GREMLIN Database
BLAP - Biotin/lipoyl attachment protein
UniProt: C0H419 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 73 (59)
Sequences: 1826 (1127)
Seq/√Len: 146.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_K30_I4.5491.00
12_W32_E3.7221.00
15_H30_I3.3961.00
7_M31_L2.9221.00
11_L29_A2.8921.00
17_K20_D2.6701.00
15_H27_E2.5291.00
23_E26_Q1.9361.00
59_V62_G1.8141.00
24_K29_A1.5941.00
5_I8_A1.5171.00
14_V29_A1.4491.00
38_I43_D1.3411.00
16_V26_Q1.3141.00
58_F62_G1.2621.00
4_S8_A1.2391.00
22_I26_Q1.2331.00
19_G32_E1.2121.00
10_N32_E1.1541.00
35_K39_P1.1070.99
57_D60_N1.0590.99
19_G33_S1.0400.99
51_V54_K1.0370.99
55_E61_E1.0350.99
13_K27_E1.0280.99
30_I33_S0.9700.98
27_E30_I0.9020.97
54_K57_D0.9020.97
41_V45_S0.8800.97
48_V51_V0.8730.97
18_A21_Q0.8660.97
18_A23_E0.8540.96
36_M40_I0.8490.96
6_Q31_L0.8330.96
25_G41_V0.8020.95
48_V52_K0.8000.95
19_G25_G0.7880.94
53_K57_D0.7830.94
11_L17_K0.7790.94
7_M33_S0.7700.94
38_I41_V0.7690.94
11_L14_V0.7470.93
34_M46_G0.7420.92
11_L31_L0.7400.92
23_E60_N0.7320.92
52_K58_F0.6900.89
24_K31_L0.6880.89
53_K58_F0.6680.88
39_P44_R0.6680.88
55_E62_G0.6660.88
16_V22_I0.6660.88
52_K55_E0.6610.87
7_M10_N0.6460.86
49_K53_K0.6420.86
44_R47_I0.6360.85
21_Q24_K0.6290.84
25_G30_I0.6250.84
47_I50_E0.6240.84
5_I29_A0.6170.83
51_V61_E0.6160.83
9_G54_K0.6110.83
57_D61_E0.6090.83
37_E40_I0.6080.82
37_E45_S0.6070.82
36_M43_D0.6050.82
50_E53_K0.6000.82
15_H29_A0.5990.81
17_K47_I0.5960.81
36_M45_S0.5900.81
35_K41_V0.5860.80
32_E37_E0.5810.79
47_I54_K0.5780.79
21_Q26_Q0.5700.78
46_G51_V0.5690.78
48_V53_K0.5690.78
12_W30_I0.5680.78
10_N18_A0.5610.77
24_K57_D0.5550.76
52_K62_G0.5530.76
19_G23_E0.5450.75
28_V34_M0.5430.75
25_G52_K0.5390.74
22_I57_D0.5320.73
49_K52_K0.5260.72
4_S31_L0.5120.70
58_F61_E0.5120.70
6_Q48_V0.5040.69
19_G55_E0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3va7A 1 0.9452 99.2 0.326 Contact Map
3hblA 4 0.9452 99.1 0.352 Contact Map
2qf7A 4 0.8493 99.1 0.356 Contact Map
4rcnA 6 0.9726 99.1 0.359 Contact Map
3bg3A 4 0.9452 99.1 0.365 Contact Map
4qshA 4 0.9589 99.1 0.367 Contact Map
3u9tA 3 0 99 0.382 Contact Map
1zy8K 1 0 99 0.385 Contact Map
3n6rA 1 0.9452 99 0.386 Contact Map
3dvaI 1 0 99 0.391 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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