GREMLIN Database
YOZV - Uncharacterized membrane protein YozV
UniProt: C0H423 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 79 (65)
Sequences: 300 (201)
Seq/√Len: 24.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_F53_F4.1201.00
24_K52_E3.2011.00
42_T45_P2.4530.99
39_F45_P2.3270.98
41_W45_P2.1070.96
11_A15_F1.9500.94
12_L16_F1.9190.94
25_F37_I1.7980.91
11_A53_F1.7370.90
36_Y45_P1.7170.89
24_K56_F1.7010.89
49_A53_F1.6250.86
43_G49_A1.5930.85
15_F49_A1.5590.84
24_K32_Q1.4640.80
39_F42_T1.4430.79
11_A14_A1.3820.75
10_A27_L1.3380.73
8_I61_E1.3270.72
55_I58_C1.2950.71
29_R32_Q1.2880.70
59_G67_K1.2430.67
36_Y39_F1.2350.67
14_A49_A1.1950.64
31_G35_L1.1930.64
20_L31_G1.1860.64
62_E66_Q1.1610.62
32_Q36_Y1.1430.61
25_F33_G1.1010.58
43_G66_Q1.0730.56
7_K11_A1.0450.54
12_L35_L1.0330.53
8_I12_L1.0000.50
63_G66_Q0.9970.50
59_G63_G0.9920.50
13_L38_L0.9560.47
10_A62_E0.9380.46
52_E56_F0.9350.46
29_R67_K0.9340.46
19_G46_S0.9300.45
16_F50_F0.9120.44
5_K26_Y0.8860.42
63_G68_Y0.8630.41
59_G68_Y0.8540.40
56_F59_G0.8500.40
60_S68_Y0.8410.39
40_C54_I0.8090.37
29_R56_F0.8020.36
16_F22_I0.7920.36
36_Y41_W0.7600.34
6_N63_G0.7590.34
7_K58_C0.7500.33
21_G33_G0.7470.33
5_K65_D0.7430.33
16_F64_F0.7390.32
36_Y67_K0.7290.32
6_N29_R0.7250.31
51_I55_I0.6960.30
20_L43_G0.6920.29
31_G51_I0.6900.29
54_I62_E0.6880.29
13_L55_I0.6880.29
36_Y42_T0.6830.29
36_Y56_F0.6810.29
19_G38_L0.6810.29
45_P67_K0.6800.29
28_G38_L0.6760.29
27_L64_F0.6760.29
29_R65_D0.6620.28
31_G58_C0.6580.27
15_F28_G0.6470.27
4_K56_F0.6420.27
32_Q56_F0.6310.26
7_K53_F0.6290.26
16_F61_E0.6220.25
39_F67_K0.6190.25
31_G36_Y0.6180.25
22_I30_V0.6060.25
59_G65_D0.6020.24
34_I65_D0.5850.23
32_Q50_F0.5780.23
54_I58_C0.5760.23
8_I15_F0.5760.23
28_G34_I0.5750.23
53_F56_F0.5750.23
6_N15_F0.5740.23
33_G42_T0.5720.23
8_I63_G0.5510.22
61_E64_F0.5380.21
8_I11_A0.5340.21
42_T67_K0.5260.21
41_W44_I0.5250.20
5_K27_L0.5180.20
47_I63_G0.5160.20
14_A46_S0.5110.20
57_L61_E0.5050.20
44_I62_E0.5010.19
24_K55_I0.5000.19
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gsmA 1 0.9494 5.9 0.927 Contact Map
1eysM 1 0.8987 3.6 0.934 Contact Map
2vxrA 1 0.5696 3.6 0.934 Contact Map
1gxyA 1 0.3291 3.3 0.935 Contact Map
1v54A 1 0.9494 3.3 0.935 Contact Map
2kncB 1 0.7089 3.1 0.936 Contact Map
2yevA 1 0.9494 2.5 0.939 Contact Map
1a8dA 1 0.6582 2.5 0.939 Contact Map
4gc0A 1 0.8734 2 0.942 Contact Map
4co6D 1 0.5063 2 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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