GREMLIN Database
YTHA - Putative cytochrome bd menaquinol oxidase subunit I
UniProt: C0SP90 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 443 (428)
Sequences: 2792 (1489)
Seq/√Len: 72.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_D169_A6.3241.00
275_D282_K5.3211.00
386_V396_V5.0041.00
235_A334_I4.5651.00
197_S364_G4.4641.00
296_A301_T4.2191.00
261_E307_N3.9711.00
275_D278_E3.9111.00
126_V130_F3.8671.00
293_F299_F3.7931.00
272_G281_V3.7751.00
265_H289_W3.4721.00
239_H243_Q3.0171.00
331_M335_L2.9601.00
185_L237_N2.9351.00
243_Q297_N2.9121.00
239_H297_N2.7911.00
224_L340_G2.7851.00
43_K121_P2.7621.00
401_G405_V2.6801.00
313_E392_K2.6091.00
193_F227_G2.5741.00
354_T358_I2.5701.00
279_E307_N2.5691.00
404_G408_L2.5431.00
279_E314_W2.5351.00
264_S302_V2.5051.00
343_W356_L2.4411.00
33_L129_F2.4091.00
329_V333_L2.3671.00
376_I380_T2.3561.00
289_W299_F2.2471.00
4_L397_V2.2301.00
251_E309_F2.1911.00
269_A286_E2.1741.00
40_Q125_I2.1581.00
262_T308_A2.1341.00
269_A320_H2.1121.00
311_R314_W2.1041.00
355_W358_I2.0671.00
267_P286_E2.0331.00
34_V38_I2.0221.00
16_G372_E1.9931.00
37_L125_I1.9791.00
119_L127_A1.9791.00
260_F281_V1.9681.00
263_R266_A1.9601.00
329_V366_F1.9301.00
231_S334_I1.9191.00
190_T371_I1.9171.00
37_L129_F1.9011.00
19_I183_V1.8741.00
325_A373_F1.8701.00
335_L339_I1.8261.00
281_V284_A1.8251.00
7_A403_I1.8211.00
392_K395_D1.8151.00
156_K165_V1.8101.00
319_I380_T1.8001.00
426_L430_R1.7931.00
185_L233_L1.7641.00
316_P319_I1.7461.00
13_T411_T1.7191.00
339_I343_W1.7141.00
17_F418_G1.7041.00
82_G85_E1.7021.00
111_I119_L1.7011.00
3_D7_A1.6711.00
340_G356_L1.6661.00
116_A124_R1.6511.00
45_D49_I1.6380.99
383_Q393_T1.6330.99
9_S407_F1.6330.99
120_S123_M1.6310.99
235_A331_M1.6250.99
46_H218_K1.6060.99
332_L363_A1.6000.99
199_A219_A1.5980.99
336_Y363_A1.5950.99
16_G376_I1.5920.99
276_P318_F1.5900.99
189_M231_S1.5720.99
221_L345_K1.5670.99
336_Y359_I1.5610.99
343_W353_P1.5550.99
164_D170_A1.5430.99
316_P380_T1.5410.99
87_I91_M1.5400.99
50_M219_A1.5380.99
32_I51_A1.5310.99
204_I354_T1.5300.99
304_K308_A1.5250.99
57_A425_L1.4900.99
298_R301_T1.4800.99
35_A50_M1.4730.99
52_K116_A1.4650.99
155_F390_L1.4470.99
293_F297_N1.4400.99
151_T175_S1.4390.99
57_A194_I1.4380.99
196_A224_L1.4250.99
86_V162_I1.4130.98
168_W171_F1.4070.98
5_V9_S1.3940.98
32_I128_V1.3880.98
412_F416_V1.3830.98
415_A419_A1.3790.98
273_F321_T1.3680.98
231_S337_S1.3270.98
272_G284_A1.3260.98
358_I362_T1.3220.98
36_E125_I1.3200.98
39_Y48_A1.3150.98
104_V134_G1.3130.98
139_A184_V1.3030.97
59_A113_V1.3020.97
24_L194_I1.3000.97
204_I361_M1.2970.97
278_E282_K1.2960.97
262_T302_V1.2950.97
363_A366_F1.2940.97
144_N176_F1.2900.97
202_K207_R1.2850.97
289_W293_F1.2770.97
54_W219_A1.2760.97
12_G380_T1.2720.97
328_G332_L1.2690.97
129_F133_V1.2670.97
256_A377_F1.2650.97
3_D400_T1.2540.97
193_F336_Y1.2540.97
13_T407_F1.2470.97
310_P313_E1.2440.97
408_L412_F1.2400.96
180_A184_V1.2320.96
38_I41_K1.2320.96
259_L269_A1.2290.96
221_L225_T1.2290.96
289_W300_D1.2260.96
196_A220_L1.2220.96
97_I167_P1.2070.96
263_R267_P1.2030.96
91_M145_V1.1920.96
192_A223_A1.1910.96
196_A223_A1.1910.96
25_G61_L1.1880.96
391_L396_V1.1860.95
38_I44_D1.1860.95
33_L37_L1.1830.95
111_I127_A1.1730.95
201_Y205_R1.1660.95
143_T176_F1.1640.95
231_S235_A1.1630.95
24_L28_L1.1610.95
423_Y427_Y1.1480.95
136_A184_V1.1430.94
181_G237_N1.1410.94
24_L368_L1.1380.94
192_A227_G1.1340.94
198_V429_F1.1340.94
193_F333_L1.1340.94
253_L303_V1.1340.94
405_V409_F1.1190.94
48_A52_K1.1150.94
30_L132_L1.1120.94
265_H300_D1.1060.93
186_S371_I1.1040.93
151_T244_M1.1030.93
246_Y253_L1.1010.93
246_Y295_A1.0840.93
328_G331_M1.0800.93
26_V187_A1.0800.93
31_M222_L1.0800.93
253_L256_A1.0790.93
338_I342_V1.0690.92
31_M226_I1.0670.92
325_A369_I1.0650.92
4_L394_S1.0590.92
409_F413_V1.0560.92
369_I373_F1.0550.92
339_I355_W1.0480.91
175_S248_Y1.0470.91
155_F165_V1.0470.91
220_L360_F1.0420.91
204_I358_I1.0390.91
406_L409_F1.0330.91
140_V144_N1.0300.91
30_L34_V1.0300.91
131_V135_A1.0180.90
227_G337_S1.0180.90
269_A272_G1.0170.90
196_A360_F1.0160.90
36_E116_A1.0150.90
336_Y366_F1.0150.90
34_V222_L1.0090.90
51_A116_A1.0050.90
122_A126_V1.0050.90
50_M215_F1.0020.90
217_R221_L1.0000.89
39_Y116_A0.9970.89
228_G341_V0.9930.89
183_V186_S0.9910.89
191_G367_S0.9900.89
193_F360_F0.9900.89
178_I244_M0.9850.89
260_F276_P0.9850.89
251_E306_L0.9820.89
125_I129_F0.9780.88
400_T403_I0.9720.88
112_Y128_V0.9670.88
178_I240_E0.9650.88
345_K349_K0.9640.88
36_E128_V0.9640.88
336_Y360_F0.9530.87
37_L41_K0.9500.87
335_L338_I0.9480.87
48_A116_A0.9470.87
35_A222_L0.9470.87
132_L136_A0.9420.86
273_F283_W0.9410.86
87_I387_I0.9410.86
259_L303_V0.9400.86
260_F307_N0.9390.86
276_P316_P0.9390.86
30_L33_L0.9380.86
356_L360_F0.9380.86
295_A303_V0.9370.86
6_L404_G0.9360.86
200_A357_L0.9360.86
15_M72_A0.9350.86
117_D121_P0.9320.86
386_V391_L0.9300.86
189_M234_T0.9270.86
349_K352_F0.9230.85
263_R286_E0.9210.85
244_M248_Y0.9210.85
332_L335_L0.9210.85
177_F181_G0.9210.85
45_D48_A0.9180.85
273_F282_K0.9180.85
269_A284_A0.9160.85
314_W317_L0.9020.84
215_F433_P0.9000.84
416_V420_A0.8980.84
133_V137_A0.8970.84
236_L240_E0.8930.83
9_S13_T0.8910.83
83_F87_I0.8900.83
123_M126_V0.8850.83
229_I233_L0.8800.82
268_L294_L0.8790.82
347_L350_D0.8790.82
175_S179_T0.8790.82
6_L407_F0.8720.82
343_W349_K0.8720.82
51_A55_T0.8690.82
201_Y361_M0.8690.82
401_G404_G0.8680.82
159_N163_T0.8650.81
184_V188_F0.8640.81
12_G319_I0.8630.81
341_V345_K0.8610.81
262_T305_G0.8600.81
144_N378_A0.8580.81
262_T304_K0.8570.81
204_I357_L0.8570.81
83_F89_R0.8540.80
259_L263_R0.8540.80
60_V428_Y0.8510.80
188_F230_F0.8490.80
307_N314_W0.8480.80
426_L429_F0.8470.80
279_E311_R0.8470.80
245_L256_A0.8470.80
200_A220_L0.8470.80
259_L304_K0.8450.80
151_T174_P0.8450.80
157_I162_I0.8410.79
89_R161_K0.8410.79
130_F134_G0.8410.79
189_M227_G0.8380.79
194_I368_L0.8360.79
158_L161_K0.8340.79
118_R430_R0.8330.79
181_G185_L0.8320.79
408_L411_T0.8310.79
156_K163_T0.8310.79
140_V171_F0.8280.78
296_A300_D0.8230.78
386_V393_T0.8220.78
121_P125_I0.8220.78
405_V408_L0.8220.78
116_A128_V0.8200.78
340_G360_F0.8160.77
195_V223_A0.8150.77
225_T341_V0.8140.77
253_L291_L0.8090.77
206_T209_K0.8080.77
40_Q122_A0.8070.77
53_R432_H0.8060.77
333_L363_A0.8040.76
49_I434_V0.8000.76
228_G338_I0.7960.76
292_S301_T0.7950.76
332_L336_Y0.7930.75
71_I414_Y0.7920.75
422_V426_L0.7890.75
230_F234_T0.7890.75
268_L327_V0.7880.75
342_V349_K0.7850.75
332_L359_I0.7840.75
147_A173_N0.7820.74
265_H302_V0.7810.74
231_S330_G0.7810.74
291_L303_V0.7790.74
187_A371_I0.7750.74
263_R302_V0.7710.73
45_D121_P0.7680.73
75_Q80_W0.7680.73
87_I148_F0.7680.73
76_L95_F0.7670.73
37_L40_Q0.7670.73
30_L129_F0.7670.73
339_I342_V0.7640.73
272_G283_W0.7600.72
44_D214_R0.7540.72
277_N280_K0.7540.72
178_I241_S0.7520.71
427_Y431_K0.7520.71
346_V349_K0.7500.71
271_G283_W0.7500.71
93_L164_D0.7460.71
322_L373_F0.7460.71
292_S303_V0.7450.71
40_Q121_P0.7420.70
309_F314_W0.7420.70
245_L378_A0.7420.70
400_T404_G0.7420.70
246_Y304_K0.7410.70
135_A188_F0.7410.70
202_K432_H0.7410.70
289_W301_T0.7400.70
30_L136_A0.7390.70
334_I338_I0.7390.70
269_A281_V0.7370.70
189_M333_L0.7370.70
61_L194_I0.7370.70
262_T303_V0.7370.70
402_S405_V0.7350.70
233_L237_N0.7300.69
55_T112_Y0.7300.69
339_I359_I0.7290.69
47_Y433_P0.7290.69
147_A179_T0.7280.69
322_L377_F0.7250.69
187_A234_T0.7250.69
23_T91_M0.7230.68
275_D280_K0.7230.68
342_V347_L0.7220.68
19_I371_I0.7200.68
123_M127_A0.7190.68
304_K309_F0.7190.68
44_D49_I0.7170.68
266_A305_G0.7150.68
225_T229_I0.7140.67
342_V346_V0.7130.67
41_K44_D0.7130.67
97_I141_L0.7130.67
60_V424_V0.7120.67
47_Y50_M0.7110.67
410_F417_L0.7090.67
31_M195_V0.7070.67
302_V308_A0.7030.66
275_D281_V0.7020.66
195_V226_I0.7010.66
17_F21_F0.6980.66
83_F90_V0.6980.66
38_I47_Y0.6980.66
108_F127_A0.6970.66
205_R362_T0.6960.65
264_S304_K0.6950.65
251_E388_Y0.6940.65
108_F134_G0.6930.65
397_V403_I0.6910.65
147_A176_F0.6900.65
242_A324_N0.6900.65
101_A138_S0.6890.65
26_V136_A0.6890.65
228_G337_S0.6880.65
101_A137_A0.6880.65
285_I290_A0.6880.65
287_I290_A0.6860.64
365_P369_I0.6860.64
90_V162_I0.6860.64
104_V130_F0.6840.64
336_Y356_L0.6830.64
226_I230_F0.6810.64
90_V164_D0.6760.63
175_S244_M0.6740.63
266_A301_T0.6730.63
6_L403_I0.6700.63
345_K348_K0.6690.62
111_I424_V0.6680.62
116_A432_H0.6670.62
319_I376_I0.6670.62
415_A418_G0.6660.62
83_F149_E0.6660.62
81_P84_M0.6660.62
259_L291_L0.6650.62
261_E302_V0.6610.61
253_L295_A0.6610.61
272_G286_E0.6610.61
231_S329_V0.6600.61
406_L429_F0.6590.61
260_F284_A0.6590.61
119_L123_M0.6570.61
221_L351_R0.6560.61
36_E40_Q0.6550.61
260_F314_W0.6530.61
193_F329_V0.6480.60
154_G170_A0.6480.60
7_A397_V0.6480.60
46_H50_M0.6480.60
57_A428_Y0.6460.60
186_S234_T0.6460.60
156_K164_D0.6460.60
44_D47_Y0.6460.60
133_V168_W0.6420.59
73_G145_V0.6410.59
329_V370_G0.6400.59
327_V370_G0.6390.59
265_H298_R0.6390.59
225_T345_K0.6380.59
74_T77_A0.6380.59
158_L163_T0.6380.59
49_I215_F0.6380.59
194_I425_L0.6370.59
359_I363_A0.6350.58
49_I56_K0.6330.58
206_T354_T0.6320.58
72_A78_L0.6320.58
311_R316_P0.6310.58
291_L294_L0.6300.58
7_A398_T0.6300.58
67_P389_H0.6300.58
77_A92_S0.6290.58
202_K216_H0.6240.57
271_G284_A0.6230.57
254_A291_L0.6230.57
82_G391_L0.6230.57
399_T402_S0.6220.57
3_D397_V0.6220.57
32_I58_Q0.6210.57
421_V425_L0.6170.56
30_L188_F0.6170.56
35_A51_A0.6160.56
356_L359_I0.6150.56
289_W298_R0.6150.56
232_L334_I0.6140.56
313_E385_W0.6140.56
34_V42_T0.6140.56
136_A140_V0.6130.56
143_T183_V0.6120.56
428_Y431_K0.6120.56
192_A230_F0.6060.55
329_V373_F0.6060.55
202_K429_F0.6050.55
391_L395_D0.6040.55
258_G306_L0.6030.55
202_K433_P0.6030.55
339_I353_P0.6030.55
293_F298_R0.6010.54
174_P244_M0.6000.54
136_A188_F0.5990.54
151_T248_Y0.5980.54
46_H214_R0.5970.54
258_G324_N0.5950.54
281_V317_L0.5940.53
42_T47_Y0.5930.53
94_P170_A0.5920.53
196_A340_G0.5910.53
42_T51_A0.5910.53
72_A75_Q0.5910.53
93_L167_P0.5910.53
412_F415_A0.5910.53
216_H219_A0.5890.53
49_I208_K0.5890.53
411_T415_A0.5890.53
148_F170_A0.5890.53
120_S126_V0.5870.53
217_R351_R0.5860.52
224_L345_K0.5860.52
55_T116_A0.5850.52
29_P144_N0.5850.52
141_L171_F0.5830.52
36_E48_A0.5830.52
237_N240_E0.5810.52
258_G272_G0.5800.52
38_I42_T0.5790.52
247_E277_N0.5780.51
404_G409_F0.5780.51
224_L343_W0.5770.51
333_L366_F0.5760.51
215_F219_A0.5760.51
50_M54_W0.5750.51
101_A142_I0.5750.51
403_I407_F0.5750.51
251_E314_W0.5750.51
110_S113_V0.5740.51
265_H299_F0.5730.51
224_L341_V0.5710.51
61_L73_G0.5710.51
331_M339_I0.5700.50
273_F318_F0.5690.50
84_M87_I0.5690.50
339_I356_L0.5680.50
29_P32_I0.5680.50
260_F279_E0.5660.50
220_L357_L0.5660.50
276_P317_L0.5660.50
7_A58_Q0.5650.50
267_P284_A0.5620.50
90_V155_F0.5610.49
155_F162_I0.5600.49
154_G169_A0.5590.49
97_I100_Y0.5580.49
26_V30_L0.5580.49
320_H324_N0.5580.49
38_I222_L0.5570.49
61_L368_L0.5560.49
372_E376_I0.5550.49
189_M192_A0.5530.48
365_P433_P0.5530.48
17_F415_A0.5520.48
390_L394_S0.5520.48
310_P314_W0.5510.48
358_I361_M0.5500.48
353_P357_L0.5500.48
208_K435_D0.5490.48
417_L421_V0.5490.48
397_V425_L0.5490.48
327_V331_M0.5490.48
19_I367_S0.5480.48
361_M364_G0.5470.48
241_S244_M0.5470.48
89_R162_I0.5460.48
21_F67_P0.5450.47
3_D404_G0.5450.47
70_T107_L0.5430.47
17_F64_V0.5420.47
17_F20_I0.5420.47
125_I128_V0.5410.47
31_M223_A0.5410.47
194_I429_F0.5410.47
228_G232_L0.5410.47
28_L194_I0.5400.47
423_Y426_L0.5400.47
140_V180_A0.5390.47
14_T72_A0.5380.47
290_A331_M0.5380.47
139_A180_A0.5380.47
265_H301_T0.5370.46
48_A117_D0.5370.46
190_T376_I0.5370.46
73_G96_Q0.5360.46
314_W319_I0.5360.46
189_M230_F0.5360.46
276_P312_D0.5350.46
130_F133_V0.5340.46
148_F162_I0.5340.46
349_K353_P0.5340.46
399_T403_I0.5320.46
112_Y124_R0.5320.46
73_G91_M0.5320.46
322_L325_A0.5310.46
233_L250_P0.5310.46
52_K121_P0.5310.46
47_Y423_Y0.5310.46
404_G407_F0.5300.46
196_A363_A0.5300.46
272_G320_H0.5290.45
106_A371_I0.5280.45
43_K205_R0.5270.45
33_L128_V0.5260.45
214_R224_L0.5250.45
351_R360_F0.5250.45
17_F68_T0.5250.45
223_A356_L0.5240.45
214_R218_K0.5240.45
273_F284_A0.5240.45
24_L61_L0.5230.45
254_A308_A0.5220.45
405_V411_T0.5220.45
62_L96_Q0.5220.45
236_L331_M0.5200.44
56_K431_K0.5200.44
179_T241_S0.5190.44
281_V286_E0.5190.44
112_Y367_S0.5180.44
24_L35_A0.5170.44
112_Y116_A0.5170.44
83_F145_V0.5170.44
83_F86_V0.5170.44
200_A360_F0.5170.44
354_T357_L0.5160.44
82_G396_V0.5150.44
25_G64_V0.5150.44
208_K214_R0.5140.44
6_L408_L0.5140.44
254_A262_T0.5140.44
106_A428_Y0.5130.44
89_R163_T0.5130.44
76_L84_M0.5130.44
409_F412_F0.5120.43
30_L226_I0.5120.43
45_D416_V0.5110.43
118_R427_Y0.5110.43
208_K434_V0.5100.43
266_A299_F0.5100.43
169_A172_F0.5100.43
9_S12_G0.5090.43
10_L77_A0.5090.43
386_V392_K0.5090.43
419_A423_Y0.5080.43
100_Y137_A0.5070.43
193_F366_F0.5060.43
227_G333_L0.5060.43
274_T321_T0.5060.43
9_S380_T0.5060.43
238_G323_F0.5050.43
280_K283_W0.5040.42
274_T279_E0.5040.42
263_R420_A0.5030.42
231_S333_L0.5030.42
277_N311_R0.5020.42
264_S296_A0.5020.42
189_M368_L0.5020.42
31_M83_F0.5010.42
44_D218_K0.5010.42
39_Y71_I0.5000.42
268_L272_G0.5000.42
150_G249_Q0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4xp4A 1 0.4447 87.7 0.967 Contact Map
3mk7A 1 0.447 52.2 0.975 Contact Map
2a65A 2 0.4086 42.8 0.977 Contact Map
3s8fA 1 0.5418 39.7 0.977 Contact Map
4us3A 1 0.3251 28.2 0.979 Contact Map
3ddlA 2 0.5124 24.1 0.98 Contact Map
2hi7B 1 0.2822 21.7 0.98 Contact Map
2ks1B 1 0.0993 19.9 0.98 Contact Map
3wfdB 1 0.4018 15.8 0.981 Contact Map
2kncA 1 0.1129 15.6 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0124 seconds.