GREMLIN Database
YEZG - Probable antitoxin YezG
UniProt: C0H3X4 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 151 (146)
Sequences: 253 (162)
Seq/√Len: 13.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_K66_K4.2361.00
18_G40_F3.3660.99
52_Q65_F3.3100.98
12_L23_I3.2050.98
83_H88_D3.1260.98
112_D115_A2.7440.95
22_K99_D2.6850.94
138_D141_D2.2820.87
135_L145_V2.1650.84
33_S69_L2.0750.81
41_R48_I1.9230.76
52_Q69_L1.8710.74
7_L78_E1.8660.74
124_I128_E1.8530.73
137_E145_V1.7980.71
5_Y8_I1.7900.71
28_E123_R1.7600.69
26_Y127_W1.7460.69
76_F92_T1.7420.68
54_I60_V1.6600.64
36_V76_F1.6530.64
81_T84_R1.6290.63
27_A76_F1.5950.61
128_E134_I1.5660.60
34_T77_E1.5490.59
42_T48_I1.5460.59
105_Q108_Y1.5380.58
104_F126_I1.5250.58
104_F127_W1.4630.54
66_K70_R1.4590.54
39_H53_D1.4370.53
54_I68_L1.4240.52
63_D68_L1.4200.52
12_L85_N1.4100.52
118_L126_I1.4020.51
93_N122_E1.3860.50
6_Q87_N1.3660.49
65_F85_N1.3510.48
97_T131_N1.3360.48
94_L108_Y1.3350.48
15_I49_I1.3330.48
56_S99_D1.2980.46
119_D122_E1.2870.45
76_F94_L1.2820.45
27_A36_V1.2500.43
15_I69_L1.2480.43
69_L123_R1.2440.43
93_N113_I1.2120.41
48_I113_I1.2030.41
60_V69_L1.1970.40
55_P75_L1.1900.40
36_V116_S1.1860.40
12_L27_A1.1820.40
40_F48_I1.1760.39
93_N109_N1.1690.39
45_N119_D1.1630.39
56_S62_K1.1540.38
26_Y95_T1.1300.37
18_G48_I1.1040.36
3_D44_E1.0950.35
57_H105_Q1.0940.35
31_D88_D1.0920.35
98_L102_G1.0910.35
142_K145_V1.0910.35
39_H45_N1.0900.35
9_G110_Y1.0760.34
68_L92_T1.0700.34
48_I58_Y1.0650.34
97_T105_Q1.0560.33
23_I92_T1.0560.33
60_V63_D1.0530.33
21_T59_N1.0510.33
26_Y126_I1.0300.32
65_F69_L1.0280.32
127_W132_L1.0140.32
26_Y39_H1.0000.31
53_D56_S0.9950.31
36_V118_L0.9900.30
125_A128_E0.9870.30
34_T73_R0.9830.30
138_D142_K0.9720.30
39_H130_K0.9570.29
4_L105_Q0.9430.28
23_I98_L0.9420.28
40_F58_Y0.9350.28
96_L112_D0.9290.28
25_L93_N0.9280.28
5_Y96_L0.9270.28
59_N67_T0.9260.28
95_T127_W0.9260.28
11_K71_E0.9200.27
46_N62_K0.9100.27
38_F42_T0.9070.27
19_E147_S0.8970.26
64_I69_L0.8970.26
63_D67_T0.8930.26
79_L108_Y0.8890.26
9_G102_G0.8890.26
21_T47_Q0.8830.26
115_A142_K0.8800.26
96_L106_L0.8780.26
39_H128_E0.8770.26
92_T112_D0.8720.25
64_I77_E0.8690.25
37_L116_S0.8660.25
88_D100_R0.8630.25
2_Q6_Q0.8620.25
73_R77_E0.8480.24
10_E14_D0.8480.24
28_E98_L0.8480.24
109_N125_A0.8360.24
37_L128_E0.8350.24
13_N98_L0.8340.24
54_I78_E0.8270.24
21_T80_R0.8270.24
70_R73_R0.8240.24
35_M138_D0.8110.23
121_Y130_K0.8100.23
32_D90_V0.8020.23
62_K70_R0.8000.23
50_Y53_D0.8000.23
103_E129_Y0.7940.22
28_E52_Q0.7830.22
42_T49_I0.7820.22
113_I118_L0.7780.22
138_D147_S0.7770.22
6_Q24_Y0.7720.22
119_D126_I0.7690.21
24_Y58_Y0.7520.21
10_E29_V0.7490.21
78_E117_E0.7440.21
65_F108_Y0.7430.21
15_I72_L0.7420.21
12_L112_D0.7400.20
33_S107_D0.7290.20
8_I17_P0.7280.20
103_E108_Y0.7260.20
59_N71_E0.7240.20
15_I65_F0.7240.20
42_T133_G0.7190.20
3_D60_V0.7160.20
135_L142_K0.7140.20
30_L33_S0.7140.20
8_I44_E0.7120.20
19_E53_D0.7100.19
33_S52_Q0.7080.19
38_F54_I0.7070.19
134_I145_V0.7030.19
61_S98_L0.7020.19
25_L35_M0.6930.19
60_V64_I0.6920.19
4_L12_L0.6880.19
86_N108_Y0.6780.18
2_Q98_L0.6760.18
74_E77_E0.6750.18
17_P72_L0.6740.18
138_D143_E0.6680.18
5_Y145_V0.6650.18
11_K19_E0.6590.18
50_Y128_E0.6500.18
12_L82_E0.6500.18
67_T74_E0.6330.17
28_E33_S0.6310.17
143_E147_S0.6300.17
93_N126_I0.6270.17
2_Q88_D0.6220.17
15_I106_L0.6210.17
41_R113_I0.6180.17
47_Q85_N0.6120.16
21_T85_N0.6120.16
139_E143_E0.6100.16
2_Q55_P0.6080.16
2_Q82_E0.6060.16
26_Y38_F0.6040.16
27_A43_P0.5980.16
58_Y68_L0.5960.16
27_A123_R0.5920.16
25_L51_S0.5900.16
113_I131_N0.5890.16
6_Q49_I0.5890.16
53_D87_N0.5840.16
23_I96_L0.5810.16
65_F123_R0.5810.16
62_K143_E0.5800.15
8_I133_G0.5770.15
45_N60_V0.5750.15
43_P47_Q0.5750.15
125_A141_D0.5740.15
63_D78_E0.5720.15
58_Y117_E0.5720.15
75_L87_N0.5660.15
4_L25_L0.5640.15
28_E94_L0.5630.15
74_E121_Y0.5560.15
18_G58_Y0.5530.15
61_S136_P0.5480.15
49_I87_N0.5430.14
2_Q14_D0.5400.14
138_D144_F0.5390.14
24_Y62_K0.5360.14
70_R97_T0.5340.14
30_L65_F0.5330.14
39_H111_D0.5330.14
137_E141_D0.5320.14
117_E136_P0.5290.14
37_L132_L0.5280.14
42_T132_L0.5260.14
7_L65_F0.5200.14
3_D23_I0.5150.14
44_E75_L0.5130.14
63_D66_K0.5110.14
26_Y37_L0.5100.14
56_S66_K0.5080.14
103_E122_E0.5070.14
88_D147_S0.5050.14
18_G42_T0.5040.13
119_D143_E0.5010.13
68_L94_L0.5000.13
26_Y94_L0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ia1A 2 0.9735 100 0.186 Contact Map
3nuaA 2 0.8808 38.5 0.942 Contact Map
2ywvA 2 0.8808 31.6 0.944 Contact Map
2h31A 6 0.7815 23.1 0.948 Contact Map
3kreA 2 0.8808 20 0.95 Contact Map
4etnA 1 0.4305 17.1 0.951 Contact Map
3r9rA 1 0.8874 12.6 0.954 Contact Map
2wjaA 1 0.4106 10.3 0.956 Contact Map
2gqrA 2 0.8874 10.2 0.956 Contact Map
4etmA 2 0.4503 9.8 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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