YYCJ - BACSU - GREMLIN Contacts

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YYCJ - Putative metallo-hydrolase YycJ

UniProt:	C0SP91	Sequences: MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQIGRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFVFPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSANVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAHLSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	264 (215)
Sequences:	7847 (5983)
Seq/√Len:	408.0

ECOLI - PHNP RBN
BACSU - YYCJ YHFI RNZ
HALSA - Q9HPR7 RNZ Q9HNK7
SULSO - RNZ Q981E1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
141_A	160_A	4.763	1.00
132_V	139_K	3.676	1.00
161_N	212_S	3.421	1.00
154_K	205_D	3.185	1.00
117_E	134_H	2.773	1.00
77_P	101_F	2.699	1.00
7_V	10_S	2.618	1.00
4_Q	20_E	2.378	1.00
115_D	134_H	2.358	1.00
162_V	215_Y	2.294	1.00
110_S	115_D	2.234	1.00
164_V	217_A	2.198	1.00
85_W	89_E	2.189	1.00
20_E	25_A	2.189	1.00
134_H	139_K	2.174	1.00
28_V	133_F	2.147	1.00
121_V	130_F	2.122	1.00
171_V	197_E	2.098	1.00
119_F	156_I	2.079	1.00
203_M	214_I	2.035	1.00
141_A	157_I	2.000	1.00
24_H	52_D	1.997	1.00
121_V	128_P	1.989	1.00
159_S	207_I	1.980	1.00
165_F	194_V	1.957	1.00
230_R	234_Q	1.934	1.00
77_P	99_Q	1.920	1.00
55_F	116_V	1.871	1.00
201_L	205_D	1.863	1.00
155_G	158_R	1.793	1.00
198_D	201_L	1.745	1.00
207_I	211_T	1.744	1.00
53_G	77_P	1.687	1.00
139_K	160_A	1.628	1.00
108_V	117_E	1.609	1.00
140_L	164_V	1.572	1.00
135_Y	138_R	1.553	1.00
203_M	211_T	1.521	1.00
24_H	112_G	1.489	1.00
55_F	131_Y	1.480	1.00
56_V	67_L	1.467	1.00
108_V	111_F	1.455	1.00
75_K	99_Q	1.454	1.00
108_V	115_D	1.451	1.00
128_P	144_T	1.449	1.00
18_Y	25_A	1.436	1.00
26_F	114_L	1.426	1.00
26_F	53_G	1.415	1.00
206_V	211_T	1.412	1.00
138_R	161_N	1.397	1.00
16_A	34_G	1.384	1.00
82_E	102_V	1.380	1.00
157_I	160_A	1.374	1.00
104_P	107_T	1.374	1.00
167_S	216_L	1.354	1.00
158_R	207_I	1.354	1.00
132_V	160_A	1.349	1.00
151_D	154_K	1.341	1.00
79_Y	101_F	1.330	1.00
81_N	129_M	1.321	1.00
122_S	147_G	1.307	1.00
139_K	161_N	1.297	1.00
143_M	165_F	1.290	1.00
33_S	36_A	1.281	1.00
80_A	85_W	1.278	1.00
151_D	205_D	1.276	1.00
53_G	79_Y	1.275	1.00
162_V	213_R	1.275	1.00
154_K	202_A	1.243	1.00
132_V	141_A	1.238	1.00
28_V	55_F	1.237	1.00
55_F	109_K	1.230	1.00
121_V	143_M	1.229	1.00
196_N	200_A	1.214	1.00
9_A	32_L	1.213	1.00
165_F	199_A	1.211	1.00
231_M	234_Q	1.209	1.00
157_I	206_V	1.194	1.00
15_N	142_L	1.176	1.00
25_A	52_D	1.174	1.00
170_D	173_M	1.170	1.00
143_M	146_T	1.161	1.00
57_T	131_Y	1.149	1.00
7_V	215_Y	1.147	1.00
61_S	65_K	1.146	1.00
54_I	67_L	1.146	1.00
13_T	16_A	1.145	1.00
149_V	152_R	1.134	1.00
165_F	202_A	1.123	1.00
30_A	56_V	1.123	1.00
197_E	201_L	1.116	1.00
47_K	50_D	1.114	1.00
201_L	204_T	1.106	1.00
85_W	102_V	1.099	1.00
119_F	153_M	1.096	1.00
116_V	133_F	1.090	1.00
204_T	236_T	1.090	1.00
26_F	116_V	1.089	1.00
7_V	17_F	1.086	1.00
25_A	50_D	1.066	1.00
82_E	86_K	1.065	1.00
211_T	214_I	1.049	1.00
63_H	218_H	1.048	1.00
5_F	140_L	1.042	1.00
80_A	84_T	1.037	1.00
87_A	91_Q	1.034	1.00
195_S	198_D	1.031	1.00
146_T	153_M	1.030	1.00
167_S	199_A	1.021	1.00
167_S	196_N	1.020	1.00
147_G	192_G	1.013	1.00
21_T	113_G	1.012	1.00
103_F	131_Y	1.008	1.00
197_E	235_Q	1.006	1.00
19_L	140_L	1.005	1.00
86_K	89_E	1.001	1.00
21_T	135_Y	0.985	1.00
147_G	194_V	0.984	1.00
147_G	198_D	0.984	1.00
105_M	120_G	0.975	1.00
227_E	231_M	0.964	1.00
7_V	164_V	0.956	1.00
17_F	217_A	0.954	1.00
152_R	155_G	0.953	1.00
6_S	20_E	0.951	1.00
118_S	131_Y	0.947	1.00
5_F	162_V	0.945	1.00
117_E	156_I	0.944	1.00
154_K	158_R	0.938	1.00
36_A	39_G	0.935	1.00
16_A	27_L	0.927	1.00
13_T	17_F	0.924	1.00
28_V	142_L	0.921	1.00
24_H	114_L	0.918	1.00
59_E	83_K	0.909	1.00
233_V	237_L	0.908	1.00
119_F	130_F	0.900	1.00
14_G	18_Y	0.893	1.00
160_A	211_T	0.889	1.00
18_Y	27_L	0.884	1.00
154_K	206_V	0.882	1.00
163_F	203_M	0.879	1.00
86_K	90_N	0.872	1.00
82_E	104_P	0.869	1.00
83_K	102_V	0.863	1.00
55_F	79_Y	0.859	1.00
59_E	84_T	0.859	1.00
227_E	230_R	0.858	1.00
124_D	192_G	0.857	1.00
19_L	133_F	0.855	1.00
18_Y	46_R	0.854	1.00
228_L	231_M	0.854	1.00
27_L	34_G	0.849	1.00
153_M	156_I	0.843	1.00
24_H	113_G	0.837	1.00
28_V	131_Y	0.834	1.00
116_V	131_Y	0.826	1.00
67_L	78_I	0.825	1.00
151_D	155_G	0.823	1.00
81_N	84_T	0.820	1.00
57_T	142_L	0.818	1.00
26_F	133_F	0.816	1.00
14_G	17_F	0.816	1.00
143_M	153_M	0.814	1.00
38_D	48_L	0.810	1.00
200_A	203_M	0.809	1.00
130_F	143_M	0.799	1.00
21_T	24_H	0.799	1.00
195_S	199_A	0.796	1.00
199_A	203_M	0.791	1.00
29_D	142_L	0.791	1.00
103_F	109_K	0.789	1.00
200_A	204_T	0.786	1.00
17_F	164_V	0.775	1.00
107_T	118_S	0.775	1.00
48_L	70_V	0.775	1.00
5_F	164_V	0.773	1.00
13_T	37_M	0.772	1.00
174_L	177_G	0.768	1.00
30_A	54_I	0.766	1.00
8_L	16_A	0.763	1.00
24_H	53_G	0.761	1.00
19_L	28_V	0.761	1.00
52_D	74_Y	0.759	1.00
15_N	20_E	0.758	1.00
103_F	129_M	0.756	1.00
59_E	64_I	0.755	1.00
3_L	135_Y	0.752	1.00
27_L	30_A	0.748	1.00
201_L	236_T	0.746	1.00
75_K	97_T	0.741	1.00
34_G	38_D	0.741	1.00
126_A	129_M	0.738	1.00
54_I	76_L	0.736	1.00
103_F	118_S	0.735	1.00
203_M	216_L	0.733	1.00
231_M	235_Q	0.732	1.00
30_A	34_G	0.730	1.00
13_T	36_A	0.730	1.00
216_L	233_V	0.729	1.00
169_H	191_V	0.727	1.00
5_F	19_L	0.726	1.00
141_A	163_F	0.725	1.00
114_L	133_F	0.724	1.00
17_F	142_L	0.723	1.00
200_A	233_V	0.723	1.00
200_A	236_T	0.721	1.00
93_G	96_D	0.720	1.00
6_S	44_I	0.720	1.00
24_H	111_F	0.713	1.00
140_L	162_V	0.711	1.00
68_G	91_Q	0.708	1.00
134_H	137_G	0.700	1.00
108_V	118_S	0.699	1.00
149_V	153_M	0.699	1.00
85_W	100_K	0.696	1.00
158_R	205_D	0.695	1.00
159_S	212_S	0.695	1.00
148_Y	151_D	0.692	1.00
118_S	129_M	0.692	1.00
142_L	164_V	0.681	1.00
166_E	194_V	0.673	0.99
35_K	69_V	0.673	0.99
219_L	223_N	0.672	0.99
59_E	81_N	0.668	0.99
35_K	39_G	0.667	0.99
27_L	51_V	0.661	0.99
167_S	233_V	0.659	0.99
34_G	69_V	0.648	0.99
110_S	113_G	0.647	0.99
32_L	66_G	0.645	0.99
56_V	84_T	0.644	0.99
171_V	232_S	0.642	0.99
232_S	237_L	0.640	0.99
12_S	220_S	0.640	0.99
107_T	117_E	0.640	0.99
157_I	163_F	0.638	0.99
122_S	192_G	0.636	0.99
114_L	135_Y	0.635	0.99
39_G	44_I	0.632	0.99
142_L	217_A	0.625	0.99
132_V	156_I	0.625	0.99
17_F	20_E	0.625	0.99
52_D	112_G	0.620	0.99
25_A	46_R	0.619	0.99
163_F	211_T	0.617	0.99
115_D	136_S	0.614	0.99
152_R	156_I	0.612	0.99
121_V	146_T	0.609	0.99
122_S	148_Y	0.607	0.99
148_Y	201_L	0.607	0.99
21_T	114_L	0.607	0.99
197_E	236_T	0.605	0.99
72_R	75_K	0.600	0.99
177_G	223_N	0.600	0.99
3_L	138_R	0.598	0.99
120_G	129_M	0.596	0.99
5_F	215_Y	0.594	0.99
119_F	132_V	0.593	0.99
143_M	202_A	0.591	0.99
165_F	214_I	0.591	0.99
234_Q	237_L	0.589	0.99
54_I	70_V	0.587	0.99
143_M	163_F	0.583	0.99
166_E	193_H	0.582	0.98
174_L	178_R	0.578	0.98
59_E	87_A	0.577	0.98
121_V	144_T	0.577	0.98
148_Y	198_D	0.573	0.98
88_M	92_I	0.570	0.98
22_E	113_G	0.570	0.98
23_D	112_G	0.569	0.98
146_T	149_V	0.568	0.98
172_G	176_M	0.566	0.98
146_T	194_V	0.565	0.98
38_D	51_V	0.564	0.98
105_M	129_M	0.561	0.98
13_T	221_Q	0.561	0.98
72_R	76_L	0.561	0.98
14_G	32_L	0.558	0.98
32_L	69_V	0.558	0.98
95_I	98_D	0.555	0.98
229_A	232_S	0.552	0.98
106_E	120_G	0.552	0.98
168_N	220_S	0.550	0.98
32_L	37_M	0.549	0.98
89_E	100_K	0.549	0.98
5_F	17_F	0.549	0.98
171_V	174_L	0.549	0.98
46_R	50_D	0.549	0.98
197_E	232_S	0.548	0.98
66_G	69_V	0.547	0.98
117_E	132_V	0.545	0.98
216_L	219_L	0.545	0.98
149_V	154_K	0.545	0.98
143_M	157_I	0.544	0.98
160_A	163_F	0.544	0.98
167_S	195_S	0.543	0.98
225_M	228_L	0.541	0.98
232_S	235_Q	0.535	0.97
228_L	232_S	0.535	0.97
56_V	88_M	0.535	0.97
194_V	202_A	0.534	0.97
12_S	168_N	0.532	0.97
199_A	211_T	0.528	0.97
15_N	18_Y	0.527	0.97
196_N	223_N	0.526	0.97
26_F	55_F	0.525	0.97
32_L	35_K	0.525	0.97
38_D	74_Y	0.524	0.97
122_S	149_V	0.517	0.97
56_V	59_E	0.516	0.97
33_S	37_M	0.516	0.97
172_G	175_Q	0.513	0.97
139_K	212_S	0.509	0.97
132_V	159_S	0.505	0.96
14_G	20_E	0.504	0.96
122_S	146_T	0.504	0.96
125_A	128_P	0.504	0.96
87_A	90_N	0.501	0.96
163_F	214_I	0.500	0.96
170_D	196_N	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zwfA	2	0.8258	100	0.328	Contact Map
2cbnA	2	0.875	100	0.345	Contact Map
1y44A	2	0.8826	100	0.36	Contact Map
3jxpA	2	0.928	100	0.389	Contact Map
1zkpA	2	0.8636	100	0.408	Contact Map
3g1pA	2	0.8333	100	0.426	Contact Map
2e7yA	2	0.8409	100	0.437	Contact Map
4ojvA	2	0.8977	100	0.44	Contact Map
3md7A	2	0.8333	100	0.446	Contact Map
3bk2A	2	0.928	100	0.513	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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