GREMLIN Database
YUKE - Uncharacterized protein YukE
UniProt: C0SP85 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 97 (93)
Sequences: 126 (87)
Seq/√Len: 9.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_R85_E4.4160.99
47_A50_E2.3690.76
62_S66_M2.3540.76
55_Q76_Q2.3310.75
34_N56_Y2.0810.66
15_M36_M2.0690.66
6_R40_L2.0550.65
86_S90_D2.0490.65
47_A89_Q2.0220.64
10_E89_Q1.9640.61
68_D72_D1.9050.59
79_Q82_N1.8040.54
3_G51_A1.6400.47
83_T87_T1.5920.45
43_M73_V1.5910.45
37_I52_F1.5740.45
14_A68_D1.5480.43
68_D71_Q1.5390.43
34_N58_Q1.5260.42
43_M95_I1.5170.42
27_L67_S1.4620.40
87_T91_I1.4490.39
26_V29_Q1.4480.39
23_S70_L1.4370.39
42_S89_Q1.3700.36
52_F76_Q1.3640.36
24_Q75_Q1.3310.34
6_R45_E1.3170.34
36_M56_Y1.3010.33
22_E26_V1.2980.33
7_V43_M1.2300.31
7_V36_M1.2180.30
65_K75_Q1.1920.29
52_F55_Q1.1790.29
6_R60_K1.1780.29
51_A92_A1.1640.28
8_T84_L1.1620.28
21_V25_E1.1540.28
12_L70_L1.1400.27
80_T83_T1.1380.27
11_E70_L1.1330.27
24_Q68_D1.1290.27
6_R80_T1.1270.27
55_Q66_M1.1230.27
12_L33_L1.1040.26
52_F95_I1.1000.26
49_S74_N1.1000.26
14_A28_N1.0920.26
36_M48_S1.0870.26
25_E60_K1.0830.25
41_K53_A1.0780.25
25_E68_D1.0770.25
19_Y77_L1.0270.24
12_L55_Q0.9910.22
82_N85_E0.9870.22
18_Q72_D0.9860.22
37_I66_M0.9670.22
36_M40_L0.9630.22
33_L70_L0.9560.21
30_V62_S0.9520.21
22_E94_Q0.9490.21
12_L74_N0.9230.20
54_D64_I0.9100.20
7_V95_I0.8550.19
63_F92_A0.8480.18
20_G74_N0.8350.18
28_N38_S0.8290.18
7_V56_Y0.8240.18
21_V42_S0.8230.18
63_F66_M0.8210.18
48_S73_V0.8140.18
15_M18_Q0.8120.18
31_D86_S0.8090.17
49_S63_F0.7840.17
52_F67_S0.7800.17
37_I49_S0.7760.17
15_M43_M0.7640.16
19_Y59_L0.7630.16
37_I55_Q0.7630.16
18_Q33_L0.7510.16
4_L45_E0.7440.16
57_E68_D0.7440.16
34_N60_K0.7440.16
86_S89_Q0.7400.16
28_N42_S0.7380.16
26_V70_L0.7280.16
4_L36_M0.7250.15
74_N78_D0.7220.15
12_L76_Q0.7170.15
45_E80_T0.7050.15
67_S71_Q0.7000.15
55_Q70_L0.6940.15
16_A87_T0.6930.15
12_L66_M0.6890.15
56_Y90_D0.6880.15
19_Y56_Y0.6850.15
63_F91_I0.6800.14
27_L31_D0.6780.14
11_E52_F0.6730.14
48_S86_S0.6710.14
53_A91_I0.6700.14
40_L61_P0.6490.14
42_S50_E0.6420.14
13_R16_A0.6350.13
17_K54_D0.6340.13
8_T86_S0.6280.13
68_D89_Q0.6250.13
23_S27_L0.6240.13
37_I76_Q0.6210.13
25_E47_A0.6190.13
23_S71_Q0.6180.13
57_E60_K0.6120.13
25_E78_D0.6100.13
36_M45_E0.6070.13
31_D35_R0.6050.13
80_T91_I0.6050.13
20_G78_D0.5900.13
37_I62_S0.5860.13
65_K71_Q0.5850.13
65_K68_D0.5750.12
11_E73_V0.5660.12
19_Y81_A0.5650.12
50_E57_E0.5500.12
40_L49_S0.5490.12
78_D90_D0.5480.12
8_T29_Q0.5440.12
62_S92_A0.5380.12
24_Q28_N0.5380.12
40_L80_T0.5350.12
66_M76_Q0.5330.12
13_R81_A0.5150.11
31_D89_Q0.5100.11
12_L19_Y0.5100.11
33_L52_F0.5100.11
66_M74_N0.5090.11
87_T94_Q0.5050.11
9_P59_L0.5030.11
15_M40_L0.5030.11
12_L49_S0.5020.11
50_E58_Q0.5000.11
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ogiB 1 0.9175 99.8 0.517 Contact Map
3gwkC 2 1 99.7 0.539 Contact Map
4lwsA 1 0.9691 99.7 0.54 Contact Map
3zbhA 2 1 99.7 0.54 Contact Map
4lwsB 1 0.8763 99.7 0.549 Contact Map
3h6pC 1 0.5773 99.7 0.555 Contact Map
3favA 1 0.9278 99.6 0.571 Contact Map
3favB 1 0.8041 99.6 0.587 Contact Map
2vs0A 2 0.8763 99.6 0.588 Contact Map
4i0xB 1 0.9072 99.5 0.6 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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