GREMLIN Database
YLXW - UPF0749 protein YlxW
UniProt: C0SPA3 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (214)
Sequences: 1493 (1093)
Seq/√Len: 74.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_Q220_N6.0441.00
157_L161_S4.7321.00
110_E218_E4.2741.00
110_E184_S3.8791.00
131_H165_C3.0991.00
105_Q222_Q2.9911.00
193_L217_K2.9681.00
154_G184_S2.7431.00
155_Q173_D2.5241.00
108_G221_V2.3611.00
188_D191_V2.3151.00
149_A186_I2.3011.00
158_T226_I2.2661.00
104_V149_A2.2351.00
103_G225_P2.1631.00
149_A223_M2.1511.00
109_V192_L2.1421.00
104_V223_M2.0661.00
103_G222_Q2.0591.00
184_S221_V2.0481.00
135_I181_F2.0301.00
109_V185_A2.0141.00
112_T216_E2.0121.00
155_Q175_V1.9691.00
63_E66_Q1.9511.00
148_A186_I1.9501.00
110_E182_T1.9131.00
139_V152_V1.9071.00
189_P192_L1.9041.00
114_E212_S1.9021.00
190_D217_K1.8941.00
115_D165_C1.8721.00
203_I213_V1.8661.00
139_V163_I1.8001.00
132_E165_C1.7391.00
153_N181_F1.7071.00
135_I170_V1.7031.00
154_G182_T1.6681.00
115_D131_H1.6581.00
111_V196_L1.6501.00
12_I19_L1.6221.00
17_G21_S1.5830.99
151_A154_G1.5420.99
89_L93_E1.5380.99
104_V148_A1.5150.99
151_A224_K1.4930.99
61_E65_Y1.4880.99
95_Y99_I1.4870.99
124_N127_S1.4720.99
206_L211_I1.4630.99
104_V186_I1.4430.99
92_T96_R1.3850.98
162_Y173_D1.3650.98
185_A194_P1.3540.98
184_S223_M1.3520.98
59_K63_E1.3470.98
66_Q70_K1.3370.98
188_D192_L1.3320.98
172_V177_H1.3240.98
45_A49_E1.3190.98
109_V189_P1.3180.98
69_N73_Q1.2980.98
18_F22_F1.2960.98
138_V183_V1.2940.98
165_C174_G1.2870.98
173_D226_I1.2860.98
165_C168_P1.2850.97
142_L147_A1.2770.97
10_S14_L1.2640.97
113_L138_V1.2470.97
164_K171_T1.2380.97
139_V150_V1.2380.97
193_L197_N1.2160.96
6_A10_S1.2150.96
107_E189_P1.1970.96
168_P178_P1.1850.96
151_A223_M1.1750.96
19_L24_F1.1750.96
119_I122_G1.1700.96
91_D94_K1.1680.96
26_M31_N1.1620.95
71_V75_E1.1600.95
12_I24_F1.1590.95
53_Q56_E1.1500.95
97_M102_V1.1490.95
112_T182_T1.1390.95
50_L53_Q1.1330.95
109_V193_L1.1320.95
72_R76_N1.1280.95
111_V215_A1.1240.95
87_N91_D1.1210.94
18_F21_S1.1140.94
198_I201_G1.1070.94
116_A128_Y1.1030.94
144_I202_L1.0950.94
8_L12_I1.0930.94
166_N171_T1.0910.94
152_V183_V1.0790.93
67_K71_V1.0750.93
132_E164_K1.0740.93
75_E96_R1.0690.93
99_I102_V1.0550.92
108_G184_S1.0410.92
143_Y150_V1.0330.92
100_G159_H1.0320.92
129_I165_C1.0290.92
139_V183_V1.0170.91
161_S168_P1.0160.91
15_I91_D1.0130.91
21_S24_F1.0010.90
72_R75_E0.9910.90
100_G158_T0.9900.90
56_E59_K0.9900.90
129_I168_P0.9880.90
142_L185_A0.9690.89
165_C169_V0.9570.88
47_R51_L0.9550.88
115_D167_G0.9540.88
143_Y158_T0.9380.87
91_D95_Y0.9240.86
27_T30_N0.9230.86
58_K151_A0.9150.86
14_L21_S0.9100.86
135_I153_N0.9070.85
163_I172_V0.9070.85
146_G187_G0.9040.85
93_E219_K0.9030.85
148_A187_G0.9020.85
114_E179_A0.8950.85
69_N207_S0.8890.84
171_T174_G0.8870.84
19_L140_N0.8810.84
140_N164_K0.8720.83
105_Q221_V0.8710.83
149_A187_G0.8700.83
141_E201_G0.8690.83
107_E148_A0.8630.82
10_S23_S0.8610.82
191_V194_P0.8590.82
206_L213_V0.8570.82
12_I16_A0.8540.82
46_L50_L0.8520.82
23_S26_M0.8500.81
165_C181_F0.8480.81
132_E168_P0.8450.81
53_Q183_V0.8400.81
116_A165_C0.8290.80
80_K113_L0.8280.80
7_V11_L0.8120.78
136_F162_Y0.8110.78
218_E221_V0.7990.77
136_F143_Y0.7950.77
109_V188_D0.7930.77
87_N90_E0.7920.77
205_Q209_D0.7890.76
103_G224_K0.7850.76
10_S21_S0.7830.76
108_G218_E0.7820.76
192_L221_V0.7700.75
153_N187_G0.7680.74
50_L202_L0.7660.74
169_V177_H0.7660.74
166_N176_Q0.7620.74
131_H134_H0.7620.74
113_L211_I0.7610.74
55_K161_S0.7600.74
176_Q181_F0.7600.74
70_K74_A0.7580.73
95_Y161_S0.7550.73
100_G221_V0.7550.73
169_V176_Q0.7500.73
85_Y89_L0.7490.73
97_M148_A0.7440.72
157_L163_I0.7370.71
6_A109_V0.7360.71
65_Y69_N0.7250.70
163_I173_D0.7230.70
74_A103_G0.7220.70
88_V91_D0.7190.69
145_S195_S0.7190.69
132_E153_N0.7180.69
49_E177_H0.7170.69
62_K73_Q0.7140.69
53_Q60_F0.7130.69
13_M16_A0.7110.69
142_L150_V0.7080.68
11_L34_A0.7080.68
14_L18_F0.6990.67
137_Q170_V0.6950.67
135_I183_V0.6930.67
33_S41_K0.6890.66
195_S201_G0.6870.66
186_I221_V0.6840.66
10_S192_L0.6790.65
77_K219_K0.6780.65
10_S17_G0.6750.65
170_V199_A0.6660.64
45_A74_A0.6650.63
16_A23_S0.6610.63
64_L68_Q0.6580.63
147_A150_V0.6560.62
22_F26_M0.6560.62
162_Y169_V0.6560.62
98_Y143_Y0.6560.62
64_L71_V0.6550.62
23_S136_F0.6540.62
171_T176_Q0.6490.62
50_L133_S0.6460.61
163_I215_A0.6450.61
163_I176_Q0.6380.60
130_V191_V0.6360.60
42_K50_L0.6340.60
48_D52_K0.6340.60
132_E206_L0.6300.59
74_A88_V0.6300.59
43_E192_L0.6290.59
113_L206_L0.6230.58
113_L135_I0.6200.58
189_P219_K0.6170.58
90_E93_E0.6170.58
113_L213_V0.6160.58
194_P198_I0.6130.57
8_L19_L0.6040.56
167_G170_V0.6040.56
137_Q155_Q0.6010.56
121_E125_V0.6000.56
11_L99_I0.5930.55
134_H162_Y0.5930.55
191_V204_D0.5920.55
29_E32_K0.5910.55
93_E96_R0.5900.54
132_E177_H0.5890.54
151_A173_D0.5870.54
81_E91_D0.5840.54
78_L219_K0.5830.54
152_V163_I0.5820.53
59_K93_E0.5810.53
29_E65_Y0.5800.53
132_E167_G0.5780.53
108_G219_K0.5770.53
184_S218_E0.5750.53
119_I222_Q0.5740.52
25_Q79_K0.5720.52
152_V190_D0.5720.52
22_F157_L0.5720.52
129_I169_V0.5700.52
151_A186_I0.5670.52
204_D213_V0.5670.52
155_Q174_G0.5660.51
90_E94_K0.5660.51
19_L23_S0.5650.51
191_V220_N0.5630.51
114_E182_T0.5620.51
120_P123_E0.5610.51
13_M99_I0.5600.51
128_Y168_P0.5580.50
7_V10_S0.5560.50
10_S13_M0.5540.50
125_V157_L0.5540.50
134_H210_H0.5540.50
19_L116_A0.5540.50
89_L216_E0.5530.50
63_E67_K0.5510.50
153_N168_P0.5510.50
131_H169_V0.5490.49
150_V157_L0.5470.49
151_A184_S0.5460.49
45_A48_D0.5460.49
9_L221_V0.5450.49
173_D206_L0.5440.49
131_H168_P0.5430.49
76_N219_K0.5430.49
13_M20_I0.5430.49
70_K73_Q0.5430.49
139_V157_L0.5430.49
114_E220_N0.5390.48
22_F161_S0.5390.48
111_V183_V0.5340.47
130_V171_T0.5340.47
49_E53_Q0.5320.47
141_E145_S0.5310.47
123_E127_S0.5300.47
139_V166_N0.5280.47
25_Q80_K0.5270.47
147_A185_A0.5260.46
115_D149_A0.5240.46
130_V164_K0.5220.46
134_H140_N0.5220.46
30_N34_A0.5210.46
81_E111_V0.5210.46
8_L94_K0.5200.46
66_Q86_Y0.5190.46
171_T181_F0.5190.46
128_Y169_V0.5170.45
86_Y90_E0.5160.45
125_V128_Y0.5160.45
130_V212_S0.5160.45
151_A225_P0.5160.45
133_S174_G0.5150.45
98_Y198_I0.5150.45
115_D130_V0.5150.45
169_V173_D0.5140.45
64_L89_L0.5140.45
19_L160_D0.5130.45
172_V205_Q0.5120.45
113_L183_V0.5110.45
89_L215_A0.5100.44
56_E111_V0.5090.44
165_C178_P0.5080.44
128_Y202_L0.5070.44
45_A62_K0.5070.44
146_G181_F0.5060.44
149_A157_L0.5060.44
79_K89_L0.5060.44
58_K77_K0.5060.44
12_I96_R0.5060.44
43_E50_L0.5050.44
97_M166_N0.5030.44
140_N160_D0.5030.44
75_E78_L0.5030.44
145_S213_V0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3gmgA 2 0.5714 100 0.333 Contact Map
4cgkA 3 0.5974 87 0.923 Contact Map
4q4gX 1 0 79.3 0.93 Contact Map
3hnwA 2 0.3896 78 0.931 Contact Map
3rvyA 3 0.1169 77.1 0.931 Contact Map
1debA 4 0.2338 73.6 0.933 Contact Map
4cbcA 3 0.1429 72.2 0.934 Contact Map
4bgnA 3 0.1732 71.6 0.934 Contact Map
2yy0A 6 0.2294 68.9 0.935 Contact Map
4ltoA 3 0.3247 67.2 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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