GREMLIN Database
YOAE - Probable oxidoreductase YoaE
UniProt: C0SP82 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 680 (642)
Sequences: 9579 (5923)
Seq/√Len: 233.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_T85_P5.5671.00
607_I626_A4.4141.00
93_D474_A4.2691.00
614_R678_E3.9781.00
462_K470_L3.6111.00
242_E288_K3.3301.00
614_R621_E3.3231.00
601_D635_G3.1811.00
270_E280_T3.1521.00
98_R101_Q3.1461.00
234_G272_V3.1421.00
565_F605_H3.1301.00
466_E470_L3.0951.00
75_T84_E3.0051.00
600_K634_P2.9731.00
94_T426_I2.9171.00
238_I242_E2.8941.00
453_P456_E2.8741.00
247_E251_S2.8671.00
255_V533_S2.7711.00
237_H241_K2.7451.00
87_S90_E2.7441.00
95_I426_I2.7321.00
236_M260_L2.7251.00
412_V424_A2.7151.00
178_W232_A2.6851.00
616_W678_E2.6651.00
92_I474_A2.6581.00
273_S280_T2.5771.00
616_W676_Q2.5431.00
219_W285_R2.5231.00
236_M323_I2.5101.00
202_K289_M2.5061.00
102_L110_S2.4621.00
101_Q105_E2.4611.00
597_I626_A2.4461.00
173_K295_P2.4451.00
533_S537_E2.4321.00
70_T460_E2.4291.00
485_S488_V2.4221.00
231_L276_T2.4221.00
617_N675_V2.4181.00
592_T625_T2.4121.00
86_I426_I2.4051.00
73_K94_T2.3961.00
597_I677_I2.3941.00
92_I470_L2.3911.00
279_S282_D2.3881.00
613_V626_A2.3881.00
280_T284_Y2.3841.00
604_K634_P2.3621.00
205_V217_A2.3601.00
282_D285_R2.3471.00
616_W621_E2.3411.00
602_A628_V2.3331.00
268_D271_K2.3031.00
243_N247_E2.2931.00
245_H250_L2.2801.00
73_K426_I2.2701.00
73_K86_I2.2211.00
171_H330_T2.2091.00
240_F257_Y2.1911.00
248_A252_E2.1491.00
609_D628_V2.1471.00
99_W381_S2.1451.00
605_H676_Q2.0851.00
95_I411_V2.0701.00
174_L289_M2.0451.00
470_L474_A2.0121.00
94_T98_R1.9931.00
221_I286_L1.9821.00
172_T175_F1.9781.00
380_R407_D1.9671.00
595_L637_V1.9631.00
607_I613_V1.9581.00
221_I278_V1.9421.00
285_R289_M1.9311.00
102_L381_S1.9181.00
395_E659_D1.9131.00
86_I94_T1.9071.00
595_L613_V1.8971.00
85_P460_E1.8961.00
231_L283_I1.8901.00
219_W282_D1.8901.00
174_L204_V1.8891.00
614_R623_E1.8581.00
595_L615_I1.8471.00
612_P623_E1.8381.00
458_Y461_S1.8341.00
237_H269_P1.8261.00
196_A201_A1.8151.00
383_F413_H1.8111.00
245_H257_Y1.8091.00
506_D509_S1.7931.00
609_D627_A1.7921.00
595_L639_S1.7921.00
624_L639_S1.7901.00
565_F637_V1.7861.00
597_I637_V1.7811.00
27_L42_P1.7691.00
240_F261_R1.7661.00
197_R218_D1.7581.00
417_L421_A1.7541.00
608_V611_A1.7481.00
73_K84_E1.7291.00
227_T275_I1.7261.00
600_K603_E1.7201.00
93_D97_S1.7061.00
637_V675_V1.6921.00
244_L291_G1.6851.00
262_E265_K1.6731.00
219_W289_M1.6721.00
509_S513_H1.6701.00
242_E284_Y1.6681.00
329_H332_G1.6491.00
69_T459_G1.6411.00
206_I231_L1.6391.00
238_I288_K1.6351.00
272_V283_I1.6321.00
238_I284_Y1.6321.00
241_K265_K1.6161.00
437_T453_P1.6101.00
290_Y296_S1.6061.00
86_I90_E1.5991.00
470_L473_E1.5931.00
406_E410_T1.5841.00
290_Y324_T1.5811.00
288_K292_E1.5711.00
72_L427_V1.5661.00
273_S279_S1.5651.00
570_G638_V1.5611.00
238_I269_P1.5591.00
612_P625_T1.5571.00
110_S380_R1.5391.00
25_G44_H1.5381.00
244_L288_K1.5181.00
239_L291_G1.5171.00
76_G81_A1.5051.00
250_L257_Y1.4981.00
431_T463_S1.4881.00
100_K104_D1.4841.00
239_L245_H1.4821.00
90_E94_T1.4781.00
97_S101_Q1.4761.00
254_T538_L1.4731.00
596_F629_G1.4701.00
240_F264_V1.4621.00
176_I206_I1.4621.00
176_I286_L1.4611.00
270_E284_Y1.4601.00
273_S283_I1.4531.00
95_I428_L1.4451.00
12_F30_K1.4451.00
484_D488_V1.4411.00
230_A275_I1.4321.00
106_E380_R1.4201.00
231_L286_L1.4201.00
219_W286_L1.4191.00
75_T82_I1.4171.00
99_W411_V1.4121.00
622_C639_S1.4101.00
259_E262_E1.4101.00
255_V537_E1.4061.00
565_F601_D1.4021.00
60_E585_K1.3991.00
261_R265_K1.3951.00
400_R404_L1.3931.00
323_I538_L1.3911.00
72_L85_P1.3891.00
487_E491_R1.3881.00
237_H265_K1.3871.00
29_H39_Q1.3841.00
174_L286_L1.3741.00
112_L379_I1.3661.00
71_P88_W1.3621.00
401_Q404_L1.3611.00
560_D618_S1.3581.00
13_K27_L1.3551.00
248_A251_S1.3471.00
508_D512_K1.3391.00
14_S28_I1.3381.00
412_V421_A1.3341.00
227_T276_T1.3321.00
415_L432_S1.3301.00
241_K284_Y1.3261.00
238_I241_K1.3191.00
384_I410_T1.3181.00
235_I286_L1.3071.00
304_P317_I1.3001.00
531_T537_E1.2991.00
208_V220_F1.2921.00
417_L427_V1.2901.00
293_T296_S1.2851.00
28_I35_I1.2761.00
463_S466_E1.2731.00
565_F676_Q1.2721.00
238_I244_L1.2721.00
452_Q511_T1.2701.00
271_K274_T1.2671.00
462_K466_E1.2651.00
488_V491_R1.2631.00
221_I282_D1.2591.00
256_G259_E1.2571.00
257_Y261_R1.2571.00
223_I278_V1.2461.00
205_V214_G1.2421.00
13_K41_D1.2401.00
235_I290_Y1.2391.00
90_E426_I1.2351.00
599_T630_E1.2341.00
277_G633_L1.2281.00
595_L624_L1.2281.00
267_Y272_V1.2261.00
326_Q332_G1.2261.00
267_Y275_I1.2221.00
541_E545_Q1.2191.00
594_K627_A1.2111.00
605_H677_I1.2111.00
92_I462_K1.2101.00
267_Y271_K1.2101.00
375_T398_K1.2071.00
35_I62_I1.2021.00
100_K103_I1.1941.00
370_R374_E1.1921.00
96_T474_A1.1901.00
103_I111_I1.1881.00
639_S653_V1.1841.00
598_N634_P1.1841.00
173_K294_S1.1841.00
168_E171_H1.1841.00
28_I38_V1.1821.00
236_M264_V1.1781.00
413_H430_A1.1761.00
240_F245_H1.1721.00
473_E478_T1.1711.00
223_I227_T1.1711.00
395_E398_K1.1661.00
235_I287_A1.1601.00
247_E261_R1.1591.00
173_K293_T1.1541.00
369_G373_L1.1491.00
562_E676_Q1.1481.00
27_L41_D1.1471.00
413_H467_V1.1471.00
385_Y468_F1.1441.00
366_N369_G1.1441.00
153_G314_V1.1411.00
398_K401_Q1.1361.00
629_G632_V1.1351.00
257_Y323_I1.1141.00
244_L292_E1.1131.00
175_F201_A1.1081.00
74_R83_F1.1081.00
562_E618_S1.1031.00
232_A317_I1.1031.00
466_E473_E1.1021.00
401_Q405_R1.1001.00
152_E664_M1.0981.00
177_F180_I1.0981.00
195_K198_K1.0981.00
238_I283_I1.0971.00
521_E525_F1.0961.00
381_S411_V1.0961.00
204_V286_L1.0951.00
111_I381_S1.0901.00
210_K631_Q1.0871.00
235_I239_L1.0811.00
239_L324_T1.0801.00
210_K215_R1.0801.00
361_R364_N1.0781.00
98_R407_D1.0761.00
266_Q271_K1.0761.00
169_T297_F1.0761.00
490_I494_L1.0751.00
112_L370_R1.0711.00
27_L39_Q1.0711.00
176_I235_I1.0711.00
178_W206_I1.0691.00
431_T461_S1.0661.00
596_F627_A1.0651.00
567_Y675_V1.0631.00
234_G283_I1.0601.00
175_F193_A1.0581.00
258_E261_R1.0571.00
250_L538_L1.0531.00
99_W475_M1.0521.00
103_I108_A1.0521.00
197_R216_L1.0521.00
428_L467_V1.0521.00
174_L296_S1.0491.00
254_T322_A1.0471.00
107_G110_S1.0461.00
370_R373_L1.0421.00
132_F138_S1.0421.00
615_I639_S1.0411.00
235_I320_L1.0411.00
173_K199_K1.0371.00
174_L293_T1.0361.00
103_I136_M1.0321.00
372_L398_K1.0311.00
353_D356_K1.0291.00
34_K63_Y1.0291.00
375_T401_Q1.0271.00
215_R631_Q1.0221.00
75_T80_Q1.0221.00
637_V677_I1.0211.00
175_F196_A1.0091.00
273_S276_T1.0071.00
111_I136_M1.0061.00
450_L511_T1.0041.00
273_S281_E1.0041.00
390_A396_A1.0011.00
597_I607_I1.0001.00
365_M373_L1.0001.00
371_V374_E0.9991.00
384_I420_T0.9981.00
370_R379_I0.9971.00
281_E284_Y0.9941.00
298_I321_P0.9931.00
232_A316_T0.9911.00
272_V276_T0.9901.00
206_I221_I0.9871.00
260_L323_I0.9841.00
225_P636_V0.9821.00
491_R508_D0.9811.00
202_K218_D0.9781.00
102_L407_D0.9771.00
597_I602_A0.9761.00
238_I287_A0.9701.00
260_L264_V0.9701.00
285_R288_K0.9701.00
369_G372_L0.9701.00
596_F631_Q0.9701.00
69_T458_Y0.9681.00
364_N368_L0.9681.00
255_V535_K0.9661.00
383_F471_L0.9651.00
615_I675_V0.9651.00
563_H676_Q0.9641.00
170_V192_I0.9631.00
564_P676_Q0.9591.00
437_T450_L0.9591.00
397_N401_Q0.9571.00
194_Q197_R0.9571.00
560_D674_R0.9561.00
62_I455_I0.9551.00
206_I286_L0.9551.00
204_V289_M0.9531.00
595_L677_I0.9521.00
290_Y298_I0.9521.00
363_F367_Q0.9511.00
224_K633_L0.9501.00
598_N632_V0.9471.00
363_F371_V0.9471.00
68_L427_V0.9461.00
38_V59_T0.9441.00
29_H37_K0.9441.00
519_K523_P0.9421.00
25_G41_D0.9421.00
491_R494_L0.9401.00
390_A400_R0.9381.00
206_I223_I0.9381.00
563_H617_N0.9361.00
322_A536_I0.9361.00
229_S313_I0.9361.00
76_G80_Q0.9351.00
260_L538_L0.9341.00
284_Y288_K0.9321.00
88_W467_V0.9301.00
430_A467_V0.9291.00
431_T457_R0.9291.00
233_L267_Y0.9271.00
599_T603_E0.9241.00
271_K275_I0.9231.00
88_W428_L0.9231.00
182_A193_A0.9221.00
364_N367_Q0.9201.00
237_H264_V0.9181.00
268_D272_V0.9181.00
95_I471_L0.9161.00
295_P329_H0.9151.00
434_F454_V0.9131.00
491_R495_D0.9131.00
296_S326_Q0.9131.00
568_V636_V0.9121.00
234_G238_I0.9121.00
92_I466_E0.9101.00
500_P504_E0.9091.00
245_H323_I0.9051.00
98_R102_L0.9031.00
96_T100_K0.9031.00
208_V222_P0.9031.00
89_K474_A0.9011.00
69_T85_P0.9000.99
601_D634_P0.8980.99
197_R203_I0.8960.99
598_N628_V0.8950.99
487_E507_Y0.8940.99
109_E362_S0.8940.99
364_N373_L0.8930.99
83_F427_V0.8910.99
565_F677_I0.8870.99
481_E484_D0.8860.99
269_P284_Y0.8860.99
157_T315_R0.8850.99
177_F203_I0.8830.99
202_K219_W0.8810.99
28_I434_F0.8740.99
239_L320_L0.8740.99
233_L263_H0.8730.99
278_V283_I0.8730.99
528_E534_G0.8730.99
204_V219_W0.8720.99
31_K36_V0.8700.99
237_H268_D0.8680.99
373_L378_P0.8660.99
99_W136_M0.8610.99
363_F369_G0.8610.99
223_I231_L0.8600.99
319_C538_L0.8600.99
73_K90_E0.8600.99
92_I471_L0.8580.99
600_K630_E0.8570.99
382_L406_E0.8560.99
96_T475_M0.8530.99
113_P133_F0.8530.99
132_F475_M0.8520.99
278_V282_D0.8500.99
72_L417_L0.8490.99
437_T487_E0.8480.99
280_T283_I0.8440.99
269_P272_V0.8430.99
560_D564_P0.8430.99
404_L423_Y0.8420.99
421_A427_V0.8420.99
13_K43_D0.8410.99
109_E139_S0.8410.99
176_I298_I0.8410.99
295_P332_G0.8400.99
258_E262_E0.8360.99
487_E511_T0.8360.99
507_Y511_T0.8340.99
375_T405_R0.8340.99
210_K630_E0.8300.99
304_P313_I0.8290.99
246_D329_H0.8250.99
66_K582_N0.8230.99
236_M320_L0.8230.99
263_H266_Q0.8210.99
269_P273_S0.8200.99
366_N370_R0.8190.99
282_D289_M0.8180.99
71_P87_S0.8160.99
12_F454_V0.8150.99
462_K467_V0.8140.99
619_R673_G0.8140.99
210_K222_P0.8120.99
26_L51_I0.8110.99
174_L202_K0.8110.99
597_I613_V0.8100.99
418_T421_A0.8090.99
238_I280_T0.8070.99
281_E285_R0.8060.99
622_C656_L0.8050.99
183_V213_T0.8040.99
520_R523_P0.8040.99
99_W383_F0.8040.99
374_E406_E0.8030.99
437_T486_D0.8020.99
618_S674_R0.8010.99
602_A607_I0.8010.99
70_T87_S0.8000.99
156_Y664_M0.8000.99
207_D211_N0.7990.99
364_N369_G0.7970.99
302_N306_H0.7950.99
364_N372_L0.7940.99
355_L359_T0.7930.99
95_I98_R0.7910.99
177_F213_T0.7900.99
362_S365_M0.7900.99
170_V195_K0.7900.99
633_L636_V0.7880.99
388_N578_S0.7880.99
222_P633_L0.7840.99
448_I505_I0.7820.99
84_E90_E0.7810.99
231_L235_I0.7800.99
455_I458_Y0.7790.99
233_L264_V0.7780.99
624_L653_V0.7770.99
560_D563_H0.7770.99
372_L376_D0.7770.99
94_T97_S0.7760.99
230_A234_G0.7760.99
232_A320_L0.7750.98
62_I432_S0.7690.98
532_P537_E0.7680.98
298_I317_I0.7670.98
390_A403_L0.7670.98
364_N374_E0.7650.98
288_K291_G0.7620.98
593_P643_W0.7600.98
356_K359_T0.7580.98
224_K277_G0.7580.98
289_M293_T0.7580.98
156_Y315_R0.7570.98
15_V449_Q0.7560.98
88_W462_K0.7560.98
364_N371_V0.7560.98
579_T582_N0.7550.98
132_F468_F0.7540.98
69_T72_L0.7530.98
669_T672_S0.7530.98
40_G49_G0.7530.98
242_E291_G0.7530.98
99_W103_I0.7520.98
374_E377_P0.7510.98
380_R406_E0.7490.98
174_L290_Y0.7480.98
437_T452_Q0.7480.98
28_I454_V0.7460.98
86_I91_A0.7440.98
97_S100_K0.7430.98
100_K475_M0.7420.98
241_K269_P0.7410.98
16_C24_C0.7400.98
12_F28_I0.7390.98
501_H504_E0.7380.98
223_I276_T0.7380.98
63_Y458_Y0.7370.98
365_M370_R0.7350.98
510_L513_H0.7340.98
31_K34_K0.7330.98
381_S426_I0.7320.98
469_R473_E0.7300.98
607_I628_V0.7300.98
234_G269_P0.7290.98
397_N655_A0.7290.98
366_N666_G0.7290.98
602_A629_G0.7270.98
447_Y517_K0.7270.98
214_G220_F0.7260.98
363_F368_L0.7250.98
48_A195_K0.7250.98
559_T619_R0.7240.98
269_P280_T0.7230.98
555_T559_T0.7220.98
529_L533_S0.7210.98
229_S316_T0.7210.98
92_I96_T0.7200.98
537_E540_S0.7200.98
234_G271_K0.7180.98
270_E273_S0.7180.98
92_I467_V0.7170.98
367_Q370_R0.7170.98
500_P503_A0.7170.98
465_T489_L0.7170.98
619_R657_T0.7160.97
414_D427_V0.7160.97
74_R81_A0.7150.97
600_K604_K0.7150.97
363_F370_R0.7150.97
22_D188_H0.7140.97
234_G268_D0.7130.97
123_L126_E0.7130.97
76_G82_I0.7120.97
20_C24_C0.7110.97
308_D669_T0.7110.97
466_E469_R0.7100.97
64_D416_F0.7100.97
33_G456_E0.7100.97
367_Q371_V0.7090.97
615_I624_L0.7090.97
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522_K525_F0.5680.91
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536_I543_M0.5540.90
257_Y538_L0.5540.90
572_N590_E0.5540.90
311_G665_G0.5530.90
205_V213_T0.5530.90
598_N601_D0.5530.90
150_G314_V0.5520.90
239_L244_L0.5500.90
158_M327_W0.5490.90
353_D360_P0.5490.90
14_S451_Q0.5490.90
165_D168_E0.5480.90
123_L133_F0.5480.90
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539_Y544_K0.5480.90
353_D358_R0.5470.90
198_K201_A0.5470.90
419_E422_A0.5470.90
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361_R368_L0.5450.90
612_P626_A0.5450.90
412_V420_T0.5440.89
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59_T63_Y0.5430.89
245_H261_R0.5420.89
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396_A400_R0.5410.89
234_G273_S0.5400.89
605_H637_V0.5400.89
366_N372_L0.5400.89
526_P531_T0.5390.89
295_P326_Q0.5380.89
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361_R366_N0.5370.89
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415_L430_A0.5340.89
536_I539_Y0.5340.89
457_R461_S0.5340.89
598_N605_H0.5340.89
76_G84_E0.5330.88
208_V568_V0.5330.88
384_I403_L0.5310.88
163_G166_P0.5310.88
30_K34_K0.5310.88
383_F468_F0.5310.88
30_K454_V0.5300.88
181_N207_D0.5300.88
225_P568_V0.5300.88
282_D286_L0.5300.88
382_L403_L0.5300.88
237_H271_K0.5290.88
340_G343_E0.5290.88
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194_Q216_L0.5280.88
530_P534_G0.5280.88
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254_T257_Y0.5270.88
147_S150_G0.5270.88
239_L292_E0.5270.88
127_G483_K0.5270.88
62_I434_F0.5260.88
235_I288_K0.5260.88
38_V58_M0.5260.88
381_S406_E0.5250.88
180_I301_G0.5250.88
60_E583_N0.5230.88
183_V190_I0.5230.88
123_L129_D0.5230.88
345_N350_Q0.5230.88
178_W320_L0.5230.88
555_T558_V0.5220.87
594_K625_T0.5220.87
370_R377_P0.5220.87
399_V403_L0.5220.87
472_A475_M0.5210.87
209_H570_G0.5210.87
207_D214_G0.5200.87
345_N348_A0.5190.87
472_A476_G0.5190.87
136_M475_M0.5190.87
148_K667_G0.5190.87
345_N349_L0.5180.87
621_E678_E0.5180.87
567_Y653_V0.5180.87
369_G374_E0.5170.87
519_K524_L0.5160.87
536_I540_S0.5160.87
410_T424_A0.5160.87
207_D220_F0.5150.87
534_G540_S0.5140.87
540_S543_M0.5140.87
366_N371_V0.5140.87
367_Q374_E0.5140.87
132_F471_L0.5130.87
149_A667_G0.5130.87
535_K541_E0.5130.87
411_V426_I0.5130.87
68_L417_L0.5120.86
362_S372_L0.5120.86
176_I290_Y0.5110.86
127_G130_R0.5110.86
242_E269_P0.5110.86
188_H191_T0.5100.86
39_Q42_P0.5100.86
567_Y637_V0.5100.86
365_M369_G0.5090.86
601_D605_H0.5090.86
564_P605_H0.5090.86
366_N373_L0.5090.86
224_K566_M0.5090.86
387_T393_A0.5080.86
531_T534_G0.5080.86
191_T195_K0.5080.86
534_G538_L0.5080.86
308_D660_R0.5080.86
144_T148_K0.5080.86
126_E130_R0.5080.86
101_Q104_D0.5080.86
193_A203_I0.5080.86
257_Y260_L0.5070.86
169_T193_A0.5070.86
127_G133_F0.5060.86
132_F472_A0.5060.86
559_T674_R0.5060.86
43_D48_A0.5060.86
310_G314_V0.5050.86
172_T296_S0.5050.86
80_Q84_E0.5040.86
103_I110_S0.5030.85
361_R369_G0.5020.85
24_C55_V0.5020.85
180_I299_R0.5020.85
611_A626_A0.5010.85
365_M368_L0.5010.85
617_N673_G0.5010.85
52_C55_V0.5000.85
30_K33_G0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e7zA 1 0.9632 100 0.173 Contact Map
2vpzA 1 0.9779 100 0.176 Contact Map
1h0hA 1 0.9838 100 0.178 Contact Map
2iv2X 1 0.9235 100 0.187 Contact Map
2ivfA 1 0.9868 100 0.191 Contact Map
1kqfA 3 0.9853 100 0.193 Contact Map
2napA 1 0.9618 100 0.199 Contact Map
1q16A 2 0.9941 100 0.199 Contact Map
3ml1A 1 0.9706 100 0.204 Contact Map
1ti6A 3 0.9794 100 0.227 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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