GREMLIN Database
YOBH - DNA repair protein homolog YobH
UniProt: C0SPA8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 217 (201)
Sequences: 7820 (5639)
Seq/√Len: 397.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_S72_E3.2431.00
145_K205_L2.9621.00
8_S12_E2.9461.00
140_K143_E2.6581.00
76_N81_S2.6011.00
9_M17_C2.3751.00
84_G88_K2.2901.00
145_K209_N2.2751.00
4_A8_S2.2521.00
81_S85_Q2.2471.00
106_Y110_H2.2061.00
10_W41_S2.1161.00
78_M97_K2.0881.00
141_R209_N2.0731.00
95_E103_N2.0601.00
6_Q41_S2.0501.00
7_S11_R2.0271.00
56_W87_A2.0101.00
91_L103_N1.9881.00
107_Y112_I1.9611.00
47_R50_D1.9311.00
62_S76_N1.9221.00
149_L201_Y1.8601.00
72_E76_N1.8291.00
80_I89_F1.8261.00
56_W84_G1.8211.00
52_P56_W1.8191.00
6_Q43_I1.7961.00
188_K206_M1.7821.00
80_I86_L1.7781.00
196_I199_D1.6921.00
131_S172_G1.6661.00
104_Q108_H1.6601.00
156_A200_I1.6581.00
156_A197_T1.6321.00
89_F93_L1.5941.00
27_L46_W1.5921.00
130_K155_V1.5621.00
73_R77_R1.5431.00
188_K210_K1.5351.00
21_I43_I1.5141.00
91_L106_Y1.5121.00
103_N107_Y1.5031.00
153_E197_T1.4741.00
78_M98_F1.4641.00
134_L147_V1.4591.00
130_K158_R1.4441.00
138_Y144_I1.4401.00
94_L106_Y1.4131.00
130_K154_E1.4101.00
141_R145_K1.3931.00
34_L44_A1.3791.00
70_R73_R1.3741.00
82_T85_Q1.3581.00
138_Y143_E1.3431.00
31_A46_W1.3381.00
89_F94_L1.3321.00
190_I203_C1.3301.00
201_Y205_L1.3201.00
35_E44_A1.3181.00
188_K203_C1.3181.00
52_P87_A1.3091.00
3_K6_Q1.3081.00
3_K7_S1.3051.00
102_G106_Y1.3001.00
159_A166_G1.2871.00
3_K43_I1.2871.00
2_A19_V1.2871.00
22_G27_L1.2831.00
152_C156_A1.2831.00
23_D51_V1.2821.00
203_C206_M1.2751.00
156_A160_R1.2551.00
93_L97_K1.2501.00
174_G183_G1.2301.00
74_N97_K1.2261.00
152_C200_I1.2251.00
168_T187_S1.2161.00
199_D203_C1.2151.00
91_L95_E1.2051.00
147_V150_E1.1971.00
152_C204_C1.1851.00
128_F162_Y1.1791.00
168_T189_T1.1561.00
25_M117_I1.1521.00
136_R143_E1.1481.00
90_P93_L1.1461.00
64_M83_V1.1421.00
205_L209_N1.1351.00
171_L207_F1.1311.00
137_D176_S1.1261.00
30_L58_V1.1241.00
50_D53_N1.1211.00
170_S187_S1.1211.00
10_W16_M1.1081.00
67_I102_G1.0951.00
19_V43_I1.0931.00
160_R197_T1.0901.00
99_G102_G1.0761.00
148_L204_C1.0701.00
190_I194_T1.0701.00
134_L138_Y1.0691.00
194_T199_D1.0671.00
165_V195_N1.0661.00
152_C201_Y1.0631.00
144_I208_F1.0591.00
206_M210_K1.0351.00
160_R195_N1.0291.00
148_L171_L1.0231.00
33_D63_K1.0161.00
26_L108_H1.0151.00
2_A21_I1.0101.00
202_K206_M1.0071.00
101_M104_Q1.0061.00
186_R211_F1.0051.00
167_R193_P1.0041.00
21_I45_R0.9981.00
148_L208_F0.9841.00
61_L80_I0.9841.00
198_M202_K0.9801.00
91_L107_Y0.9611.00
197_T201_Y0.9451.00
10_W14_G0.9431.00
16_M35_E0.9421.00
22_G28_S0.9351.00
93_L96_K0.9291.00
146_A150_E0.9261.00
73_R76_N0.9211.00
35_E42_G0.9181.00
175_Y184_F0.9181.00
87_A110_H0.9151.00
87_A109_A0.9141.00
132_Q147_V0.9091.00
61_L76_N0.9081.00
167_R189_T0.9061.00
149_L205_L0.9011.00
57_K84_G0.8961.00
107_Y114_L0.8871.00
30_L65_W0.8771.00
100_I104_Q0.8731.00
98_F102_G0.8601.00
94_L98_F0.8521.00
71_M98_F0.8491.00
188_K207_F0.8461.00
120_P123_Q0.8421.00
113_D116_E0.8411.00
170_S185_H0.8381.00
65_W108_H0.8371.00
152_C197_T0.8371.00
34_L54_R0.8371.00
46_W54_R0.8361.00
184_F211_F0.8281.00
32_L35_E0.8211.00
74_N98_F0.8191.00
53_N56_W0.8121.00
192_F199_D0.8111.00
154_E157_R0.8061.00
148_L205_L0.8031.00
60_P76_N0.8021.00
138_Y147_V0.7971.00
85_Q88_K0.7961.00
71_M74_N0.7941.00
141_R208_F0.7891.00
172_G183_G0.7841.00
24_N27_L0.7821.00
86_L94_L0.7811.00
58_V63_K0.7761.00
61_L72_E0.7691.00
92_E96_K0.7691.00
145_K149_L0.7631.00
153_E157_R0.7601.00
133_I137_D0.7571.00
158_R162_Y0.7571.00
50_D54_R0.7561.00
90_P110_H0.7531.00
67_I72_E0.7521.00
74_N77_R0.7521.00
23_D27_L0.7451.00
60_P63_K0.7431.00
86_L106_Y0.7431.00
142_E145_K0.7411.00
46_W51_V0.7391.00
125_Q162_Y0.7381.00
54_R58_V0.7361.00
98_F105_L0.7351.00
27_L51_V0.7351.00
78_M93_L0.7341.00
84_G87_A0.7331.00
130_K151_I0.7321.00
186_R210_K0.7291.00
4_A7_S0.7291.00
8_S11_R0.7231.00
175_Y179_E0.7211.00
169_I200_I0.7171.00
16_M41_S0.7151.00
51_V55_L0.7141.00
172_G185_H0.7141.00
2_A43_I0.7131.00
9_M13_F0.7121.00
7_S10_W0.7041.00
26_L64_M0.7041.00
6_Q19_V0.7031.00
67_I105_L0.7011.00
148_L201_Y0.6991.00
200_I204_C0.6951.00
173_I208_F0.6931.00
169_I203_C0.6891.00
48_Y51_V0.6881.00
80_I85_Q0.6860.99
25_M116_E0.6830.99
186_R207_F0.6800.99
157_R161_T0.6750.99
78_M89_F0.6740.99
57_K82_T0.6710.99
142_E146_A0.6660.99
10_W13_F0.6640.99
143_E146_A0.6600.99
137_D179_E0.6600.99
199_D202_K0.6590.99
48_Y52_P0.6570.99
146_A149_L0.6500.99
128_F164_K0.6460.99
23_D47_R0.6380.99
132_Q154_E0.6350.99
171_L208_F0.6340.99
52_P88_K0.6340.99
107_Y110_H0.6290.99
18_T44_A0.6240.99
131_S174_G0.6210.99
128_F159_A0.6200.99
198_M201_Y0.6140.99
51_V56_W0.6120.99
61_L86_L0.6100.99
26_L105_L0.6050.99
149_L153_E0.6050.99
124_G164_K0.6030.99
153_E201_Y0.6020.99
26_L30_L0.6000.99
18_T32_L0.5970.99
6_Q35_E0.5970.99
118_G123_Q0.5950.99
69_G73_R0.5930.99
40_K44_A0.5900.98
155_V166_G0.5870.98
86_L98_F0.5860.98
128_F158_R0.5840.98
86_L109_A0.5830.98
125_Q164_K0.5820.98
77_R97_K0.5790.98
71_M101_M0.5780.98
35_E43_I0.5760.98
18_T35_E0.5760.98
55_L83_V0.5720.98
61_L75_L0.5720.98
173_I211_F0.5710.98
156_A194_T0.5680.98
160_R196_I0.5660.98
102_G105_L0.5660.98
67_I86_L0.5660.98
174_G177_K0.5650.98
75_L105_L0.5630.98
91_L110_H0.5620.98
188_K191_D0.5590.98
95_E102_G0.5590.98
119_A123_Q0.5580.98
103_N106_Y0.5580.98
100_I103_N0.5570.98
155_V169_I0.5530.98
133_I178_D0.5510.98
129_G155_V0.5490.98
143_E147_V0.5490.98
171_L204_C0.5470.98
52_P110_H0.5440.97
61_L82_T0.5430.97
94_L102_G0.5420.97
5_I8_S0.5380.97
155_V159_A0.5350.97
149_L197_T0.5340.97
194_T203_C0.5320.97
57_K83_V0.5310.97
191_D203_C0.5290.97
30_L70_R0.5250.97
34_L63_K0.5250.97
203_C207_F0.5220.97
82_T86_L0.5220.97
108_H113_D0.5200.97
101_M105_L0.5200.97
169_I190_I0.5170.97
75_L80_I0.5170.97
53_N57_K0.5150.96
132_Q151_I0.5150.96
206_M209_N0.5140.96
64_M108_H0.5120.96
30_L63_K0.5070.96
51_V54_R0.5070.96
15_L42_G0.5060.96
75_L89_F0.5060.96
166_G200_I0.5030.96
56_W88_K0.5020.96
175_Y178_D0.5020.96
5_I12_E0.5010.96
89_F106_Y0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dezA 2 0.53 100 0.18 Contact Map
3osnA 1 0.9677 100 0.183 Contact Map
3gqcA 3 0.9724 100 0.187 Contact Map
4f50A 1 0.9401 100 0.193 Contact Map
4tqrA 1 0.9401 100 0.194 Contact Map
4ecqA 1 0.9631 100 0.2 Contact Map
3pzpA 1 0.9493 100 0.2 Contact Map
2aq4A 1 0.9816 100 0.2 Contact Map
3mfiA 1 0.9585 100 0.204 Contact Map
1t94A 1 0.9355 100 0.205 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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