187_L194_W0.8760.25
54_V189_Q0.8730.25
22_D48_S0.8660.25
3_V48_S0.8640.25
99_P206_W0.8610.24
30_K40_R0.8590.24
168_N178_N0.8580.24
3_V156_T0.8500.24
163_H166_Q0.8440.24
64_S180_S0.8380.24
73_M185_G0.8380.24
29_V143_P0.8380.24
10_K73_M0.8310.23
55_L60_D0.8300.23
140_K161_N0.8240.23
64_S159_M0.8220.23
9_L13_V0.8150.23
94_G181_W0.8120.23
138_G183_D0.8080.22
138_G184_G0.8080.22
162_I176_K0.8060.22
67_I207_C0.8050.22
209_D212_G0.7950.22
66_S73_M0.7900.22
64_S207_C0.7870.22
42_A186_I0.7860.22
67_I123_Y0.7800.21
1_M8_V0.7790.21
80_I120_I0.7790.21
114_N194_W0.7780.21
188_I196_A0.7770.21
48_S107_H0.7750.21
80_I216_R0.7740.21
58_A168_N0.7700.21
97_F181_W0.7680.21
31_M178_N0.7650.21
174_W178_N0.7620.21
16_M83_A0.7620.21
207_C215_V0.7610.21
28_Q42_A0.7580.21
39_Y200_A0.7570.21
23_D169_A0.7530.21
11_G134_V0.7490.20
7_G159_M0.7480.20
111_G114_N0.7450.20
159_M194_W0.7450.20
7_G80_I0.7440.20
23_D141_F0.7430.20
57_L202_L0.7390.20
53_E57_L0.7370.20
121_E174_W0.7360.20
203_S210_E0.7330.20
214_P217_D0.7310.20
125_K217_D0.7270.20
5_Q121_E0.7230.20
104_P177_D0.7230.20
134_V214_P0.7210.19
9_L55_L0.7200.19
19_E117_N0.7160.19
124_M207_C0.7140.19
67_I185_G0.7130.19
59_D96_L0.7120.19
43_I128_Q0.7120.19
110_T208_T0.7090.19
12_I78_T0.7090.19
137_F141_F0.7080.19
74_P195_A0.7080.19
167_G208_T0.7060.19
94_G182_H0.7050.19
19_E103_K0.7040.19
36_N175_K0.7030.19
139_S181_W0.7030.19
3_V185_G0.7010.19
18_R117_N0.7010.19
101_E120_I0.6970.19
130_E169_A0.6950.19
18_R77_Y0.6930.19
138_G201_F0.6880.18
189_Q211_N0.6870.18
51_E202_L0.6850.18
38_Y172_T0.6800.18
31_M162_I0.6760.18
105_L119_F0.6760.18
31_M136_I0.6750.18
132_T190_F0.6710.18
104_P141_F0.6700.18
97_F186_I0.6700.18
194_W199_L0.6680.18
26_H203_S0.6630.18
92_V97_F0.6600.18
1_M174_W0.6600.18
8_V179_G0.6580.17
17_K62_F0.6580.17
108_E168_N0.6540.17
64_S186_I0.6520.17
123_Y178_N0.6480.17
40_R156_T0.6480.17
9_L53_E0.6460.17
48_S51_E0.6440.17
78_T213_N0.6430.17
24_S91_Y0.6400.17
57_L102_M0.6370.17
11_G34_E0.6310.17
163_H167_G0.6230.16
3_V182_H0.6210.16
26_H163_H0.6190.16
30_K213_N0.6190.16
19_E28_Q0.6170.16
27_F55_L0.6170.16
34_E120_I0.6110.16
4_Q176_K0.6090.16
124_M186_I0.6080.16
158_G166_Q0.6070.16
38_Y54_V0.6060.16
162_I178_N0.6030.16
47_S106_P0.6010.16
166_Q204_Q0.6010.16
16_M121_E0.6010.16
41_C118_D0.6010.16
2_A185_G0.5990.16
43_I104_P0.5990.16
77_Y110_T0.5950.16
132_T168_N0.5940.16
59_D97_F0.5940.16
127_A204_Q0.5930.16
10_K41_C0.5910.16
112_P190_F0.5900.16
104_P133_P0.5870.15
45_V199_L0.5870.15
59_D74_P0.5820.15
29_V120_I0.5800.15
82_E121_E0.5790.15
96_L196_A0.5780.15
136_I202_L0.5780.15
141_F158_G0.5760.15
15_D196_A0.5740.15
7_G46_M0.5730.15
110_T207_C0.5680.15
67_I126_K0.5670.15
44_N202_L0.5640.15
17_K206_W0.5610.15
92_V205_S0.5580.15
52_S159_M0.5540.15
34_E58_A0.5500.14
50_E131_K0.5490.14
11_G41_C0.5470.14
74_P175_K0.5450.14
156_T159_M0.5450.14
2_A213_N0.5430.14
12_I217_D0.5430.14
85_R180_S0.5400.14
83_A88_A0.5400.14
102_M136_I0.5370.14
143_P157_N0.5340.14
29_V122_T0.5330.14
127_A194_W0.5310.14
7_G93_R0.5310.14
120_I197_V0.5310.14
189_Q203_S0.5280.14
110_T191_A0.5270.14
73_M107_H0.5270.14
188_I217_D0.5270.14
10_K43_I0.5240.14
42_A185_G0.5190.14
29_V215_V0.5190.14
11_G54_V0.5160.14
41_C121_E0.5160.14
107_H185_G0.5150.14
90_D204_Q0.5140.14
178_N196_A0.5120.13
7_G140_K0.5120.13
159_M197_V0.5110.13
157_N199_L0.5090.13
15_D186_I0.5070.13
52_S197_V0.5060.13
91_Y192_D0.5030.13
28_Q142_G0.5030.13
39_Y195_A0.5030.13
19_E97_F0.5030.13
15_D177_D0.5020.13
119_F123_Y0.5010.13
92_V186_I0.5010.13
116_L206_W0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ccdA 1 0.6267 36.2 0.962 Contact Map
2nt0A 4 0.8578 17.9 0.967 Contact Map
2je2A 2 0.4178 11.2 0.97 Contact Map
2y24A 1 0.6 8.6 0.972 Contact Map
3lazA 2 0.1422 6.3 0.974 Contact Map
4qawA 3 0.5956 5.6 0.974 Contact Map
2khrA 1 0.3244 4.9 0.975 Contact Map
2yy0A 6 0.2356 4.7 0.975 Contact Map
1vbvA 3 0.2889 3.7 0.976 Contact Map
3hwuA 3 0.3378 3.4 0.977 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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