GREMLIN Database
YHFQ - Putative ABC transporter substrate-binding lipoprotein YhfQ
UniProt: C0SP94 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (288)
Sequences: 14058 (11224)
Seq/√Len: 661.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
251_D283_K4.1191.00
157_A166_M4.0561.00
154_L167_E3.7891.00
162_K165_E3.4901.00
176_K312_D3.2481.00
150_I174_E3.1871.00
158_K163_E3.1631.00
283_K287_N3.0491.00
37_T42_K2.9921.00
54_V60_I2.9161.00
165_E168_K2.6911.00
178_S182_Q2.6571.00
35_A42_K2.5881.00
154_L170_L2.5881.00
167_E171_T2.5571.00
171_T175_E2.5521.00
214_L219_Y2.5401.00
107_K110_S2.4291.00
246_Q249_K2.3001.00
38_H43_T2.2451.00
53_V108_I2.1931.00
63_L160_V2.1471.00
190_S220_R2.1061.00
176_K308_N2.0911.00
52_V160_V2.0861.00
174_E178_S2.0781.00
211_S215_T2.0581.00
51_R71_V2.0211.00
175_E179_E2.0081.00
179_E183_K1.9851.00
68_I160_V1.9761.00
129_Q132_K1.9721.00
274_E288_G1.9531.00
253_D283_K1.9511.00
68_I162_K1.9081.00
148_D151_D1.8731.00
35_A44_N1.8551.00
168_K172_A1.8421.00
62_T153_S1.8391.00
271_R275_K1.8311.00
117_I156_I1.7491.00
127_Y131_K1.7281.00
72_G111_L1.7281.00
164_K168_K1.7281.00
282_L285_V1.7161.00
254_V291_Y1.6971.00
33_K44_N1.6951.00
178_S181_K1.6711.00
254_V289_H1.6271.00
283_K286_K1.6121.00
103_P108_I1.5621.00
34_V158_K1.5531.00
145_D148_D1.5501.00
172_A176_K1.5361.00
151_D154_L1.5281.00
281_K286_K1.5021.00
128_D132_K1.4901.00
270_K274_E1.4831.00
165_E169_K1.4671.00
279_W285_V1.4671.00
53_V111_L1.4661.00
104_S107_K1.4541.00
95_T107_K1.4521.00
191_V219_Y1.4491.00
124_K128_D1.4471.00
271_R274_E1.4421.00
312_D316_K1.4371.00
135_P140_N1.4151.00
244_L276_N1.4041.00
189_Q254_V1.4031.00
109_A133_I1.3931.00
291_Y317_E1.3901.00
154_L174_E1.3801.00
182_Q185_S1.3731.00
180_T311_L1.3691.00
128_D131_K1.3681.00
66_L162_K1.3641.00
53_V72_G1.3591.00
71_V111_L1.3531.00
200_T241_K1.3521.00
255_I284_A1.3461.00
163_E167_E1.3431.00
180_T315_Q1.3271.00
38_H41_G1.3121.00
54_V63_L1.2971.00
171_T174_E1.2941.00
188_S220_R1.2841.00
246_Q250_T1.2781.00
106_E245_E1.2751.00
169_K172_A1.2721.00
176_K179_E1.2651.00
74_A77_N1.2571.00
164_K167_E1.2531.00
49_P114_D1.2401.00
151_D155_T1.2341.00
63_L68_I1.2291.00
179_E182_Q1.2251.00
50_K114_D1.2231.00
313_E316_K1.2181.00
175_E178_S1.2151.00
12_L15_V1.2151.00
192_L195_G1.2001.00
225_T250_T1.1991.00
155_T158_K1.1971.00
13_L16_L1.1851.00
45_V48_H1.1821.00
150_I170_L1.1821.00
105_M129_Q1.1821.00
51_R112_K1.1741.00
206_E215_T1.1701.00
222_A250_T1.1691.00
123_H126_V1.1681.00
170_L174_E1.1591.00
20_C23_S1.1481.00
223_I250_T1.1431.00
144_A147_Q1.1321.00
147_Q150_I1.1281.00
183_K315_Q1.1221.00
268_D271_R1.1141.00
181_K216_Q1.1121.00
135_P138_A1.1061.00
190_S253_D1.1011.00
172_A175_E1.1001.00
38_H127_Y1.0991.00
147_Q174_E1.0981.00
193_L214_L1.0821.00
136_T140_N1.0811.00
137_I159_A1.0711.00
50_K69_T1.0501.00
116_I134_A1.0451.00
52_V115_L1.0441.00
118_A138_A1.0401.00
33_K47_E1.0371.00
181_K185_S1.0371.00
146_Y149_T1.0361.00
126_V129_Q1.0221.00
65_D169_K1.0201.00
220_R224_S1.0161.00
189_Q289_H1.0081.00
177_L311_L1.0081.00
279_W282_L1.0041.00
251_D255_I0.9821.00
90_K94_Y0.9791.00
70_P94_Y0.9781.00
153_S166_M0.9751.00
177_L181_K0.9731.00
32_H161_G0.9691.00
223_I226_S0.9651.00
173_H216_Q0.9631.00
63_L117_I0.9621.00
191_V214_L0.9551.00
176_K180_T0.9551.00
95_T98_G0.9461.00
157_A170_L0.9451.00
223_I246_Q0.9451.00
45_V49_P0.9451.00
40_L131_K0.9441.00
192_L203_A0.9381.00
63_L70_P0.9301.00
219_Y318_M0.9271.00
91_I94_Y0.9251.00
311_L315_Q0.9201.00
254_V318_M0.9181.00
38_H42_K0.9171.00
75_D96_S0.9171.00
155_T159_A0.9141.00
10_V14_S0.9131.00
154_L158_K0.9131.00
33_K48_H0.9101.00
166_M170_L0.9061.00
305_D308_N0.9021.00
167_E170_L0.9011.00
285_V290_V0.8961.00
283_K289_H0.8911.00
73_V94_Y0.8911.00
137_I155_T0.8911.00
212_R215_T0.8831.00
48_H162_K0.8821.00
277_V280_K0.8811.00
52_V63_L0.8781.00
272_P275_K0.8781.00
64_L91_I0.8751.00
252_P255_I0.8741.00
69_T162_K0.8731.00
15_V18_A0.8711.00
191_V195_G0.8661.00
247_L282_L0.8651.00
212_R216_Q0.8641.00
40_L138_A0.8611.00
85_K88_L0.8611.00
32_H47_E0.8611.00
11_L15_V0.8551.00
191_V194_I0.8531.00
194_I276_N0.8521.00
156_I160_V0.8511.00
192_L252_P0.8511.00
9_T12_L0.8501.00
14_S17_T0.8491.00
66_L160_V0.8461.00
48_H161_G0.8451.00
49_P115_L0.8431.00
34_V45_V0.8411.00
222_A225_T0.8401.00
66_L169_K0.8381.00
62_T156_I0.8371.00
274_E290_V0.8361.00
248_L282_L0.8351.00
115_L137_I0.8251.00
91_I95_T0.8241.00
117_I159_A0.8241.00
184_I315_Q0.8231.00
189_Q219_Y0.8231.00
54_V70_P0.8221.00
115_L159_A0.8201.00
294_D313_E0.8161.00
168_K171_T0.8151.00
173_H177_L0.8121.00
294_D297_V0.8121.00
298_W301_R0.8111.00
47_E50_K0.8101.00
81_Q85_K0.8051.00
113_P116_I0.8001.00
64_L70_P0.7971.00
33_K46_P0.7951.00
116_I133_I0.7881.00
192_L196_N0.7881.00
312_D315_Q0.7841.00
194_I197_T0.7831.00
55_L116_I0.7791.00
59_F117_I0.7791.00
257_L292_H0.7731.00
308_N312_D0.7651.00
125_K128_D0.7641.00
248_L281_K0.7641.00
61_D305_D0.7621.00
56_E119_D0.7621.00
280_K285_V0.7601.00
66_L157_A0.7591.00
66_L165_E0.7571.00
256_I314_L0.7561.00
192_L247_L0.7541.00
73_V96_S0.7541.00
156_I159_A0.7521.00
196_N199_D0.7511.00
311_L316_K0.7481.00
65_D305_D0.7421.00
146_Y150_I0.7341.00
11_L14_S0.7311.00
72_G98_G0.7271.00
169_K173_H0.7261.00
268_D272_P0.7261.00
176_K315_Q0.7251.00
147_Q151_D0.7251.00
269_G272_P0.7241.00
221_Y225_T0.7231.00
204_R208_F0.7211.00
256_I291_Y0.7211.00
61_D303_S0.7191.00
276_N280_K0.7191.00
297_V301_R0.7141.00
131_K136_T0.7131.00
193_L258_M0.7131.00
32_H48_H0.7131.00
67_G165_E0.7131.00
206_E226_S0.7121.00
90_K93_G0.7121.00
13_L17_T0.7101.00
17_T20_C0.7061.00
139_L155_T0.7041.00
180_T184_I0.7031.00
89_K92_D0.7021.00
86_D89_K0.7011.00
194_I199_D0.7001.00
203_A223_I0.7001.00
177_L216_Q0.6981.00
36_V45_V0.6971.00
9_T13_L0.6921.00
242_M250_T0.6921.00
45_V135_P0.6911.00
160_V163_E0.6891.00
53_V113_P0.6851.00
97_V111_L0.6841.00
208_F211_S0.6841.00
16_L19_A0.6791.00
18_A21_S0.6781.00
243_T246_Q0.6761.00
150_I154_L0.6731.00
99_T102_Q0.6721.00
153_S169_K0.6691.00
213_L311_L0.6681.00
45_V115_L0.6671.00
257_L290_V0.6671.00
152_A155_T0.6661.00
137_I141_N0.6621.00
183_K186_A0.6591.00
297_V300_L0.6591.00
136_T142_L0.6591.00
303_S306_G0.6571.00
206_E224_S0.6571.00
154_L157_A0.6571.00
122_R126_V0.6521.00
67_G162_K0.6521.00
51_R114_D0.6511.00
304_V308_N0.6501.00
53_V97_V0.6501.00
45_V159_A0.6491.00
10_V16_L0.6481.00
10_V13_L0.6481.00
248_L252_P0.6451.00
124_K127_Y0.6441.00
149_T153_S0.6421.00
259_T292_H0.6421.00
181_K217_V0.6401.00
95_T111_L0.6381.00
258_M293_V0.6381.00
14_S18_A0.6341.00
92_D95_T0.6321.00
297_V313_E0.6301.00
310_I314_L0.6271.00
72_G97_V0.6261.00
204_R239_N0.6261.00
191_V256_I0.6261.00
313_E317_E0.6231.00
105_M108_I0.6181.00
20_C24_S0.6181.00
19_A23_S0.6171.00
270_K292_H0.6171.00
193_L210_T0.6151.00
66_L166_M0.6141.00
106_E109_A0.6121.00
273_I276_N0.6111.00
43_T137_I0.6091.00
53_V116_I0.6061.00
64_L90_K0.6051.00
192_L255_I0.6041.00
9_T16_L0.6031.00
255_I258_M0.6031.00
150_I173_H0.6001.00
194_I255_I0.5991.00
194_I203_A0.5981.00
298_W310_I0.5961.00
293_V298_W0.5951.00
173_H176_K0.5951.00
29_S32_H0.5951.00
135_P139_L0.5891.00
63_L156_I0.5861.00
32_H46_P0.5851.00
39_D155_T0.5801.00
170_L173_H0.5801.00
214_L217_V0.5791.00
108_I130_L0.5771.00
221_Y224_S0.5751.00
306_G310_I0.5711.00
180_T217_V0.5711.00
182_Q186_A0.5701.00
54_V59_F0.5681.00
276_N279_W0.5671.00
127_Y130_L0.5641.00
135_P141_N0.5621.00
247_L250_T0.5621.00
49_P160_V0.5611.00
48_H114_D0.5611.00
223_I242_M0.5601.00
105_M133_I0.5581.00
207_N211_S0.5581.00
208_F238_V0.5581.00
244_L279_W0.5551.00
147_Q216_Q0.5521.00
53_V71_V0.5521.00
126_V130_L0.5511.00
98_G103_P0.5511.00
107_K111_L0.5501.00
32_H49_P0.5471.00
217_V315_Q0.5451.00
310_I313_E0.5441.00
60_I73_V0.5421.00
254_V258_M0.5421.00
59_F156_I0.5411.00
173_H307_A0.5411.00
136_T139_L0.5391.00
177_L307_A0.5391.00
255_I279_W0.5381.00
192_L222_A0.5371.00
62_T65_D0.5361.00
179_E312_D0.5361.00
54_V73_V0.5351.00
180_T183_K0.5341.00
190_S254_V0.5321.00
105_M126_V0.5321.00
248_L278_L0.5321.00
260_G295_R0.5301.00
181_K184_I0.5290.99
79_A305_D0.5280.99
120_T140_N0.5280.99
149_T152_A0.5270.99
65_D153_S0.5270.99
204_R211_S0.5270.99
211_S224_S0.5260.99
204_R210_T0.5260.99
298_W313_E0.5250.99
242_M247_L0.5250.99
202_M241_K0.5240.99
151_D167_E0.5230.99
177_L180_T0.5220.99
163_E166_M0.5200.99
135_P142_L0.5180.99
106_E243_T0.5180.99
34_V47_E0.5160.99
40_L124_K0.5160.99
36_V155_T0.5150.99
279_W290_V0.5140.99
130_L136_T0.5130.99
49_P52_V0.5130.99
205_D211_S0.5130.99
19_A22_S0.5120.99
40_L127_Y0.5110.99
62_T304_V0.5110.99
251_D282_L0.5090.99
215_T224_S0.5080.99
70_P73_V0.5080.99
59_F62_T0.5070.99
150_I177_L0.5070.99
208_F239_N0.5060.99
191_V196_N0.5050.99
201_I204_R0.5040.99
137_I140_N0.5040.99
59_F139_L0.5030.99
56_E59_F0.5030.99
149_T306_G0.5020.99
314_L318_M0.5020.99
69_T160_V0.5010.99
307_A310_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3lhsA 1 0.8978 100 0.249 Contact Map
4n01A 1 0.8638 100 0.255 Contact Map
4mlzA 1 0.8638 100 0.265 Contact Map
3tlkA 1 0.87 100 0.284 Contact Map
3mwfA 1 0.87 100 0.287 Contact Map
3tnyA 1 0.8545 100 0.288 Contact Map
2x4lA 1 0.8607 100 0.29 Contact Map
3tefA 1 0.8514 100 0.293 Contact Map
4hn9A 1 0.8545 100 0.295 Contact Map
4ovkA 1 0.8545 100 0.302 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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