ACCD - BACSU - GREMLIN Contacts

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ACCD - Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

UniProt:	C0SP93	Sequences: MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKELDKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDREKTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFIIFTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDYNFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLLDMHQTGGDIEWLQD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	290 (241)
Sequences:	7475 (3296)
Seq/√Len:	212.3

ECOLI - ACCD ACCA
BACSU - ACCD PCCB YNGE ACCA
HALSA - Q9HRN1 Q9HPQ0
SULSO - Q97VY8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
70_M	115_G	4.390	1.00
236_E	242_K	4.023	1.00
70_M	124_V	3.409	1.00
123_V	147_A	3.160	1.00
199_V	272_L	3.046	1.00
123_V	156_V	2.772	1.00
48_M	52_M	2.716	1.00
149_E	185_A	2.519	1.00
74_S	116_T	2.481	1.00
222_E	264_H	2.424	1.00
59_P	202_H	2.409	1.00
150_K	154_D	2.383	1.00
75_F	113_G	2.361	1.00
118_G	273_E	2.293	1.00
116_T	121_P	2.212	1.00
152_K	189_F	2.190	1.00
112_T	147_A	2.183	1.00
254_L	259_L	2.177	1.00
198_S	216_G	2.154	1.00
264_H	267_D	2.074	1.00
161_F	199_V	2.058	1.00
125_A	160_I	2.057	1.00
129_S	133_M	2.037	1.00
122_A	159_I	2.009	1.00
263_I	271_T	2.009	1.00
60_M	68_S	1.984	1.00
232_R	246_D	1.957	1.00
109_A	140_V	1.919	1.00
220_F	261_A	1.910	1.00
250_A	262_V	1.857	1.00
52_M	56_Y	1.856	1.00
114_K	154_D	1.849	1.00
162_T	198_S	1.848	1.00
118_G	277_D	1.832	1.00
261_A	271_T	1.785	1.00
155_K	192_E	1.771	1.00
110_V	144_I	1.743	1.00
271_T	274_N	1.714	1.00
254_L	262_V	1.662	1.00
51_C	55_D	1.628	1.00
152_K	192_E	1.626	1.00
69_L	161_F	1.617	1.00
69_L	117_I	1.603	1.00
189_F	194_G	1.597	1.00
120_H	280_Q	1.591	1.00
66_I	124_V	1.567	1.00
61_N	64_Q	1.560	1.00
251_E	255_K	1.554	1.00
187_K	191_E	1.538	1.00
267_D	271_T	1.537	1.00
79_N	146_L	1.513	1.00
145_T	185_A	1.512	1.00
148_I	158_F	1.508	1.00
62_A	126_V	1.492	1.00
79_N	112_T	1.489	1.00
168_R	171_E	1.483	1.00
78_F	150_K	1.473	1.00
51_C	54_C	1.472	1.00
144_I	182_T	1.462	1.00
150_K	153_A	1.450	1.00
76_E	114_K	1.436	1.00
34_K	38_I	1.419	1.00
85_E	138_S	1.405	1.00
120_H	277_D	1.399	1.00
159_I	199_V	1.394	1.00
55_D	264_H	1.384	1.00
39_M	80_Q	1.382	1.00
114_K	121_P	1.380	1.00
77_E	80_Q	1.376	1.00
62_A	111_V	1.373	1.00
138_S	174_L	1.373	1.00
117_I	122_A	1.347	1.00
33_P	37_K	1.343	1.00
77_E	143_K	1.323	1.00
135_S	165_G	1.312	1.00
121_P	156_V	1.309	1.00
63_K	77_E	1.304	1.00
114_K	156_V	1.295	1.00
118_G	270_K	1.287	1.00
82_M	139_V	1.285	1.00
64_Q	67_E	1.276	1.00
55_D	64_Q	1.274	1.00
147_A	158_F	1.261	1.00
32_C	35_C	1.259	1.00
152_K	194_G	1.257	1.00
42_K	45_D	1.245	1.00
136_M	140_V	1.242	1.00
222_E	262_V	1.228	1.00
40_L	43_E	1.224	1.00
30_T	41_T	1.213	1.00
66_I	70_M	1.197	1.00
217_D	221_A	1.195	1.00
141_G	178_Q	1.188	1.00
70_M	74_S	1.171	1.00
267_D	270_K	1.153	1.00
115_G	124_V	1.152	1.00
125_A	158_F	1.150	1.00
187_K	190_S	1.129	1.00
79_N	82_M	1.128	1.00
156_V	194_G	1.121	1.00
188_L	191_E	1.100	1.00
205_T	226_L	1.093	1.00
142_E	181_K	1.091	1.00
219_N	272_L	1.085	1.00
152_K	188_L	1.083	1.00
49_R	64_Q	1.078	1.00
270_K	274_N	1.074	1.00
222_E	251_E	1.072	1.00
70_M	122_A	1.067	1.00
148_I	186_L	1.063	1.00
263_I	268_M	1.062	1.00
114_K	123_V	1.053	1.00
68_S	270_K	1.044	1.00
75_F	79_N	1.034	1.00
125_A	147_A	1.025	1.00
184_S	188_L	1.019	1.00
38_I	41_T	1.016	1.00
68_S	269_K	1.001	1.00
216_G	221_A	0.992	1.00
232_R	249_T	0.991	1.00
161_F	269_K	0.983	1.00
43_E	80_Q	0.979	1.00
29_M	40_L	0.979	1.00
74_S	113_G	0.979	1.00
159_I	276_L	0.978	1.00
108_E	139_V	0.975	1.00
45_D	49_R	0.971	1.00
63_K	111_V	0.965	1.00
161_F	201_T	0.960	1.00
42_K	46_K	0.960	1.00
123_V	151_A	0.943	0.99
83_L	107_N	0.942	0.99
217_D	222_E	0.941	0.99
44_L	48_M	0.941	0.99
112_T	123_V	0.937	0.99
29_M	33_P	0.935	0.99
39_M	43_E	0.931	0.99
198_S	215_L	0.930	0.99
31_K	34_K	0.929	0.99
37_K	40_L	0.924	0.99
75_F	78_F	0.923	0.99
110_V	125_A	0.920	0.99
209_S	214_S	0.915	0.99
114_K	150_K	0.915	0.99
219_N	271_T	0.913	0.99
34_K	37_K	0.910	0.99
162_T	213_A	0.908	0.99
67_E	72_E	0.908	0.99
118_G	269_K	0.907	0.99
220_F	263_I	0.903	0.99
35_C	54_C	0.900	0.99
148_I	185_A	0.899	0.99
197_I	275_L	0.897	0.99
243_L	247_F	0.895	0.99
219_N	268_M	0.894	0.99
195_L	279_H	0.888	0.99
44_L	58_F	0.884	0.99
217_D	220_F	0.884	0.99
220_F	225_A	0.882	0.99
268_M	272_L	0.880	0.99
148_I	189_F	0.878	0.99
199_V	268_M	0.876	0.99
31_K	38_I	0.872	0.99
251_E	262_V	0.868	0.99
129_S	203_P	0.867	0.99
36_K	39_M	0.861	0.99
53_N	56_Y	0.860	0.99
186_L	196_I	0.856	0.99
145_T	181_K	0.848	0.99
123_V	150_K	0.844	0.99
47_N	51_C	0.844	0.99
112_T	125_A	0.841	0.99
149_E	153_A	0.838	0.99
118_G	281_T	0.836	0.99
201_T	269_K	0.834	0.99
35_C	51_C	0.832	0.99
78_F	123_V	0.818	0.99
92_G	100_D	0.816	0.99
180_A	184_S	0.815	0.99
150_K	156_V	0.813	0.98
28_I	31_K	0.812	0.98
219_N	263_I	0.809	0.98
268_M	271_T	0.809	0.98
51_C	61_N	0.807	0.98
144_I	160_I	0.805	0.98
63_K	106_L	0.799	0.98
49_R	52_M	0.797	0.98
142_E	146_L	0.790	0.98
44_L	47_N	0.789	0.98
61_N	130_S	0.778	0.98
47_N	50_V	0.777	0.98
274_N	278_M	0.776	0.98
140_V	144_I	0.775	0.98
186_L	190_S	0.774	0.98
181_K	185_A	0.768	0.98
123_V	154_D	0.768	0.98
137_G	168_R	0.767	0.98
230_A	234_I	0.760	0.98
164_S	208_V	0.758	0.98
66_I	111_V	0.758	0.98
148_I	152_K	0.753	0.98
106_L	128_D	0.751	0.97
83_L	108_E	0.747	0.97
101_R	107_N	0.746	0.97
269_K	273_E	0.745	0.97
223_P	264_H	0.743	0.97
66_I	126_V	0.742	0.97
145_T	148_I	0.741	0.97
216_G	222_E	0.740	0.97
30_T	33_P	0.738	0.97
266_D	269_K	0.737	0.97
139_V	142_E	0.732	0.97
78_F	114_K	0.731	0.97
50_V	57_H	0.730	0.97
151_A	158_F	0.726	0.97
40_L	44_L	0.725	0.97
120_H	276_L	0.720	0.97
219_N	259_L	0.719	0.97
46_K	50_V	0.717	0.97
205_T	228_G	0.714	0.97
143_K	146_L	0.711	0.96
117_I	120_H	0.711	0.96
43_E	46_K	0.710	0.96
42_K	81_G	0.705	0.96
75_F	111_V	0.703	0.96
33_P	56_Y	0.700	0.96
37_K	41_T	0.698	0.96
186_L	211_S	0.693	0.96
136_M	144_I	0.693	0.96
55_D	61_N	0.691	0.96
145_T	149_E	0.691	0.96
122_A	276_L	0.688	0.96
48_M	51_C	0.682	0.96
108_E	168_R	0.682	0.96
65_R	224_G	0.680	0.95
226_L	232_R	0.679	0.95
221_A	259_L	0.677	0.95
33_P	36_K	0.675	0.95
218_Y	221_A	0.673	0.95
164_S	203_P	0.669	0.95
105_S	132_R	0.669	0.95
133_M	195_L	0.669	0.95
148_I	160_I	0.664	0.95
60_M	266_D	0.662	0.95
77_E	82_M	0.654	0.94
155_K	194_G	0.654	0.94
44_L	51_C	0.653	0.94
230_A	235_I	0.652	0.94
79_N	143_K	0.649	0.94
54_C	59_P	0.648	0.94
69_L	272_L	0.648	0.94
84_S	101_R	0.647	0.94
215_L	218_Y	0.645	0.94
71_D	74_S	0.639	0.94
41_T	44_L	0.639	0.94
31_K	43_E	0.638	0.94
28_I	43_E	0.637	0.94
216_G	219_N	0.637	0.94
245_E	248_Q	0.637	0.94
42_K	107_N	0.637	0.94
159_I	272_L	0.636	0.94
157_P	194_G	0.633	0.93
120_H	273_E	0.630	0.93
100_D	104_T	0.623	0.93
69_L	124_V	0.620	0.93
29_M	32_C	0.619	0.93
223_P	251_E	0.618	0.93
37_K	53_N	0.614	0.92
36_K	40_L	0.614	0.92
274_N	277_D	0.612	0.92
78_F	154_D	0.612	0.92
231_G	234_I	0.612	0.92
215_L	221_A	0.612	0.92
160_I	196_I	0.608	0.92
83_L	139_V	0.606	0.92
253_L	256_H	0.603	0.92
66_I	113_G	0.600	0.91
149_E	188_L	0.599	0.91
271_T	275_L	0.599	0.91
121_P	154_D	0.598	0.91
52_M	55_D	0.598	0.91
120_H	281_T	0.595	0.91
81_G	107_N	0.595	0.91
217_D	261_A	0.594	0.91
132_R	170_Q	0.593	0.91
200_M	219_N	0.592	0.91
112_T	143_K	0.591	0.91
272_L	275_L	0.590	0.91
115_G	122_A	0.589	0.91
252_F	256_H	0.588	0.91
232_R	236_E	0.587	0.91
54_C	57_H	0.586	0.91
133_M	161_F	0.585	0.90
124_V	161_F	0.582	0.90
77_E	81_G	0.582	0.90
63_K	67_E	0.578	0.90
32_C	36_K	0.576	0.90
78_F	147_A	0.576	0.90
167_A	176_L	0.576	0.90
45_D	48_M	0.576	0.90
30_T	34_K	0.574	0.90
127_M	140_V	0.572	0.89
263_I	267_D	0.572	0.89
70_M	75_F	0.571	0.89
41_T	45_D	0.569	0.89
189_F	195_L	0.568	0.89
160_I	186_L	0.567	0.89
77_E	111_V	0.565	0.89
175_S	178_Q	0.562	0.89
83_L	104_T	0.558	0.88
201_T	266_D	0.558	0.88
30_T	40_L	0.557	0.88
176_L	179_M	0.556	0.88
163_A	201_T	0.556	0.88
221_A	224_G	0.555	0.88
198_S	219_N	0.554	0.88
39_M	52_M	0.553	0.88
29_M	41_T	0.547	0.87
183_S	215_L	0.547	0.87
127_M	212_F	0.546	0.87
207_G	231_G	0.544	0.87
35_C	39_M	0.542	0.87
38_I	42_K	0.541	0.87
39_M	81_G	0.540	0.87
32_C	44_L	0.539	0.87
202_H	249_T	0.537	0.86
49_R	53_N	0.535	0.86
275_L	279_H	0.534	0.86
30_T	44_L	0.534	0.86
198_S	212_F	0.533	0.86
158_F	189_F	0.530	0.86
218_Y	275_L	0.530	0.86
209_S	258_Q	0.530	0.86
107_N	143_K	0.529	0.86
201_T	221_A	0.529	0.86
163_A	202_H	0.527	0.85
100_D	103_K	0.526	0.85
83_L	115_G	0.524	0.85
186_L	215_L	0.524	0.85
46_K	130_S	0.524	0.85
250_A	259_L	0.522	0.85
197_I	276_L	0.518	0.84
53_N	57_H	0.516	0.84
216_G	220_F	0.516	0.84
201_T	204_T	0.516	0.84
133_M	165_G	0.515	0.84
253_L	259_L	0.515	0.84
227_I	253_L	0.515	0.84
186_L	198_S	0.512	0.84
63_K	130_S	0.511	0.84
234_I	238_T	0.510	0.83
249_T	253_L	0.509	0.83
41_T	104_T	0.508	0.83
62_A	128_D	0.508	0.83
226_L	249_T	0.508	0.83
137_G	172_G	0.507	0.83
33_P	58_F	0.506	0.83
42_K	47_N	0.503	0.83
28_I	38_I	0.502	0.82
105_S	137_G	0.502	0.82
243_L	246_D	0.500	0.82
44_L	52_M	0.500	0.82

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vrgA	4	0.8759	100	0.241	Contact Map
3u9rB	5	0.931	100	0.241	Contact Map
1pixA	4	0.931	100	0.253	Contact Map
3gf3A	4	0.9241	100	0.264	Contact Map
4rcnA	6	0.9138	100	0.264	Contact Map
2f9iB	1	0.8966	100	0.289	Contact Map
3n6rB	4	0.8552	100	0.29	Contact Map
2bzrA	4	0.8828	100	0.305	Contact Map
2f9yB	1	0.8759	100	0.313	Contact Map
1on3A	6	0.8966	100	0.341	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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