GREMLIN Database
YTLA - Putative binding protein YtlA
UniProt: C0SP84 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 334 (304)
Sequences: 14149 (10663)
Seq/√Len: 611.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_E242_K3.5791.00
254_H258_D3.5001.00
59_E246_K3.4521.00
32_K62_D3.3821.00
250_W254_H3.3031.00
137_T167_D3.2131.00
229_Y233_N3.1231.00
227_Q231_K3.0951.00
134_K165_D2.9941.00
32_K64_D2.9681.00
58_E246_K2.9531.00
228_S232_K2.9011.00
34_K64_D2.8221.00
238_V242_K2.7881.00
317_P320_Q2.7841.00
261_D272_P2.7201.00
139_L186_G2.7181.00
36_A83_S2.6461.00
102_K227_Q2.5541.00
257_K276_E2.5301.00
56_F244_I2.4951.00
104_P227_Q2.4781.00
129_D132_Q2.4701.00
300_E304_T2.4281.00
249_Q253_N2.3681.00
233_N236_T2.2681.00
304_T308_K2.2561.00
193_E197_S2.2361.00
52_S265_D2.1121.00
53_K258_D2.0631.00
225_A230_L2.0441.00
161_D165_D2.0241.00
307_D315_H2.0151.00
128_F132_Q1.9831.00
148_Q152_E1.9821.00
85_I225_A1.9741.00
136_K187_E1.9721.00
272_P276_E1.9341.00
55_F246_K1.9291.00
156_N308_K1.8671.00
55_F243_A1.8011.00
258_D261_D1.7751.00
276_E280_E1.7711.00
235_D239_K1.7511.00
225_A237_A1.7271.00
55_F250_W1.7071.00
210_S213_E1.6901.00
245_Y249_Q1.6721.00
31_T233_N1.6651.00
271_D274_V1.6641.00
131_D158_H1.6521.00
160_I165_D1.6401.00
34_K66_N1.6371.00
261_D265_D1.6361.00
229_Y237_A1.6281.00
230_L237_A1.5921.00
172_I180_A1.5801.00
30_L62_D1.5711.00
296_E319_N1.5501.00
296_E300_E1.5441.00
138_F188_Y1.5291.00
137_T169_I1.5291.00
54_G57_K1.5141.00
59_E239_K1.5111.00
251_V259_I1.5081.00
53_K250_W1.5081.00
88_V224_M1.5041.00
97_E227_Q1.5031.00
133_L188_Y1.5001.00
304_T315_H1.4971.00
239_K243_A1.4851.00
131_D134_K1.4791.00
250_W258_D1.4691.00
234_E238_V1.4661.00
55_F58_E1.4661.00
155_L160_I1.4631.00
85_I240_F1.4511.00
85_I237_A1.4411.00
260_T276_E1.4411.00
198_L202_K1.4371.00
229_Y236_T1.4321.00
277_T280_E1.4311.00
257_K261_D1.3971.00
59_E243_A1.3961.00
73_K76_T1.3911.00
68_T77_S1.3401.00
34_K84_D1.3391.00
50_A247_A1.3341.00
122_R184_G1.3291.00
74_T86_A1.3281.00
177_I189_V1.3261.00
235_D238_V1.3161.00
128_F206_H1.3161.00
137_T187_E1.3071.00
273_D276_E1.3011.00
77_S82_G1.2901.00
155_L166_I1.2891.00
51_E57_K1.2721.00
130_W154_V1.2691.00
127_H136_K1.2601.00
130_W158_H1.2541.00
200_E277_T1.2521.00
106_I227_Q1.2441.00
305_I309_S1.2401.00
186_G189_V1.2361.00
201_K277_T1.2321.00
297_K301_L1.2231.00
173_D176_N1.2221.00
81_N228_S1.2211.00
50_A56_F1.2151.00
226_K229_Y1.1961.00
46_P248_Q1.1951.00
264_K272_P1.1931.00
182_A202_K1.1851.00
55_F59_E1.1821.00
78_L86_A1.1811.00
122_R125_V1.1761.00
52_S266_E1.1701.00
31_T236_T1.1581.00
17_L20_A1.1401.00
49_V262_A1.1381.00
49_V250_W1.1171.00
153_Y156_N1.1131.00
260_T272_P1.1041.00
121_A125_V1.0941.00
118_F196_A1.0711.00
180_A186_G1.0671.00
49_V53_K1.0641.00
61_L239_K1.0601.00
26_Q29_T1.0581.00
36_A68_T1.0581.00
140_G168_L1.0551.00
261_D264_K1.0511.00
303_Q316_I1.0441.00
179_N182_A1.0361.00
178_A182_A1.0361.00
254_H257_K1.0301.00
93_S224_M1.0291.00
71_G92_T1.0201.00
151_G168_L1.0201.00
297_K300_E1.0201.00
20_A24_C1.0161.00
249_Q252_E1.0111.00
236_T239_K1.0051.00
201_K273_D1.0051.00
288_Y291_D1.0021.00
56_F63_V0.9991.00
121_A188_Y0.9991.00
123_E206_H0.9901.00
31_T36_A0.9891.00
119_L190_Q0.9871.00
153_Y157_K0.9861.00
52_S262_A0.9851.00
179_N183_S0.9741.00
77_S83_S0.9701.00
303_Q315_H0.9681.00
122_R181_F0.9661.00
258_D262_A0.9581.00
255_S280_E0.9521.00
57_K62_D0.9481.00
134_K160_I0.9451.00
78_L224_M0.9391.00
301_L304_T0.9321.00
79_L101_A0.9301.00
33_V229_Y0.9271.00
15_I18_M0.9241.00
35_V63_V0.9231.00
53_K262_A0.9191.00
17_L21_L0.9151.00
123_E205_G0.9131.00
138_F166_I0.9121.00
120_V196_A0.9111.00
98_A313_P0.9091.00
124_D184_G0.9041.00
20_A23_A0.9021.00
255_S260_T0.9011.00
250_W259_I0.8981.00
223_F240_F0.8911.00
228_S231_K0.8891.00
16_F19_F0.8871.00
121_A207_I0.8871.00
286_H289_S0.8871.00
304_T307_D0.8861.00
121_A208_V0.8841.00
21_L24_C0.8831.00
97_E321_L0.8801.00
225_A229_Y0.8791.00
49_V247_A0.8791.00
81_N226_K0.8761.00
248_Q252_E0.8741.00
56_F243_A0.8671.00
273_D277_T0.8621.00
154_V158_H0.8621.00
14_S20_A0.8611.00
152_E162_P0.8591.00
35_V240_F0.8591.00
49_V251_V0.8531.00
55_F247_A0.8431.00
207_I210_S0.8391.00
61_L236_T0.8371.00
24_C27_E0.8351.00
227_Q230_L0.8351.00
303_Q307_D0.8301.00
231_K234_E0.8231.00
88_V93_S0.8231.00
108_F237_A0.8201.00
13_G19_F0.8181.00
229_Y234_E0.8161.00
75_M96_V0.8141.00
118_F207_I0.8091.00
295_N298_E0.8091.00
243_A246_K0.8061.00
31_T34_K0.8041.00
60_G239_K0.8041.00
307_D314_K0.8021.00
139_L177_I0.8011.00
181_F186_G0.7971.00
127_H132_Q0.7971.00
242_K246_K0.7961.00
85_I236_T0.7881.00
293_L297_K0.7831.00
90_S222_T0.7821.00
250_W253_N0.7821.00
99_Q313_P0.7801.00
40_H67_T0.7761.00
89_G92_T0.7751.00
107_N110_Q0.7741.00
197_S200_E0.7701.00
151_G190_Q0.7701.00
239_K242_K0.7701.00
70_G73_K0.7661.00
122_R126_E0.7631.00
229_Y232_K0.7631.00
148_Q168_L0.7611.00
244_I248_Q0.7591.00
296_E322_V0.7581.00
197_S201_K0.7571.00
84_D226_K0.7531.00
201_K274_V0.7531.00
293_L296_E0.7501.00
240_F244_I0.7471.00
94_I303_Q0.7461.00
300_E318_Y0.7431.00
176_N179_N0.7421.00
303_Q318_Y0.7411.00
275_I278_S0.7351.00
33_V85_I0.7341.00
294_L297_K0.7291.00
252_E255_S0.7291.00
237_A241_T0.7281.00
155_L158_H0.7201.00
50_A55_F0.7201.00
318_Y322_V0.7181.00
300_E303_Q0.7181.00
200_E205_G0.7181.00
119_L188_Y0.7171.00
84_D229_Y0.7151.00
198_L201_K0.7111.00
280_E283_K0.7091.00
194_P197_S0.7081.00
30_L233_N0.7071.00
193_E196_A0.7071.00
33_V236_T0.7071.00
144_G148_Q0.7071.00
104_P230_L0.7061.00
180_A185_T0.7051.00
30_L34_K0.7051.00
143_K148_Q0.7021.00
230_L234_E0.7011.00
156_N309_S0.7001.00
126_E206_H0.6961.00
12_V15_I0.6961.00
13_G16_F0.6951.00
260_T279_I0.6951.00
151_G155_L0.6921.00
153_Y301_L0.6911.00
24_C28_E0.6881.00
279_I283_K0.6871.00
277_T281_R0.6861.00
90_S299_W0.6861.00
162_P165_D0.6851.00
196_A200_E0.6841.00
307_D312_L0.6811.00
181_F189_V0.6811.00
287_S291_D0.6811.00
41_S44_Y0.6741.00
247_A251_V0.6711.00
262_A265_D0.6711.00
44_Y48_Y0.6701.00
48_Y51_E0.6701.00
76_T80_S0.6681.00
32_K36_A0.6671.00
149_M305_I0.6661.00
124_D128_F0.6651.00
294_L299_W0.6641.00
243_A247_A0.6631.00
43_F46_P0.6621.00
16_F20_A0.6621.00
257_K260_T0.6621.00
48_Y52_S0.6601.00
61_L243_A0.6601.00
278_S282_Y0.6591.00
78_L83_S0.6591.00
257_K272_P0.6581.00
107_N222_T0.6571.00
54_G58_E0.6531.00
200_E207_I0.6491.00
45_A263_I0.6461.00
147_P192_F0.6451.00
31_T239_K0.6451.00
31_T61_L0.6421.00
119_L133_L0.6421.00
10_A13_G0.6411.00
143_K171_N0.6411.00
28_E31_T0.6411.00
22_A25_K0.6411.00
152_E156_N0.6391.00
49_V259_I0.6391.00
109_A241_T0.6381.00
126_E136_K0.6371.00
274_V278_S0.6371.00
30_L60_G0.6351.00
85_I108_F0.6341.00
123_E204_I0.6331.00
10_A14_S0.6321.00
75_M224_M0.6321.00
152_E168_L0.6281.00
134_K161_D0.6251.00
182_A204_I0.6251.00
85_I229_Y0.6241.00
106_I241_T0.6201.00
154_V214_E0.6201.00
233_N237_A0.6201.00
156_N161_D0.6171.00
15_I19_F0.6171.00
131_D160_I0.6161.00
286_H290_P0.6161.00
95_Y99_Q0.6141.00
137_T186_G0.6131.00
270_T275_I0.6121.00
110_Q113_Q0.6121.00
35_V85_I0.6121.00
51_E65_V0.6121.00
225_A240_F0.6111.00
49_V54_G0.6111.00
138_F151_G0.6101.00
106_I225_A0.6101.00
135_G165_D0.6091.00
75_M88_V0.6091.00
250_W262_A0.6081.00
18_M21_L0.6071.00
124_D206_H0.6041.00
223_F244_I0.6001.00
56_F61_L0.5991.00
184_G187_E0.5971.00
310_G313_P0.5961.00
62_D65_V0.5931.00
66_N77_S0.5911.00
292_P295_N0.5891.00
51_E266_E0.5881.00
97_E320_Q0.5881.00
78_L226_K0.5881.00
245_Y248_Q0.5871.00
86_A224_M0.5821.00
209_A213_E0.5821.00
136_K188_Y0.5811.00
307_D310_G0.5801.00
264_K275_I0.5791.00
28_E32_K0.5791.00
257_K280_E0.5781.00
27_E30_L0.5761.00
10_A17_L0.5761.00
90_S302_L0.5741.00
56_F59_E0.5711.00
50_A53_K0.5711.00
303_Q312_L0.5701.00
84_D233_N0.5691.00
93_S97_E0.5681.00
246_K249_Q0.5661.00
105_V222_T0.5651.00
120_V200_E0.5651.00
137_T185_T0.5641.00
15_I20_A0.5621.00
38_V41_S0.5621.00
195_Q199_F0.5611.00
298_E301_L0.5611.00
96_V101_A0.5601.00
180_A183_S0.5601.00
123_E203_G0.5601.00
301_L305_I0.5591.00
139_L189_V0.5581.00
14_S18_M0.5561.00
95_Y98_A0.5551.00
19_F22_A0.5541.00
145_G148_Q0.5531.00
88_V92_T0.5521.00
156_N162_P0.5510.99
106_I230_L0.5510.99
139_L169_I0.5500.99
107_N294_L0.5470.99
30_L57_K0.5460.99
210_S214_E0.5460.99
118_F121_A0.5430.99
36_A39_T0.5420.99
51_E62_D0.5410.99
21_L25_K0.5400.99
162_P168_L0.5400.99
61_L240_F0.5390.99
14_S17_L0.5390.99
152_E309_S0.5380.99
89_G145_G0.5370.99
238_V241_T0.5350.99
10_A20_A0.5340.99
241_T245_Y0.5330.99
121_A206_H0.5320.99
73_K77_S0.5300.99
127_H130_W0.5280.99
262_A266_E0.5270.99
107_N241_T0.5260.99
13_G18_M0.5260.99
200_E203_G0.5240.99
47_L244_I0.5230.99
121_A126_E0.5210.99
168_L171_N0.5210.99
287_S290_P0.5210.99
141_Q147_P0.5200.99
191_L195_Q0.5200.99
264_K271_D0.5200.99
50_A243_A0.5190.99
316_I321_L0.5170.99
104_P108_F0.5170.99
234_E237_A0.5170.99
130_W133_L0.5160.99
91_E306_M0.5150.99
211_F214_E0.5150.99
181_F205_G0.5140.99
208_V211_F0.5130.99
223_F241_T0.5120.99
300_E307_D0.5120.99
271_D275_I0.5120.99
189_V199_F0.5100.99
197_S277_T0.5080.99
83_S86_A0.5070.99
11_C15_I0.5060.99
77_S80_S0.5030.99
38_V65_V0.5030.99
12_V16_F0.5030.99
93_S222_T0.5020.99
46_P247_A0.5020.99
38_V67_T0.5010.99
30_L33_V0.5010.99
11_C17_L0.5010.99
283_K286_H0.5000.99
174_F177_I0.5000.99
153_Y305_I0.5000.99
10_A24_C0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qslA 1 0.9162 100 0.282 Contact Map
2g29A 1 0.9012 100 0.303 Contact Map
4nmyA 1 0.8683 100 0.306 Contact Map
3un6A 1 0.8653 100 0.315 Contact Map
2de3A 1 0.8772 100 0.319 Contact Map
2i49A 1 0.9072 100 0.326 Contact Map
3ix1A 2 0.8683 100 0.337 Contact Map
2x26A 1 0.8772 100 0.354 Contact Map
2x7qA 1 0.8623 100 0.378 Contact Map
4eswA 2 0.8952 100 0.379 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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