GREMLIN Database
SFTA - DNA translocase SftA
UniProt: C0SP86 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 952 (791)
Sequences: 359 (294)
Seq/√Len: 10.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
710_R714_L4.7871.00
704_V744_V4.7241.00
892_A925_M4.3350.99
754_M769_Q3.5290.97
669_L678_A3.4630.97
605_F612_L3.4290.97
597_R601_R3.3600.97
902_A922_I3.2670.96
921_L924_M3.0660.94
653_L745_I2.9520.93
723_I843_L2.9240.93
844_Q938_K2.9190.93
608_S613_T2.9170.93
540_R620_I2.7490.90
545_P892_A2.7480.90
819_A911_F2.7060.89
288_P291_S2.6990.89
555_T678_A2.6720.89
517_D691_I2.5900.87
896_V902_A2.4930.85
720_V796_A2.4920.85
553_K921_L2.4520.84
687_V774_C2.4330.83
542_E620_I2.3880.82
714_L762_E2.3830.82
508_W800_T2.3800.82
598_Q629_L2.3740.82
562_K569_D2.3610.81
545_P832_F2.3450.81
268_E274_E2.3430.81
620_I943_L2.3360.81
703_W814_T2.3310.80
611_P741_Y2.3210.80
562_K649_I2.3020.80
616_L741_Y2.2640.78
800_T833_L2.2620.78
746_I749_L2.2590.78
665_V779_L2.2550.78
525_V808_S2.2320.77
669_L904_T2.2170.77
895_F911_F2.2120.77
705_V754_M2.2000.76
768_A920_R2.1930.76
907_L923_D2.1920.76
649_I749_L2.1790.76
561_I586_V2.1690.75
527_A911_F2.1490.75
611_P632_M2.1450.74
527_A819_A2.1430.74
670_I932_S2.1430.74
640_A938_K2.1360.74
532_V613_T2.1140.73
706_E800_T2.0540.71
678_A834_E2.0440.71
519_T563_L2.0370.70
808_S840_P2.0370.70
564_S925_M2.0350.70
675_V844_Q2.0320.70
640_A844_Q2.0260.70
635_G678_A2.0210.70
698_T774_C2.0160.70
774_C853_I1.9990.69
896_V925_M1.9930.69
770_K932_S1.9780.68
467_V726_F1.9740.68
616_L915_Y1.9720.68
687_V698_T1.9620.67
905_S926_E1.9520.67
789_V929_G1.9500.67
543_V653_L1.9250.66
567_A572_I1.8940.65
861_R923_D1.8840.64
566_S594_V1.8770.64
517_D893_C1.8660.63
770_K833_L1.8660.63
850_D920_R1.8560.63
674_M771_A1.8530.63
674_M692_T1.8430.62
551_V559_D1.8400.62
715_F757_P1.8390.62
620_I796_A1.8370.62
832_F943_L1.8330.62
905_S915_Y1.8110.61
616_L895_F1.7930.60
548_G845_G1.7920.60
545_P581_T1.7890.60
624_P912_R1.7870.60
652_I715_F1.7860.60
755_V876_V1.7800.59
519_T533_T1.7530.58
522_N595_D1.7480.58
601_R606_R1.7440.58
544_H911_F1.7430.58
767_I877_R1.7370.58
615_A667_V1.7330.57
714_L739_L1.7260.57
840_P848_V1.7180.57
600_I734_Q1.7160.57
678_A904_T1.6990.56
677_L920_R1.6980.56
710_R762_E1.6980.56
726_F930_M1.6960.56
584_I689_P1.6880.55
737_E902_A1.6800.55
540_R943_L1.6800.55
756_A780_V1.6770.55
808_S852_E1.6770.55
675_V938_K1.6710.54
616_L905_S1.6580.54
917_R920_R1.6540.54
579_K700_A1.6510.54
715_F758_N1.6490.53
525_V624_P1.6390.53
625_V847_F1.6360.53
541_F746_I1.6330.53
553_K582_I1.6330.53
561_I652_I1.6270.52
703_W845_G1.6260.52
596_L745_I1.6180.52
808_S848_V1.6170.52
664_E738_K1.6150.52
227_G239_P1.6110.52
555_T669_L1.6100.52
696_A800_T1.6060.51
937_S945_T1.6040.51
611_P635_G1.6030.51
498_P611_P1.5960.51
541_F935_K1.5950.51
810_V849_S1.5950.51
892_A904_T1.5940.51
840_P852_E1.5920.51
545_P594_V1.5900.51
597_R802_I1.5860.51
161_S165_E1.5830.50
522_N545_P1.5810.50
832_F892_A1.5780.50
665_V719_G1.5780.50
517_D637_I1.5730.50
620_I832_F1.5690.50
515_L558_S1.5630.49
715_F844_Q1.5620.49
652_I793_L1.5560.49
649_I656_L1.5440.49
599_M837_S1.5410.48
524_N681_N1.5370.48
540_R850_D1.5370.48
793_L850_D1.5290.48
726_F928_E1.5040.47
663_S666_K1.5030.47
683_I758_N1.5020.47
569_D758_N1.5020.47
656_L739_L1.4980.46
333_A344_D1.4930.46
648_C844_Q1.4900.46
508_W875_L1.4800.46
156_K161_S1.4790.46
566_S575_P1.4750.45
505_D541_F1.4740.45
749_L870_F1.4720.45
660_A719_G1.4700.45
835_N860_V1.4670.45
630_K724_D1.4660.45
540_R586_V1.4650.45
652_I844_Q1.4650.45
770_K800_T1.4610.45
537_S796_A1.4610.45
543_V713_E1.4580.45
554_I582_I1.4550.44
566_S844_Q1.4550.44
559_D575_P1.4480.44
560_D814_T1.4400.44
546_E823_K1.4360.44
558_S928_E1.4320.43
844_Q936_G1.4290.43
709_E888_L1.4270.43
538_V678_A1.4250.43
575_P863_Q1.4240.43
648_C944_I1.4240.43
512_Q519_T1.4240.43
551_V575_P1.4230.43
722_D765_A1.4210.43
527_A669_L1.4160.43
875_L901_S1.4160.43
586_V849_S1.4140.43
648_C715_F1.4130.42
551_V925_M1.4060.42
561_I648_C1.4050.42
586_V681_N1.4030.42
540_R796_A1.4030.42
705_V769_Q1.4010.42
666_K675_V1.3990.42
838_G928_E1.3950.42
677_L850_D1.3870.41
679_P875_L1.3870.41
489_F656_L1.3840.41
819_A843_L1.3720.41
566_S580_N1.3660.40
322_V349_E1.3650.40
616_L635_G1.3600.40
630_K876_V1.3570.40
519_T844_Q1.3550.40
541_F611_P1.3540.40
538_V555_T1.3540.40
565_L628_D1.3530.40
835_N932_S1.3530.40
688_S871_E1.3500.40
563_L574_A1.3500.40
516_L681_N1.3480.40
559_D574_A1.3470.39
262_D265_V1.3460.39
558_S566_S1.3460.39
550_K911_F1.3440.39
713_E860_V1.3420.39
526_R564_S1.3410.39
534_Q575_P1.3400.39
696_A911_F1.3370.39
780_V798_I1.3360.39
575_P860_V1.3320.39
653_L726_F1.3310.39
599_M941_E1.3280.39
496_D597_R1.3270.39
869_L887_E1.3270.39
508_W562_K1.3260.39
757_P844_Q1.3250.38
737_E929_G1.3250.38
385_D389_E1.3230.38
624_P651_T1.3190.38
562_K870_F1.3190.38
624_P810_V1.3040.38
618_L893_C1.3020.37
600_I606_R1.3000.37
537_S573_E1.2970.37
573_E704_V1.2970.37
656_L665_V1.2910.37
164_I175_T1.2910.37
611_P616_L1.2850.37
575_P580_N1.2850.37
667_V689_P1.2850.37
648_C757_P1.2850.37
632_M805_S1.2840.37
191_F203_D1.2820.37
692_T796_A1.2800.37
282_P288_P1.2790.36
800_T932_S1.2770.36
157_V173_S1.2760.36
690_V705_V1.2750.36
594_V803_A1.2730.36
562_K635_G1.2710.36
718_S780_V1.2690.36
632_M911_F1.2640.36
613_T932_S1.2630.36
569_D889_F1.2600.36
823_K844_Q1.2600.36
679_P863_Q1.2590.36
692_T761_E1.2580.36
291_S317_P1.2580.36
566_S938_K1.2570.36
651_T846_N1.2550.35
921_L925_M1.2550.35
497_V597_R1.2550.35
572_I675_V1.2530.35
534_Q710_R1.2520.35
548_G703_W1.2490.35
581_T586_V1.2490.35
640_A715_F1.2440.35
627_I832_F1.2440.35
864_M869_L1.2380.35
658_Y752_L1.2380.35
566_S581_T1.2370.35
715_F893_C1.2340.35
582_I832_F1.2340.35
531_H600_I1.2320.34
276_E300_A1.2320.34
857_V934_A1.2290.34
537_S757_P1.2290.34
692_T793_L1.2270.34
648_C652_I1.2240.34
651_T805_S1.2240.34
595_D865_P1.2220.34
653_L691_I1.2210.34
543_V921_L1.2210.34
663_S729_L1.2130.34
745_I836_G1.2130.34
618_L635_G1.2110.34
696_A932_S1.2070.33
580_N863_Q1.2060.33
575_P675_V1.2040.33
534_Q756_A1.2020.33
433_P440_P1.2000.33
762_E906_S1.2000.33
540_R920_R1.1930.33
561_I823_K1.1890.33
687_V757_P1.1890.33
612_L624_P1.1850.32
690_V798_I1.1840.32
669_L924_M1.1810.32
651_T827_K1.1790.32
678_A779_L1.1790.32
534_Q893_C1.1790.32
580_N694_A1.1790.32
563_L844_Q1.1760.32
758_N809_Q1.1760.32
292_A308_V1.1750.32
489_F789_V1.1750.32
704_V833_L1.1750.32
564_S749_L1.1730.32
614_A873_E1.1720.32
678_A725_R1.1710.32
665_V912_R1.1700.32
726_F881_A1.1670.32
687_V767_I1.1670.32
563_L938_K1.1670.32
527_A860_V1.1660.32
563_L622_G1.1660.32
594_V779_L1.1620.32
852_E892_A1.1620.32
696_A770_K1.1590.31
789_V902_A1.1560.31
524_N555_T1.1540.31
690_V916_N1.1530.31
574_A759_D1.1520.31
902_A925_M1.1480.31
534_Q860_V1.1450.31
635_G901_S1.1440.31
654_V924_M1.1420.31
749_L869_L1.1390.31
756_A900_N1.1390.31
780_V818_I1.1360.31
512_Q611_P1.1340.30
669_L679_P1.1340.30
843_L924_M1.1330.30
729_L924_M1.1310.30
675_V704_V1.1300.30
846_N853_I1.1290.30
221_K224_F1.1280.30
439_E443_R1.1270.30
675_V759_D1.1270.30
245_E264_E1.1260.30
563_L575_P1.1240.30
272_T284_K1.1190.30
675_V715_F1.1180.30
796_A920_R1.1170.30
695_K800_T1.1170.30
165_E171_P1.1150.30
440_P448_E1.1140.30
704_V835_N1.1140.30
635_G809_Q1.1140.30
847_F923_D1.1130.30
591_S668_L1.1110.30
652_I698_T1.1090.29
694_A846_N1.1090.29
807_S857_V1.1080.29
805_S899_Q1.1040.29
606_R921_L1.1030.29
562_K591_S1.1000.29
809_Q835_N1.0990.29
505_D530_V1.0990.29
541_F932_S1.0980.29
228_V288_P1.0970.29
545_P902_A1.0970.29
846_N893_C1.0960.29
555_T570_I1.0940.29
632_M771_A1.0940.29
653_L702_K1.0920.29
515_L779_L1.0900.29
631_K769_Q1.0890.29
749_L863_Q1.0890.29
635_G669_L1.0850.29
818_I861_R1.0840.28
660_A665_V1.0830.28
541_F670_I1.0800.28
687_V694_A1.0800.28
400_D404_E1.0790.28
694_A906_S1.0770.28
843_L861_R1.0760.28
679_P767_I1.0740.28
654_V809_Q1.0710.28
528_N856_V1.0700.28
669_L860_V1.0670.28
527_A545_P1.0630.28
573_E869_L1.0630.28
670_I790_I1.0610.28
558_S911_F1.0600.28
279_E293_E1.0590.28
590_T730_T1.0580.28
761_E768_A1.0570.27
692_T920_R1.0560.27
542_E768_A1.0550.27
477_Q600_I1.0540.27
527_A863_Q1.0540.27
563_L809_Q1.0540.27
652_I938_K1.0530.27
570_I696_A1.0520.27
559_D637_I1.0510.27
652_I687_V1.0510.27
832_F838_G1.0510.27
251_M263_S1.0510.27
793_L932_S1.0510.27
162_E172_A1.0510.27
624_P808_S1.0500.27
835_N938_K1.0500.27
558_S564_S1.0490.27
515_L621_S1.0490.27
719_G741_Y1.0480.27
814_T845_G1.0480.27
575_P581_T1.0480.27
692_T757_P1.0440.27
619_D622_G1.0430.27
525_V615_A1.0430.27
675_V936_G1.0430.27
833_L875_L1.0420.27
273_A279_E1.0420.27
543_V627_I1.0380.27
555_T819_A1.0350.27
520_L659_K1.0330.27
715_F809_Q1.0300.26
728_Q837_S1.0280.26
658_Y722_D1.0280.26
690_V917_R1.0280.26
637_I715_F1.0240.26
614_A658_Y1.0230.26
612_L771_A1.0210.26
342_Q353_T1.0200.26
560_D610_S1.0190.26
653_L790_I1.0190.26
721_R845_G1.0160.26
515_L547_P1.0140.26
562_K758_N1.0130.26
629_L742_L1.0130.26
675_V835_N1.0130.26
709_E770_K1.0110.26
229_Q239_P1.0090.26
516_L553_K1.0080.26
524_N678_A1.0060.26
762_E833_L1.0050.26
624_P915_Y1.0050.26
902_A929_G1.0050.26
749_L780_V1.0030.26
759_D937_S1.0030.26
522_N715_F1.0020.25
245_E270_P1.0010.25
762_E793_L1.0000.25
545_P570_I0.9990.25
505_D674_M0.9990.25
537_S864_M0.9970.25
561_I757_P0.9960.25
721_R790_I0.9900.25
923_D945_T0.9900.25
519_T938_K0.9880.25
559_D563_L0.9870.25
272_T297_E0.9860.25
537_S846_N0.9850.25
722_D763_S0.9840.25
512_Q635_G0.9800.25
581_T854_D0.9800.25
196_S215_A0.9800.25
698_T848_V0.9780.25
714_L793_L0.9760.25
678_A702_K0.9750.25
515_L709_E0.9710.24
563_L827_K0.9690.24
620_I768_A0.9670.24
681_N690_V0.9670.24
692_T886_D0.9650.24
544_H581_T0.9650.24
491_N856_V0.9640.24
631_K695_K0.9640.24
377_E435_E0.9640.24
574_A675_V0.9620.24
745_I849_S0.9570.24
654_V835_N0.9560.24
703_W770_K0.9560.24
713_E819_A0.9540.24
648_C938_K0.9520.24
666_K827_K0.9500.24
566_S936_G0.9470.24
716_A904_T0.9460.24
408_T424_N0.9450.23
725_R774_C0.9450.23
565_L913_I0.9450.23
517_D534_Q0.9440.23
935_K941_E0.9440.23
632_M760_V0.9420.23
287_E292_A0.9420.23
546_E945_T0.9420.23
527_A905_S0.9410.23
818_I887_E0.9400.23
530_V541_F0.9380.23
575_P749_L0.9370.23
669_L834_E0.9370.23
527_A710_R0.9370.23
517_D864_M0.9360.23
704_V763_S0.9360.23
703_W771_A0.9350.23
534_Q716_A0.9340.23
537_S844_Q0.9340.23
618_L688_S0.9310.23
695_K916_N0.9310.23
581_T805_S0.9300.23
895_F917_R0.9280.23
637_I640_A0.9270.23
233_K238_F0.9260.23
273_A276_E0.9260.23
530_V932_S0.9250.23
529_V911_F0.9210.23
580_N629_L0.9210.23
677_L690_V0.9200.23
694_A763_S0.9200.23
362_L377_E0.9200.23
883_K928_E0.9170.23
519_T848_V0.9150.22
900_N944_I0.9140.22
854_D923_D0.9110.22
540_R845_G0.9110.22
503_Q629_L0.9080.22
598_Q622_G0.9060.22
553_K832_F0.9060.22
668_L854_D0.9060.22
802_I871_E0.9050.22
540_R703_W0.9010.22
573_E715_F0.9000.22
674_M709_E0.8980.22
612_L724_D0.8980.22
537_S715_F0.8970.22
625_V763_S0.8970.22
804_F807_S0.8960.22
285_F289_V0.8930.22
550_K903_S0.8920.22
316_E334_E0.8920.22
608_S837_S0.8910.22
513_R625_V0.8910.22
466_N629_L0.8910.22
574_A637_I0.8900.22
872_Q937_S0.8890.22
648_C761_E0.8890.22
555_T911_F0.8840.21
754_M836_G0.8840.21
899_Q906_S0.8830.21
511_E897_V0.8830.21
605_F626_V0.8830.21
613_T722_D0.8820.21
722_D744_V0.8810.21
876_V923_D0.8800.21
834_E873_E0.8800.21
580_N819_A0.8790.21
612_L630_K0.8760.21
157_V161_S0.8750.21
771_A814_T0.8750.21
275_E300_A0.8750.21
765_A805_S0.8750.21
649_I869_L0.8740.21
706_E944_I0.8740.21
704_V944_I0.8730.21
551_V863_Q0.8700.21
505_D853_I0.8700.21
688_S696_A0.8690.21
512_Q669_L0.8680.21
693_D893_C0.8670.21
291_S321_P0.8660.21
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510_E832_F0.5290.12
489_F800_T0.5280.12
770_K814_T0.5270.12
355_H391_Q0.5270.12
683_I738_K0.5270.12
397_V427_E0.5270.12
487_Y863_Q0.5260.12
677_L804_F0.5250.12
297_E307_A0.5250.12
678_A860_V0.5250.12
277_Q313_K0.5240.12
545_P626_V0.5240.12
160_L167_E0.5230.12
341_E345_I0.5220.12
737_E930_M0.5220.12
929_G943_L0.5220.12
377_E419_T0.5210.12
691_I860_V0.5210.12
505_D924_M0.5210.12
670_I770_K0.5210.12
615_A689_P0.5200.12
332_G335_S0.5190.12
554_I611_P0.5190.12
603_S606_R0.5180.12
256_A309_S0.5170.12
564_S837_S0.5160.12
698_T840_P0.5160.12
635_G802_I0.5160.12
574_A844_Q0.5160.12
682_K729_L0.5160.12
870_F939_P0.5160.12
581_T809_Q0.5150.12
629_L873_E0.5150.12
540_R573_E0.5140.12
498_P932_S0.5140.12
800_T888_L0.5130.12
635_G725_R0.5120.12
754_M814_T0.5120.12
586_V599_M0.5120.12
591_S767_I0.5100.12
563_L762_E0.5100.12
844_Q945_T0.5090.12
679_P725_R0.5080.12
693_D768_A0.5080.12
632_M814_T0.5070.12
327_E361_A0.5070.12
532_V596_L0.5070.12
563_L640_A0.5070.12
694_A774_C0.5070.12
715_F860_V0.5060.12
517_D527_A0.5060.12
899_Q910_R0.5050.12
296_E361_A0.5040.12
665_V745_I0.5040.12
516_L586_V0.5030.12
378_S381_N0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iusA 1 0.3992 100 0.531 Contact Map
2iutA 2 0.4055 100 0.541 Contact Map
4nh0A 1 0.3466 100 0.863 Contact Map
2ve8A 1 0.0714 100 0.913 Contact Map
4lyaA 1 0.3466 100 0.913 Contact Map
4d2iA 3 0.333 100 0.92 Contact Map
4ag6A 2 0.2511 99.8 0.938 Contact Map
1e9rA 3 0.2826 99.5 0.953 Contact Map
2v1uA 1 0.3288 98.5 0.969 Contact Map
2qbyA 1 0.3288 98.5 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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