GREMLIN Database
ACCD - Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
UniProt: C0SP93 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (241)
Sequences: 7475 (3296)
Seq/√Len: 212.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_M115_G4.3901.00
236_E242_K4.0231.00
70_M124_V3.4091.00
123_V147_A3.1601.00
199_V272_L3.0461.00
123_V156_V2.7721.00
48_M52_M2.7161.00
149_E185_A2.5191.00
74_S116_T2.4811.00
222_E264_H2.4241.00
59_P202_H2.4091.00
150_K154_D2.3831.00
75_F113_G2.3611.00
118_G273_E2.2931.00
116_T121_P2.2121.00
152_K189_F2.1901.00
112_T147_A2.1831.00
254_L259_L2.1771.00
198_S216_G2.1541.00
264_H267_D2.0741.00
161_F199_V2.0581.00
125_A160_I2.0571.00
129_S133_M2.0371.00
122_A159_I2.0091.00
263_I271_T2.0091.00
60_M68_S1.9841.00
232_R246_D1.9571.00
109_A140_V1.9191.00
220_F261_A1.9101.00
250_A262_V1.8571.00
52_M56_Y1.8561.00
114_K154_D1.8491.00
162_T198_S1.8481.00
118_G277_D1.8321.00
261_A271_T1.7851.00
155_K192_E1.7711.00
110_V144_I1.7431.00
271_T274_N1.7141.00
254_L262_V1.6621.00
51_C55_D1.6281.00
152_K192_E1.6261.00
69_L161_F1.6171.00
69_L117_I1.6031.00
189_F194_G1.5971.00
120_H280_Q1.5911.00
66_I124_V1.5671.00
61_N64_Q1.5601.00
251_E255_K1.5541.00
187_K191_E1.5381.00
267_D271_T1.5371.00
79_N146_L1.5131.00
145_T185_A1.5121.00
148_I158_F1.5081.00
62_A126_V1.4921.00
79_N112_T1.4891.00
168_R171_E1.4831.00
78_F150_K1.4731.00
51_C54_C1.4721.00
144_I182_T1.4621.00
150_K153_A1.4501.00
76_E114_K1.4361.00
34_K38_I1.4191.00
85_E138_S1.4051.00
120_H277_D1.3991.00
159_I199_V1.3941.00
55_D264_H1.3841.00
39_M80_Q1.3821.00
114_K121_P1.3801.00
77_E80_Q1.3761.00
62_A111_V1.3731.00
138_S174_L1.3731.00
117_I122_A1.3471.00
33_P37_K1.3431.00
77_E143_K1.3231.00
135_S165_G1.3121.00
121_P156_V1.3091.00
63_K77_E1.3041.00
114_K156_V1.2951.00
118_G270_K1.2871.00
82_M139_V1.2851.00
64_Q67_E1.2761.00
55_D64_Q1.2741.00
147_A158_F1.2611.00
32_C35_C1.2591.00
152_K194_G1.2571.00
42_K45_D1.2451.00
136_M140_V1.2421.00
222_E262_V1.2281.00
40_L43_E1.2241.00
30_T41_T1.2131.00
66_I70_M1.1971.00
217_D221_A1.1951.00
141_G178_Q1.1881.00
70_M74_S1.1711.00
267_D270_K1.1531.00
115_G124_V1.1521.00
125_A158_F1.1501.00
187_K190_S1.1291.00
79_N82_M1.1281.00
156_V194_G1.1211.00
188_L191_E1.1001.00
205_T226_L1.0931.00
142_E181_K1.0911.00
219_N272_L1.0851.00
152_K188_L1.0831.00
49_R64_Q1.0781.00
270_K274_N1.0741.00
222_E251_E1.0721.00
70_M122_A1.0671.00
148_I186_L1.0631.00
263_I268_M1.0621.00
114_K123_V1.0531.00
68_S270_K1.0441.00
75_F79_N1.0341.00
125_A147_A1.0251.00
184_S188_L1.0191.00
38_I41_T1.0161.00
68_S269_K1.0011.00
216_G221_A0.9921.00
232_R249_T0.9911.00
161_F269_K0.9831.00
43_E80_Q0.9791.00
29_M40_L0.9791.00
74_S113_G0.9791.00
159_I276_L0.9781.00
108_E139_V0.9751.00
45_D49_R0.9711.00
63_K111_V0.9651.00
161_F201_T0.9601.00
42_K46_K0.9601.00
123_V151_A0.9430.99
83_L107_N0.9420.99
217_D222_E0.9410.99
44_L48_M0.9410.99
112_T123_V0.9370.99
29_M33_P0.9350.99
39_M43_E0.9310.99
198_S215_L0.9300.99
31_K34_K0.9290.99
37_K40_L0.9240.99
75_F78_F0.9230.99
110_V125_A0.9200.99
209_S214_S0.9150.99
114_K150_K0.9150.99
219_N271_T0.9130.99
34_K37_K0.9100.99
162_T213_A0.9080.99
67_E72_E0.9080.99
118_G269_K0.9070.99
220_F263_I0.9030.99
35_C54_C0.9000.99
148_I185_A0.8990.99
197_I275_L0.8970.99
243_L247_F0.8950.99
219_N268_M0.8940.99
195_L279_H0.8880.99
44_L58_F0.8840.99
217_D220_F0.8840.99
220_F225_A0.8820.99
268_M272_L0.8800.99
148_I189_F0.8780.99
199_V268_M0.8760.99
31_K38_I0.8720.99
251_E262_V0.8680.99
129_S203_P0.8670.99
36_K39_M0.8610.99
53_N56_Y0.8600.99
186_L196_I0.8560.99
145_T181_K0.8480.99
123_V150_K0.8440.99
47_N51_C0.8440.99
112_T125_A0.8410.99
149_E153_A0.8380.99
118_G281_T0.8360.99
201_T269_K0.8340.99
35_C51_C0.8320.99
78_F123_V0.8180.99
92_G100_D0.8160.99
180_A184_S0.8150.99
150_K156_V0.8130.98
28_I31_K0.8120.98
219_N263_I0.8090.98
268_M271_T0.8090.98
51_C61_N0.8070.98
144_I160_I0.8050.98
63_K106_L0.7990.98
49_R52_M0.7970.98
142_E146_L0.7900.98
44_L47_N0.7890.98
61_N130_S0.7780.98
47_N50_V0.7770.98
274_N278_M0.7760.98
140_V144_I0.7750.98
186_L190_S0.7740.98
181_K185_A0.7680.98
123_V154_D0.7680.98
137_G168_R0.7670.98
230_A234_I0.7600.98
164_S208_V0.7580.98
66_I111_V0.7580.98
148_I152_K0.7530.98
106_L128_D0.7510.97
83_L108_E0.7470.97
101_R107_N0.7460.97
269_K273_E0.7450.97
223_P264_H0.7430.97
66_I126_V0.7420.97
145_T148_I0.7410.97
216_G222_E0.7400.97
30_T33_P0.7380.97
266_D269_K0.7370.97
139_V142_E0.7320.97
78_F114_K0.7310.97
50_V57_H0.7300.97
151_A158_F0.7260.97
40_L44_L0.7250.97
120_H276_L0.7200.97
219_N259_L0.7190.97
46_K50_V0.7170.97
205_T228_G0.7140.97
143_K146_L0.7110.96
117_I120_H0.7110.96
43_E46_K0.7100.96
42_K81_G0.7050.96
75_F111_V0.7030.96
33_P56_Y0.7000.96
37_K41_T0.6980.96
186_L211_S0.6930.96
136_M144_I0.6930.96
55_D61_N0.6910.96
145_T149_E0.6910.96
122_A276_L0.6880.96
48_M51_C0.6820.96
108_E168_R0.6820.96
65_R224_G0.6800.95
226_L232_R0.6790.95
221_A259_L0.6770.95
33_P36_K0.6750.95
218_Y221_A0.6730.95
164_S203_P0.6690.95
105_S132_R0.6690.95
133_M195_L0.6690.95
148_I160_I0.6640.95
60_M266_D0.6620.95
77_E82_M0.6540.94
155_K194_G0.6540.94
44_L51_C0.6530.94
230_A235_I0.6520.94
79_N143_K0.6490.94
54_C59_P0.6480.94
69_L272_L0.6480.94
84_S101_R0.6470.94
215_L218_Y0.6450.94
71_D74_S0.6390.94
41_T44_L0.6390.94
31_K43_E0.6380.94
28_I43_E0.6370.94
216_G219_N0.6370.94
245_E248_Q0.6370.94
42_K107_N0.6370.94
159_I272_L0.6360.94
157_P194_G0.6330.93
120_H273_E0.6300.93
100_D104_T0.6230.93
69_L124_V0.6200.93
29_M32_C0.6190.93
223_P251_E0.6180.93
37_K53_N0.6140.92
36_K40_L0.6140.92
274_N277_D0.6120.92
78_F154_D0.6120.92
231_G234_I0.6120.92
215_L221_A0.6120.92
160_I196_I0.6080.92
83_L139_V0.6060.92
253_L256_H0.6030.92
66_I113_G0.6000.91
149_E188_L0.5990.91
271_T275_L0.5990.91
121_P154_D0.5980.91
52_M55_D0.5980.91
120_H281_T0.5950.91
81_G107_N0.5950.91
217_D261_A0.5940.91
132_R170_Q0.5930.91
200_M219_N0.5920.91
112_T143_K0.5910.91
272_L275_L0.5900.91
115_G122_A0.5890.91
252_F256_H0.5880.91
232_R236_E0.5870.91
54_C57_H0.5860.91
133_M161_F0.5850.90
124_V161_F0.5820.90
77_E81_G0.5820.90
63_K67_E0.5780.90
32_C36_K0.5760.90
78_F147_A0.5760.90
167_A176_L0.5760.90
45_D48_M0.5760.90
30_T34_K0.5740.90
127_M140_V0.5720.89
263_I267_D0.5720.89
70_M75_F0.5710.89
41_T45_D0.5690.89
189_F195_L0.5680.89
160_I186_L0.5670.89
77_E111_V0.5650.89
175_S178_Q0.5620.89
83_L104_T0.5580.88
201_T266_D0.5580.88
30_T40_L0.5570.88
176_L179_M0.5560.88
163_A201_T0.5560.88
221_A224_G0.5550.88
198_S219_N0.5540.88
39_M52_M0.5530.88
29_M41_T0.5470.87
183_S215_L0.5470.87
127_M212_F0.5460.87
207_G231_G0.5440.87
35_C39_M0.5420.87
38_I42_K0.5410.87
39_M81_G0.5400.87
32_C44_L0.5390.87
202_H249_T0.5370.86
49_R53_N0.5350.86
275_L279_H0.5340.86
30_T44_L0.5340.86
198_S212_F0.5330.86
158_F189_F0.5300.86
218_Y275_L0.5300.86
209_S258_Q0.5300.86
107_N143_K0.5290.86
201_T221_A0.5290.86
163_A202_H0.5270.85
100_D103_K0.5260.85
83_L115_G0.5240.85
186_L215_L0.5240.85
46_K130_S0.5240.85
250_A259_L0.5220.85
197_I276_L0.5180.84
53_N57_H0.5160.84
216_G220_F0.5160.84
201_T204_T0.5160.84
133_M165_G0.5150.84
253_L259_L0.5150.84
227_I253_L0.5150.84
186_L198_S0.5120.84
63_K130_S0.5110.84
234_I238_T0.5100.83
249_T253_L0.5090.83
41_T104_T0.5080.83
62_A128_D0.5080.83
226_L249_T0.5080.83
137_G172_G0.5070.83
33_P58_F0.5060.83
42_K47_N0.5030.83
28_I38_I0.5020.82
105_S137_G0.5020.82
243_L246_D0.5000.82
44_L52_M0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vrgA 4 0.8759 100 0.241 Contact Map
3u9rB 5 0.931 100 0.241 Contact Map
1pixA 4 0.931 100 0.253 Contact Map
3gf3A 4 0.9241 100 0.264 Contact Map
4rcnA 6 0.9138 100 0.264 Contact Map
2f9iB 1 0.8966 100 0.289 Contact Map
3n6rB 4 0.8552 100 0.29 Contact Map
2bzrA 4 0.8828 100 0.305 Contact Map
2f9yB 1 0.8759 100 0.313 Contact Map
1on3A 6 0.8966 100 0.341 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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