GREMLIN Database
ADHA - Probable formaldehyde dehydrogenase AdhA
UniProt: C0SPA5 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 349 (301)
Sequences: 52678 (36123)
Seq/√Len: 2082.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K153_M3.0741.00
37_D73_T2.9811.00
39_K71_V2.9131.00
325_Q328_E2.8751.00
35_L73_T2.6121.00
83_A86_D2.5211.00
152_E155_V2.4191.00
34_V144_V2.4151.00
180_K203_E2.4011.00
154_D320_V2.3921.00
86_D146_R2.3901.00
26_R136_K2.3521.00
321_I332_R2.3361.00
87_R147_I2.3141.00
186_V206_V2.3051.00
319_E332_R2.3021.00
198_H223_N2.2931.00
176_G179_K2.2751.00
320_V345_D2.2431.00
37_D71_V2.2271.00
215_E219_E2.2161.00
37_D136_K2.2001.00
181_V197_A2.1871.00
31_P77_T2.1301.00
214_K218_L2.1281.00
81_K141_D2.1211.00
30_R33_D2.0891.00
31_P78_K2.0871.00
150_R310_A2.0731.00
322_G325_Q2.0211.00
68_I90_V2.0191.00
13_S22_T2.0171.00
307_D311_E2.0061.00
235_T238_A2.0021.00
73_T136_K1.9531.00
35_L138_V1.9451.00
194_I222_A1.9431.00
68_I132_G1.9391.00
52_F334_L1.9371.00
331_E335_R1.9271.00
32_H78_K1.9141.00
199_A313_G1.8951.00
69_A153_M1.8381.00
87_R153_M1.8261.00
215_E218_L1.7941.00
266_T290_S1.7781.00
242_D262_R1.7541.00
182_A207_L1.7511.00
163_G192_L1.7491.00
332_R337_D1.7241.00
182_A241_F1.7131.00
214_K225_Y1.7011.00
328_E331_E1.6901.00
147_I153_M1.6871.00
28_G74_A1.6841.00
266_T292_A1.6821.00
205_T241_F1.6801.00
328_E332_R1.6651.00
211_M215_E1.6541.00
216_E219_E1.6421.00
13_S20_E1.6261.00
321_I329_A1.6051.00
147_I156_A1.5881.00
35_L136_K1.5831.00
74_A84_V1.5701.00
154_D345_D1.5631.00
71_V87_R1.5371.00
75_V84_V1.5331.00
11_S22_T1.5321.00
208_S214_K1.5251.00
184_V257_Y1.5181.00
82_L86_D1.5181.00
82_L146_R1.5071.00
173_W243_V1.4951.00
261_L267_L1.4921.00
327_D331_E1.4871.00
211_M227_A1.4861.00
33_D140_T1.4851.00
261_L289_R1.4851.00
32_H140_T1.4771.00
227_A230_D1.4761.00
244_I261_L1.4721.00
35_L74_A1.4511.00
38_I68_I1.4451.00
211_M230_D1.4361.00
33_D138_V1.4311.00
179_K266_T1.4221.00
203_E224_H1.4131.00
76_G79_V1.4131.00
261_L265_G1.4081.00
29_L138_V1.4011.00
29_L35_L1.3931.00
133_Y330_Y1.3921.00
233_T236_A1.3751.00
244_I257_Y1.3651.00
40_F154_D1.3601.00
14_H20_E1.3511.00
203_E223_N1.3491.00
87_R149_D1.3481.00
199_A308_F1.3471.00
307_D310_A1.3401.00
34_V82_L1.3391.00
71_V153_M1.3231.00
180_K205_T1.3181.00
72_V82_L1.3011.00
211_M214_K1.2961.00
15_A18_K1.2621.00
40_F345_D1.2621.00
209_R228_T1.2551.00
171_K301_E1.2551.00
193_A245_L1.2481.00
39_K87_R1.2431.00
184_V207_L1.2261.00
38_I137_I1.2241.00
26_R35_L1.2141.00
14_H18_K1.2111.00
82_L144_V1.2101.00
194_I206_V1.2081.00
159_L309_A1.1901.00
218_L225_Y1.1831.00
180_K242_D1.1781.00
32_H141_D1.1701.00
51_A330_Y1.1611.00
171_K304_E1.1591.00
259_S283_S1.1471.00
216_E339_R1.1431.00
308_F313_G1.1411.00
214_K227_A1.1391.00
195_Q315_E1.1141.00
322_G345_D1.1131.00
304_E307_D1.1131.00
175_V202_A1.0971.00
139_V144_V1.0951.00
179_K242_D1.0851.00
326_V344_I1.0841.00
36_I88_V1.0781.00
21_Q324_D1.0601.00
218_L224_H1.0531.00
234_F238_A1.0521.00
205_T224_H1.0501.00
155_V315_E1.0481.00
36_I70_G1.0431.00
234_F237_L1.0421.00
168_S301_E1.0351.00
43_I329_A1.0301.00
303_Q307_D1.0271.00
73_T84_V1.0271.00
256_A259_S1.0271.00
41_S133_Y1.0231.00
173_W268_V1.0171.00
166_T193_A1.0171.00
40_F153_M1.0131.00
172_H290_S1.0091.00
224_H237_L1.0071.00
10_L21_Q1.0041.00
197_A202_A1.0031.00
51_A334_L1.0021.00
175_V179_K1.0011.00
79_V141_D0.9991.00
331_E334_L0.9991.00
332_R342_F0.9971.00
248_V253_D0.9841.00
29_L33_D0.9781.00
167_Y304_E0.9761.00
155_V317_K0.9681.00
80_T141_D0.9601.00
255_D259_S0.9461.00
169_P270_V0.9411.00
304_E308_F0.9321.00
133_Y326_V0.9301.00
169_P245_L0.9301.00
163_G305_M0.9281.00
194_I204_V0.9281.00
191_H216_E0.9251.00
62_M130_Y0.9221.00
206_V217_A0.9201.00
232_A235_T0.9181.00
48_I333_I0.9171.00
39_K69_A0.9171.00
14_H17_A0.9141.00
10_L326_V0.9141.00
151_L156_A0.9131.00
283_S287_G0.9071.00
209_R229_S0.9071.00
205_T226_F0.9061.00
186_V208_S0.9021.00
166_T196_F0.9011.00
210_S213_K0.9001.00
186_V217_A0.8991.00
212_N215_E0.8971.00
321_I325_Q0.8931.00
89_G306_L0.8911.00
206_V222_A0.8911.00
179_K243_V0.8881.00
40_F343_V0.8881.00
182_A260_M0.8871.00
213_K339_R0.8871.00
207_L228_T0.8861.00
75_V83_A0.8831.00
232_A236_A0.8791.00
186_V194_I0.8781.00
172_H292_A0.8721.00
183_I197_A0.8701.00
10_L13_S0.8691.00
41_S132_G0.8601.00
75_V79_V0.8571.00
246_N249_S0.8551.00
26_R74_A0.8551.00
264_D288_R0.8541.00
184_V244_I0.8511.00
37_D135_Q0.8491.00
164_I301_E0.8491.00
183_I193_A0.8481.00
26_R73_T0.8401.00
83_A146_R0.8401.00
44_C67_E0.8331.00
300_Q304_E0.8291.00
196_F305_M0.8271.00
209_R214_K0.8221.00
68_I137_I0.8171.00
174_N266_T0.8151.00
184_V253_D0.8131.00
197_A204_V0.8121.00
181_V202_A0.8091.00
28_G35_L0.8061.00
300_Q303_Q0.8061.00
338_V342_F0.8051.00
180_K241_F0.8041.00
145_V303_Q0.8031.00
42_G67_E0.7961.00
244_I267_L0.7961.00
284_L291_I0.7941.00
24_I130_Y0.7911.00
208_S225_Y0.7881.00
308_F311_E0.7871.00
24_I63_V0.7851.00
257_Y267_L0.7841.00
149_D310_A0.7821.00
217_A222_A0.7821.00
10_L323_A0.7801.00
196_F308_F0.7781.00
319_E328_E0.7761.00
32_H76_G0.7751.00
34_V141_D0.7751.00
43_I333_I0.7751.00
30_R138_V0.7741.00
200_M304_E0.7731.00
21_Q323_A0.7711.00
133_Y344_I0.7711.00
132_G137_I0.7671.00
280_S283_S0.7651.00
321_I342_F0.7611.00
14_H22_T0.7581.00
170_L197_A0.7561.00
90_V139_V0.7521.00
180_K239_G0.7461.00
319_E342_F0.7461.00
269_S291_I0.7411.00
247_T270_V0.7401.00
89_G147_I0.7381.00
88_V144_V0.7331.00
151_L309_A0.7321.00
332_R335_R0.7311.00
333_I342_F0.7271.00
175_V243_V0.7271.00
255_D283_S0.7251.00
29_L74_A0.7241.00
210_S227_A0.7211.00
44_C66_H0.7201.00
69_A157_S0.7201.00
169_P193_A0.7181.00
204_V223_N0.7171.00
148_P310_A0.7141.00
233_T238_A0.7131.00
166_T192_L0.7111.00
174_N292_A0.7111.00
46_S66_H0.7101.00
32_H77_T0.7091.00
306_L310_A0.7051.00
202_A243_V0.7021.00
216_E317_K0.7021.00
230_D233_T0.6971.00
32_H142_R0.6961.00
174_N290_S0.6941.00
263_I287_G0.6861.00
308_F312_H0.6861.00
145_V302_T0.6841.00
58_G62_M0.6821.00
86_D149_D0.6821.00
11_S63_V0.6791.00
183_I206_V0.6791.00
216_E220_L0.6791.00
48_I334_L0.6781.00
11_S24_I0.6771.00
251_N255_D0.6771.00
167_Y308_F0.6751.00
167_Y305_M0.6751.00
16_K331_E0.6741.00
191_H317_K0.6731.00
168_S288_R0.6721.00
17_A331_E0.6691.00
243_V268_V0.6681.00
284_L293_G0.6651.00
241_F244_I0.6651.00
29_L76_G0.6641.00
34_V72_V0.6631.00
27_R138_V0.6621.00
194_I220_L0.6611.00
284_L289_R0.6611.00
44_C47_D0.6571.00
89_G160_L0.6561.00
171_K200_M0.6551.00
321_I344_I0.6551.00
145_V306_L0.6531.00
196_F200_M0.6531.00
246_N267_L0.6521.00
195_Q220_L0.6491.00
239_G262_R0.6491.00
254_V267_L0.6491.00
38_I41_S0.6481.00
166_T189_L0.6461.00
40_F69_A0.6401.00
167_Y301_E0.6391.00
283_S286_M0.6381.00
36_I90_V0.6371.00
12_V18_K0.6371.00
255_D278_T0.6341.00
241_F260_M0.6321.00
177_P201_G0.6321.00
49_H54_E0.6301.00
69_A147_I0.6281.00
87_R150_R0.6251.00
166_T170_L0.6251.00
39_K345_D0.6241.00
158_P343_V0.6241.00
90_V144_V0.6231.00
222_A225_Y0.6201.00
40_F320_V0.6201.00
141_D144_V0.6201.00
219_E315_E0.6201.00
66_H161_C0.6191.00
178_G203_E0.6161.00
59_I62_M0.6151.00
208_S228_T0.6151.00
198_H204_V0.6141.00
243_V266_T0.6131.00
250_A253_D0.6061.00
288_R298_G0.6041.00
43_I133_Y0.6041.00
82_L141_D0.6031.00
332_R338_V0.6021.00
276_P280_S0.6001.00
69_A87_R0.5951.00
81_K84_V0.5941.00
162_A192_L0.5931.00
41_S344_I0.5921.00
46_S50_S0.5911.00
91_G145_V0.5911.00
36_I144_V0.5891.00
173_W266_T0.5881.00
159_L305_M0.5871.00
224_H227_A0.5861.00
169_P268_V0.5861.00
27_R33_D0.5841.00
214_K217_A0.5831.00
181_V243_V0.5821.00
165_T189_L0.5821.00
233_T256_A0.5791.00
44_C162_A0.5791.00
193_A270_V0.5761.00
302_T306_L0.5711.00
48_I52_F0.5711.00
309_A316_P0.5701.00
75_V86_D0.5691.00
182_A244_I0.5661.00
25_E28_G0.5661.00
330_Y334_L0.5661.00
43_I344_I0.5601.00
158_P316_P0.5601.00
50_S55_W0.5581.00
81_K146_R0.5581.00
231_P256_A0.5581.00
61_P65_G0.5571.00
65_G133_Y0.5571.00
234_F241_F0.5571.00
244_I260_M0.5551.00
209_R217_A0.5531.00
27_R136_K0.5521.00
329_A344_I0.5501.00
301_E304_E0.5501.00
140_T143_F0.5501.00
194_I217_A0.5481.00
44_C161_C0.5481.00
192_L196_F0.5471.00
67_E161_C0.5461.00
183_I194_I0.5461.00
207_L226_F0.5451.00
208_S227_A0.5431.00
253_D257_Y0.5431.00
19_F330_Y0.5421.00
63_V131_G0.5391.00
45_H49_H0.5381.00
213_K337_D0.5381.00
44_C341_R0.5381.00
233_T237_L0.5371.00
170_L196_F0.5361.00
80_T83_A0.5351.00
46_S49_H0.5351.00
152_E320_V0.5351.00
169_P294_S0.5341.00
162_A188_G0.5311.00
321_I328_E0.5291.00
26_R138_V0.5281.00
42_G157_S0.5281.00
208_S213_K0.5271.00
174_N200_M0.5271.00
192_L314_I0.5261.00
33_D129_T0.5251.00
171_K174_N0.5251.00
18_K327_D0.5241.00
235_T240_R0.5241.00
177_P200_M0.5241.00
171_K300_Q0.5211.00
294_S297_G0.5211.00
217_A225_Y0.5211.00
254_V269_S0.5211.00
198_H222_A0.5201.00
240_R262_R0.5191.00
191_H220_L0.5171.00
180_K224_H0.5161.00
286_M295_L0.5161.00
289_R293_G0.5161.00
90_V132_G0.5161.00
38_I90_V0.5161.00
180_K240_R0.5141.00
268_V294_S0.5141.00
168_S172_H0.5121.00
212_N337_D0.5121.00
281_V284_L0.5121.00
75_V82_L0.5111.00
69_A156_A0.5111.00
294_S299_I0.5111.00
146_R149_D0.5091.00
282_F286_M0.5081.00
162_A341_R0.5061.00
90_V137_I0.5041.00
67_E341_R0.5041.00
165_T270_V0.5021.00
163_G195_Q0.5021.00
195_Q314_I0.5021.00
21_Q326_V0.5011.00
167_Y196_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uufA 2 0.9599 100 0.175 Contact Map
2cf5A 1 0.9914 100 0.176 Contact Map
4oaqA 2 1 100 0.178 Contact Map
1piwA 2 0.9914 100 0.184 Contact Map
3twoA 2 0.9771 100 0.186 Contact Map
1yqdA 2 0.9885 100 0.187 Contact Map
4c4oA 4 0.957 100 0.188 Contact Map
1h2bA 4 0.9427 100 0.19 Contact Map
1rjwA 4 0.957 100 0.192 Contact Map
4gkvA 4 0.9513 100 0.196 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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