GREMLIN Database
C0H460 - Uncharacterized protein
UniProt: C0H460 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 64 (56)
Sequences: 702 (366)
Seq/√Len: 48.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_K21_E4.4221.00
33_A40_S3.1451.00
21_E25_D3.0841.00
39_S42_D2.2611.00
21_E30_D2.1491.00
48_V60_K2.0951.00
18_K22_L2.0801.00
59_Y63_S1.9550.99
34_R37_E1.9350.99
12_L16_A1.8650.99
43_R47_T1.8300.99
13_G20_A1.6870.98
11_Q14_E1.6380.98
42_D45_M1.6200.98
50_A53_T1.6070.98
28_F63_S1.4220.95
27_L44_S1.3620.94
32_W44_S1.2750.91
12_L19_F1.2160.89
28_F59_Y1.2060.89
30_D34_R1.1420.86
27_L32_W1.0480.81
16_A26_V1.0420.80
52_I55_C1.0330.80
15_F20_A1.0120.78
26_V44_S0.9940.77
40_S62_G0.9880.77
58_A61_S0.9780.76
9_R12_L0.9610.75
8_G24_D0.9380.73
45_M61_S0.9170.71
45_M54_D0.8710.67
18_K30_D0.8250.63
39_S52_I0.8070.61
35_E61_S0.8000.61
27_L31_I0.7930.60
53_T56_F0.7910.60
10_E19_F0.7860.59
28_F44_S0.7650.57
48_V62_G0.7570.56
11_Q62_G0.7470.55
50_A54_D0.7420.55
35_E39_S0.7370.54
51_L63_S0.7150.52
8_G57_S0.6910.50
52_I57_S0.6780.48
32_W42_D0.6720.48
22_L47_T0.6680.47
7_A29_G0.6600.46
9_R14_E0.6450.45
24_D29_G0.6400.44
51_L61_S0.6360.44
44_S51_L0.6260.43
35_E50_A0.6200.42
55_C58_A0.6060.41
11_Q15_F0.6050.41
43_R62_G0.6030.41
28_F58_A0.6000.41
16_A29_G0.5920.40
45_M49_S0.5890.39
32_W46_I0.5860.39
8_G13_G0.5820.39
40_S63_S0.5740.38
17_P39_S0.5710.38
55_C63_S0.5690.38
31_I62_G0.5630.37
32_W41_R0.5540.36
28_F55_C0.5420.35
41_R45_M0.5410.35
10_E13_G0.5390.35
16_A37_E0.5320.34
18_K35_E0.5300.34
49_S52_I0.5290.34
20_A33_A0.5260.34
27_L42_D0.5210.33
23_H32_W0.5170.33
24_D44_S0.5160.33
18_K34_R0.5090.32
10_E23_H0.5090.32
12_L15_F0.5080.32
7_A12_L0.5050.32
8_G29_G0.5050.32
19_F35_E0.5020.31
23_H61_S0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4g9qA 3 0.9844 99.3 0.448 Contact Map
2af7A 6 0.9844 98.5 0.601 Contact Map
2q0tA 3 0.9688 97.8 0.665 Contact Map
3d7iA 6 0.875 97.7 0.676 Contact Map
1vkeA 6 0.9531 97.6 0.679 Contact Map
1p8cA 6 0.9688 97.5 0.687 Contact Map
3beyA 6 0.8906 97.4 0.694 Contact Map
2qeuA 6 1 96.8 0.718 Contact Map
2cwqA 4 0.9375 95 0.759 Contact Map
2ouwA 6 0.9688 90.2 0.795 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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