GREMLIN Database
YTAF - Putative membrane protein YtaF
UniProt: C0SP79 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 210 (202)
Sequences: 471 (405)
Seq/√Len: 28.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_P35_A5.9571.00
13_V145_D3.1761.00
150_G182_G2.8071.00
44_G168_A2.5010.99
75_V206_G2.4930.99
21_G139_G2.4890.99
123_D127_S2.4400.99
46_V143_S2.3440.99
20_V23_T2.3180.99
68_K82_L2.2940.99
36_I145_D2.2690.98
13_V17_S2.2510.98
27_R81_V2.2120.98
124_I137_L2.2050.98
14_S17_S2.2030.98
18_F152_G2.1820.98
12_A198_P2.1380.98
145_D149_A1.9820.96
47_M145_D1.9410.96
62_P66_T1.9140.96
9_L14_S1.8440.95
12_A122_A1.8380.94
61_F75_V1.8230.94
110_G113_I1.8170.94
17_S154_A1.7850.93
46_V167_V1.7750.93
17_S145_D1.7670.93
8_L72_L1.7590.93
42_C168_A1.7250.92
38_V132_G1.7140.92
82_L136_V1.6890.91
116_L119_P1.6560.91
20_V116_L1.6170.90
123_D134_E1.6090.89
44_G172_S1.6080.89
122_A125_D1.5640.88
146_A167_V1.5610.88
48_F55_S1.5590.88
43_S167_V1.5560.88
70_G152_G1.5520.87
143_S163_M1.4730.85
49_I59_K1.4670.84
128_G198_P1.4650.84
82_L199_G1.4370.83
28_K203_I1.4310.83
133_I184_F1.4250.82
36_I47_M1.4220.82
202_L206_G1.4070.82
113_I145_D1.4060.82
75_V203_I1.3710.80
105_E118_K1.3490.79
86_F104_L1.3450.79
145_D171_S1.3400.78
107_R110_G1.3390.78
33_F41_C1.3310.78
7_L197_L1.3300.78
52_L155_I1.3270.78
41_C45_A1.3210.77
3_M47_M1.3100.77
11_L174_F1.3030.76
19_S186_S1.2930.76
29_M132_G1.2920.76
203_I207_L1.2820.75
45_A96_L1.2800.75
122_A128_G1.2790.75
43_S170_M1.2790.75
23_T26_L1.2500.73
65_V165_I1.2350.72
62_P205_I1.2290.72
14_S145_D1.2250.72
66_T79_A1.2200.71
62_P147_F1.2170.71
20_V205_I1.2060.71
119_P134_E1.2060.71
151_I159_S1.1810.69
139_G164_S1.1660.68
114_H121_S1.1650.68
22_F132_G1.1630.68
57_L151_I1.1370.66
43_S146_A1.1220.65
155_I165_I1.1200.65
153_A171_S1.1110.64
109_L113_I1.1070.64
173_L197_L1.1070.64
10_A110_G1.0970.63
30_K67_E1.0960.63
19_S114_H1.0930.63
35_A185_L1.0780.62
14_S26_L1.0780.62
119_P139_G1.0750.61
198_P203_I1.0730.61
9_L153_A1.0690.61
16_D150_G1.0680.61
21_G25_G1.0680.61
67_E156_L1.0640.61
133_I205_I1.0590.60
17_S171_S1.0550.60
154_A174_F1.0540.60
122_A141_A1.0490.60
154_A190_W1.0440.59
40_A199_G1.0380.59
18_F178_G1.0350.58
145_D209_K1.0340.58
115_I135_A1.0220.57
57_L75_V1.0190.57
13_V47_M1.0130.57
22_F163_M1.0130.57
40_A140_F1.0120.57
143_S209_K1.0110.57
35_A135_A1.0110.57
33_F45_A1.0100.57
190_W206_G1.0090.56
46_V50_S1.0020.56
17_S47_M1.0010.56
12_A149_A0.9920.55
72_L76_G0.9910.55
166_A201_L0.9870.55
21_G27_R0.9830.55
42_C47_M0.9820.54
104_L111_I0.9790.54
40_A172_S0.9770.54
66_T70_G0.9710.54
7_L75_V0.9660.53
127_S134_E0.9630.53
24_Y127_S0.9590.53
46_V146_A0.9580.53
71_G120_M0.9340.51
125_D134_E0.9280.50
79_A200_L0.9250.50
125_D131_N0.9230.50
64_Y76_G0.9230.50
106_V109_L0.9190.50
145_D202_L0.9140.49
7_L69_L0.9070.49
22_F44_G0.9030.48
194_M209_K0.9010.48
24_Y134_E0.9000.48
49_I169_I0.8950.48
59_K200_L0.8860.47
13_V36_I0.8850.47
13_V209_K0.8800.47
3_M185_L0.8730.46
61_F139_G0.8690.46
61_F187_K0.8680.46
38_V155_I0.8610.45
119_P123_D0.8560.45
46_V163_M0.8550.45
76_G87_K0.8530.44
164_S171_S0.8520.44
6_I166_A0.8500.44
4_V94_Y0.8380.43
37_L109_L0.8380.43
60_F208_W0.8370.43
93_E169_I0.8350.43
149_A202_L0.8310.43
10_A112_V0.8300.43
125_D128_G0.8200.42
73_I152_G0.8160.42
160_P164_S0.8130.41
61_F76_G0.8060.41
60_F173_L0.8010.41
125_D130_I0.7960.40
116_L122_A0.7940.40
44_G171_S0.7920.40
155_I209_K0.7910.40
36_I198_P0.7830.39
21_G84_Q0.7790.39
14_S74_L0.7750.39
135_A142_L0.7710.38
60_F197_L0.7690.38
42_C175_V0.7660.38
145_D198_P0.7650.38
155_I197_L0.7630.38
115_I118_K0.7610.38
78_G199_G0.7590.37
97_H177_I0.7530.37
45_A62_P0.7510.37
137_L140_F0.7490.37
191_I205_I0.7440.36
77_I163_M0.7350.36
35_A73_I0.7340.36
21_G36_I0.7320.36
123_D135_A0.7290.35
53_I95_L0.7290.35
156_L159_S0.7270.35
33_F165_I0.7260.35
27_R70_G0.7260.35
119_P122_A0.7200.35
66_T73_I0.7150.34
7_L112_V0.7130.34
32_P131_N0.7120.34
148_G202_L0.7060.34
69_L184_F0.7020.33
15_L36_I0.7020.33
65_V185_L0.6940.33
119_P125_D0.6900.33
134_E138_L0.6880.32
183_H201_L0.6870.32
16_D182_G0.6860.32
112_V115_I0.6820.32
67_E175_V0.6810.32
43_S186_S0.6780.32
90_K103_N0.6770.32
57_L96_L0.6740.32
20_V146_A0.6720.31
44_G164_S0.6700.31
143_S150_G0.6700.31
128_G167_V0.6690.31
145_D194_M0.6670.31
65_V75_V0.6670.31
55_S76_G0.6570.30
44_G83_Y0.6540.30
119_P153_A0.6420.29
174_F178_G0.6410.29
47_M209_K0.6380.29
80_W147_F0.6380.29
26_L71_G0.6380.29
146_A209_K0.6370.29
37_L185_L0.6350.29
13_V149_A0.6350.29
43_S182_G0.6330.29
33_F72_L0.6300.29
147_F191_I0.6230.28
145_D193_K0.6230.28
70_G138_L0.6230.28
139_G143_S0.6230.28
7_L160_P0.6210.28
82_L122_A0.6210.28
95_L181_A0.6200.28
24_Y125_D0.6160.28
7_L49_I0.6160.28
204_T207_L0.6130.28
149_A174_F0.6130.28
39_I142_L0.6120.28
96_L161_I0.6110.27
71_G128_G0.6090.27
14_S209_K0.6090.27
110_G114_H0.6080.27
202_L205_I0.6070.27
71_G206_G0.6060.27
17_S36_I0.6060.27
31_I46_V0.6060.27
19_S205_I0.6060.27
47_M171_S0.6050.27
10_A118_K0.6030.27
143_S152_G0.6020.27
53_I60_F0.5990.27
156_L204_T0.5970.27
138_L142_L0.5970.27
21_G128_G0.5960.27
47_M163_M0.5950.26
73_I202_L0.5940.26
43_S142_L0.5940.26
21_G70_G0.5930.26
159_S201_L0.5920.26
7_L61_F0.5910.26
165_I197_L0.5890.26
155_I190_W0.5890.26
47_M81_V0.5740.25
31_I85_F0.5730.25
69_L183_H0.5710.25
40_A171_S0.5700.25
175_V200_L0.5670.25
134_E142_L0.5640.25
155_I201_L0.5620.25
30_K126_K0.5590.24
122_A138_L0.5590.24
17_S67_E0.5500.24
37_L169_I0.5500.24
115_I177_I0.5500.24
41_C86_F0.5500.24
21_G147_F0.5460.24
29_M156_L0.5440.24
22_F66_T0.5440.24
69_L105_E0.5420.23
104_L197_L0.5420.23
32_P138_L0.5420.23
14_S175_V0.5400.23
95_L185_L0.5400.23
29_M122_A0.5400.23
164_S195_A0.5370.23
130_I178_G0.5350.23
30_K59_K0.5330.23
51_M163_M0.5320.23
41_C173_L0.5310.23
165_I192_D0.5310.23
70_G128_G0.5290.23
36_I171_S0.5290.23
31_I138_L0.5280.23
11_L133_I0.5230.22
22_F53_I0.5170.22
24_Y27_R0.5150.22
30_K49_I0.5150.22
75_V162_V0.5070.22
14_S18_F0.5060.21
32_P39_I0.5060.21
14_S146_A0.5060.21
3_M194_M0.5050.21
79_A207_L0.5050.21
152_G208_W0.5050.21
77_I188_W0.5030.21
61_F169_I0.5030.21
81_V84_Q0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2cfqA 1 0.9095 37 0.941 Contact Map
4xnjA 1 0.9714 34.1 0.942 Contact Map
3o7qA 1 0.8905 20.4 0.948 Contact Map
4fc4A 3 0.4 12.9 0.952 Contact Map
4zw9A 1 0.3952 9.3 0.955 Contact Map
3w4tA 1 0.4238 9 0.956 Contact Map
3tdsE 3 0.3524 8.9 0.956 Contact Map
4ldsA 2 0.9619 8.5 0.956 Contact Map
3j1zP 8 0.4238 8.3 0.956 Contact Map
4dveA 3 0.3524 7.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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