PULA - BACSU - GREMLIN Contacts

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PULA - Pullulanase

UniProt:	C0SPA0	Sequences: MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFPLAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYYDGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLHGYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIYETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDFAGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVILDVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVVYWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAALANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALAPIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIHSGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSAADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLCDPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	718 (569)
Sequences:	6264 (4099)
Seq/√Len:	171.8

ECOLI - GLGB GLGX YGAQ MALZ
BACSU - PULA GLGB BBMA
SULSO - Q7LX99 TREZ

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
608_R	689_E	4.027	1.00
345_E	348_P	4.018	1.00
240_L	317_E	3.775	1.00
262_E	607_R	3.579	1.00
143_M	153_V	3.546	1.00
240_L	320_Q	3.531	1.00
208_P	211_H	3.434	1.00
318_L	322_I	3.405	1.00
554_A	705_T	3.298	1.00
268_V	325_L	3.223	1.00
558_L	707_I	3.156	1.00
324_T	327_Q	3.042	1.00
114_H	154_T	2.935	1.00
558_L	643_Y	2.892	1.00
261_K	328_H	2.778	1.00
572_F	602_D	2.754	1.00
278_G	287_A	2.738	1.00
319_K	397_E	2.736	1.00
226_S	255_S	2.725	1.00
119_V	352_T	2.668	1.00
258_A	328_H	2.667	1.00
393_Y	398_Y	2.600	1.00
202_W	399_N	2.581	1.00
220_T	225_F	2.487	1.00
384_R	418_Y	2.476	1.00
424_T	455_P	2.450	1.00
611_S	615_A	2.438	1.00
661_H	705_T	2.377	1.00
616_H	709_Y	2.354	1.00
338_F	390_C	2.297	1.00
270_L	273_V	2.271	1.00
115_T	158_D	2.218	1.00
558_L	659_V	2.138	1.00
200_M	323_N	2.130	1.00
395_L	430_I	2.119	1.00
203_T	323_N	2.114	1.00
205_P	399_N	2.113	1.00
130_K	176_E	2.097	1.00
316_T	319_K	2.075	1.00
127_A	168_I	2.064	1.00
679_R	709_Y	2.064	1.00
320_Q	324_T	2.040	1.00
126_S	142_Q	2.031	1.00
159_L	162_Y	2.012	1.00
680_L	708_L	2.008	1.00
191_K	195_L	2.000	1.00
669_E	695_K	1.966	1.00
318_L	400_V	1.955	1.00
324_T	328_H	1.950	1.00
522_E	569_Q	1.947	1.00
669_E	697_T	1.936	1.00
553_A	606_I	1.907	1.00
298_F	390_C	1.901	1.00
273_V	318_L	1.896	1.00
214_D	620_R	1.896	1.00
260_V	268_V	1.891	1.00
181_Y	357_F	1.885	1.00
215_A	267_H	1.881	1.00
257_L	328_H	1.879	1.00
262_E	603_V	1.875	1.00
635_T	638_E	1.873	1.00
163_E	186_T	1.853	1.00
119_V	127_A	1.851	1.00
108_A	115_T	1.842	1.00
138_G	167_C	1.829	1.00
473_G	531_D	1.829	1.00
423_A	430_I	1.826	1.00
178_V	185_V	1.813	1.00
126_S	169_C	1.812	1.00
270_L	321_M	1.812	1.00
571_F	591_L	1.810	1.00
321_M	325_L	1.805	1.00
343_K	366_P	1.798	1.00
128_A	169_C	1.794	1.00
244_E	324_T	1.789	1.00
350_E	353_V	1.785	1.00
193_V	196_R	1.772	1.00
167_C	176_E	1.770	1.00
168_I	352_T	1.753	1.00
306_S	317_E	1.744	1.00
217_I	519_N	1.743	1.00
119_V	168_I	1.742	1.00
318_L	321_M	1.737	1.00
604_H	607_R	1.733	1.00
128_A	167_C	1.730	1.00
117_F	166_F	1.727	1.00
612_L	681_L	1.723	1.00
553_A	565_I	1.702	1.00
639_H	664_S	1.695	1.00
158_D	162_Y	1.688	1.00
349_F	353_V	1.669	1.00
616_H	657_I	1.657	1.00
110_Y	115_T	1.651	1.00
415_T	419_M	1.642	1.00
215_A	431_L	1.641	1.00
220_T	260_V	1.636	1.00
323_N	327_Q	1.636	1.00
260_V	330_L	1.635	1.00
422_K	425_K	1.623	1.00
228_H	231_S	1.619	1.00
216_V	610_I	1.612	1.00
200_M	320_Q	1.607	1.00
376_I	383_A	1.607	1.00
118_K	152_A	1.601	1.00
603_V	607_R	1.600	1.00
202_W	205_P	1.600	1.00
125_T	169_C	1.599	1.00
508_A	549_Q	1.594	1.00
497_G	500_G	1.588	1.00
600_K	604_H	1.582	1.00
660_I	670_W	1.582	1.00
385_K	389_D	1.568	1.00
349_F	386_F	1.560	1.00
510_I	514_P	1.558	1.00
644_R	656_D	1.554	1.00
317_E	320_Q	1.552	1.00
557_L	610_I	1.550	1.00
222_L	242_L	1.549	1.00
349_F	352_T	1.549	1.00
567_S	591_L	1.546	1.00
132_S	162_Y	1.540	1.00
229_E	232_G	1.538	1.00
644_R	658_I	1.537	1.00
595_R	599_F	1.535	1.00
101_Y	104_G	1.526	1.00
509_P	559_A	1.526	1.00
225_F	256_G	1.523	1.00
326_H	401_D	1.522	1.00
464_N	468_R	1.521	1.00
210_S	267_H	1.520	1.00
605_Y	684_P	1.515	1.00
274_N	294_P	1.509	1.00
467_F	559_A	1.508	1.00
115_T	194_V	1.507	1.00
228_H	232_G	1.505	1.00
223_R	227_I	1.498	1.00
274_N	390_C	1.496	1.00
182_A	192_G	1.495	1.00
220_T	268_V	1.488	1.00
672_L	696_K	1.484	1.00
592_D	595_R	1.479	1.00
382_M	385_K	1.477	1.00
275_D	302_G	1.477	1.00
393_Y	397_E	1.475	1.00
185_V	296_H	1.472	1.00
549_Q	572_F	1.472	1.00
204_A	207_K	1.471	1.00
141_F	153_V	1.465	1.00
698_V	708_L	1.453	1.00
118_K	150_V	1.446	1.00
395_L	423_A	1.440	1.00
111_T	154_T	1.440	1.00
128_A	142_Q	1.438	1.00
204_A	399_N	1.438	1.00
396_E	426_A	1.436	1.00
267_H	333_I	1.434	1.00
215_A	266_T	1.431	1.00
660_I	700_V	1.426	1.00
414_D	417_L	1.421	1.00
349_F	354_P	1.418	1.00
300_P	393_Y	1.398	1.00
244_E	255_S	1.395	1.00
300_P	318_L	1.393	1.00
659_V	707_I	1.387	1.00
333_I	433_F	1.373	1.00
605_Y	682_C	1.363	1.00
632_E	635_T	1.351	1.00
586_D	589_N	1.343	1.00
590_Q	594_D	1.342	1.00
667_S	699_A	1.333	1.00
200_M	399_N	1.330	1.00
106_L	118_K	1.329	1.00
128_A	140_T	1.324	1.00
350_E	354_P	1.319	1.00
239_Y	305_A	1.318	1.00
360_H	364_G	1.311	1.00
243_T	320_Q	1.306	1.00
110_Y	160_H	1.304	1.00
375_D	410_I	1.298	1.00
377_A	380_R	1.291	1.00
420_K	424_T	1.285	1.00
185_V	299_A	1.284	1.00
631_L	658_I	1.282	1.00
392_V	422_K	1.280	1.00
235_N	244_E	1.278	1.00
155_V	158_D	1.277	1.00
200_M	319_K	1.276	1.00
414_D	418_Y	1.273	1.00
222_L	270_L	1.271	1.00
548_R	703_I	1.271	1.00
361_D	365_M	1.270	1.00
629_R	646_Y	1.267	1.00
546_R	549_Q	1.264	1.00
106_L	150_V	1.263	1.00
351_K	354_P	1.261	1.00
116_V	154_T	1.259	1.00
318_L	398_Y	1.258	1.00
260_V	264_G	1.255	1.00
165_L	176_E	1.254	1.00
680_L	683_D	1.252	1.00
105_E	118_K	1.247	1.00
243_T	324_T	1.247	1.00
655_K	709_Y	1.243	1.00
608_R	688_Q	1.243	1.00
672_L	678_Y	1.240	1.00
140_T	167_C	1.236	1.00
450_A	453_N	1.234	1.00
225_F	242_L	1.234	1.00
576_Q	588_I	1.231	1.00
604_H	608_R	1.230	1.00
541_N	574_T	1.229	1.00
647_D	654_W	1.224	1.00
498_I	637_K	1.222	1.00
496_H	499_A	1.220	1.00
130_K	167_C	1.220	1.00
257_L	324_T	1.220	1.00
425_K	428_P	1.219	1.00
642_A	660_I	1.207	1.00
590_Q	593_W	1.206	1.00
553_A	609_L	1.203	1.00
300_P	394_W	1.202	1.00
131_L	141_F	1.202	1.00
220_T	242_L	1.198	1.00
296_H	299_A	1.187	1.00
132_S	163_E	1.178	1.00
127_A	352_T	1.178	1.00
640_L	700_V	1.172	1.00
388_A	422_K	1.170	1.00
242_L	321_M	1.164	1.00
419_M	432_L	1.162	1.00
418_Y	422_K	1.161	1.00
413_I	417_L	1.161	1.00
160_H	199_Q	1.158	1.00
167_C	174_W	1.156	1.00
216_V	614_K	1.156	1.00
418_Y	421_E	1.154	1.00
188_N	286_D	1.154	1.00
508_A	540_E	1.154	1.00
518_I	563_P	1.152	1.00
497_G	501_S	1.151	1.00
258_A	262_E	1.148	1.00
468_R	503_G	1.143	1.00
551_L	705_T	1.140	1.00
612_L	682_C	1.139	1.00
565_I	569_Q	1.136	1.00
621_L	648_L	1.136	1.00
504_W	641_I	1.134	1.00
132_S	191_K	1.133	1.00
169_C	174_W	1.131	1.00
122_P	149_G	1.130	1.00
388_A	419_M	1.122	1.00
105_E	116_V	1.121	1.00
220_T	567_S	1.116	1.00
129_V	153_V	1.113	1.00
120_W	382_M	1.111	1.00
472_K	503_G	1.107	1.00
344_R	348_P	1.106	1.00
596_R	603_V	1.106	1.00
116_V	152_A	1.101	1.00
242_L	325_L	1.099	1.00
267_H	331_R	1.094	1.00
391_V	419_M	1.094	1.00
189_G	193_V	1.087	1.00
415_T	420_K	1.087	1.00
657_I	709_Y	1.082	1.00
605_Y	609_L	1.080	1.00
115_T	159_L	1.078	1.00
533_M	553_A	1.077	1.00
495_M	498_I	1.072	1.00
263_L	603_V	1.068	1.00
258_A	261_K	1.068	1.00
378_S	387_I	1.067	1.00
546_R	550_R	1.065	1.00
203_T	327_Q	1.063	1.00
207_K	399_N	1.063	1.00
275_D	301_E	1.063	1.00
597_E	600_K	1.061	1.00
508_A	512_P	1.061	1.00
370_T	410_I	1.059	1.00
257_L	325_L	1.059	1.00
612_L	616_H	1.055	1.00
125_T	171_N	1.055	1.00
163_E	193_V	1.052	0.99
182_A	185_V	1.049	0.99
610_I	614_K	1.048	0.99
325_L	330_L	1.042	0.99
199_Q	316_T	1.039	0.99
102_Y	181_Y	1.035	0.99
224_D	288_Y	1.031	0.99
657_I	707_I	1.028	0.99
341_V	358_F	1.014	0.99
244_E	258_A	1.013	0.99
274_N	334_L	1.013	0.99
550_R	601_E	1.013	0.99
608_R	611_S	1.012	0.99
367_S	375_D	1.011	0.99
619_F	657_I	1.010	0.99
612_L	707_I	1.010	0.99
197_P	319_K	1.009	0.99
578_V	584_S	1.006	0.99
238_K	241_A	1.002	0.99
225_F	259_Y	0.998	0.99
593_W	596_R	0.997	0.99
200_M	203_T	0.995	0.99
360_H	363_C	0.995	0.99
221_H	271_L	0.991	0.99
141_F	155_V	0.991	0.99
549_Q	602_D	0.984	0.99
294_P	297_F	0.980	0.99
240_L	243_T	0.976	0.99
640_L	643_Y	0.975	0.99
660_I	708_L	0.972	0.99
575_K	581_S	0.970	0.99
681_L	709_Y	0.970	0.99
554_A	684_P	0.968	0.99
205_P	208_P	0.965	0.99
244_E	320_Q	0.963	0.99
643_Y	659_V	0.962	0.99
421_E	448_K	0.959	0.99
451_L	484_A	0.954	0.99
233_M	236_K	0.953	0.99
495_M	501_S	0.953	0.99
129_V	155_V	0.951	0.99
184_A	195_L	0.950	0.99
548_R	551_L	0.946	0.99
204_A	323_N	0.945	0.99
133_H	137_S	0.944	0.99
235_N	240_L	0.942	0.99
522_E	552_A	0.941	0.99
359_R	377_A	0.941	0.99
468_R	471_V	0.940	0.99
216_V	557_L	0.940	0.99
222_L	239_Y	0.937	0.99
537_L	543_S	0.937	0.99
600_K	603_V	0.936	0.99
109_V	183_K	0.935	0.99
108_A	166_F	0.934	0.99
231_S	256_G	0.929	0.99
160_H	196_R	0.929	0.99
683_D	686_G	0.928	0.99
581_S	588_I	0.924	0.99
640_L	668_V	0.924	0.99
192_G	196_R	0.924	0.99
220_T	256_G	0.921	0.99
183_K	197_P	0.920	0.99
392_V	427_K	0.919	0.99
553_A	602_D	0.918	0.99
442_P	449_A	0.916	0.99
607_R	611_S	0.915	0.99
273_V	334_L	0.914	0.99
588_I	593_W	0.913	0.99
344_R	347_S	0.913	0.99
557_L	565_I	0.912	0.99
667_S	702_G	0.912	0.99
656_D	710_L	0.909	0.99
633_C	641_I	0.908	0.99
239_Y	300_P	0.908	0.99
660_I	706_V	0.904	0.98
558_L	661_H	0.903	0.98
640_L	645_L	0.903	0.98
540_E	544_R	0.902	0.98
205_P	323_N	0.902	0.98
698_V	706_V	0.900	0.98
466_M	552_A	0.898	0.98
356_Y	359_R	0.897	0.98
184_A	193_V	0.896	0.98
183_K	393_Y	0.895	0.98
471_V	555_I	0.894	0.98
419_M	422_K	0.894	0.98
131_L	162_Y	0.890	0.98
551_L	661_H	0.885	0.98
473_G	529_F	0.884	0.98
680_L	686_G	0.883	0.98
298_F	386_F	0.881	0.98
210_S	329_G	0.880	0.98
192_G	195_L	0.877	0.98
391_V	403_F	0.876	0.98
554_A	558_L	0.876	0.98
147_E	152_A	0.874	0.98
108_A	117_F	0.871	0.98
196_R	199_Q	0.869	0.98
181_Y	389_D	0.868	0.98
117_F	129_V	0.866	0.98
259_Y	603_V	0.863	0.98
495_M	499_A	0.862	0.98
269_E	463_F	0.860	0.98
297_F	376_I	0.854	0.98
298_F	389_D	0.852	0.98
191_K	196_R	0.851	0.98
133_H	136_K	0.848	0.98
144_T	153_V	0.848	0.98
449_A	453_N	0.846	0.98
222_L	273_V	0.843	0.98
391_V	405_F	0.841	0.98
514_P	528_T	0.840	0.98
230_N	233_M	0.838	0.97
192_G	197_P	0.838	0.97
361_D	367_S	0.836	0.97
226_S	237_G	0.836	0.97
554_A	605_Y	0.836	0.97
125_T	170_N	0.834	0.97
609_L	682_C	0.834	0.97
381_R	384_R	0.833	0.97
177_T	352_T	0.829	0.97
671_R	695_K	0.829	0.97
104_G	397_E	0.829	0.97
540_E	543_S	0.829	0.97
366_P	371_G	0.828	0.97
680_L	706_V	0.823	0.97
421_E	425_K	0.822	0.97
544_R	548_R	0.822	0.97
278_G	293_N	0.822	0.97
395_L	403_F	0.821	0.97
203_T	399_N	0.816	0.97
334_L	400_V	0.814	0.97
162_Y	194_V	0.814	0.97
278_G	286_D	0.812	0.97
396_E	427_K	0.812	0.97
580_N	583_Q	0.810	0.97
577_G	580_N	0.809	0.97
618_A	657_I	0.808	0.97
565_I	606_I	0.808	0.97
368_N	410_I	0.807	0.97
384_R	414_D	0.805	0.97
451_L	454_A	0.805	0.97
359_R	364_G	0.804	0.97
226_S	256_G	0.804	0.97
667_S	697_T	0.802	0.97
346_N	351_K	0.802	0.97
112_A	154_T	0.801	0.97
490_S	493_A	0.801	0.97
392_V	426_A	0.798	0.97
130_K	140_T	0.795	0.97
189_G	195_L	0.794	0.97
158_D	194_V	0.793	0.96
186_T	189_G	0.793	0.96
553_A	569_Q	0.792	0.96
532_K	536_A	0.790	0.96
494_V	497_G	0.790	0.96
554_A	707_I	0.789	0.96
623_S	626_D	0.789	0.96
618_A	621_L	0.788	0.96
123_A	353_V	0.787	0.96
545_K	574_T	0.784	0.96
276_F	294_P	0.783	0.96
546_R	599_F	0.782	0.96
647_D	655_K	0.779	0.96
508_A	572_F	0.779	0.96
203_T	207_K	0.779	0.96
265_V	330_L	0.778	0.96
134_P	137_S	0.778	0.96
122_P	356_Y	0.776	0.96
392_V	396_E	0.775	0.96
622_R	625_A	0.774	0.96
294_P	390_C	0.774	0.96
220_T	270_L	0.770	0.96
214_D	614_K	0.769	0.96
665_P	703_I	0.768	0.96
535_F	544_R	0.767	0.96
588_I	591_L	0.765	0.96
408_L	434_G	0.762	0.96
229_E	233_M	0.762	0.96
160_H	195_L	0.761	0.96
513_E	528_T	0.759	0.96
117_F	194_V	0.759	0.96
316_T	320_Q	0.758	0.95
257_L	261_K	0.755	0.95
350_E	355_G	0.754	0.95
235_N	241_A	0.754	0.95
228_H	233_M	0.752	0.95
496_H	500_G	0.751	0.95
688_Q	691_P	0.751	0.95
616_H	655_K	0.750	0.95
105_E	109_V	0.750	0.95
102_Y	105_E	0.747	0.95
266_T	330_L	0.746	0.95
541_N	545_K	0.746	0.95
420_K	432_L	0.745	0.95
417_L	421_E	0.739	0.95
297_F	386_F	0.739	0.95
438_D	444_P	0.734	0.95
619_F	622_R	0.734	0.95
554_A	661_H	0.732	0.95
146_L	152_A	0.728	0.94
305_A	308_P	0.727	0.94
165_L	191_K	0.726	0.94
533_M	544_R	0.725	0.94
627_I	631_L	0.724	0.94
274_N	400_V	0.724	0.94
183_K	397_E	0.724	0.94
121_A	149_G	0.722	0.94
216_V	265_V	0.722	0.94
616_H	654_W	0.720	0.94
212_P	215_A	0.720	0.94
701_N	704_G	0.719	0.94
228_H	237_G	0.719	0.94
127_A	166_F	0.719	0.94
185_V	275_D	0.717	0.94
228_H	590_Q	0.717	0.94
376_I	386_F	0.716	0.94
186_T	193_V	0.715	0.94
641_I	645_L	0.713	0.94
468_R	472_K	0.711	0.94
369_G	375_D	0.710	0.94
423_A	432_L	0.708	0.94
259_Y	571_F	0.708	0.94
587_S	590_Q	0.707	0.93
323_N	399_N	0.706	0.93
143_M	166_F	0.705	0.93
604_H	688_Q	0.704	0.93
642_A	645_L	0.703	0.93
258_A	324_T	0.703	0.93
223_R	304_Y	0.703	0.93
575_K	592_D	0.701	0.93
550_R	602_D	0.701	0.93
202_W	207_K	0.701	0.93
620_R	623_S	0.698	0.93
495_M	500_G	0.695	0.93
237_G	255_S	0.694	0.93
266_T	614_K	0.693	0.93
601_E	604_H	0.692	0.93
449_A	452_A	0.692	0.93
364_G	377_A	0.691	0.93
555_I	661_H	0.691	0.93
260_V	325_L	0.689	0.93
298_F	393_Y	0.688	0.93
109_V	116_V	0.686	0.92
218_Y	570_E	0.686	0.92
111_T	114_H	0.686	0.92
318_L	334_L	0.685	0.92
348_P	353_V	0.685	0.92
575_K	589_N	0.685	0.92
682_C	687_F	0.685	0.92
633_C	643_Y	0.685	0.92
198_D	397_E	0.684	0.92
278_G	303_S	0.683	0.92
202_W	206_L	0.682	0.92
550_R	605_Y	0.681	0.92
226_S	241_A	0.681	0.92
535_F	548_R	0.680	0.92
454_A	457_M	0.680	0.92
643_Y	647_D	0.679	0.92
277_A	295_L	0.678	0.92
320_Q	323_N	0.678	0.92
422_K	427_K	0.677	0.92
336_V	391_V	0.676	0.92
268_V	321_M	0.676	0.92
189_G	192_G	0.676	0.92
423_A	427_K	0.674	0.92
496_H	501_S	0.673	0.92
356_Y	380_R	0.672	0.92
675_D	678_Y	0.671	0.92
415_T	422_K	0.671	0.92
161_G	193_V	0.670	0.92
604_H	689_E	0.669	0.91
622_R	626_D	0.669	0.91
142_Q	151_Y	0.668	0.91
489_E	493_A	0.667	0.91
188_N	302_G	0.665	0.91
178_V	182_A	0.664	0.91
155_V	159_L	0.664	0.91
573_R	591_L	0.664	0.91
589_N	592_D	0.663	0.91
494_V	500_G	0.663	0.91
126_S	167_C	0.663	0.91
406_D	525_D	0.663	0.91
263_L	610_I	0.661	0.91
203_T	206_L	0.661	0.91
685_S	691_P	0.659	0.91
646_Y	656_D	0.659	0.91
639_H	642_A	0.658	0.91
603_V	606_I	0.657	0.91
331_R	431_L	0.657	0.91
123_A	352_T	0.657	0.91
521_V	552_A	0.657	0.91
675_D	694_I	0.654	0.91
424_T	431_L	0.654	0.91
106_L	181_Y	0.654	0.91
144_T	152_A	0.652	0.90
239_Y	321_M	0.650	0.90
123_A	355_G	0.650	0.90
472_K	496_H	0.649	0.90
348_P	351_K	0.648	0.90
264_G	611_S	0.647	0.90
415_T	421_E	0.647	0.90
295_L	342_Y	0.646	0.90
669_E	699_A	0.645	0.90
422_K	426_A	0.644	0.90
584_S	588_I	0.644	0.90
498_I	501_S	0.644	0.90
178_V	192_G	0.643	0.90
268_V	332_V	0.643	0.90
461_G	562_V	0.641	0.90
642_A	647_D	0.641	0.90
658_I	678_Y	0.641	0.90
166_F	181_Y	0.638	0.89
240_L	244_E	0.638	0.89
632_E	642_A	0.636	0.89
631_L	645_L	0.635	0.89
549_Q	553_A	0.634	0.89
359_R	363_C	0.634	0.89
633_C	645_L	0.633	0.89
416_V	419_M	0.633	0.89
384_R	415_T	0.632	0.89
443_L	452_A	0.631	0.89
448_K	452_A	0.630	0.89
260_V	265_V	0.630	0.89
275_D	303_S	0.630	0.89
463_F	564_F	0.629	0.89
201_K	204_A	0.629	0.89
319_K	393_Y	0.628	0.89
348_P	354_P	0.628	0.89
596_R	599_F	0.628	0.89
186_T	190_E	0.627	0.89
190_E	295_L	0.626	0.89
301_E	304_Y	0.625	0.88
345_E	351_K	0.624	0.88
231_S	255_S	0.623	0.88
120_W	380_R	0.621	0.88
573_R	589_N	0.621	0.88
640_L	670_W	0.620	0.88
199_Q	319_K	0.619	0.88
574_T	595_R	0.619	0.88
555_I	559_A	0.618	0.88
256_G	260_V	0.618	0.88
101_Y	426_A	0.617	0.88
657_I	681_L	0.617	0.88
376_I	411_L	0.616	0.88
239_Y	243_T	0.616	0.88
589_N	593_W	0.616	0.88
586_D	590_Q	0.616	0.88
630_H	633_C	0.616	0.88
208_P	331_R	0.616	0.88
643_Y	646_Y	0.616	0.88
395_L	427_K	0.614	0.88
450_A	454_A	0.614	0.88
546_R	601_E	0.614	0.88
110_Y	113_D	0.613	0.88
602_D	605_Y	0.612	0.87
686_G	691_P	0.612	0.87
416_V	460_I	0.611	0.87
660_I	698_V	0.611	0.87
684_P	689_E	0.611	0.87
524_H	528_T	0.611	0.87
387_I	411_L	0.608	0.87
197_P	200_M	0.608	0.87
552_A	555_I	0.607	0.87
546_R	602_D	0.607	0.87
499_A	503_G	0.607	0.87
271_L	567_S	0.606	0.87
340_H	406_D	0.605	0.87
473_G	476_F	0.605	0.87
465_D	527_H	0.604	0.87
581_S	589_N	0.603	0.87
212_P	461_G	0.603	0.87
664_S	668_V	0.603	0.87
190_E	193_V	0.602	0.87
631_L	634_L	0.602	0.87
343_K	371_G	0.601	0.86
209_F	212_P	0.601	0.86
683_D	687_F	0.601	0.86
654_W	657_I	0.601	0.86
639_H	645_L	0.601	0.86
231_S	235_N	0.601	0.86
193_V	197_P	0.600	0.86
265_V	570_E	0.600	0.86
188_N	236_K	0.599	0.86
335_D	406_D	0.599	0.86
255_S	258_A	0.598	0.86
322_I	400_V	0.597	0.86
102_Y	389_D	0.597	0.86
527_H	531_D	0.596	0.86
685_S	701_N	0.596	0.86
566_H	573_R	0.596	0.86
170_N	173_E	0.594	0.86
241_A	321_M	0.594	0.86
585_S	590_Q	0.593	0.86
108_A	194_V	0.593	0.86
201_K	205_P	0.593	0.86
665_P	702_G	0.592	0.86
381_R	385_K	0.591	0.86
345_E	349_F	0.591	0.86
571_F	603_V	0.590	0.85
494_V	501_S	0.590	0.85
606_I	610_I	0.589	0.85
367_S	410_I	0.588	0.85
467_F	470_A	0.588	0.85
202_W	208_P	0.587	0.85
378_S	412_D	0.586	0.85
120_W	356_Y	0.586	0.85
360_H	366_P	0.585	0.85
414_D	425_K	0.585	0.85
183_K	398_Y	0.584	0.85
700_V	706_V	0.584	0.85
535_F	545_K	0.584	0.85
319_K	398_Y	0.583	0.85
421_E	424_T	0.583	0.85
113_D	154_T	0.582	0.85
225_F	593_W	0.581	0.85
417_L	420_K	0.580	0.85
667_S	701_N	0.579	0.84
640_L	646_Y	0.578	0.84
611_S	614_K	0.578	0.84
204_A	327_Q	0.577	0.84
404_R	435_E	0.576	0.84
554_A	609_L	0.574	0.84
201_K	323_N	0.574	0.84
582_Y	585_S	0.573	0.84
191_K	197_P	0.573	0.84
121_A	124_A	0.573	0.84
276_F	301_E	0.572	0.84
423_A	426_A	0.570	0.83
293_N	372_V	0.570	0.83
406_D	435_E	0.570	0.83
228_H	256_G	0.569	0.83
671_R	693_E	0.568	0.83
196_R	316_T	0.567	0.83
349_F	383_A	0.567	0.83
222_L	257_L	0.567	0.83
563_P	613_R	0.567	0.83
452_A	462_F	0.566	0.83
449_A	454_A	0.565	0.83
232_G	235_N	0.564	0.83
608_R	682_C	0.563	0.83
359_R	375_D	0.562	0.83
361_D	364_G	0.561	0.83
491_A	494_V	0.559	0.82
658_I	708_L	0.559	0.82
453_N	457_M	0.559	0.82
578_V	583_Q	0.559	0.82
618_A	623_S	0.559	0.82
452_A	457_M	0.558	0.82
627_I	630_H	0.558	0.82
671_R	697_T	0.557	0.82
412_D	417_L	0.556	0.82
232_G	236_K	0.555	0.82
495_M	502_S	0.555	0.82
258_A	325_L	0.555	0.82
352_T	355_G	0.555	0.82
680_L	698_V	0.554	0.82
115_T	160_H	0.554	0.82
585_S	588_I	0.553	0.82
404_R	525_D	0.552	0.82
163_E	191_K	0.552	0.82
448_K	451_L	0.551	0.81
211_H	214_D	0.550	0.81
547_S	550_R	0.550	0.81
369_G	410_I	0.550	0.81
607_R	610_I	0.550	0.81
360_H	365_M	0.549	0.81
341_V	376_I	0.548	0.81
594_D	598_T	0.548	0.81
191_K	194_V	0.548	0.81
228_H	255_S	0.546	0.81
238_K	317_E	0.545	0.81
235_N	306_S	0.544	0.81
422_K	428_P	0.544	0.81
384_R	388_A	0.544	0.81
388_A	418_Y	0.544	0.81
666_D	702_G	0.544	0.81
437_W	468_R	0.543	0.80
232_G	255_S	0.543	0.80
424_T	432_L	0.543	0.80
129_V	166_F	0.542	0.80
414_D	421_E	0.542	0.80
170_N	175_M	0.542	0.80
326_H	332_V	0.541	0.80
233_M	241_A	0.541	0.80
409_G	437_W	0.540	0.80
627_I	645_L	0.540	0.80
619_F	623_S	0.539	0.80
449_A	455_P	0.538	0.80
536_A	539_Q	0.538	0.80
542_D	704_G	0.538	0.80
424_T	448_K	0.537	0.80
99_E	102_Y	0.536	0.80
238_K	242_L	0.536	0.80
579_E	583_Q	0.536	0.80
297_F	390_C	0.535	0.79
293_N	342_Y	0.535	0.79
465_D	469_D	0.535	0.79
347_S	354_P	0.535	0.79
497_G	502_S	0.534	0.79
367_S	370_T	0.534	0.79
353_V	360_H	0.534	0.79
493_A	496_H	0.533	0.79
208_P	212_P	0.533	0.79
339_N	407_L	0.532	0.79
347_S	351_K	0.532	0.79
130_K	165_L	0.532	0.79
522_E	533_M	0.532	0.79
369_G	441_T	0.531	0.79
686_G	689_E	0.531	0.79
544_R	703_I	0.531	0.79
267_H	330_L	0.530	0.79
419_M	428_P	0.529	0.79
319_K	399_N	0.529	0.79
489_E	492_Q	0.529	0.79
493_A	497_G	0.528	0.79
632_E	640_L	0.528	0.79
298_F	338_F	0.527	0.78
169_C	173_E	0.526	0.78
521_V	524_H	0.526	0.78
391_V	423_A	0.526	0.78
499_A	502_S	0.525	0.78
687_F	691_P	0.525	0.78
346_N	350_E	0.525	0.78
378_S	415_T	0.524	0.78
188_N	301_E	0.524	0.78
464_N	517_S	0.524	0.78
346_N	349_F	0.523	0.78
439_L	442_P	0.523	0.78
348_P	352_T	0.522	0.78
683_D	698_V	0.521	0.78
416_V	454_A	0.520	0.78
413_I	420_K	0.519	0.77
207_K	331_R	0.519	0.77
198_D	316_T	0.519	0.77
287_A	588_I	0.518	0.77
123_A	356_Y	0.518	0.77
121_A	353_V	0.518	0.77
424_T	427_K	0.516	0.77
682_C	690_D	0.516	0.77
633_C	639_H	0.514	0.77
633_C	636_L	0.513	0.77
155_V	162_Y	0.513	0.77
223_R	586_D	0.512	0.76
140_T	144_T	0.512	0.76
321_M	324_T	0.512	0.76
273_V	321_M	0.512	0.76
588_I	592_D	0.511	0.76
269_E	433_F	0.511	0.76
638_E	668_V	0.510	0.76
440_A	443_L	0.510	0.76
345_E	352_T	0.510	0.76
618_A	622_R	0.510	0.76
187_V	302_G	0.507	0.76
642_A	658_I	0.507	0.76
699_A	702_G	0.507	0.76
496_H	503_G	0.505	0.76
534_S	574_T	0.505	0.76
470_A	663_A	0.505	0.76
198_D	201_K	0.505	0.76
475_T	555_I	0.505	0.76
219_E	290_W	0.503	0.75
126_S	144_T	0.503	0.75
476_F	531_D	0.503	0.75
498_I	502_S	0.503	0.75
451_L	457_M	0.502	0.75
126_S	139_R	0.501	0.75
259_Y	606_I	0.501	0.75
683_D	706_V	0.501	0.75
326_H	399_N	0.500	0.75
580_N	588_I	0.500	0.75

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2e8yA	1	0.9916	100	0.231	Contact Map
3wdhA	1	0.9638	100	0.253	Contact Map
2wanA	1	0.9638	100	0.274	Contact Map
3fawA	1	0.9359	100	0.337	Contact Map
2ya1A	1	0.9095	100	0.337	Contact Map
4j3vA	1	0.961	100	0.341	Contact Map
2fhfA	1	0.9847	100	0.348	Contact Map
1bf2A	1	0.8036	100	0.352	Contact Map
2ya0A	1	0.8412	100	0.359	Contact Map
4j7rA	2	0.8412	100	0.361	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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