GREMLIN Database
YYCJ - Putative metallo-hydrolase YycJ
UniProt: C0SP91 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 264 (215)
Sequences: 7847 (5983)
Seq/√Len: 408.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_A160_A4.7631.00
132_V139_K3.6761.00
161_N212_S3.4211.00
154_K205_D3.1851.00
117_E134_H2.7731.00
77_P101_F2.6991.00
7_V10_S2.6181.00
4_Q20_E2.3781.00
115_D134_H2.3581.00
162_V215_Y2.2941.00
110_S115_D2.2341.00
164_V217_A2.1981.00
85_W89_E2.1891.00
20_E25_A2.1891.00
134_H139_K2.1741.00
28_V133_F2.1471.00
121_V130_F2.1221.00
171_V197_E2.0981.00
119_F156_I2.0791.00
203_M214_I2.0351.00
141_A157_I2.0001.00
24_H52_D1.9971.00
121_V128_P1.9891.00
159_S207_I1.9801.00
165_F194_V1.9571.00
230_R234_Q1.9341.00
77_P99_Q1.9201.00
55_F116_V1.8711.00
201_L205_D1.8631.00
155_G158_R1.7931.00
198_D201_L1.7451.00
207_I211_T1.7441.00
53_G77_P1.6871.00
139_K160_A1.6281.00
108_V117_E1.6091.00
140_L164_V1.5721.00
135_Y138_R1.5531.00
203_M211_T1.5211.00
24_H112_G1.4891.00
55_F131_Y1.4801.00
56_V67_L1.4671.00
108_V111_F1.4551.00
75_K99_Q1.4541.00
108_V115_D1.4511.00
128_P144_T1.4491.00
18_Y25_A1.4361.00
26_F114_L1.4261.00
26_F53_G1.4151.00
206_V211_T1.4121.00
138_R161_N1.3971.00
16_A34_G1.3841.00
82_E102_V1.3801.00
157_I160_A1.3741.00
104_P107_T1.3741.00
167_S216_L1.3541.00
158_R207_I1.3541.00
132_V160_A1.3491.00
151_D154_K1.3411.00
79_Y101_F1.3301.00
81_N129_M1.3211.00
122_S147_G1.3071.00
139_K161_N1.2971.00
143_M165_F1.2901.00
33_S36_A1.2811.00
80_A85_W1.2781.00
151_D205_D1.2761.00
53_G79_Y1.2751.00
162_V213_R1.2751.00
154_K202_A1.2431.00
132_V141_A1.2381.00
28_V55_F1.2371.00
55_F109_K1.2301.00
121_V143_M1.2291.00
196_N200_A1.2141.00
9_A32_L1.2131.00
165_F199_A1.2111.00
231_M234_Q1.2091.00
157_I206_V1.1941.00
15_N142_L1.1761.00
25_A52_D1.1741.00
170_D173_M1.1701.00
143_M146_T1.1611.00
57_T131_Y1.1491.00
7_V215_Y1.1471.00
61_S65_K1.1461.00
54_I67_L1.1461.00
13_T16_A1.1451.00
149_V152_R1.1341.00
165_F202_A1.1231.00
30_A56_V1.1231.00
197_E201_L1.1161.00
47_K50_D1.1141.00
201_L204_T1.1061.00
85_W102_V1.0991.00
119_F153_M1.0961.00
116_V133_F1.0901.00
204_T236_T1.0901.00
26_F116_V1.0891.00
7_V17_F1.0861.00
25_A50_D1.0661.00
82_E86_K1.0651.00
211_T214_I1.0491.00
63_H218_H1.0481.00
5_F140_L1.0421.00
80_A84_T1.0371.00
87_A91_Q1.0341.00
195_S198_D1.0311.00
146_T153_M1.0301.00
167_S199_A1.0211.00
167_S196_N1.0201.00
147_G192_G1.0131.00
21_T113_G1.0121.00
103_F131_Y1.0081.00
197_E235_Q1.0061.00
19_L140_L1.0051.00
86_K89_E1.0011.00
21_T135_Y0.9851.00
147_G194_V0.9841.00
147_G198_D0.9841.00
105_M120_G0.9751.00
227_E231_M0.9641.00
7_V164_V0.9561.00
17_F217_A0.9541.00
152_R155_G0.9531.00
6_S20_E0.9511.00
118_S131_Y0.9471.00
5_F162_V0.9451.00
117_E156_I0.9441.00
154_K158_R0.9381.00
36_A39_G0.9351.00
16_A27_L0.9271.00
13_T17_F0.9241.00
28_V142_L0.9211.00
24_H114_L0.9181.00
59_E83_K0.9091.00
233_V237_L0.9081.00
119_F130_F0.9001.00
14_G18_Y0.8931.00
160_A211_T0.8891.00
18_Y27_L0.8841.00
154_K206_V0.8821.00
163_F203_M0.8791.00
86_K90_N0.8721.00
82_E104_P0.8691.00
83_K102_V0.8631.00
55_F79_Y0.8591.00
59_E84_T0.8591.00
227_E230_R0.8581.00
124_D192_G0.8571.00
19_L133_F0.8551.00
18_Y46_R0.8541.00
228_L231_M0.8541.00
27_L34_G0.8491.00
153_M156_I0.8431.00
24_H113_G0.8371.00
28_V131_Y0.8341.00
116_V131_Y0.8261.00
67_L78_I0.8251.00
151_D155_G0.8231.00
81_N84_T0.8201.00
57_T142_L0.8181.00
26_F133_F0.8161.00
14_G17_F0.8161.00
143_M153_M0.8141.00
38_D48_L0.8101.00
200_A203_M0.8091.00
130_F143_M0.7991.00
21_T24_H0.7991.00
195_S199_A0.7961.00
199_A203_M0.7911.00
29_D142_L0.7911.00
103_F109_K0.7891.00
200_A204_T0.7861.00
17_F164_V0.7751.00
107_T118_S0.7751.00
48_L70_V0.7751.00
5_F164_V0.7731.00
13_T37_M0.7721.00
174_L177_G0.7681.00
30_A54_I0.7661.00
8_L16_A0.7631.00
24_H53_G0.7611.00
19_L28_V0.7611.00
52_D74_Y0.7591.00
15_N20_E0.7581.00
103_F129_M0.7561.00
59_E64_I0.7551.00
3_L135_Y0.7521.00
27_L30_A0.7481.00
201_L236_T0.7461.00
75_K97_T0.7411.00
34_G38_D0.7411.00
126_A129_M0.7381.00
54_I76_L0.7361.00
103_F118_S0.7351.00
203_M216_L0.7331.00
231_M235_Q0.7321.00
30_A34_G0.7301.00
13_T36_A0.7301.00
216_L233_V0.7291.00
169_H191_V0.7271.00
5_F19_L0.7261.00
141_A163_F0.7251.00
114_L133_F0.7241.00
17_F142_L0.7231.00
200_A233_V0.7231.00
200_A236_T0.7211.00
93_G96_D0.7201.00
6_S44_I0.7201.00
24_H111_F0.7131.00
140_L162_V0.7111.00
68_G91_Q0.7081.00
134_H137_G0.7001.00
108_V118_S0.6991.00
149_V153_M0.6991.00
85_W100_K0.6961.00
158_R205_D0.6951.00
159_S212_S0.6951.00
148_Y151_D0.6921.00
118_S129_M0.6921.00
142_L164_V0.6811.00
166_E194_V0.6730.99
35_K69_V0.6730.99
219_L223_N0.6720.99
59_E81_N0.6680.99
35_K39_G0.6670.99
27_L51_V0.6610.99
167_S233_V0.6590.99
34_G69_V0.6480.99
110_S113_G0.6470.99
32_L66_G0.6450.99
56_V84_T0.6440.99
171_V232_S0.6420.99
232_S237_L0.6400.99
12_S220_S0.6400.99
107_T117_E0.6400.99
157_I163_F0.6380.99
122_S192_G0.6360.99
114_L135_Y0.6350.99
39_G44_I0.6320.99
142_L217_A0.6250.99
132_V156_I0.6250.99
17_F20_E0.6250.99
52_D112_G0.6200.99
25_A46_R0.6190.99
163_F211_T0.6170.99
115_D136_S0.6140.99
152_R156_I0.6120.99
121_V146_T0.6090.99
122_S148_Y0.6070.99
148_Y201_L0.6070.99
21_T114_L0.6070.99
197_E236_T0.6050.99
72_R75_K0.6000.99
177_G223_N0.6000.99
3_L138_R0.5980.99
120_G129_M0.5960.99
5_F215_Y0.5940.99
119_F132_V0.5930.99
143_M202_A0.5910.99
165_F214_I0.5910.99
234_Q237_L0.5890.99
54_I70_V0.5870.99
143_M163_F0.5830.99
166_E193_H0.5820.98
174_L178_R0.5780.98
59_E87_A0.5770.98
121_V144_T0.5770.98
148_Y198_D0.5730.98
88_M92_I0.5700.98
22_E113_G0.5700.98
23_D112_G0.5690.98
146_T149_V0.5680.98
172_G176_M0.5660.98
146_T194_V0.5650.98
38_D51_V0.5640.98
105_M129_M0.5610.98
13_T221_Q0.5610.98
72_R76_L0.5610.98
14_G32_L0.5580.98
32_L69_V0.5580.98
95_I98_D0.5550.98
229_A232_S0.5520.98
106_E120_G0.5520.98
168_N220_S0.5500.98
32_L37_M0.5490.98
89_E100_K0.5490.98
5_F17_F0.5490.98
171_V174_L0.5490.98
46_R50_D0.5490.98
197_E232_S0.5480.98
66_G69_V0.5470.98
117_E132_V0.5450.98
216_L219_L0.5450.98
149_V154_K0.5450.98
143_M157_I0.5440.98
160_A163_F0.5440.98
167_S195_S0.5430.98
225_M228_L0.5410.98
232_S235_Q0.5350.97
228_L232_S0.5350.97
56_V88_M0.5350.97
194_V202_A0.5340.97
12_S168_N0.5320.97
199_A211_T0.5280.97
15_N18_Y0.5270.97
196_N223_N0.5260.97
26_F55_F0.5250.97
32_L35_K0.5250.97
38_D74_Y0.5240.97
122_S149_V0.5170.97
56_V59_E0.5160.97
33_S37_M0.5160.97
172_G175_Q0.5130.97
139_K212_S0.5090.97
132_V159_S0.5050.96
14_G20_E0.5040.96
122_S146_T0.5040.96
125_A128_P0.5040.96
87_A90_N0.5010.96
163_F214_I0.5000.96
170_D196_N0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zwfA 2 0.8258 100 0.328 Contact Map
2cbnA 2 0.875 100 0.345 Contact Map
1y44A 2 0.8826 100 0.36 Contact Map
3jxpA 2 0.928 100 0.389 Contact Map
1zkpA 2 0.8636 100 0.408 Contact Map
3g1pA 2 0.8333 100 0.426 Contact Map
2e7yA 2 0.8409 100 0.437 Contact Map
4ojvA 2 0.8977 100 0.44 Contact Map
3md7A 2 0.8333 100 0.446 Contact Map
3bk2A 2 0.928 100 0.513 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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