GREMLIN Database
YYZM - Uncharacterized protein YyzM
UniProt: C0H3V8 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 68 (59)
Sequences: 736 (425)
Seq/√Len: 55.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_A40_G3.2661.00
35_R44_S2.8901.00
51_E55_K2.5791.00
13_E23_N2.1071.00
13_E58_K2.0961.00
9_N26_K1.9641.00
6_F53_E1.8600.99
26_K37_K1.7950.99
12_V52_F1.7580.99
24_S39_E1.5290.98
26_K39_E1.5190.98
28_I35_R1.4760.97
13_E57_K1.4470.97
24_S61_V1.4460.97
35_R46_M1.4410.97
6_F27_I1.4180.96
28_I44_S1.4070.96
30_M34_I1.4040.96
17_P23_N1.3980.96
21_G43_H1.3850.96
52_F56_L1.3560.95
19_P40_G1.3490.95
7_G62_K1.3300.95
25_W36_I1.3040.94
48_P51_E1.2980.94
6_F52_F1.2570.93
11_I61_V1.1800.91
24_S60_L1.1380.89
14_M55_K1.1080.88
11_I39_E1.0800.86
12_V27_I1.0670.86
8_L30_M1.0600.85
7_G27_I1.0530.85
53_E56_L1.0400.84
14_M52_F1.0230.83
43_H55_K0.9990.82
40_G43_H0.9520.79
25_W45_V0.9340.77
36_I52_F0.9120.76
29_R46_M0.8410.69
7_G61_V0.8370.69
34_I53_E0.7920.65
24_S45_V0.7880.64
6_F56_L0.7770.63
28_I34_I0.7540.61
19_P53_E0.7390.59
19_P48_P0.7370.59
39_E61_V0.7200.57
51_E54_R0.7160.57
22_A39_E0.7050.56
37_K42_S0.6880.54
43_H48_P0.6850.54
6_F59_V0.6830.53
14_M46_M0.6830.53
47_I52_F0.6600.51
13_E60_L0.6550.50
34_I56_L0.6500.50
9_N50_R0.6450.49
21_G47_I0.6340.48
56_L59_V0.6330.48
30_M56_L0.6110.46
11_I24_S0.6090.45
5_D8_L0.6000.45
27_I30_M0.5930.44
14_M59_V0.5770.42
19_P22_A0.5750.42
37_K44_S0.5710.41
7_G10_D0.5700.41
13_E62_K0.5690.41
42_S46_M0.5580.40
12_V56_L0.5560.40
47_I51_E0.5520.39
24_S42_S0.5500.39
14_M36_I0.5470.39
14_M51_E0.5430.39
36_I40_G0.5420.38
6_F12_V0.5410.38
36_I45_V0.5370.38
14_M57_K0.5300.37
32_M50_R0.5260.37
28_I55_K0.5190.36
14_M44_S0.5160.36
24_S32_M0.5150.36
30_M52_F0.5130.36
29_R33_D0.5130.36
39_E43_H0.5130.36
35_R50_R0.5060.35
23_N60_L0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3na7A 1 0.6912 47 0.89 Contact Map
1vq8Z 1 0.6324 16 0.913 Contact Map
4p1tA 1 0.6176 15.4 0.914 Contact Map
2yk0A 1 0.5882 14.8 0.915 Contact Map
4hw9A 3 0.9118 13.2 0.917 Contact Map
2e9hA 1 0.9559 11.9 0.918 Contact Map
3h2yA 1 0.0588 11.6 0.918 Contact Map
3sgiA 1 0.2794 10.8 0.92 Contact Map
4aybN 1 0.4853 10.8 0.92 Contact Map
5ajiA 3 0.8971 10.3 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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