GREMLIN Database
YXZK - Putative integral membrane protein YxzK
UniProt: C0H3T7 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 134 (114)
Sequences: 1830 (1415)
Seq/√Len: 132.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_F44_C4.5571.00
43_I47_L2.7891.00
108_F111_Q2.7641.00
105_A109_A2.6991.00
107_G111_Q2.4671.00
39_V43_I2.3681.00
104_I108_F2.3621.00
24_Q36_V2.1501.00
97_L101_V2.1341.00
20_G33_G1.9021.00
15_V19_I1.9001.00
16_F40_L1.8341.00
87_N90_M1.7961.00
90_M94_T1.7751.00
78_I81_P1.7671.00
36_V40_L1.7671.00
17_F21_E1.7561.00
8_L54_I1.7501.00
9_Q58_G1.7461.00
21_E25_H1.7021.00
19_I44_C1.6931.00
84_I91_L1.6381.00
17_F34_S1.5881.00
34_S69_L1.5721.00
22_A26_L1.5431.00
109_A112_L1.5071.00
51_P54_I1.4901.00
108_F112_L1.4881.00
38_L74_M1.4621.00
32_S73_A1.4591.00
52_V55_I1.4281.00
112_L116_K1.3891.00
93_I97_L1.3711.00
40_L44_C1.3691.00
77_V80_Y1.3621.00
23_I26_L1.3331.00
52_V56_E1.2601.00
48_R51_P1.2401.00
56_E60_G1.2020.99
80_Y83_L1.1870.99
23_I40_L1.1840.99
82_S85_S1.1650.99
116_K119_K1.1440.99
110_S114_E1.1200.99
24_Q28_H1.1130.99
113_L116_K1.1040.99
81_P85_S1.1030.99
10_V58_G1.0950.99
16_F20_G1.0850.99
39_V61_F1.0650.99
82_S86_F1.0610.99
38_L110_S1.0490.99
20_G36_V1.0290.98
44_C50_V1.0170.98
83_L87_N1.0120.98
102_T106_A1.0110.98
64_S73_A1.0090.98
78_I96_V1.0060.98
22_A25_H0.9910.98
35_I67_P0.9860.98
24_Q33_G0.9860.98
95_V102_T0.9820.98
106_A110_S0.9820.98
8_L11_L0.9750.98
24_Q27_F0.9740.98
23_I36_V0.9740.98
67_P71_I0.9500.97
13_L58_G0.9450.97
23_I56_E0.9450.97
112_L115_K0.9430.97
41_L50_V0.9390.97
44_C49_I0.9340.97
20_G76_G0.9180.97
49_I52_V0.9130.97
9_Q16_F0.8930.96
21_E33_G0.8880.96
38_L55_I0.8850.96
23_I28_H0.8570.95
42_L46_G0.8530.95
87_N91_L0.8430.95
100_I104_I0.8400.95
19_I40_L0.8390.95
99_T102_T0.8200.94
35_I63_L0.8160.94
10_V20_G0.8010.93
70_F73_A0.7970.93
50_V55_I0.7940.93
56_E76_G0.7860.93
14_Y106_A0.7840.92
65_F68_L0.7820.92
6_I57_D0.7700.92
19_I118_K0.7660.92
17_F32_S0.7650.91
23_I27_F0.7530.91
12_I15_V0.7400.90
79_N82_S0.7390.90
8_L53_S0.7390.90
63_L66_L0.7350.90
44_C47_L0.7330.90
9_Q61_F0.7330.90
20_G40_L0.7320.90
39_V42_L0.7300.89
14_Y76_G0.7280.89
62_L67_P0.7260.89
55_I63_L0.7230.89
93_I119_K0.7200.89
67_P74_M0.7140.88
53_S62_L0.7040.88
43_I109_A0.7030.88
95_V99_T0.6980.87
24_Q29_L0.6910.87
10_V98_S0.6830.86
74_M81_P0.6770.86
111_Q116_K0.6750.85
34_S103_I0.6640.85
50_V54_I0.6600.84
75_T78_I0.6550.84
31_V37_G0.6550.84
94_T103_I0.6440.83
110_S113_L0.6430.83
99_T103_I0.6370.82
107_G116_K0.6360.82
8_L12_I0.6330.82
46_G49_I0.6300.81
30_P35_I0.6300.81
33_G36_V0.6290.81
74_M77_V0.6260.81
50_V66_L0.6260.81
67_P98_S0.6200.80
14_Y20_G0.6200.80
52_V87_N0.6190.80
22_A96_V0.6080.79
28_H39_V0.6050.79
61_F66_L0.6030.78
7_I11_L0.6020.78
25_H84_I0.5990.78
48_R52_V0.5890.77
52_V59_A0.5880.77
34_S42_L0.5880.77
66_L102_T0.5850.76
74_M80_Y0.5820.76
68_L83_L0.5810.76
20_G38_L0.5790.76
27_F36_V0.5750.75
7_I117_A0.5730.75
44_C48_R0.5700.74
31_V76_G0.5690.74
17_F110_S0.5640.74
7_I26_L0.5640.74
75_T82_S0.5630.74
9_Q57_D0.5570.73
41_L55_I0.5550.73
94_T104_I0.5540.72
35_I75_T0.5530.72
56_E102_T0.5520.72
18_M100_I0.5490.72
13_L98_S0.5390.70
73_A84_I0.5390.70
51_P97_L0.5380.70
86_F97_L0.5380.70
59_A100_I0.5350.70
58_G80_Y0.5310.69
87_N97_L0.5220.68
66_L81_P0.5210.68
49_I53_S0.5170.67
17_F38_L0.5160.67
55_I59_A0.5130.67
16_F84_I0.5100.66
35_I80_Y0.5080.66
66_L70_F0.5080.66
24_Q31_V0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cz8A 2 0.9701 67.9 0.895 Contact Map
4mt1A 3 0.8507 61 0.9 Contact Map
4czbA 2 0.9701 55.5 0.903 Contact Map
3w9iA 3 0.8881 51.8 0.905 Contact Map
2kluA 1 0.3806 44.5 0.909 Contact Map
3aqpA 1 0.8358 41.3 0.911 Contact Map
4j72A 2 0.291 30.3 0.917 Contact Map
3ne5A 3 0.9104 30.1 0.917 Contact Map
4dx5A 3 0.9552 23.5 0.922 Contact Map
4bwzA 2 0.9254 23.1 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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