GREMLIN Database
MPRF - Phosphatidylglycerol lysyltransferase
UniProt: C0H3X7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 856 (818)
Sequences: 487 (379)
Seq/√Len: 13.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
684_K688_D7.4301.00
636_E775_N6.1341.00
689_E748_G5.8941.00
739_I766_A5.7721.00
684_K706_P5.2811.00
709_L729_N5.2131.00
669_H718_K5.1701.00
640_D643_T4.9151.00
671_D716_Y4.5081.00
709_L714_I4.1241.00
536_R566_G4.0521.00
364_R427_S4.0211.00
755_M812_G3.6940.99
682_E686_I3.6500.99
671_D679_F3.6410.99
565_D591_S3.6170.99
94_S295_G3.4680.99
568_A595_V3.2820.98
584_D623_Y3.2820.98
416_F436_I3.2360.98
689_E747_R3.2170.98
753_G756_D3.0950.97
682_E723_E3.0920.97
638_Y773_S3.0720.97
474_L500_T3.0660.97
67_L207_A2.9910.97
357_S364_R2.8200.95
358_V383_S2.8060.95
357_S422_K2.7860.95
396_E404_S2.7390.95
563_S567_N2.7200.94
679_F716_Y2.6330.93
658_N761_R2.5960.93
633_L829_L2.5540.92
716_Y724_I2.5510.92
661_F666_Y2.5480.92
649_K659_N2.5090.91
499_I502_A2.5080.91
756_D775_N2.5040.91
701_L750_A2.4750.91
744_M759_F2.4570.91
409_I436_I2.4510.90
357_S428_A2.4400.90
686_I714_I2.4370.90
579_L608_F2.4260.90
686_I689_E2.4240.90
537_L560_F2.3200.88
139_L246_G2.3050.87
422_K428_A2.2770.87
169_G175_P2.2740.87
364_R422_K2.2710.87
381_G506_A2.2710.87
717_M757_A2.2700.87
655_R812_G2.2550.86
472_Y476_A2.2400.86
655_R755_M2.2250.85
251_V255_F2.2090.85
702_G742_D2.1930.85
570_L581_V2.1660.84
755_M819_K2.1590.84
540_F569_L2.1530.83
756_D759_F2.1530.83
343_L397_L2.1200.82
655_R744_M2.1140.82
354_V357_S2.1100.82
434_M466_T2.1020.82
396_E729_N2.1000.82
568_A591_S2.0820.81
670_V730_V2.0770.81
536_R562_F2.0560.80
35_S38_R2.0530.80
538_A711_K2.0210.79
529_G559_R2.0190.79
615_I830_A2.0180.79
239_F527_P1.9960.78
555_L703_F1.9930.78
55_V680_L1.9810.78
553_G560_F1.9800.78
393_L408_A1.9730.77
505_M509_I1.9620.77
683_L724_I1.9530.77
171_A175_P1.9470.76
744_M755_M1.9450.76
584_D827_K1.9430.76
290_I294_L1.9210.75
13_I775_N1.9210.75
11_L14_V1.9000.75
416_F433_P1.8950.74
662_E757_A1.8800.74
101_F277_V1.8650.73
285_L289_F1.8630.73
701_L751_P1.8600.73
58_G96_N1.8590.73
774_F812_G1.8500.73
744_M812_G1.8480.72
569_L586_S1.8280.72
812_G819_K1.8270.72
288_S816_F1.8170.71
415_G425_N1.8040.71
355_L387_A1.7920.70
364_R425_N1.7890.70
561_Y602_E1.7630.69
765_W769_E1.7610.69
682_E718_K1.7440.68
514_F590_E1.7290.67
648_G655_R1.7190.67
13_I347_V1.7180.67
292_F746_Y1.7170.67
642_N772_T1.7150.67
80_I85_V1.7110.66
21_L79_S1.6960.66
418_F425_N1.6950.66
210_V408_A1.6940.66
167_V170_F1.6900.65
660_R664_E1.6880.65
664_E750_A1.6850.65
646_L776_M1.6840.65
624_H794_E1.6770.65
172_L175_P1.6740.65
648_G755_M1.6730.65
785_G794_E1.6720.65
667_T722_G1.6680.64
755_M774_F1.6650.64
808_Y819_K1.6600.64
813_L819_K1.6590.64
545_G550_S1.6560.64
168_I590_E1.6540.64
39_T283_Y1.6540.64
135_M138_G1.6490.63
463_A782_A1.6390.63
207_A261_L1.6310.63
563_S566_G1.6240.62
131_L138_G1.6210.62
672_H680_L1.6200.62
259_D831_Y1.6170.62
584_D616_E1.6160.62
648_G812_G1.6060.61
289_F293_I1.6010.61
292_F296_L1.5960.61
582_L816_F1.5950.61
669_H686_I1.5890.60
74_Y680_L1.5840.60
91_I775_N1.5780.60
546_G732_P1.5620.59
239_F574_K1.5530.59
715_A728_A1.5510.58
120_D123_A1.5440.58
438_L767_K1.5440.58
614_Q654_L1.5420.58
741_V775_N1.5350.58
167_V171_A1.5270.57
347_V621_A1.5230.57
60_L285_L1.5200.57
534_P537_L1.5110.56
22_F26_Q1.5080.56
668_F743_L1.5040.56
393_L816_F1.5020.56
677_D706_P1.5010.56
557_D812_G1.4990.56
782_A816_F1.4940.56
283_Y414_G1.4920.55
216_G281_V1.4810.55
119_K127_G1.4790.55
509_I767_K1.4790.55
614_Q633_L1.4660.54
355_L359_S1.4600.54
784_V797_A1.4530.53
111_M115_K1.4520.53
364_R429_I1.4460.53
288_S763_F1.4410.53
703_F782_A1.4410.53
251_V848_I1.4270.52
420_F433_P1.4230.52
364_R423_G1.4220.52
66_S82_N1.4180.52
615_I720_A1.4170.51
99_L105_A1.4160.51
682_E685_Q1.4110.51
615_I686_I1.4100.51
671_D818_E1.4030.51
446_F847_L1.4030.51
782_A814_R1.4030.51
70_Y82_N1.3960.50
354_V429_I1.3950.50
615_I660_R1.3940.50
380_N701_L1.3920.50
744_M753_G1.3870.50
401_T411_A1.3810.50
19_V47_E1.3780.49
220_Y844_V1.3770.49
755_M759_F1.3740.49
391_L405_Y1.3740.49
843_L847_L1.3630.49
681_E706_P1.3610.49
725_V747_R1.3520.48
640_D772_T1.3490.48
95_F99_L1.3450.48
560_F615_I1.3330.47
740_S765_W1.3320.47
541_L628_Y1.3320.47
405_Y611_L1.3290.47
644_F812_G1.3230.47
540_F588_Q1.3200.46
520_V764_L1.3130.46
642_N706_P1.3100.46
391_L580_V1.3090.46
231_D748_G1.3080.46
683_L767_K1.3050.46
409_I440_V1.2940.45
187_K782_A1.2890.45
430_F795_R1.2890.45
490_E716_Y1.2880.45
582_L633_L1.2850.45
223_L279_S1.2800.44
138_G601_N1.2740.44
490_E764_L1.2740.44
624_H791_F1.2740.44
253_G288_S1.2710.44
389_I642_N1.2680.44
347_V435_I1.2660.44
425_N429_I1.2650.44
566_G686_I1.2650.44
648_G691_L1.2620.43
396_E403_R1.2600.43
56_L678_A1.2580.43
653_G656_A1.2570.43
649_K730_V1.2550.43
262_F342_S1.2490.43
61_A283_Y1.2440.42
97_N395_I1.2430.42
97_N130_W1.2430.42
551_H732_P1.2420.42
759_F763_F1.2390.42
239_F253_G1.2370.42
262_F266_M1.2370.42
472_Y475_I1.2330.42
682_E818_E1.2330.42
390_L397_L1.2330.42
286_A310_R1.2320.42
19_V608_F1.2290.42
744_M819_K1.2290.42
244_I506_A1.2270.42
56_L67_L1.2190.41
669_H716_Y1.2170.41
77_R135_M1.2170.41
551_H712_A1.2160.41
659_N753_G1.2130.41
41_M184_K1.2120.41
101_F801_F1.2110.41
656_A659_N1.2100.41
736_E769_E1.2090.41
621_A633_L1.2090.41
394_P594_L1.2070.41
259_D630_F1.2070.41
653_G659_N1.2070.41
387_A446_F1.2060.40
76_L135_M1.2040.40
162_W631_F1.2040.40
552_L778_M1.2020.40
717_M746_Y1.1980.40
289_F730_V1.1970.40
36_F353_I1.1960.40
208_S713_P1.1940.40
580_V847_L1.1940.40
410_T414_G1.1930.40
343_L582_L1.1900.40
573_G847_L1.1860.39
624_H630_F1.1860.39
755_M808_Y1.1850.39
392_I686_I1.1830.39
139_L212_W1.1820.39
582_L829_L1.1810.39
65_M105_A1.1810.39
108_G209_V1.1790.39
179_A782_A1.1780.39
88_V96_N1.1770.39
403_R730_V1.1760.39
510_V686_I1.1730.39
463_A605_Q1.1700.39
657_I661_F1.1700.39
718_K724_I1.1700.39
564_S598_E1.1700.39
682_E722_G1.1620.38
756_D816_F1.1590.38
361_P744_M1.1590.38
534_P560_F1.1560.38
248_I471_N1.1510.38
669_H675_F1.1510.38
796_F826_G1.1460.37
220_Y235_V1.1450.37
364_R426_I1.1420.37
171_A178_L1.1370.37
687_S742_D1.1370.37
34_L531_K1.1360.37
644_F755_M1.1330.37
580_V747_R1.1320.37
507_I724_I1.1320.37
169_G172_L1.1310.37
177_S765_W1.1290.37
845_T848_I1.1280.37
102_G832_R1.1280.37
408_A542_N1.1260.36
651_K654_L1.1260.36
251_V257_S1.1260.36
351_G387_A1.1240.36
395_I461_A1.1200.36
101_F510_V1.1190.36
10_I148_A1.1170.36
500_T503_T1.1160.36
9_S716_Y1.1120.36
746_Y752_N1.1110.36
437_V724_I1.1110.36
106_G142_F1.1080.36
180_V589_R1.1070.36
648_G819_K1.1060.36
570_L595_V1.1060.36
405_Y440_V1.1060.36
715_A729_N1.1050.35
86_F718_K1.1050.35
11_L106_G1.1050.35
663_R744_M1.1050.35
423_G428_A1.1040.35
655_R813_L1.1020.35
153_V580_V1.0980.35
684_K782_A1.0970.35
352_L466_T1.0960.35
570_L741_V1.0950.35
348_F379_F1.0940.35
688_D760_I1.0930.35
720_A723_E1.0900.35
538_A554_F1.0890.35
361_P448_R1.0860.35
147_A764_L1.0850.34
725_V750_A1.0840.34
44_N800_I1.0810.34
483_M488_R1.0800.34
124_L211_E1.0800.34
189_G469_L1.0800.34
298_F746_Y1.0800.34
422_K425_N1.0800.34
677_D741_V1.0780.34
58_G286_A1.0780.34
283_Y669_H1.0780.34
98_V292_F1.0770.34
54_L59_L1.0730.34
686_I724_I1.0730.34
552_L701_L1.0690.34
17_I706_P1.0660.34
382_L418_F1.0660.34
808_Y812_G1.0650.34
18_A454_T1.0620.33
402_K451_A1.0620.33
667_T796_F1.0600.33
764_L767_K1.0600.33
266_M659_N1.0540.33
138_G141_V1.0510.33
352_L715_A1.0490.33
206_G710_Q1.0480.33
209_V348_F1.0470.33
208_S376_L1.0450.33
425_N428_A1.0430.33
473_N618_E1.0420.32
633_L766_A1.0420.32
699_F779_A1.0420.32
542_N605_Q1.0400.32
619_D623_Y1.0380.32
56_L277_V1.0380.32
746_Y759_F1.0370.32
361_P558_K1.0360.32
361_P387_A1.0310.32
800_I828_Y1.0280.32
360_L428_A1.0240.32
53_M57_I1.0240.32
691_L704_F1.0230.32
96_N103_G1.0200.31
93_N167_V1.0180.31
596_L622_L1.0160.31
214_M247_M1.0160.31
231_D722_G1.0160.31
11_L367_V1.0160.31
269_L580_V1.0150.31
568_A592_F1.0150.31
739_I765_W1.0130.31
368_I462_V1.0050.31
590_E615_I1.0020.31
350_A415_G1.0020.31
346_I640_D0.9990.31
249_S644_F0.9990.31
235_V266_M0.9990.31
574_K579_L0.9980.30
777_G824_W0.9980.30
572_F782_A0.9970.30
92_A96_N0.9950.30
73_K89_S0.9940.30
530_E533_D0.9900.30
55_V828_Y0.9890.30
781_L797_A0.9890.30
89_S539_A0.9870.30
62_V93_N0.9860.30
582_L623_Y0.9840.30
157_I245_G0.9830.30
154_D282_L0.9810.30
755_M783_N0.9800.30
435_I830_A0.9800.30
665_E725_V0.9780.30
759_F812_G0.9740.29
732_P756_D0.9730.29
157_I618_E0.9690.29
17_I148_A0.9690.29
726_A743_L0.9670.29
553_G569_L0.9660.29
30_E250_L0.9650.29
199_N723_E0.9640.29
280_I404_S0.9640.29
508_I760_I0.9640.29
351_G361_P0.9630.29
75_S130_W0.9610.29
607_G795_R0.9600.29
785_G789_T0.9600.29
105_A607_G0.9580.29
550_S706_P0.9580.29
357_S424_L0.9580.29
355_L818_E0.9570.29
78_L123_A0.9570.29
255_F552_L0.9550.29
589_R592_F0.9540.29
430_F434_M0.9530.29
653_G657_I0.9520.28
549_L582_L0.9510.28
297_F769_E0.9470.28
247_M274_E0.9460.28
293_I297_F0.9460.28
95_F598_E0.9450.28
727_F774_F0.9440.28
728_A804_V0.9430.28
56_L530_E0.9430.28
14_V670_V0.9410.28
655_R819_K0.9400.28
698_G701_L0.9380.28
418_F790_S0.9370.28
89_S261_L0.9370.28
96_N108_G0.9370.28
239_F560_F0.9370.28
238_V594_L0.9320.28
708_Y727_F0.9310.28
92_A109_L0.9310.28
361_P557_D0.9300.28
206_G410_T0.9300.28
377_L499_I0.9300.28
518_T795_R0.9300.28
204_Y292_F0.9290.27
655_R659_N0.9250.27
11_L74_Y0.9210.27
14_V714_I0.9210.27
246_G613_Y0.9200.27
657_I760_I0.9200.27
661_F665_E0.9190.27
740_S771_C0.9180.27
448_R628_Y0.9160.27
102_G295_G0.9140.27
55_V663_R0.9140.27
14_V56_L0.9130.27
696_E702_G0.9130.27
124_L475_I0.9130.27
179_A769_E0.9110.27
498_H503_T0.9100.27
69_D76_L0.9100.27
343_L633_L0.9090.27
52_F684_K0.9090.27
180_V586_S0.9080.27
55_V236_F0.9080.27
551_H771_C0.9080.27
375_A686_I0.9080.27
759_F816_F0.9080.27
709_L831_Y0.9060.27
648_G808_Y0.9060.27
426_I429_I0.9050.26
104_L721_E0.9040.26
127_G135_M0.9030.26
51_L309_K0.9020.26
249_S516_I0.9010.26
237_G623_Y0.9000.26
102_G731_M0.8990.26
498_H502_A0.8970.26
69_D603_A0.8960.26
72_L127_G0.8950.26
735_Q795_R0.8950.26
744_M780_P0.8910.26
115_K746_Y0.8900.26
596_L626_F0.8900.26
572_F804_V0.8900.26
130_W204_Y0.8890.26
437_V441_L0.8890.26
51_L760_I0.8890.26
19_V134_S0.8880.26
93_N259_D0.8880.26
755_M813_L0.8860.26
729_N740_S0.8860.26
215_A260_L0.8820.26
551_H740_S0.8820.26
620_M633_L0.8810.26
749_D796_F0.8800.25
252_P256_G0.8800.25
355_L447_V0.8790.25
18_A29_K0.8790.25
784_V794_E0.8770.25
102_G694_K0.8750.25
405_Y581_V0.8750.25
96_N135_M0.8750.25
240_V605_Q0.8750.25
250_L286_A0.8740.25
357_S427_S0.8740.25
629_N756_D0.8740.25
662_E761_R0.8720.25
354_V359_S0.8700.25
223_L397_L0.8690.25
570_L775_N0.8690.25
410_T749_D0.8670.25
237_G450_Q0.8670.25
346_I432_L0.8660.25
252_P258_F0.8640.25
208_S212_W0.8630.25
65_M97_N0.8630.25
65_M636_E0.8630.25
89_S108_G0.8620.25
355_L379_F0.8590.25
820_Y832_R0.8590.25
694_K749_D0.8570.25
717_M760_I0.8570.25
831_Y837_L0.8570.25
419_S826_G0.8560.25
304_T822_P0.8560.25
175_P561_Y0.8560.25
238_V664_E0.8550.24
358_V364_R0.8540.24
750_A754_I0.8540.24
124_L128_I0.8530.24
364_R428_A0.8530.24
277_V462_V0.8510.24
244_I599_F0.8490.24
172_L293_I0.8490.24
179_A515_L0.8470.24
121_H832_R0.8460.24
584_D619_D0.8460.24
530_E570_L0.8450.24
34_L263_L0.8450.24
240_V607_G0.8430.24
643_T714_I0.8430.24
104_L107_V0.8420.24
278_T567_N0.8410.24
741_V759_F0.8410.24
557_D814_R0.8400.24
164_W169_G0.8400.24
393_L694_K0.8390.24
174_L586_S0.8380.24
355_L415_G0.8340.24
266_M766_A0.8330.24
624_H784_V0.8300.24
758_L826_G0.8300.24
15_F134_S0.8290.23
598_E650_K0.8290.23
53_M409_I0.8290.23
220_Y794_E0.8290.23
391_L438_L0.8280.23
374_P390_L0.8270.23
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387_A804_V0.5340.14
239_F242_A0.5330.14
99_L599_F0.5330.14
62_V94_S0.5330.14
559_R572_F0.5320.14
98_V666_Y0.5320.14
687_S691_L0.5310.14
192_E520_V0.5300.14
219_I262_F0.5300.14
687_S704_F0.5300.14
150_V255_F0.5290.14
778_M848_I0.5290.14
491_Y501_H0.5270.14
46_L556_G0.5270.14
57_I214_M0.5270.14
302_D816_F0.5260.14
27_S830_A0.5260.14
211_E791_F0.5260.14
383_S758_L0.5260.14
130_W623_Y0.5250.14
68_Y742_D0.5250.14
100_G258_F0.5250.14
342_S511_P0.5250.14
343_L782_A0.5240.14
399_K623_Y0.5240.14
395_I829_L0.5240.14
206_G748_G0.5240.14
271_Y763_F0.5230.14
11_L531_K0.5230.14
434_M532_A0.5230.14
57_I404_S0.5210.14
805_R811_S0.5210.14
412_L583_G0.5210.14
304_T573_G0.5200.14
672_H830_A0.5200.14
741_V744_M0.5200.14
20_L848_I0.5190.14
187_K293_I0.5190.14
212_W215_A0.5180.14
161_P410_T0.5170.14
186_R678_A0.5170.14
416_F788_F0.5160.14
210_V213_L0.5160.14
740_S774_F0.5150.14
795_R832_R0.5140.14
60_L475_I0.5140.14
34_L128_I0.5140.14
142_F294_L0.5130.14
383_S781_L0.5130.14
805_R847_L0.5130.14
659_N772_T0.5120.14
134_S388_L0.5120.14
168_I680_L0.5120.14
437_V844_V0.5120.14
218_V221_F0.5120.14
407_M796_F0.5120.14
60_L645_T0.5110.14
92_A840_T0.5110.14
749_D801_F0.5110.14
355_L427_S0.5100.14
725_V801_F0.5100.14
220_Y729_N0.5100.14
394_P562_F0.5090.14
389_I716_Y0.5080.13
431_V570_L0.5080.13
355_L604_H0.5080.13
787_A820_Y0.5080.13
383_S794_E0.5070.13
77_R89_S0.5070.13
91_I208_S0.5060.13
173_I360_L0.5060.13
625_D775_N0.5060.13
345_L464_L0.5050.13
588_Q749_D0.5050.13
251_V834_N0.5050.13
512_L593_P0.5050.13
678_A782_A0.5050.13
474_L663_R0.5040.13
435_I729_N0.5030.13
551_H733_M0.5030.13
580_V701_L0.5030.13
349_V386_S0.5030.13
165_A297_F0.5010.13
369_P376_L0.5010.13
71_V837_L0.5000.13
206_G285_L0.5000.13
374_P418_F0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hqyA 2 0.3119 100 0.787 Contact Map
3gkrA 1 0.3329 99.7 0.934 Contact Map
1lrzA 1 0.3189 98.2 0.966 Contact Map
2wpxA 1 0.3178 96.4 0.975 Contact Map
3frmA 3 0.2862 96.1 0.976 Contact Map
4iusA 1 0.2921 96 0.976 Contact Map
2ft0A 2 0.229 93.9 0.979 Contact Map
3h4qA 1 0.1519 93.8 0.979 Contact Map
2ozhA 2 0.1647 93.7 0.979 Contact Map
3iwgA 2 0.2897 93.2 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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