GREMLIN Database
PTMA - Mannitol-specific phosphotransferase enzyme IIA component
UniProt: C0H3V2 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 143 (135)
Sequences: 6860 (5282)
Seq/√Len: 454.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
94_K127_I3.3391.00
6_K133_E2.5611.00
131_S134_D2.2621.00
23_K40_I2.2531.00
26_G40_I2.1501.00
27_Q31_D2.1171.00
38_D70_E2.0571.00
36_T72_L2.0341.00
81_I96_V1.9931.00
25_A98_G1.9561.00
124_E128_S1.9481.00
10_K28_T1.9401.00
15_V24_L1.9291.00
43_M98_G1.8451.00
14_T82_P1.8411.00
17_S20_E1.8381.00
34_Y73_H1.7871.00
8_N32_N1.7721.00
12_N82_P1.7331.00
30_I35_V1.6981.00
84_G94_K1.6741.00
13_Q79_I1.6611.00
34_Y75_G1.6591.00
15_V21_A1.6531.00
12_N80_Q1.6181.00
7_E32_N1.6121.00
41_S45_E1.5891.00
75_G100_A1.5791.00
25_A79_I1.5571.00
71_V100_A1.5361.00
39_Y100_A1.4831.00
19_E48_E1.4781.00
86_E92_T1.4371.00
74_S102_K1.4351.00
129_A135_L1.4291.00
16_S20_E1.4161.00
45_E48_E1.4151.00
130_K134_D1.4081.00
23_K44_F1.3991.00
6_K136_I1.3801.00
57_F94_K1.3731.00
42_K45_E1.3571.00
21_A96_V1.3531.00
42_K63_G1.3501.00
81_I84_G1.2951.00
10_K24_L1.2841.00
28_T32_N1.2781.00
11_L80_Q1.2781.00
28_T31_D1.2491.00
56_N123_I1.2461.00
133_E137_A1.2441.00
19_E44_F1.2371.00
22_I43_M1.2361.00
47_E54_M1.2351.00
26_G43_M1.1871.00
36_T70_E1.1841.00
129_A134_D1.1701.00
93_A96_V1.1531.00
87_Y96_V1.1511.00
69_S103_N1.1421.00
78_I135_L1.1291.00
123_I127_I1.1221.00
45_E49_T1.1181.00
5_A8_N1.1161.00
13_Q24_L1.0701.00
40_I44_F1.0621.00
6_K132_E1.0471.00
35_V39_Y1.0361.00
19_E23_K1.0151.00
125_R138_I1.0141.00
47_E52_T1.0131.00
10_K13_Q1.0101.00
95_V127_I0.9961.00
15_V81_I0.9901.00
24_L28_T0.9901.00
111_S115_I0.9771.00
65_E70_E0.9771.00
84_G92_T0.9621.00
26_G98_G0.9601.00
86_E90_G0.9581.00
74_S101_G0.9551.00
30_I37_E0.9471.00
11_L135_L0.9411.00
14_T83_E0.9341.00
116_I122_N0.9321.00
132_E136_I0.9311.00
9_I132_E0.9201.00
33_G72_L0.9141.00
129_A138_I0.9141.00
114_A118_S0.9121.00
80_Q135_L0.9081.00
27_Q30_I0.9031.00
28_T77_S0.8991.00
76_I109_I0.8981.00
20_E23_K0.8971.00
29_L77_S0.8921.00
9_I135_L0.8911.00
81_I94_K0.8891.00
119_E122_N0.8881.00
134_D137_A0.8811.00
44_F48_E0.8721.00
18_K88_G0.8611.00
78_I95_V0.8591.00
29_L100_A0.8561.00
30_I40_I0.8461.00
125_R128_S0.8431.00
136_I140_N0.8411.00
23_K41_S0.8361.00
20_E24_L0.8241.00
122_N138_I0.8191.00
21_A81_I0.8121.00
80_Q95_V0.8091.00
37_E41_S0.8091.00
22_I40_I0.8071.00
74_S105_E0.7911.00
16_S83_E0.7891.00
24_L27_Q0.7881.00
11_L132_E0.7871.00
111_S114_A0.7841.00
24_L79_I0.7841.00
39_Y43_M0.7811.00
42_K70_E0.7631.00
60_I110_L0.7581.00
79_I98_G0.7581.00
38_D42_K0.7511.00
27_Q40_I0.7501.00
137_A140_N0.7431.00
42_K65_E0.7361.00
18_K47_E0.7241.00
81_I85_V0.7111.00
78_I97_F0.7071.00
8_N34_Y0.7041.00
25_A77_S0.7021.00
58_I117_C0.6961.00
5_A73_H0.6921.00
113_I117_C0.6911.00
23_K27_Q0.6901.00
21_A85_V0.6891.00
55_G58_I0.6861.00
101_G109_I0.6811.00
15_V79_I0.6801.00
5_A32_N0.6801.00
106_H110_L0.6761.00
125_R134_D0.6701.00
116_I139_F0.6631.00
83_E94_K0.6621.00
46_R61_P0.6611.00
13_Q82_P0.6601.00
57_F127_I0.6571.00
77_S98_G0.6551.00
88_G91_N0.6551.00
22_I44_F0.6471.00
114_A117_C0.6421.00
53_F91_N0.6370.99
29_L75_G0.6310.99
12_N130_K0.6300.99
46_R50_S0.6300.99
29_L35_V0.6170.99
120_E124_E0.6150.99
58_I123_I0.6080.99
9_I136_I0.6020.99
59_A93_A0.6020.99
14_T24_L0.5980.99
39_Y98_G0.5950.99
38_D41_S0.5840.99
5_A34_Y0.5820.99
76_I97_F0.5820.99
26_G30_I0.5800.99
77_S100_A0.5770.99
10_K132_E0.5720.99
29_L39_Y0.5690.99
101_G106_H0.5660.99
46_R52_T0.5650.99
132_E135_L0.5640.99
53_F89_E0.5620.99
5_A136_I0.5600.99
97_F113_I0.5600.99
47_E51_S0.5580.99
71_V75_G0.5510.98
112_N116_I0.5490.98
125_R129_A0.5390.98
56_N91_N0.5380.98
121_E125_R0.5340.98
38_D69_S0.5340.98
65_E71_V0.5330.98
107_L111_S0.5300.98
115_I119_E0.5300.98
18_K22_I0.5270.98
23_K37_E0.5230.98
39_Y63_G0.5210.98
4_L78_I0.5210.98
39_Y75_G0.5190.98
108_D111_S0.5170.98
108_D115_I0.5160.98
124_E127_I0.5160.98
53_F87_Y0.5100.98
25_A96_V0.5100.98
10_K79_I0.5100.98
106_H114_A0.5030.97
80_Q130_K0.5010.97
80_Q126_L0.5010.97
126_L135_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a3aA 2 1 100 0.158 Contact Map
1a6jA 4 0.979 100 0.168 Contact Map
2oqtA 2 0.979 100 0.172 Contact Map
3bjvA 2 0.979 100 0.177 Contact Map
2oq3A 1 0.972 100 0.185 Contact Map
2a0jA 1 0.958 100 0.191 Contact Map
4m62S 1 0.979 100 0.194 Contact Map
3oxpA 2 0.979 100 0.194 Contact Map
3urrA 2 0.979 100 0.198 Contact Map
3t43A 2 0.8741 100 0.248 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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