GREMLIN Database
YRZS - Uncharacterized membrane protein YrzS
UniProt: C0H463 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 66 (61)
Sequences: 337 (276)
Seq/√Len: 35.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_K40_T4.1681.00
58_L62_F3.5311.00
9_M16_L2.9921.00
13_A16_L2.5901.00
46_V50_I2.4291.00
33_F40_T2.3050.99
6_K35_K1.8260.97
48_C53_V1.7540.96
56_S60_N1.6890.95
5_P23_H1.5610.93
4_F22_L1.5410.92
13_A17_I1.5180.92
8_I15_L1.4720.90
34_V37_G1.4690.90
36_K39_V1.4340.89
60_N63_G1.4200.89
55_L59_L1.3970.88
9_M20_A1.3710.87
9_M36_K1.3440.86
14_V58_L1.3080.84
33_F42_F1.3080.84
50_I61_L1.2360.80
14_V54_V1.2220.80
9_M19_G1.2000.78
25_V37_G1.1270.74
7_I11_L1.1240.74
9_M13_A1.0890.71
56_S63_G1.0540.69
57_I64_R0.9500.61
24_F51_I0.9450.60
8_I18_I0.9350.59
57_I60_N0.9140.58
41_F51_I0.9130.58
10_I50_I0.8990.56
42_F47_T0.8930.56
9_M15_L0.8770.54
5_P63_G0.8170.49
39_V42_F0.8040.48
5_P16_L0.8020.48
21_V54_V0.7740.46
27_K35_K0.7700.45
46_V60_N0.7690.45
16_L62_F0.7690.45
4_F64_R0.7670.45
24_F34_V0.7590.44
23_H39_V0.7560.44
14_V18_I0.7460.43
17_I63_G0.7420.43
35_K64_R0.7350.42
51_I59_L0.7330.42
20_A35_K0.7330.42
20_A23_H0.7280.42
27_K53_V0.7220.41
59_L63_G0.7170.41
11_L54_V0.7110.40
18_I25_V0.6950.39
27_K47_T0.6860.38
48_C59_L0.6690.37
9_M22_L0.6680.37
8_I11_L0.6640.36
6_K64_R0.6550.36
39_V46_V0.6360.34
38_N59_L0.6350.34
21_V57_I0.6310.34
13_A20_A0.6250.33
49_I53_V0.6220.33
25_V28_M0.6210.33
36_K60_N0.6170.33
13_A25_V0.6100.32
22_L51_I0.5980.31
5_P22_L0.5980.31
17_I21_V0.5960.31
4_F7_I0.5840.30
8_I16_L0.5840.30
36_K64_R0.5830.30
60_N64_R0.5820.30
21_V63_G0.5750.30
35_K48_C0.5730.30
34_V41_F0.5730.30
50_I57_I0.5700.29
10_I17_I0.5660.29
14_V21_V0.5590.29
20_A58_L0.5440.27
48_C63_G0.5430.27
18_I60_N0.5390.27
9_M46_V0.5380.27
17_I61_L0.5380.27
43_F51_I0.5280.26
7_I10_I0.5180.26
17_I32_I0.5140.25
41_F49_I0.5070.25
27_K60_N0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.8788 38.8 0.882 Contact Map
4i0uA 4 0.8788 26.1 0.892 Contact Map
4djkA 2 0.9242 11.5 0.908 Contact Map
1fftA 1 0.8636 10.7 0.909 Contact Map
3ayfA 2 0.8788 10.6 0.909 Contact Map
1pfiA 7 0.4242 7.8 0.915 Contact Map
3w9iA 3 0.9242 5.9 0.919 Contact Map
1fftB 1 0.6667 5.5 0.921 Contact Map
2m59A 2 0.4848 5 0.922 Contact Map
2yevB 1 0.697 4.9 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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